Result of FASTA (omim) for
pFN21AE2289
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2289, 508 aa
1>>>pF1KE2289 508 - 508 aa - 508 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.4096+/-0.000337; mu= 13.8630+/- 0.021
mean_var=102.6008+/-20.382, 0's: 0 Z-trim(117.8): 76 B-trim: 0 in 0/53
Lambda= 0.126619
statistics sampled from 30148 (30224) to 30148 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.722), E-opt: 0.2 (0.354), width: 16
Scan time: 10.090
The best scores are: opt bits E(85289)
NP_002420 (OMIM: 601807,611543) matrix metalloprot ( 508) 3547 658.4 1.4e-188
XP_016874798 (OMIM: 601807,611543) PREDICTED: matr ( 366) 2455 458.9 1.2e-128
XP_016874797 (OMIM: 601807,611543) PREDICTED: matr ( 387) 2051 385.1 2e-106
XP_006719464 (OMIM: 601807,611543) PREDICTED: matr ( 279) 1989 373.7 4e-103
XP_011536661 (OMIM: 601807,611543) PREDICTED: matr ( 426) 1802 339.6 1.1e-92
NP_001259030 (OMIM: 601807,611543) matrix metallop ( 305) 1190 227.7 3.7e-59
NP_005931 (OMIM: 185261) stromelysin-3 preproprote ( 488) 854 166.5 1.6e-40
NP_002416 (OMIM: 185260) stromelysin-2 preproprote ( 476) 848 165.4 3.4e-40
NP_002413 (OMIM: 185250,614466) stromelysin-1 prep ( 477) 805 157.5 7.9e-38
NP_004762 (OMIM: 604629,612529) matrix metalloprot ( 483) 723 142.5 2.6e-33
XP_011523529 (OMIM: 608417) PREDICTED: matrix meta ( 435) 658 130.6 8.9e-30
XP_011523531 (OMIM: 608417) PREDICTED: matrix meta ( 435) 658 130.6 8.9e-30
XP_011523530 (OMIM: 608417) PREDICTED: matrix meta ( 435) 658 130.6 8.9e-30
XP_011523528 (OMIM: 608417) PREDICTED: matrix meta ( 435) 658 130.6 8.9e-30
NP_077278 (OMIM: 608417) matrix metalloproteinase- ( 520) 658 130.7 1e-29
NP_002418 (OMIM: 250400,600108,602111) collagenase ( 471) 654 129.9 1.6e-29
NP_004986 (OMIM: 277950,600754) matrix metalloprot ( 582) 633 126.1 2.7e-28
XP_011523532 (OMIM: 608417) PREDICTED: matrix meta ( 418) 622 124.0 8.2e-28
NP_116568 (OMIM: 608417) matrix metalloproteinase- ( 393) 614 122.6 2.2e-27
XP_011523533 (OMIM: 608417) PREDICTED: matrix meta ( 390) 613 122.4 2.4e-27
NP_002417 (OMIM: 601046) macrophage metalloelastas ( 470) 607 121.3 6e-27
NP_002412 (OMIM: 120353,226600,606963) interstitia ( 469) 589 118.1 5.9e-26
NP_001139410 (OMIM: 120353,226600,606963) intersti ( 403) 562 113.1 1.6e-24
XP_016880552 (OMIM: 608417) PREDICTED: matrix meta ( 378) 532 107.6 6.7e-23
XP_016880553 (OMIM: 608417) PREDICTED: matrix meta ( 378) 532 107.6 6.7e-23
XP_016880551 (OMIM: 608417) PREDICTED: matrix meta ( 378) 532 107.6 6.7e-23
NP_002414 (OMIM: 178990) matrilysin preproprotein ( 267) 507 102.9 1.2e-21
XP_016874796 (OMIM: 602285) PREDICTED: matrix meta ( 434) 498 101.4 5.6e-21
XP_016883087 (OMIM: 604871) PREDICTED: matrix meta ( 614) 497 101.3 8.4e-21
NP_006681 (OMIM: 604871) matrix metalloproteinase- ( 645) 497 101.3 8.8e-21
XP_016883086 (OMIM: 604871) PREDICTED: matrix meta ( 591) 496 101.1 9.3e-21
XP_016880550 (OMIM: 608417) PREDICTED: matrix meta ( 409) 491 100.1 1.3e-20
XP_011523534 (OMIM: 608417) PREDICTED: matrix meta ( 494) 491 100.2 1.5e-20
NP_068573 (OMIM: 605470) matrix metalloproteinase- ( 261) 475 97.1 6.8e-20
NP_005932 (OMIM: 602262) matrix metalloproteinase- ( 607) 479 98.0 8.1e-20
XP_011541138 (OMIM: 120355) PREDICTED: neutrophil ( 377) 475 97.2 9.2e-20
XP_011541136 (OMIM: 120355) PREDICTED: neutrophil ( 476) 475 97.2 1.1e-19
XP_011518521 (OMIM: 605470) PREDICTED: matrix meta ( 191) 467 95.5 1.5e-19
NP_001291371 (OMIM: 120355) neutrophil collagenase ( 444) 470 96.3 2e-19
XP_016873260 (OMIM: 120355) PREDICTED: neutrophil ( 444) 470 96.3 2e-19
NP_001291370 (OMIM: 120355) neutrophil collagenase ( 444) 470 96.3 2e-19
XP_011541137 (OMIM: 120355) PREDICTED: neutrophil ( 444) 470 96.3 2e-19
NP_002415 (OMIM: 120355) neutrophil collagenase is ( 467) 470 96.3 2.1e-19
XP_011523527 (OMIM: 608417) PREDICTED: matrix meta ( 445) 434 89.7 1.9e-17
NP_671724 (OMIM: 608416,616749) matrix metalloprot ( 569) 421 87.4 1.2e-16
XP_011536659 (OMIM: 602285) PREDICTED: matrix meta ( 519) 381 80.1 1.8e-14
XP_011536657 (OMIM: 602285) PREDICTED: matrix meta ( 519) 381 80.1 1.8e-14
XP_011536658 (OMIM: 602285) PREDICTED: matrix meta ( 519) 381 80.1 1.8e-14
NP_057239 (OMIM: 602285) matrix metalloproteinase- ( 603) 381 80.1 2e-14
NP_008914 (OMIM: 603321) matrix metalloproteinase- ( 390) 371 78.2 4.9e-14
>>NP_002420 (OMIM: 601807,611543) matrix metalloproteina (508 aa)
initn: 3547 init1: 3547 opt: 3547 Z-score: 3506.7 bits: 658.4 E(85289): 1.4e-188
Smith-Waterman score: 3547; 100.0% identity (100.0% similar) in 508 aa overlap (1-508:1-508)
10 20 30 40 50 60
pF1KE2 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 DIPELGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DIPELGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 FKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 RGKTYAFKGDYVWTVSDSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RGKTYAFKGDYVWTVSDSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 INFKMSPGFPKKLNRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 INFKMSPGFPKKLNRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 LFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQLRVEKGYPRNISHNWMHCRPRTIDTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQLRVEKGYPRNISHNWMHCRPRTIDTT
430 440 450 460 470 480
490 500
pF1KE2 PSGGNTTPSGTGITLDTTLSATETTFEY
::::::::::::::::::::::::::::
NP_002 PSGGNTTPSGTGITLDTTLSATETTFEY
490 500
>>XP_016874798 (OMIM: 601807,611543) PREDICTED: matrix m (366 aa)
initn: 2477 init1: 2455 opt: 2455 Z-score: 2430.7 bits: 458.9 E(85289): 1.2e-128
Smith-Waterman score: 2455; 99.4% identity (99.7% similar) in 357 aa overlap (1-357:1-357)
10 20 30 40 50 60
pF1KE2 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 DIPELGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DIPELGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 FKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 RGKTYAFKGDYVWTVSDSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRY
:::::::::::::::::::::::::::::::::::::::::::::::::::::: .:
XP_016 RGKTYAFKGDYVWTVSDSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGLRVLAV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 INFKMSPGFPKKLNRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKG
XP_016 GRASPN
>>XP_016874797 (OMIM: 601807,611543) PREDICTED: matrix m (387 aa)
initn: 2051 init1: 2051 opt: 2051 Z-score: 2031.5 bits: 385.1 E(85289): 2e-106
Smith-Waterman score: 2053; 90.9% identity (92.7% similar) in 342 aa overlap (1-333:1-340)
10 20 30 40 50 60
pF1KE2 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 DIPELGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DIPELGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 FKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGE
250 260 270 280 290 300
310 320 330 340 350
pF1KE2 R------GKTYAFKGD-YVWTV-SDSG-PGPLFRVSALWEGLPGNLDAAVYSPRTQWIHF
:. .. .: .:: :: : .: : :: :
XP_016 APPLQAVGRRWGQPADPEAWTNGSDMGLQHEQWR--APWEDLCFQGGLCVDCIRFRTGPL
310 320 330 340 350
360 370 380 390 400 410
pF1KE2 FKGDKVWRYINFKMSPGFPKKLNRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDF
XP_016 VPSVCPLGGAPRKPGCCCLLASNTMDSLL
360 370 380
>>XP_006719464 (OMIM: 601807,611543) PREDICTED: matrix m (279 aa)
initn: 1989 init1: 1989 opt: 1989 Z-score: 1972.4 bits: 373.7 E(85289): 4e-103
Smith-Waterman score: 1989; 100.0% identity (100.0% similar) in 279 aa overlap (230-508:1-279)
200 210 220 230 240 250
pF1KE2 TYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPHFKLHPDDVAGIQALYGKKS
::::::::::::::::::::::::::::::
XP_006 MAPVYEGYRPHFKLHPDDVAGIQALYGKKS
10 20 30
260 270 280 290 300 310
pF1KE2 PVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGPRGKTYAFKGDYVWTVSDSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGPRGKTYAFKGDYVWTVSDSG
40 50 60 70 80 90
320 330 340 350 360 370
pF1KE2 PGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRYINFKMSPGFPKKLNRVEPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRYINFKMSPGFPKKLNRVEPN
100 110 120 130 140 150
380 390 400 410 420 430
pF1KE2 LDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQDGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQDGR
160 170 180 190 200 210
440 450 460 470 480 490
pF1KE2 VYFFKGKVYWRLNQQLRVEKGYPRNISHNWMHCRPRTIDTTPSGGNTTPSGTGITLDTTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VYFFKGKVYWRLNQQLRVEKGYPRNISHNWMHCRPRTIDTTPSGGNTTPSGTGITLDTTL
220 230 240 250 260 270
500
pF1KE2 SATETTFEY
:::::::::
XP_006 SATETTFEY
>>XP_011536661 (OMIM: 601807,611543) PREDICTED: matrix m (426 aa)
initn: 1802 init1: 1802 opt: 1802 Z-score: 1785.1 bits: 339.6 E(85289): 1.1e-92
Smith-Waterman score: 2807; 83.9% identity (83.9% similar) in 508 aa overlap (1-508:1-426)
10 20 30 40 50 60
pF1KE2 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPG------
130 140 150 160 170
190 200 210 220 230 240
pF1KE2 DIPELGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPH
XP_011 ------------------------------------------------------------
250 260 270 280 290 300
pF1KE2 FKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGP
::::::::::::::::::::::::::::::::::::::::::::
XP_011 ----------------KKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGP
180 190 200 210
310 320 330 340 350 360
pF1KE2 RGKTYAFKGDYVWTVSDSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGKTYAFKGDYVWTVSDSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRY
220 230 240 250 260 270
370 380 390 400 410 420
pF1KE2 INFKMSPGFPKKLNRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 INFKMSPGFPKKLNRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKG
280 290 300 310 320 330
430 440 450 460 470 480
pF1KE2 LFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQLRVEKGYPRNISHNWMHCRPRTIDTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQLRVEKGYPRNISHNWMHCRPRTIDTT
340 350 360 370 380 390
490 500
pF1KE2 PSGGNTTPSGTGITLDTTLSATETTFEY
::::::::::::::::::::::::::::
XP_011 PSGGNTTPSGTGITLDTTLSATETTFEY
400 410 420
>>NP_001259030 (OMIM: 601807,611543) matrix metalloprote (305 aa)
initn: 1190 init1: 1190 opt: 1190 Z-score: 1183.0 bits: 227.7 E(85289): 3.7e-59
Smith-Waterman score: 1313; 67.0% identity (68.7% similar) in 342 aa overlap (1-333:1-258)
10 20 30 40 50 60
pF1KE2 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPG------
130 140 150 160 170
190 200 210 220 230 240
pF1KE2 DIPELGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPH
NP_001 ------------------------------------------------------------
250 260 270 280 290 300
pF1KE2 FKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGP
:::::::::::::::::::::::::::::::::::::::::::
NP_001 ----------------KKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGE
180 190 200 210
310 320 330 340 350
pF1KE2 R------GKTYAFKGD-YVWTV-SDSG-PGPLFRVSALWEGLPGNLDAAVYSPRTQWIHF
:. .. .: .:: :: : .: : :: :
NP_001 APPLQAVGRRWGQPADPEAWTNGSDMGLQHEQWR--APWEDLCFQGGLCVDCIRFRTGPL
220 230 240 250 260 270
360 370 380 390 400 410
pF1KE2 FKGDKVWRYINFKMSPGFPKKLNRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDF
NP_001 VPSVCPLGGAPRKPGCCCLLASNTMDSLL
280 290 300
>>NP_005931 (OMIM: 185261) stromelysin-3 preproprotein [ (488 aa)
initn: 657 init1: 180 opt: 854 Z-score: 848.3 bits: 166.5 E(85289): 1.6e-40
Smith-Waterman score: 854; 36.0% identity (63.3% similar) in 411 aa overlap (80-472:75-480)
50 60 70 80 90 100
pF1KE2 PEDITEALRAFQEASELPVSGQLDDATRARMRQPRCGLEDPFN----QKTLKYLLL--GR
.: ::::. :: . .. : ..: ::
NP_005 RRGPQPWHAALPSSPAPAPATQEAPRPASSLRPPRCGVPDPSDGLSARNRQKRFVLSGGR
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE2 WRKKHLTFRILNLPSTLPPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQS
:.: ::.::: .: : . .: .. .:.. ::.:.:::: ::. : ::: ..: .:
NP_005 WEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIMIDF-ARYW
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE2 SYCSNTFDGPGRVLAHADIPEL---GSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGL
. ::::: .:::: .:. :.:::: :: :: : .:..: .:::: ::.:::
NP_005 HGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHEFGHVLGL
170 180 190 200 210 220
230 240 250 260 270
pF1KE2 GHSRYSQALMAPVYEGYRPHFKLHPDDVAGIQALYGKKSPVIRDEEEE---ETELPTVPP
:. ..:::. : .: ..: ::: :.: :::. :.. .. .. . :
NP_005 QHTTAAKALMSAFYT-FRYPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEI
230 240 250 260 270 280
280 290 300 310 320 330
pF1KE2 VPTEPSPMPDPCSSELDAMMLGPRGKTYAFKGDYVWTVSDSG--PGPLFRVSALWEGLPG
.: ::. :: : . .::. ::. . ::. .:: . . :: .: :.:::.
NP_005 APLEPDAPPDACEASFDAVST-IRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPS
290 300 310 320 330 340
340 350 360 370 380 390
pF1KE2 NLDAAVYSPRTQWIHFFKGDKVWRYINFK--MSPGFPKKLNRVEPNLDAALYW-PLNQKV
.::: . . . : ::.: . : : . : ..:. .:. :. . ::: : : ..:.
NP_005 PVDAAFEDAQGH-IWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPEKNKI
350 360 370 380 390 400
400 410 420 430 440 450
pF1KE2 FLFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLN
..:.: ::.. .: : :. . :::.. .::.. :: .::..:..::...
NP_005 YFFRGRDYWRFHPSTRRVDSPVPRRATD-WRGVPSEIDAAFQDADGYAYFLRGRLYWKFD
410 420 430 440 450
460 470 480 490 500
pF1KE2 Q-QLRVEKGYPRNISHNWMHCRPRTIDTTPSGGNTTPSGTGITLDTTLSATETTFEY
.... .:.:: .. ... :
NP_005 PVKVKALEGFPRLVGPDFFGCAEPANTFL
460 470 480
>>NP_002416 (OMIM: 185260) stromelysin-2 preproprotein [ (476 aa)
initn: 645 init1: 178 opt: 848 Z-score: 842.6 bits: 165.4 E(85289): 3.4e-40
Smith-Waterman score: 848; 35.2% identity (62.0% similar) in 460 aa overlap (31-472:37-476)
10 20 30 40 50
pF1KE2 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPED---ITEAL
:: .: :.: .. .:. .: :.. .
NP_002 LVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVK---QFRRKDSNLIVKKI
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 RAFQEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLP
...:. : :.:.:: : ::.::::. : . ... . .::: :::.::.:
NP_002 QGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGM--PKWRKTHLTYRIVNYT
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 STLPPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVL
:: .. .:...:.. : .:.::::... : ::: .:: .. . .:::::. :
NP_002 PDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFY-SFDGPGHSL
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 AHADIPE---LGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVY
::: : :..:::.:: ::: . :.:: ..::::.::.::: :: ..::: :.:
NP_002 AHAYPPGPGLYGDIHFDDDEKWTEDA-SGTNLFLVAAHELGHSLGLFHSANTEALMYPLY
190 200 210 220 230
240 250 260 270 280 290
pF1KE2 EGYRP--HFKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPP--VPTEPSPMPDPCS
... .:.: ::: :::.::: : :: : :: ::. : :: :.
NP_002 NSFTELAQFRLSQDDVNGIQSLYGP--PPASTEE------PLVPTKSVPS-GSEMPAKCD
240 250 260 270 280 290
300 310 320 330 340
pF1KE2 SEL--DAMMLGPRGKTYAFKGDYVWTVSDSGPGPLFR-VSALWEGLPGNLDAAVYSPRTQ
: ::. ::. :: : : : .: : :. .::.: .::. :::: .
NP_002 PALSFDAISTL-RGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRD
300 310 320 330 340
350 360 370 380 390 400
pF1KE2 WIHFFKGDKVWRYINFKMSPGFPKKLNRV--EPNL---DAALYWPLNQKVFLFKGSGYWQ
. .:::.. : . ... :.:. .. . :.. :::. ..:...: .. ::.
NP_002 TVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWR
350 360 370 380 390 400
410 420 430 440 450 460
pF1KE2 WDELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQLRVEKGYP
.:: ... ...:. : : :: . .:... : :::.:. .... . :.
NP_002 FDENSQSMEQGFPRLIADDFPGVEPKVDAVLQ-AFGFFYFFSGSSQFEFDPNARMVTHIL
410 420 430 440 450 460
470 480 490 500
pF1KE2 RNISHNWMHCRPRTIDTTPSGGNTTPSGTGITLDTTLSATETTFEY
. :..:.::
NP_002 K--SNSWLHC
470
>>NP_002413 (OMIM: 185250,614466) stromelysin-1 prepropr (477 aa)
initn: 720 init1: 181 opt: 805 Z-score: 800.1 bits: 157.5 E(85289): 7.9e-38
Smith-Waterman score: 805; 34.5% identity (59.2% similar) in 458 aa overlap (31-472:37-477)
10 20 30 40 50
pF1KE2 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPED-ITEALRA
:: .: :.: .. : ... .:
NP_002 LLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIRE
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 FQEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPST
.:. : :.:.::. : ::.::::. : . .:. . .::: :::.::.:
NP_002 MQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGI--PKWRKTHLTYRIVNYTPD
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 LPPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAH
:: .. .:...:.. : .:.::::... : ::: .:: :. . ::::: ::::
NP_002 LPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFY-PFDGPGNVLAH
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 ADIPELG---SVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEG
: : : ..:::.:: ::. : :.:: ..::::.::.::: :: ..::: :.:..
NP_002 AYAPGPGINGDAHFDDDEQWTKDT-TGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHS
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE2 YRP--HFKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVP--PVPTEPSPMPDPCSSE
.:.: ::. :::.::: : . : : :: ::: ::. : :.
NP_002 LTDLTRFRLSQDDINGIQSLYGPP-P-------DSPETPLVPTEPVPPEPGT-PANCDPA
250 260 270 280 290
300 310 320 330 340
pF1KE2 L--DAMMLGPRGKTYAFKGDYVWTVSDSGPGP-LFRVSALWEGLPGNLDAAVYSPRTQWI
: ::. ::. :: . : : : : .:..: .::...::: . .
NP_002 LSFDAVSTL-RGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLV
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE2 HFFKGDKVWRYINFKMSPGFPKKLNRV--EPN---LDAALYWPLNQKVFLFKGSGYWQWD
.:::.. : . .. :.:. .. . :. .:::. ..:...: . ::..:
NP_002 FIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFD
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE2 ELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQLRVEKGYPRN
: . ..:: : : :. .. .:.. . : ::: :. ... . . :
NP_002 EKRNSMEPGFPKQIAEDFPGIDSKIDAVFE-EFGFFYFFTGSSQLEFDPNAK--KVTHTL
420 430 440 450 460
470 480 490 500
pF1KE2 ISHNWMHCRPRTIDTTPSGGNTTPSGTGITLDTTLSATETTFEY
:..:..:
NP_002 KSNSWLNC
470
>>NP_004762 (OMIM: 604629,612529) matrix metalloproteina (483 aa)
initn: 486 init1: 143 opt: 723 Z-score: 719.1 bits: 142.5 E(85289): 2.6e-33
Smith-Waterman score: 723; 34.7% identity (58.2% similar) in 450 aa overlap (44-472:64-483)
20 30 40 50 60 70
pF1KE2 MTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAFQEASELPVSGQLD
:::. . . .. .: : :.:.::
NP_004 WRNNYRLAQAYLDKYYTNKEGHQIGEMVARGSNS-----MIRKIKELQAFFGLQVTGKLD
40 50 60 70 80
80 90 100 110 120 130
pF1KE2 DATRARMRQPRCGLEDPFNQKTLKYLLLG--RWRKKHLTFRILNLPSTLPPHTARAALRQ
..: ...::::. : : . :. : .:.:. ::.:: . .. . :...
NP_004 QTTMNVIKKPRCGVPDVANYR----LFPGEPKWKKNTLTYRISKYTPSMSSVEVDKAVEM
90 100 110 120 130 140
140 150 160 170 180
pF1KE2 AFQDWSNVAPLTFQEVQAGAADIRLSF-HGRQSSYCSNTFDGPGRVLAHADIPELG---S
:.: ::...::.: ....: ::: .:: .: ... : :::: .:::: : : .
NP_004 ALQAWSSAVPLSFVRINSGEADIMISFENGDHGD--SYPFDGPRGTLAHAFAPGEGLGGD
150 160 170 180 190 200
190 200 210 220 230 240
pF1KE2 VHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPH-FKLHPD
.:::. : :: :: : :: .:::: ::::::.:: .::: :.:. :. :.: :
NP_004 THFDNAEKWTMGT-NGFNLFTVAAHEFGHALGLAHSTDPSALMYPTYKYKNPYGFHLPKD
210 220 230 240 250 260
250 260 270 280 290 300
pF1KE2 DVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPC--SSELDAM-MLGPRGK
:: ::::::: .. . ::.: .: . .:: : :: .::. ::: .
NP_004 DVKGIQALYGPRKVFLGK--------PTLPHAPHHKPSIPDLCDSSSSFDAVTMLGK--E
270 280 290 300 310
310 320 330 340 350 360
pF1KE2 TYAFKGDYVWTVS---DSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRY
:: : . .: : ... . : .:.::: . .:::: . :
NP_004 LLLFKDRIFWRRQVHLRTGIRPS-TITSSFPQLMSNVDAAYEVAERGTAYFFKGPHYWIT
320 330 340 350 360 370
370 380 390 400 410
pF1KE2 INFKMS-P-------GFPKKLNRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFS
.:.:. : :::...... :::.: ::...: :. :...:: : .
NP_004 RGFQMQGPPRTIYDFGFPRHVQQI----DAAVYLREPQKTLFFVGDEYYSYDERKRKMEK
380 390 400 410 420
420 430 440 450 460 470
pF1KE2 SYPKPIKGLFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQLRVEKGYPRNISHNWMHC
.::: . :.:: .: .::. .: .:::.: .. . . : : .:. :
NP_004 DYPKNTEEEFSGVNGQIDAAVEL-NGYIYFFSGPKTYKYDTE--KEDVVSVVKSSSWIGC
430 440 450 460 470 480
480 490 500
pF1KE2 RPRTIDTTPSGGNTTPSGTGITLDTTLSATETTFEY
508 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 05:18:49 2016 done: Tue Nov 8 05:18:50 2016
Total Scan time: 10.090 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]