Result of FASTA (ccds) for
pFN21AE2246
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2246, 300 aa
1>>>pF1KE2246 300 - 300 aa - 300 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.9036+/-0.000724; mu= 15.6122+/- 0.044
mean_var=135.5740+/-25.754, 0's: 0 Z-trim(115.2): 56 B-trim: 11 in 1/52
Lambda= 0.110150
statistics sampled from 15707 (15768) to 15707 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.808), E-opt: 0.2 (0.484), width: 16
Scan time: 2.770
The best scores are: opt bits E(32554)
CCDS13532.1 TNFRSF6B gene_id:8771|Hs108|chr20 ( 300) 2139 350.4 9.5e-97
CCDS6326.1 TNFRSF11B gene_id:4982|Hs108|chr8 ( 401) 597 105.5 6.7e-23
CCDS145.1 TNFRSF1B gene_id:7133|Hs108|chr1 ( 461) 472 85.7 7e-17
CCDS8544.1 LTBR gene_id:4055|Hs108|chr12 ( 435) 417 77.0 2.9e-14
CCDS4921.1 TNFRSF21 gene_id:27242|Hs108|chr6 ( 655) 412 76.4 6.5e-14
CCDS59233.1 LTBR gene_id:4055|Hs108|chr12 ( 416) 405 75.0 1.1e-13
CCDS44046.1 TNFRSF14 gene_id:8764|Hs108|chr1 ( 283) 353 66.6 2.5e-11
CCDS74227.1 TNFRSF11A gene_id:8792|Hs108|chr18 ( 263) 342 64.8 8.1e-11
CCDS74228.1 TNFRSF11A gene_id:8792|Hs108|chr18 ( 337) 342 64.9 9.5e-11
>>CCDS13532.1 TNFRSF6B gene_id:8771|Hs108|chr20 (300 aa)
initn: 2139 init1: 2139 opt: 2139 Z-score: 1850.4 bits: 350.4 E(32554): 9.5e-97
Smith-Waterman score: 2139; 100.0% identity (100.0% similar) in 300 aa overlap (1-300:1-300)
10 20 30 40 50 60
pF1KE2 MRALEGPGLSLLCLVLALPALLPVPAVRGVAETPTYPWRDAETGERLVCAQCPPGTFVQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 MRALEGPGLSLLCLVLALPALLPVPAVRGVAETPTYPWRDAETGERLVCAQCPPGTFVQR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 PCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEARACHATHNRACRCRTGFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 PCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEARACHATHNRACRCRTGFF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSASSSSSEQCQPHRNCTALGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 AHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSASSSSSEQCQPHRNCTALGLA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 LNVPGSSSHDTLCTSCTGFPLSTRVPGAEECERAVIDFVAFQDISIKRLQRLLQALEAPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 LNVPGSSSHDTLCTSCTGFPLSTRVPGAEECERAVIDFVAFQDISIKRLQRLLQALEAPE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 GWGPTPRAGRAALQLKLRRRLTELLGAQDGALLVRLLQALRVARMPGLERSVRERFLPVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 GWGPTPRAGRAALQLKLRRRLTELLGAQDGALLVRLLQALRVARMPGLERSVRERFLPVH
250 260 270 280 290 300
>>CCDS6326.1 TNFRSF11B gene_id:4982|Hs108|chr8 (401 aa)
initn: 637 init1: 564 opt: 597 Z-score: 524.6 bits: 105.5 E(32554): 6.7e-23
Smith-Waterman score: 597; 37.7% identity (64.5% similar) in 231 aa overlap (10-236:3-227)
10 20 30 40 50
pF1KE2 MRALEGPGLSLLCLVLALPALLPVPAVRGVAET--PTYPWRDAETGERLVCAQCPPGTFV
.::: .: ..: . . :: : : : ::...:.: .:::::..
CCDS63 MNNLLCCAL---VFLDISIKWTTQETFPPKYLHYDEETSHQLLCDKCPPGTYL
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 QRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEARACHATHNRACRCRTG
.. : :.:.::: ..::. :. ..: ::. .: : . . :. ::::.:.:. :
CCDS63 KQHCTAKWKTVCAPCPDHYYTDSWHTSDECLYCSPVCKELQYVKQECNRTHNRVCECKEG
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 FFAHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSASSSSSEQCQPHRNCTALG
. . :::.: ::::: ::. ::: .:: :. :: : :: .::. :. : ::...:
CCDS63 RYLEIEFCLKHRSCPPGFGVVQAGTPERNTVCKRCPDGFFSNETSSKAPCRKHTNCSVFG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 LALNVPGSSSHDTLCTSCTGFPLSTRVPGAEE--CERAVIDFVAFQDISIKRLQRLLQAL
: :. :...::..: .: ::. : . ::.: . :.. .. . :. :.. :
CCDS63 LLLTQKGNATHDNIC---SGNSESTQKCGIDVTLCEEAFFRFAVPTKFTPNWLSVLVDNL
180 190 200 210 220
240 250 260 270 280 290
pF1KE2 EAPEGWGPTPRAGRAALQLKLRRRLTELLGAQDGALLVRLLQALRVARMPGLERSVRERF
CCDS63 PGTKVNAESVERIKRQHSSQEQTFQLLKLWKHQNKDQDIVKKIIQDIDLCENSVQRHIGH
230 240 250 260 270 280
>>CCDS145.1 TNFRSF1B gene_id:7133|Hs108|chr1 (461 aa)
initn: 446 init1: 234 opt: 472 Z-score: 416.5 bits: 85.7 E(32554): 7e-17
Smith-Waterman score: 472; 34.8% identity (58.1% similar) in 210 aa overlap (8-208:13-213)
10 20 30 40 50
pF1KE2 MRALEGPGLSLLCLVLALPALLPVPAVRGVAETPTYPWRDAETGER---LVCAQC
:: : . :::: . : : : : : .. . :..:
CCDS14 MAPVAVWAALAVGLELWAAAHALPAQV---AFTPYAPEPGSTCRLREYYDQTAQMCCSKC
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 PPGTFVQRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEARACHATHNRA
:: .. : . : :.: : :::.::.. .: :. :. . :..:: .::
CCDS14 SPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQVETQACTREQNRI
60 70 80 90 100 110
120 130 140 150 160
pF1KE2 CRCRTGFFA----HAG--FCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSASSSSSE
: :: :.. . : .: .: :: :: ::: .... :.:: ::::: ..::..
CCDS14 CTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVARPGTETSDVVCKPCAPGTFSNTTSSTD
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE2 QCQPHRNCTALGLALNVPGSSSHDTLCTSCTGFPLSTRVPGAEECERAVIDFVAFQDISI
:.::. :.... .::..: :..::: . : . .:::
CCDS14 ICRPHQICNVVA----IPGNASMDAVCTSTS--PTRSMAPGAVHLPQPVSTRSQHTQPTP
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE2 KRLQRLLQALEAPEGWGPTPRAGRAALQLKLRRRLTELLGAQDGALLVRLLQALRVARMP
CCDS14 EPSTAPSTSFLLPMGPSPPAEGSTGDFALPVGLIVGVTALGLLIIGVVNCVIMTQVKKKP
240 250 260 270 280 290
>>CCDS8544.1 LTBR gene_id:4055|Hs108|chr12 (435 aa)
initn: 366 init1: 182 opt: 417 Z-score: 369.6 bits: 77.0 E(32554): 2.9e-14
Smith-Waterman score: 434; 31.8% identity (52.6% similar) in 274 aa overlap (3-249:6-276)
10 20 30 40 50
pF1KE2 MRALEGPGLSLLCLVLALPALLPVPAVRGVAETPTYPW--RDAET-----GERLVCA
: .:::. :::.: .:: . ..: . :: : .:. :.
CCDS85 MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICCS
10 20 30 40 50 60
60 70 80 90 100
pF1KE2 QCPPGTFVQRPCRRDSPTTCGPCPPRHYTQFWNYL---ERCRYCNVLCGEREEEARACHA
.:::::.:. : : :.:. : :.. :::: . :: :. . : :: : .
CCDS85 RCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGL--EEIAPCTS
70 80 90 100 110
110 120 130 140 150 160
pF1KE2 THNRACRCRTGFFAHA-----GFCLEHASCPPGAGV-IAPGTPSQNTQCQPCPPGTFSAS
.. :::. :.: : : ..::::. . . . . :..: :: : :. .
CCDS85 KRKTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNT
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE2 SSSSEQCQPHRNCTALGLALNVPGSSSHDTLCTSCTGFPLSTRVPGAEECERAVIDFVAF
:: : .:::: : ::. .::... :: : . :: .. :. ... .. :
CCDS85 SSPSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLE-PLPPEMSGTMLMLAVLLPLAFF
180 190 200 210 220 230
230 240 250 260 270
pF1KE2 QDI---------SIKRLQRLLQAL--EAPEGWGPTPRAGRAALQLKLRRRLTELLGAQDG
. : : : : .: . :.: ::.: ::
CCDS85 LLLATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPI
240 250 260 270 280 290
280 290 300
pF1KE2 ALLVRLLQALRVARMPGLERSVRERFLPVH
CCDS85 SGDVSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHVTGGSMTI
300 310 320 330 340 350
>>CCDS4921.1 TNFRSF21 gene_id:27242|Hs108|chr6 (655 aa)
initn: 408 init1: 408 opt: 412 Z-score: 363.2 bits: 76.4 E(32554): 6.5e-14
Smith-Waterman score: 412; 33.2% identity (54.3% similar) in 199 aa overlap (10-207:29-226)
10 20 30 40
pF1KE2 MRALEGPGLSLLCLVLALPALLPVPAVRGVAETPTYPWRDA
::: : . : . : .. :: :
CCDS49 MGTSPSSSTALASCSRIARRATATMIAGSLLLLGF-LSTTTAQPEQKASNLIGTYRHVDR
10 20 30 40 50
50 60 70 80 90 100
pF1KE2 ETGERLVCAQCPPGTFVQRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEE
::. :.: .:: ::.:.. : : .:. :: .:. : .:.:. :. : :
CCDS49 ATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVGTFTRHENGIEKCHDCSQPCPWPMIE
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE2 ARACHATHNRACRCRTGFFAHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSAS
: : .: : : :.: . : :. :: : :: :: .....:. : ::::
CCDS49 KLPCAALTDRECTCPPGMFQSNATCAPHTVCPVGWGVRKKGTETEDVRCKQCARGTFSDV
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE2 SSSSEQCQPHRNCTALGLALNVPGSSSHDTLCTSCTGFPLSTR-VPGAEECERAVIDFVA
:: .:. . .: . .:.. ::.. :..: . .: :: ::
CCDS49 PSSVMKCKAYTDCLSQNLVVIKPGTKETDNVCGTLPSFSSSTSPSPGTAIFPRPEHMETH
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE2 FQDISIKRLQRLLQALEAPEGWGPTPRAGRAALQLKLRRRLTELLGAQDGALLVRLLQAL
CCDS49 EVPSSTYVPKGMNSTESNSSASVRPKVLSSIQEGTVPDNTSSARGKEDVNKTLPNLQVVN
240 250 260 270 280 290
>>CCDS59233.1 LTBR gene_id:4055|Hs108|chr12 (416 aa)
initn: 365 init1: 182 opt: 405 Z-score: 359.5 bits: 75.0 E(32554): 1.1e-13
Smith-Waterman score: 422; 31.0% identity (52.9% similar) in 255 aa overlap (16-249:6-257)
10 20 30 40 50
pF1KE2 MRALEGPGLSLLCLVLALPALLPVPAVRGVAETPTYPWRDA-ETGERLVCAQCPPGTFVQ
..: . : :: . .: .. : .:. :..:::::.:.
CCDS59 MEATGISLASQLKVPPYASENQTCRDQEKEYYEPQHRICCSRCPPGTYVS
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 RPCRRDSPTTCGPCPPRHYTQFWNYL---ERCRYCNVLCGEREEEARACHATHNRACRCR
: : :.:. : :.. :::: . :: :. . : :: : . .. :::.
CCDS59 AKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMG--LEEIAPCTSKRKTQCRCQ
60 70 80 90 100
120 130 140 150 160 170
pF1KE2 TGFFAHA-----GFCLEHASCPPGAGV-IAPGTPSQNTQCQPCPPGTFSASSSSSEQCQP
:.: : : ..::::. . . . . :..: :: : :. .:: : .:::
CCDS59 PGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSSPSARCQP
110 120 130 140 150 160
180 190 200 210 220
pF1KE2 HRNCTALGLALNVPGSSSHDTLCTSCTGFPLSTRVPGAEECERAVIDFVAFQDI------
: : ::. .::... :: : . :: .. :. ... .. : .
CCDS59 HTRCENQGLVEAAPGTAQSDTTCKNPLE-PLPPEMSGTMLMLAVLLPLAFFLLLATVFSC
170 180 190 200 210 220
230 240 250 260 270
pF1KE2 ---SIKRLQRLLQAL--EAPEGWGPTPRAGRAALQLKLRRRLTELLGAQDGALLVRLLQA
: : : : .: . :.: ::.: ::
CCDS59 IWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISGDVSPVST
230 240 250 260 270 280
>>CCDS44046.1 TNFRSF14 gene_id:8764|Hs108|chr1 (283 aa)
initn: 272 init1: 145 opt: 353 Z-score: 316.8 bits: 66.6 E(32554): 2.5e-11
Smith-Waterman score: 353; 34.0% identity (52.9% similar) in 191 aa overlap (7-189:16-200)
10 20 30 40 50
pF1KE2 MRALEGPGLSLLCLVLALPALLPVPAVRGVAETPTYPWRDAETGERLVCAQ
: ..: ::: : ..: .: . :. . .: . : .
CCDS44 MEPPGDWGPPPWRSTPKTDVLRLVLYL-TFLGAPCY--APALPSCKEDEYPVGSE-CCPK
10 20 30 40 50
60 70 80 90 100
pF1KE2 CPPGTFVQRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGERE--EEARACHATH
: :: :.. : . . :.: :::: : : : .: :. .: . .: : :.
CCDS44 CSPGYRVKEACGELTGTVCEPCPPGTYIAHLNGLSKCLQCQ-MCDPAMGLRASRNCSRTE
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE2 NRACRCRTGFFA------HAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSASSS
: .: : : : : . : .:. :: : :: ::.: :: ::::::: ...
CCDS44 NAVCGCSPGHFCIVQDGDHCAACRAYATSSPGQRVQKGGTESQDTLCQNCPPGTFSPNGT
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE2 SSEQCQPHRNCTALGLALNVPGSSSHDTLCTSCTGFPLSTRVPGAEECERAVIDFVAFQD
:.:: . .:. : .. ::::
CCDS44 L-EECQHQTKCSWLVTKAGAGTSSSHWVWWFLSGSLVIVIVCSTVGLIICVKRRKPRGDV
180 190 200 210 220 230
>>CCDS74227.1 TNFRSF11A gene_id:8792|Hs108|chr18 (263 aa)
initn: 300 init1: 168 opt: 342 Z-score: 307.7 bits: 64.8 E(32554): 8.1e-11
Smith-Waterman score: 342; 31.3% identity (55.4% similar) in 166 aa overlap (49-209:47-206)
20 30 40 50 60 70
pF1KE2 PALLPVPAVRGVAETPTYPWRDAETGERLVCAQCPPGTFVQRPCRRDSPTTCGPCPPRHY
: .: :: ... : : ..: :: : .:
CCDS74 LCALLARLQVALQIAPPCTSEKHYEHLGRCCNKCEPGKYMSSKCTTTSDSVCLPCGPDEY
20 30 40 50 60 70
80 90 100 110 120 130
pF1KE2 TQFWNYLERC---RYCNVLCGEREEEARACHATHNRACRCRTGFFAHAGF--CLEHASCP
. :: ..: . :.. :. . : ..: : : : .:. : ... :
CCDS74 LDSWNEEDKCLLHKVCDT--GKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRRNTECA
80 90 100 110 120 130
140 150 160 170 180 190
pF1KE2 PGAGVIAPGTPSQNTQCQPCPPGTFSASSSSSEQCQPHRNCTALGLALNVPGSSSHDTLC
:: :. : ...: :.:: : :: . ::...:.: ::: :: .. :. . :..:
CCDS74 PGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCRPWTNCTFLGKRVEHHGTEKSDAVC
140 150 160 170 180 190
200 210 220 230 240 250
pF1KE2 TSCTGFPLSTRVPGAEECERAVIDFVAFQDISIKRLQRLLQALEAPEGWGPTPRAGRAAL
.: : .: : :
CCDS74 SSS----LPARKPPNEPHVYLPGLIILLLFASVALVAAIIFGVCYRKKGKALTANLWHWI
200 210 220 230 240 250
>>CCDS74228.1 TNFRSF11A gene_id:8792|Hs108|chr18 (337 aa)
initn: 300 init1: 168 opt: 342 Z-score: 306.5 bits: 64.9 E(32554): 9.5e-11
Smith-Waterman score: 342; 31.3% identity (55.4% similar) in 166 aa overlap (49-209:47-206)
20 30 40 50 60 70
pF1KE2 PALLPVPAVRGVAETPTYPWRDAETGERLVCAQCPPGTFVQRPCRRDSPTTCGPCPPRHY
: .: :: ... : : ..: :: : .:
CCDS74 LCALLARLQVALQIAPPCTSEKHYEHLGRCCNKCEPGKYMSSKCTTTSDSVCLPCGPDEY
20 30 40 50 60 70
80 90 100 110 120 130
pF1KE2 TQFWNYLERC---RYCNVLCGEREEEARACHATHNRACRCRTGFFAHAGF--CLEHASCP
. :: ..: . :.. :. . : ..: : : : .:. : ... :
CCDS74 LDSWNEEDKCLLHKVCDT--GKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRRNTECA
80 90 100 110 120 130
140 150 160 170 180 190
pF1KE2 PGAGVIAPGTPSQNTQCQPCPPGTFSASSSSSEQCQPHRNCTALGLALNVPGSSSHDTLC
:: :. : ...: :.:: : :: . ::...:.: ::: :: .. :. . :..:
CCDS74 PGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCRPWTNCTFLGKRVEHHGTEKSDAVC
140 150 160 170 180 190
200 210 220 230 240 250
pF1KE2 TSCTGFPLSTRVPGAEECERAVIDFVAFQDISIKRLQRLLQALEAPEGWGPTPRAGRAAL
.: : .: : :
CCDS74 SSS----LPARKPPNEPHVYLPGLIILLLFASVALVAAIIFGVCYRKKGKALTGNVTGNS
200 210 220 230 240 250
300 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 13:00:33 2016 done: Sun Nov 6 13:00:33 2016
Total Scan time: 2.770 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]