Result of FASTA (omim) for
pFN21AE2245
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2245, 217 aa
1>>>pF1KE2245 217 - 217 aa - 217 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2563+/-0.000375; mu= 13.2577+/- 0.023
mean_var=68.4249+/-14.331, 0's: 0 Z-trim(113.3): 157 B-trim: 717 in 2/49
Lambda= 0.155048
statistics sampled from 22418 (22585) to 22418 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.653), E-opt: 0.2 (0.265), width: 16
Scan time: 5.830
The best scores are: opt bits E(85289)
NP_543152 (OMIM: 611437) dual specificity protein ( 217) 1419 326.4 2.2e-89
NP_001308448 (OMIM: 611437) dual specificity prote ( 121) 605 144.2 9e-35
NP_001135786 (OMIM: 611437) dual specificity prote ( 166) 601 143.3 2.2e-34
NP_009138 (OMIM: 608867) dual specificity protein ( 482) 344 86.1 1e-16
XP_016873431 (OMIM: 606780) PREDICTED: protein pho ( 559) 332 83.5 7.6e-16
NP_060327 (OMIM: 606780) protein phosphatase Sling ( 659) 332 83.5 8.7e-16
NP_001938 (OMIM: 602749) dual specificity protein ( 419) 328 82.5 1.1e-15
NP_004409 (OMIM: 603068) dual specificity protein ( 314) 313 79.1 9e-15
XP_016859035 (OMIM: 603068) PREDICTED: dual specif ( 342) 313 79.1 9.7e-15
XP_016883144 (OMIM: 616776) PREDICTED: dual specif ( 332) 310 78.4 1.5e-14
NP_001307407 (OMIM: 616776) dual specificity prote ( 232) 308 77.9 1.5e-14
NP_001937 (OMIM: 602748,615269) dual specificity p ( 381) 310 78.5 1.7e-14
NP_001386 (OMIM: 300134) dual specificity protein ( 384) 310 78.5 1.7e-14
XP_011529426 (OMIM: 300134) PREDICTED: dual specif ( 384) 310 78.5 1.7e-14
NP_001305432 (OMIM: 300134) dual specificity prote ( 384) 310 78.5 1.7e-14
XP_011529425 (OMIM: 300134) PREDICTED: dual specif ( 415) 310 78.5 1.8e-14
XP_016883145 (OMIM: 616776) PREDICTED: dual specif ( 311) 308 78.0 1.9e-14
XP_016883143 (OMIM: 616776) PREDICTED: dual specif ( 335) 308 78.0 2.1e-14
NP_542178 (OMIM: 616776) dual specificity protein ( 235) 306 77.5 2.1e-14
NP_001307408 (OMIM: 616776) dual specificity prote ( 295) 307 77.7 2.2e-14
NP_004408 (OMIM: 600714) dual specificity protein ( 367) 307 77.8 2.6e-14
XP_016883146 (OMIM: 616776) PREDICTED: dual specif ( 298) 305 77.3 3e-14
NP_001154802 (OMIM: 606778) protein phosphatase Sl ( 692) 304 77.3 6.9e-14
NP_001154803 (OMIM: 606778) protein phosphatase Sl ( 703) 304 77.3 7e-14
XP_011535410 (OMIM: 615814) PREDICTED: serine/thre ( 199) 297 75.4 7.4e-14
NP_001124173 (OMIM: 615814) serine/threonine/tyros ( 223) 297 75.4 8.1e-14
NP_660294 (OMIM: 615814) serine/threonine/tyrosine ( 223) 297 75.4 8.1e-14
XP_016874981 (OMIM: 606778) PREDICTED: protein pho ( 923) 304 77.4 8.8e-14
NP_476499 (OMIM: 602747) dual specificity protein ( 303) 298 75.7 9e-14
XP_011542730 (OMIM: 602747) PREDICTED: dual specif ( 303) 298 75.7 9e-14
XP_011536803 (OMIM: 606778) PREDICTED: protein pho ( 969) 304 77.4 9.1e-14
XP_005269042 (OMIM: 606778) PREDICTED: protein pho ( 969) 304 77.4 9.1e-14
XP_011536802 (OMIM: 606778) PREDICTED: protein pho ( 969) 304 77.4 9.1e-14
XP_016874980 (OMIM: 606778) PREDICTED: protein pho (1033) 304 77.4 9.6e-14
XP_005269041 (OMIM: 606778) PREDICTED: protein pho (1049) 304 77.4 9.7e-14
NP_061857 (OMIM: 606778) protein phosphatase Sling (1049) 304 77.4 9.7e-14
XP_011536799 (OMIM: 606778) PREDICTED: protein pho (1060) 304 77.4 9.8e-14
NP_001385 (OMIM: 602747) dual specificity protein ( 394) 298 75.8 1.1e-13
NP_004410 (OMIM: 603069) dual specificity protein ( 384) 294 74.9 2e-13
XP_016880743 (OMIM: 606779) PREDICTED: protein pho ( 480) 290 74.1 4.5e-13
XP_016880742 (OMIM: 606779) PREDICTED: protein pho ( 529) 290 74.1 4.9e-13
NP_009171 (OMIM: 604835) dual specificity protein ( 340) 287 73.3 5.4e-13
XP_016880741 (OMIM: 606779) PREDICTED: protein pho (1328) 290 74.3 1e-12
XP_011523708 (OMIM: 606779) PREDICTED: protein pho (1347) 290 74.3 1e-12
XP_011523709 (OMIM: 606779) PREDICTED: protein pho (1347) 290 74.3 1e-12
XP_011523707 (OMIM: 606779) PREDICTED: protein pho (1394) 290 74.3 1.1e-12
XP_006722212 (OMIM: 606779) PREDICTED: protein pho (1401) 290 74.3 1.1e-12
XP_011523706 (OMIM: 606779) PREDICTED: protein pho (1405) 290 74.3 1.1e-12
NP_203747 (OMIM: 606779) protein phosphatase Sling (1423) 290 74.4 1.1e-12
XP_005258116 (OMIM: 606779) PREDICTED: protein pho (1430) 290 74.4 1.1e-12
>>NP_543152 (OMIM: 611437) dual specificity protein phos (217 aa)
initn: 1419 init1: 1419 opt: 1419 Z-score: 1725.6 bits: 326.4 E(85289): 2.2e-89
Smith-Waterman score: 1419; 100.0% identity (100.0% similar) in 217 aa overlap (1-217:1-217)
10 20 30 40 50 60
pF1KE2 MYSLNQEIKAFSRNNLRKQCTRVTTLTGKKIIETWKDARIHVVEEVEPSSGGGCGYVQDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 MYSLNQEIKAFSRNNLRKQCTRVTTLTGKKIIETWKDARIHVVEEVEPSSGGGCGYVQDL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SSDLQVGVIKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVENAFLSDFTYKSISILDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 SSDLQVGVIKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVENAFLSDFTYKSISILDL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLMNSEQTSFTSAFSLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 PETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLMNSEQTSFTSAFSLV
130 140 150 160 170 180
190 200 210
pF1KE2 KNARPSICPNSGFMEQLRTYQEGKESNKCDRIQENSS
:::::::::::::::::::::::::::::::::::::
NP_543 KNARPSICPNSGFMEQLRTYQEGKESNKCDRIQENSS
190 200 210
>>NP_001308448 (OMIM: 611437) dual specificity protein p (121 aa)
initn: 601 init1: 601 opt: 605 Z-score: 745.2 bits: 144.2 E(85289): 9e-35
Smith-Waterman score: 605; 94.9% identity (98.0% similar) in 98 aa overlap (1-98:1-96)
10 20 30 40 50 60
pF1KE2 MYSLNQEIKAFSRNNLRKQCTRVTTLTGKKIIETWKDARIHVVEEVEPSSGGGCGYVQDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MYSLNQEIKAFSRNNLRKQCTRVTTLTGKKIIETWKDARIHVVEEVEPSSGGGCGYVQDL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SSDLQVGVIKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVENAFLSDFTYKSISILDL
::::::::::::::::::::::::::::::: ..::.
NP_001 SSDLQVGVIKPWLLLGSQDAAHDLDTLKKNK--NVLNLLKKQKEKMEWFLFIVMQAFPGL
70 80 90 100 110
130 140 150 160 170 180
pF1KE2 PETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLMNSEQTSFTSAFSLV
NP_001 LQL
120
>>NP_001135786 (OMIM: 611437) dual specificity protein p (166 aa)
initn: 601 init1: 601 opt: 601 Z-score: 738.4 bits: 143.3 E(85289): 2.2e-34
Smith-Waterman score: 979; 76.5% identity (76.5% similar) in 217 aa overlap (1-217:1-166)
10 20 30 40 50 60
pF1KE2 MYSLNQEIKAFSRNNLRKQCTRVTTLTGKKIIETWKDARIHVVEEVEPSSGGGCGYVQDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MYSLNQEIKAFSRNNLRKQCTRVTTLTGKKIIETWKDARIHVVEEVEPSSGGGCGYVQDL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SSDLQVGVIKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVENAFLSDFTYKSISILDL
:::::::::::::::::::::::::::::::
NP_001 SSDLQVGVIKPWLLLGSQDAAHDLDTLKKNK-----------------------------
70 80 90
130 140 150 160 170 180
pF1KE2 PETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLMNSEQTSFTSAFSLV
::::::::::::::::::::::::::::::::::::::
NP_001 ----------------------DGVVLVHCNAGVSRAAAIVIGFLMNSEQTSFTSAFSLV
100 110 120
190 200 210
pF1KE2 KNARPSICPNSGFMEQLRTYQEGKESNKCDRIQENSS
:::::::::::::::::::::::::::::::::::::
NP_001 KNARPSICPNSGFMEQLRTYQEGKESNKCDRIQENSS
130 140 150 160
>>NP_009138 (OMIM: 608867) dual specificity protein phos (482 aa)
initn: 354 init1: 277 opt: 344 Z-score: 420.9 bits: 86.1 E(85289): 1e-16
Smith-Waterman score: 344; 39.6% identity (71.1% similar) in 149 aa overlap (69-212:325-470)
40 50 60 70 80 90
pF1KE2 RIHVVEEVEPSSGGGCGYVQDLSSDLQVGVIKPWLLLGSQDAAHDLDTLKKNKVTHILNV
: :.:.::... :.::::... .. ...::
NP_009 EVGGGASAASSLLPQPIPTTPDIENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINV
300 310 320 330 340 350
100 110 120 130 140 150
pF1KE2 A-----YGVENAFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAG
. : :... :.:: . : . :. .:: : :::::::.. .:.::.::
NP_009 TTHLPLYHYEKGL---FNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAG
360 370 380 390 400 410
160 170 180 190 200 210
pF1KE2 VSRAAAIVIGFLMNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQEGKESNKCDRIQ
:::.:.:::..::. . ..:.:...::. :: : :: .:: :: ..: ... ::
NP_009 VSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRIL
420 430 440 450 460 470
pF1KE2 ENSS
NP_009 TPKLMGVETVV
480
>>XP_016873431 (OMIM: 606780) PREDICTED: protein phospha (559 aa)
initn: 352 init1: 332 opt: 332 Z-score: 405.5 bits: 83.5 E(85289): 7.6e-16
Smith-Waterman score: 332; 40.6% identity (69.2% similar) in 133 aa overlap (69-201:232-364)
40 50 60 70 80 90
pF1KE2 RIHVVEEVEPSSGGGCGYVQDLSSDLQVGVIKPWLLLGSQDAAHDLDTLKKNKVTHILNV
: : : :::. : .:. :..:.::::::.
XP_016 LRLGLPLQQYRDFIDNQMLLLVAQRDRASRIFPHLYLGSEWNAANLEELQRNRVTHILNM
210 220 230 240 250 260
100 110 120 130 140 150
pF1KE2 AYGVENAFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAA
: ..: . :::... . : ...: .. : .::: :. . :::::. ::::.:
XP_016 AREIDNFYPERFTYHNVRLWDEESAQLLPHWKETHRFIEAARAQGTHVLVHCKMGVSRSA
270 280 290 300 310 320
160 170 180 190 200 210
pF1KE2 AIVIGFLMNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQEGKESNKCDRIQENSS
: :... :.. . :. .:. :.. :: :: ::..::. ::
XP_016 ATVLAYAMKQYECSLEQALRHVQELRPIARPNPGFLRQLQIYQGILTASRQSHVWEQKVG
330 340 350 360 370 380
XP_016 GVSPEEHPAPEVSTPFPPLPPEPEGGGEEKVVGMEESQAAPKEEPGPRPRINLRGVMRSI
390 400 410 420 430 440
>>NP_060327 (OMIM: 606780) protein phosphatase Slingshot (659 aa)
initn: 332 init1: 332 opt: 332 Z-score: 404.4 bits: 83.5 E(85289): 8.7e-16
Smith-Waterman score: 332; 40.6% identity (69.2% similar) in 133 aa overlap (69-201:332-464)
40 50 60 70 80 90
pF1KE2 RIHVVEEVEPSSGGGCGYVQDLSSDLQVGVIKPWLLLGSQDAAHDLDTLKKNKVTHILNV
: : : :::. : .:. :..:.::::::.
NP_060 LRLGLPLQQYRDFIDNQMLLLVAQRDRASRIFPHLYLGSEWNAANLEELQRNRVTHILNM
310 320 330 340 350 360
100 110 120 130 140 150
pF1KE2 AYGVENAFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAA
: ..: . :::... . : ...: .. : .::: :. . :::::. ::::.:
NP_060 AREIDNFYPERFTYHNVRLWDEESAQLLPHWKETHRFIEAARAQGTHVLVHCKMGVSRSA
370 380 390 400 410 420
160 170 180 190 200 210
pF1KE2 AIVIGFLMNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQEGKESNKCDRIQENSS
: :... :.. . :. .:. :.. :: :: ::..::. ::
NP_060 ATVLAYAMKQYECSLEQALRHVQELRPIARPNPGFLRQLQIYQGILTASRQSHVWEQKVG
430 440 450 460 470 480
NP_060 GVSPEEHPAPEVSTPFPPLPPEPEGGGEEKVVGMEESQAAPKEEPGPRPRINLRGVMRSI
490 500 510 520 530 540
>>NP_001938 (OMIM: 602749) dual specificity protein phos (419 aa)
initn: 322 init1: 247 opt: 328 Z-score: 402.5 bits: 82.5 E(85289): 1.1e-15
Smith-Waterman score: 328; 39.3% identity (69.0% similar) in 145 aa overlap (69-210:248-392)
40 50 60 70 80 90
pF1KE2 RIHVVEEVEPSSGGGCGYVQDLSSDLQVGVIKPWLLLGSQDAAHDLDTLKKNKVTHILNV
: :.: :: . .::.: : . .::::
NP_001 DGESDRELPSSATESDGSPVPSSQPAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNV
220 230 240 250 260 270
100 110 120 130 140 150
pF1KE2 AYGVENAFL--SDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSR
. .. ::: ..::::.: : : :. ..::: . ::.::. : ::::: ::.::
NP_001 TPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISR
280 290 300 310 320 330
160 170 180 190 200 210
pF1KE2 AAAIVIGFLMNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQEG-KESNKCDRIQEN
........::.. . :...:...:: . .: :: .:: :: ... :. ::
NP_001 SVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTLGLSSPCDNHASS
340 350 360 370 380 390
pF1KE2 SS
NP_001 EQLYFSTPTNHNLFPLNTLEST
400 410
>>NP_004409 (OMIM: 603068) dual specificity protein phos (314 aa)
initn: 293 init1: 293 opt: 313 Z-score: 386.2 bits: 79.1 E(85289): 9e-15
Smith-Waterman score: 313; 40.6% identity (69.2% similar) in 133 aa overlap (69-201:176-308)
40 50 60 70 80 90
pF1KE2 RIHVVEEVEPSSGGGCGYVQDLSSDLQVGVIKPWLLLGSQDAAHDLDTLKKNKVTHILNV
: :.:.::: . . ::. :. .: .:::
NP_004 APAPALPPTGDKTSRSDSRAPVYDQGGPVEILPYLFLGSCSHSSDLQGLQACGITAVLNV
150 160 170 180 190 200
100 110 120 130 140 150
pF1KE2 AYGVENAFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAA
. . : : . : :::: . : ..: ..: : . ::. .: . : :::::.::.::.:
NP_004 SASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSA
210 220 230 240 250 260
160 170 180 190 200 210
pF1KE2 AIVIGFLMNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQEGKESNKCDRIQENSS
.: ...::.:... . ::..::. : : :: .:: :: ..
NP_004 TICLAYLMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQVLCH
270 280 290 300 310
>>XP_016859035 (OMIM: 603068) PREDICTED: dual specificit (342 aa)
initn: 293 init1: 293 opt: 313 Z-score: 385.6 bits: 79.1 E(85289): 9.7e-15
Smith-Waterman score: 313; 40.6% identity (69.2% similar) in 133 aa overlap (69-201:204-336)
40 50 60 70 80 90
pF1KE2 RIHVVEEVEPSSGGGCGYVQDLSSDLQVGVIKPWLLLGSQDAAHDLDTLKKNKVTHILNV
: :.:.::: . . ::. :. .: .:::
XP_016 APAPALPPTGDKTSRSDSRAPVYDQGGPVEILPYLFLGSCSHSSDLQGLQACGITAVLNV
180 190 200 210 220 230
100 110 120 130 140 150
pF1KE2 AYGVENAFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAA
. . : : . : :::: . : ..: ..: : . ::. .: . : :::::.::.::.:
XP_016 SASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSA
240 250 260 270 280 290
160 170 180 190 200 210
pF1KE2 AIVIGFLMNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQEGKESNKCDRIQENSS
.: ...::.:... . ::..::. : : :: .:: :: ..
XP_016 TICLAYLMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQVLCH
300 310 320 330 340
>>XP_016883144 (OMIM: 616776) PREDICTED: dual specificit (332 aa)
initn: 302 init1: 217 opt: 310 Z-score: 382.2 bits: 78.4 E(85289): 1.5e-14
Smith-Waterman score: 310; 37.5% identity (66.7% similar) in 144 aa overlap (67-210:4-143)
40 50 60 70 80 90
pF1KE2 DARIHVVEEVEPSSGGGCGYVQDLSSDLQVGVIKPWLLLGSQDAAHDLDTLKKNKVTHIL
::. : : ::. :.::: : .::.:::.
XP_016 MTEGVL-PGLYLGNFIDAKDLDQLGRNKITHII
10 20 30
100 110 120 130 140 150
pF1KE2 NVAYGVENAFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSR
.. . . .:.:.:: : . : ::. : ..: ::..::. . . : :::: ::.::
XP_016 SI-HESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISR
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE2 AAAIVIGFLMNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQEGKESNKCDRIQENS
...:: ...:. .. ... .: .:: :: :: .::. . : :.. :
XP_016 STTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF--GWASSQKDGSGFAT
100 110 120 130 140
pF1KE2 S
XP_016 EDEDKEWPHRLAQQGSLLPPILLQALWLTTGARHRTSKTSGAQCPPMTSATCLLAARVAL
150 160 170 180 190 200
217 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 23:55:08 2016 done: Sun Nov 6 23:55:09 2016
Total Scan time: 5.830 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]