Result of FASTA (omim) for
pFN21AE2236
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2236, 476 aa
1>>>pF1KE2236 476 - 476 aa - 476 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.9796+/-0.000317; mu= 14.7623+/- 0.020
mean_var=74.6764+/-15.038, 0's: 0 Z-trim(117.1): 76 B-trim: 79 in 1/49
Lambda= 0.148417
statistics sampled from 28811 (28889) to 28811 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.704), E-opt: 0.2 (0.339), width: 16
Scan time: 10.090
The best scores are: opt bits E(85289)
NP_002416 (OMIM: 185260) stromelysin-2 preproprote ( 476) 3286 712.7 5.4e-205
NP_002413 (OMIM: 185250,614466) stromelysin-1 prep ( 477) 2651 576.8 4.6e-164
NP_002417 (OMIM: 601046) macrophage metalloelastas ( 470) 1633 358.8 1.9e-98
NP_004762 (OMIM: 604629,612529) matrix metalloprot ( 483) 1442 317.9 4e-86
NP_002418 (OMIM: 250400,600108,602111) collagenase ( 471) 1009 225.2 3.1e-58
NP_002412 (OMIM: 120353,226600,606963) interstitia ( 469) 967 216.2 1.6e-55
NP_002415 (OMIM: 120355) neutrophil collagenase is ( 467) 909 203.8 8.7e-52
NP_005931 (OMIM: 185261) stromelysin-3 preproprote ( 488) 880 197.6 6.7e-50
XP_011541138 (OMIM: 120355) PREDICTED: neutrophil ( 377) 859 193.0 1.2e-48
XP_016873260 (OMIM: 120355) PREDICTED: neutrophil ( 444) 859 193.0 1.4e-48
XP_011541137 (OMIM: 120355) PREDICTED: neutrophil ( 444) 859 193.0 1.4e-48
NP_001291370 (OMIM: 120355) neutrophil collagenase ( 444) 859 193.0 1.4e-48
NP_001291371 (OMIM: 120355) neutrophil collagenase ( 444) 859 193.0 1.4e-48
XP_011541136 (OMIM: 120355) PREDICTED: neutrophil ( 476) 859 193.1 1.5e-48
NP_002420 (OMIM: 601807,611543) matrix metalloprot ( 508) 848 190.7 8e-48
NP_002414 (OMIM: 178990) matrilysin preproprotein ( 267) 835 187.8 3.1e-47
NP_001139410 (OMIM: 120353,226600,606963) intersti ( 403) 836 188.1 3.9e-47
XP_016874798 (OMIM: 601807,611543) PREDICTED: matr ( 366) 692 157.3 6.8e-38
NP_004521 (OMIM: 120360,259600) 72 kDa type IV col ( 660) 638 145.8 3.5e-34
NP_001121363 (OMIM: 120360,259600) 72 kDa type IV ( 610) 619 141.7 5.4e-33
NP_068573 (OMIM: 605470) matrix metalloproteinase- ( 261) 600 137.5 4.3e-32
NP_004985 (OMIM: 120361,613073) matrix metalloprot ( 707) 603 138.3 6.7e-32
NP_001289439 (OMIM: 120360,259600) 72 kDa type IV ( 584) 599 137.4 1e-31
NP_001289438 (OMIM: 120360,259600) 72 kDa type IV ( 584) 599 137.4 1e-31
NP_001289437 (OMIM: 120360,259600) 72 kDa type IV ( 584) 599 137.4 1e-31
XP_011526802 (OMIM: 604871) PREDICTED: matrix meta ( 556) 590 135.5 3.7e-31
XP_016883087 (OMIM: 604871) PREDICTED: matrix meta ( 614) 590 135.5 4e-31
NP_006681 (OMIM: 604871) matrix metalloproteinase- ( 645) 590 135.5 4.2e-31
XP_016874797 (OMIM: 601807,611543) PREDICTED: matr ( 387) 582 133.7 8.8e-31
XP_011518521 (OMIM: 605470) PREDICTED: matrix meta ( 191) 577 132.5 9.9e-31
XP_016874796 (OMIM: 602285) PREDICTED: matrix meta ( 434) 544 125.6 2.7e-28
NP_004986 (OMIM: 277950,600754) matrix metalloprot ( 582) 544 125.6 3.6e-28
NP_057239 (OMIM: 602285) matrix metalloproteinase- ( 603) 544 125.6 3.7e-28
XP_011536657 (OMIM: 602285) PREDICTED: matrix meta ( 519) 535 123.7 1.2e-27
XP_011536659 (OMIM: 602285) PREDICTED: matrix meta ( 519) 535 123.7 1.2e-27
XP_011536658 (OMIM: 602285) PREDICTED: matrix meta ( 519) 535 123.7 1.2e-27
NP_671724 (OMIM: 608416,616749) matrix metalloprot ( 569) 455 106.6 1.9e-22
XP_016880552 (OMIM: 608417) PREDICTED: matrix meta ( 378) 449 105.2 3.2e-22
XP_016880553 (OMIM: 608417) PREDICTED: matrix meta ( 378) 449 105.2 3.2e-22
XP_016880551 (OMIM: 608417) PREDICTED: matrix meta ( 378) 449 105.2 3.2e-22
XP_011523533 (OMIM: 608417) PREDICTED: matrix meta ( 390) 449 105.2 3.3e-22
NP_116568 (OMIM: 608417) matrix metalloproteinase- ( 393) 449 105.2 3.3e-22
XP_011523532 (OMIM: 608417) PREDICTED: matrix meta ( 418) 449 105.2 3.5e-22
XP_011523529 (OMIM: 608417) PREDICTED: matrix meta ( 435) 449 105.3 3.6e-22
XP_011523530 (OMIM: 608417) PREDICTED: matrix meta ( 435) 449 105.3 3.6e-22
XP_011523531 (OMIM: 608417) PREDICTED: matrix meta ( 435) 449 105.3 3.6e-22
XP_011523528 (OMIM: 608417) PREDICTED: matrix meta ( 435) 449 105.3 3.6e-22
NP_077278 (OMIM: 608417) matrix metalloproteinase- ( 520) 449 105.3 4.3e-22
XP_016880550 (OMIM: 608417) PREDICTED: matrix meta ( 409) 433 101.8 3.7e-21
XP_011523534 (OMIM: 608417) PREDICTED: matrix meta ( 494) 433 101.8 4.4e-21
>>NP_002416 (OMIM: 185260) stromelysin-2 preproprotein [ (476 aa)
initn: 3286 init1: 3286 opt: 3286 Z-score: 3801.3 bits: 712.7 E(85289): 5.4e-205
Smith-Waterman score: 3286; 100.0% identity (100.0% similar) in 476 aa overlap (1-476:1-476)
10 20 30 40 50 60
pF1KE2 MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 AHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIST
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 LRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFW
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 AIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQG
370 380 390 400 410 420
430 440 450 460 470
pF1KE2 FPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
430 440 450 460 470
>>NP_002413 (OMIM: 185250,614466) stromelysin-1 prepropr (477 aa)
initn: 2726 init1: 2443 opt: 2651 Z-score: 3066.4 bits: 576.8 E(85289): 4.6e-164
Smith-Waterman score: 2651; 78.2% identity (92.0% similar) in 477 aa overlap (1-476:1-477)
10 20 30 40 50
pF1KE2 MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQF-RRKDSNLI
: : .:.:::. :::::::.:::. ::.. .:.:.:::.::.:.:::::: :::::. .
NP_002 MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 VKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVN
::::. ::::::::::::::.::::::::::::::::::: .:::.::::::::::::::
NP_002 VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 YTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHS
::::::.::::::.:::::::::::::::::::::::::::::::.:::::: :::::.
NP_002 YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 LAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLY
::::: ::::. :: ::::::.::.:..:::::::::::.::::::::::::::::::::
NP_002 LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE2 NSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIS
.:.:.:..:::::::.::::::::::: : : :::::. :: ::.:::::::::.:
NP_002 HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE2 TLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEF
::::: :.::::.:::.: . :::.::::.::::::: .::::::.:.: :::::::.:
NP_002 TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE2 WAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQ
::::::::.:::::::::::::::.::::::.:::::.:::::. ::::::::. .:::
NP_002 WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE2 GFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
:::. ::.::::.. :.:::.. :::::::.::::.::::::. ::: :::::::.:
NP_002 GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
430 440 450 460 470
>>NP_002417 (OMIM: 601046) macrophage metalloelastase pr (470 aa)
initn: 1672 init1: 794 opt: 1633 Z-score: 1888.5 bits: 358.8 E(85289): 1.9e-98
Smith-Waterman score: 1633; 49.6% identity (76.2% similar) in 478 aa overlap (2-476:1-470)
10 20 30 40 50
pF1KE2 MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKD-VKQFRRKDS-NL
:.. ...:: . .: ::..... : .: ....::::.:.:: . . . : : ::
NP_002 MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNL
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 IVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIV
. .::: ::.::::.:::.:::.:::.:. :::::::: :: .:: : ::: ..::::
NP_002 MKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRIN
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 NYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGH
:::::. :. :: ::.::..:: .:::: ::.. : :::.. :: ::::..::: :
NP_002 NYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 SLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPL
::::. :: :. :: :::.:: :: ..::::::.:.::.:::::: ::.. .:.:.:
NP_002 ILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPT
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 YNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAI
:. .... :::: ::. ::::::: : . . : :..:: :: ::: :::::.
NP_002 YK-YVDINTFRLSADDIRGIQSLYGDPKENQRLP------NPDNSE-PALCDPNLSFDAV
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE2 STLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNE
.:. .. .:::::.:: . :. .:::..::.::: ..::::...:. ::.:: ..
NP_002 TTVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDK
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE2 FWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSME
.: : . . . .::..::..::: ..:::::: . . .::::. ..:::.:: : :.
NP_002 YWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMD
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE2 QGFPRLIADDFPGVEPKVDAVLQAFG-FFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
:.:.::. .: :. ::.:::. . . ..:::.::.:::.: . .:. ::::::. :
NP_002 PGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
420 430 440 450 460 470
>>NP_004762 (OMIM: 604629,612529) matrix metalloproteina (483 aa)
initn: 1326 init1: 764 opt: 1442 Z-score: 1667.3 bits: 317.9 E(85289): 4e-86
Smith-Waterman score: 1442; 45.6% identity (71.5% similar) in 478 aa overlap (4-476:9-483)
10 20 30 40 50
pF1KE2 MMHLAFLVLLCLPVCSAYP--LSGAAKEEDSNKDLAQQYLEKYY-NLE-KDVKQF
:: .... : .: : .... . .: ::: ::.::: : : ... ..
NP_004 MKVLPASGLAVFLIMALKFSTAAPSLVAASPRTWRNNYRLAQAYLDKYYTNKEGHQIGEM
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 RRKDSNLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKT
. :: ...::. .: :.::.:::::: :..:..:::::::::... ::: :::.:.
NP_004 VARGSNSMIRKIKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPDVANYRLFPGEPKWKKN
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 HLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFY
::::: .:::.. ::.:.: ::..: ..::.: :. ::::::::: .::: :
NP_004 TLTYRISKYTPSMSSVEVDKAVEMALQAWSSAVPLSFVRINSGEADIMISFENGDHGDSY
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 SFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANT
:::: .::::. :: :: :: :::. :::: ..: ::: :::::.::.::: ::..
NP_004 PFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMGTNGFNLFTVAAHEFGHALGLAHSTDP
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE2 EALMYPLYNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDP
::::: :. . . :.: .:::.:::.:::: . .: .: . : .: ::
NP_004 SALMYPTYK-YKNPYGFHLPKDDVKGIQALYGPRKVFLGKPTLPHAPHHKPS-IPDLCDS
250 260 270 280 290
300 310 320 330 340 350
pF1KE2 ALSFDAISTLRGEYLFFKDRYFWRRS-HWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDT
. ::::.. : : :.:::: ::::. : . :.. .:.: : .:::::: : :
NP_004 SSSFDAVTMLGKELLLFKDRIFWRRQVHLRTGIRPSTITSSFPQLMSNVDAAYEVAERGT
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE2 VFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRF
...::: ..: :: ..: : :: :. .::: ...::::: .: .:: ::..:.:. .
NP_004 AYFFKGPHYWITRGFQMQ-GPPRTIYDFGFPRHVQQIDAAVYLREPQKTLFFVGDEYYSY
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE2 DENSQSMEQGFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKS
:: ...::. .:. ..: ::. ..::... :..::::: . ...: . . :. ..::
NP_004 DERKRKMEKDYPKNTEEEFSGVNGQIDAAVELNGYIYFFSGPKTYKYDTEKEDVVSVVKS
420 430 440 450 460 470
pF1KE2 NSWLHC
.::. :
NP_004 SSWIGC
480
>>NP_002418 (OMIM: 250400,600108,602111) collagenase 3 p (471 aa)
initn: 1638 init1: 865 opt: 1009 Z-score: 1166.4 bits: 225.2 E(85289): 3.1e-58
Smith-Waterman score: 1637; 49.7% identity (76.3% similar) in 481 aa overlap (2-476:1-471)
10 20 30 40 50
pF1KE2 MMH---LAFLVLLCLPVCSAYPLSGAAKEED-SNKDL--AQQYLEKYYNLEKDVKQFRRK
:: :: ...: : : :: ... :.: :..:: :..::..::. . . ....
NP_002 MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKEN
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 DSNLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLT
.. ...... ::.:.::::::::: .::.::.::::::::::... :: :: : .::
NP_002 AASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLT
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 YRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFD
:::::::::. .. :..:..::.::: .::::.:.::..: :::::::..::::::: ::
NP_002 YRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFD
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 GPGHSLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEAL
::. ::::.::::. :: :::::: :: ...: :::::::::.:::::: :: . ::
NP_002 GPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGAL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 MYPLYNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALS
:.:.: ..: ..: : .:::.:::::::: . :.: :. . : ::::.::
NP_002 MFPIY-TYTGKSHFMLPDDDVQGIQSLYGP---GDEDP------NPKHPKTPDKCDPSLS
240 250 260 270 280
300 310 320 330 340 350
pF1KE2 FDAISTLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIF
.:::..:::: ..::::.::: . . :. : ..::: ::. .::::: :.: .:::
NP_002 LDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIF
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE2 KGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENS
.: .:::. : .. :::. : ::.: ..::.::: .. :: .:.... ::.:...
NP_002 RGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTN
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE2 QSMEQGFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWL
. :.. .:::: .::::. ::::: . :..:::.: :::.. . ..... .:: :
NP_002 HIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSIL
410 420 430 440 450 460
pF1KE2 HC
:
NP_002 WC
470
>>NP_002412 (OMIM: 120353,226600,606963) interstitial co (469 aa)
initn: 1691 init1: 772 opt: 967 Z-score: 1117.8 bits: 216.2 E(85289): 1.6e-55
Smith-Waterman score: 1722; 52.3% identity (78.5% similar) in 474 aa overlap (6-476:7-466)
10 20 30 40 50
pF1KE2 MMHLAFLVLLCLPVCS-AYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQF-RRKDSN
.:.:: : : ..: . ..:.: ::.:.::::::::..: .: .:..:.
NP_002 MHSFPPLLLLLFWGVVSHSFPATLETQEQDV--DLVQKYLEKYYNLKNDGRQVEKRRNSG
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 LIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRI
.:.:.. ::.:.::.:::: :..::.::..::::::::..: : :.:..:::::::
NP_002 PVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRI
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 VNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPG
:::::::: :: :::::...: .::::::... ::.:::::::. .: : :::::
NP_002 ENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 HSLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYP
.::::. ::::. :: :::.::.::.. :: :::::::::::: ::.. :::::
NP_002 GNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYP
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 LYNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDA
:.: .. .:.:::..:::..:: ...:. : : . : :: :.:::
NP_002 ---SYTFSGDVQLAQDDIDGIQAIYG----RSQNPVQPI-----GPQTPKACDSKLTFDA
240 250 260 270 280
300 310 320 330 340 350
pF1KE2 ISTLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGN
:.:.::: .:::::.. : . . :: :...::.:::.::. :.:::: .:: : .::::
NP_002 ITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGN
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE2 EFWAIRGNEVQAGYPRGIHT-LGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQS
..::..:..: :::. :.. .::: :...::::.:... :::::.:.::::.:: ..:
NP_002 KYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRS
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE2 MEQGFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
:. :.:..:: ::::. :::::.. :::::: :. :..:::... . . :.:::..:
NP_002 MDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNC
410 420 430 440 450 460
NP_002 RKN
>>NP_002415 (OMIM: 120355) neutrophil collagenase isofor (467 aa)
initn: 1557 init1: 716 opt: 909 Z-score: 1050.7 bits: 203.8 E(85289): 8.7e-52
Smith-Waterman score: 1614; 50.2% identity (74.1% similar) in 474 aa overlap (4-476:7-464)
10 20 30 40 50
pF1KE2 MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKD-S
: ::.:: . . .:.:.: .::. : .:.::::.:.: .. : ::. .
NP_002 MFSLKTLPFLLLLHVQISKAFPVS--SKEK--NTKTVQDYLEKFYQLPSNQYQSTRKNGT
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 NLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYR
:.::.:.. ::.:.::.:::: . .::..:.:::::::: : : :: :::..:.::::
NP_002 NVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 IVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGP
: ::::.: . :. ::. :...: ..:: :.:. .::::: :.: ..::: ::::
NP_002 IRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGP
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 GHSLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMY
. ::::. :: :. :: ::: .: ::. ... :::::::::.:::::: ::.. ::::
NP_002 NGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMY
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 PLYNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFD
: : .: : ... : :::..:::..:: . .:. :: : : :::.:.::
NP_002 PNY-AFRETSNYSLPQDDIDGIQAIYG----LSSNPIQPT-----GPSTPKPCDPSLTFD
240 250 260 270 280
300 310 320 330 340 350
pF1KE2 AISTLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKG
::.::::: ::::::::::: . :...:: ::::::. ..:::: .:: .:.:::
NP_002 AITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKG
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE2 NEFWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQS
:..::. : .. :::. : . ::: ... ::::: ..:::::. :..::.:.. :
NP_002 NQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVF--YRSKTYFFVNDQFWRYDNQRQF
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE2 MEQGFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
:: :.:. :. :::.: :::::.: ::. ::: . :: :. ::.. ..:.::.:
NP_002 MEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNC
410 420 430 440 450 460
NP_002 RYG
>>NP_005931 (OMIM: 185261) stromelysin-3 preproprotein [ (488 aa)
initn: 780 init1: 352 opt: 880 Z-score: 1016.9 bits: 197.6 E(85289): 6.7e-50
Smith-Waterman score: 880; 41.3% identity (63.0% similar) in 395 aa overlap (86-459:75-460)
60 70 80 90 100
pF1KE2 SNLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPK--------
.: ::::::: . : . :
NP_005 RRGPQPWHAALPSSPAPAPATQEAPRPASSLRPPRCGVPDPSDGLSARNRQKRFVLSGGR
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE2 WRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEH
:.:: :::::. . .: .. : ... .::::: .::::::....::.:::::.:: :
NP_005 WEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIMIDFARYWH
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE2 GDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWT-EDASGTNLFLVAAHELGHSLGLF
:: ::::: ::::. : ::.::: :: :: : .::.:. :::::.:: :::
NP_005 GDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQ
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE2 HSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYGPP-PA-STEEP-LVPTKSVPSGS
:.. ..::: .:. :. :: :: :.: ::: : :. ... : : : .. ..
NP_005 HTTAAKALMSAFYTFRYPLS---LSPDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNE
230 240 250 260 270 280
290 300 310 320 330
pF1KE2 EMPAKCD-PA----LSFDAISTLRGEYLFFKDRYFWRRSHWNPEPEFH-LISAFWPSLPS
: . : : ::::.::.::: .::: . :: . .: . : : : .:::
NP_005 IAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPS
290 300 310 320 330 340
340 350 360 370 380 390
pF1KE2 YLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIR-KIDAA-VSDKE
.:::.: ... ...:.: ..:. :.. : : . ::. .: . :: : :
NP_005 PVDAAFE-DAQGHIWFFQGAQYWVYDGEKPVLG-PAPLTELGL---VRFPVHAALVWGPE
350 360 370 380 390
400 410 420 430 440 450
pF1KE2 KKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKVDAVLQ-AFGFFYFFSGSSQ
:.: ::: . :::: ... ... :: : :. :: ..::..: : :. ::. :
NP_005 KNKIYFFRGRDYWRFHPSTRRVDSPVPRR-ATDWRGVPSEIDAAFQDADGYAYFLRGRLY
400 410 420 430 440 450
460 470
pF1KE2 FEFDPNARMVTHILKSNSWLHC
..:::
NP_005 WKFDPVKVKALEGFPRLVGPDFFGCAEPANTFL
460 470 480
>>XP_011541138 (OMIM: 120355) PREDICTED: neutrophil coll (377 aa)
initn: 1181 init1: 716 opt: 859 Z-score: 994.3 bits: 193.0 E(85289): 1.2e-48
Smith-Waterman score: 1144; 53.1% identity (75.3% similar) in 320 aa overlap (37-355:45-354)
10 20 30 40 50 60
pF1KE2 LVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKD-SNLIVKKIQG
::::.:.: .. : ::. .:.::.:..
XP_011 KIQKLFSTRPSQKPTRCSHLILDFPASRIDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKE
20 30 40 50 60 70
70 80 90 100 110 120
pF1KE2 MQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNYTPDLP
::.:.::.:::: . .::..:.:::::::: : : :: :::..:.::::: ::::.:
XP_011 MQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLS
80 90 100 110 120 130
130 140 150 160 170 180
pF1KE2 RDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYP
. :. ::. :...: ..:: :.:. .::::: :.: ..::: ::::. ::::.
XP_011 EAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQ
140 150 160 170 180 190
190 200 210 220 230 240
pF1KE2 PGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTEL
:: :. :: ::: .: ::. ... :::::::::.:::::: ::.. ::::: : .: :
XP_011 PGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNY-AFRET
200 210 220 230 240 250
250 260 270 280 290 300
pF1KE2 AQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLRGEY
... : :::..:::..:: . .:. :: : : :::.:.::::.:::::
XP_011 SNYSLPQDDIDGIQAIYG----LSSNPIQPT-----GPSTPKPCDPSLTFDAITTLRGEI
260 270 280 290 300
310 320 330 340 350 360
pF1KE2 LFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGN
::::::::::: . :...:: ::::::. ..:::: .:: .:.::
XP_011 LFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKDMITKDNSWS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 EVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLI
XP_011 QVIPKAYQVPFQE
370
>>XP_016873260 (OMIM: 120355) PREDICTED: neutrophil coll (444 aa)
initn: 1557 init1: 716 opt: 859 Z-score: 993.2 bits: 193.0 E(85289): 1.4e-48
Smith-Waterman score: 1564; 51.2% identity (74.6% similar) in 441 aa overlap (37-476:13-441)
10 20 30 40 50 60
pF1KE2 LVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKD-SNLIVKKIQG
::::.:.: .. : ::. .:.::.:..
XP_016 MQQIPQEKSINDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKE
10 20 30 40
70 80 90 100 110 120
pF1KE2 MQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNYTPDLP
::.:.::.:::: . .::..:.:::::::: : : :: :::..:.::::: ::::.:
XP_016 MQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLS
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE2 RDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYP
. :. ::. :...: ..:: :.:. .::::: :.: ..::: ::::. ::::.
XP_016 EAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQ
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE2 PGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTEL
:: :. :: ::: .: ::. ... :::::::::.:::::: ::.. ::::: : .: :
XP_016 PGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNY-AFRET
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE2 AQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLRGEY
... : :::..:::..:: . .:. :: : : :::.:.::::.:::::
XP_016 SNYSLPQDDIDGIQAIYG----LSSNPIQPT-----GPSTPKPCDPSLTFDAITTLRGEI
230 240 250 260 270
310 320 330 340 350 360
pF1KE2 LFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGN
::::::::::: . :...:: ::::::. ..:::: .:: .:.::::..::. :
XP_016 LFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGY
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 EVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLI
.. :::. : . ::: ... ::::: ..:::::. :..::.:.. : :: :.:. :
XP_016 DILQGYPKDISNYGFPSSVQAIDAAVF--YRSKTYFFVNDQFWRYDNQRQFMEPGYPKSI
340 350 360 370 380 390
430 440 450 460 470
pF1KE2 ADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
. :::.: :::::.: ::. ::: . :: :. ::.. ..:.::.:
XP_016 SGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
400 410 420 430 440
476 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 15:38:05 2016 done: Mon Nov 7 15:38:07 2016
Total Scan time: 10.090 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]