Result of FASTA (omim) for
pFN21AE2220
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2220, 174 aa
1>>>pF1KE2220 174 - 174 aa - 174 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1501+/-0.000326; mu= 13.3929+/- 0.020
mean_var=66.7333+/-13.020, 0's: 0 Z-trim(116.2): 31 B-trim: 0 in 0/53
Lambda= 0.157001
statistics sampled from 27085 (27119) to 27085 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.695), E-opt: 0.2 (0.318), width: 16
Scan time: 4.920
The best scores are: opt bits E(85289)
XP_011508964 (OMIM: 123680,604307) PREDICTED: gamm ( 174) 1251 291.7 4.1e-79
NP_066269 (OMIM: 123680,604307) gamma-crystallin C ( 174) 1251 291.7 4.1e-79
NP_005201 (OMIM: 123670,615188) gamma-crystallin B ( 175) 1020 239.4 2.3e-63
XP_016858891 (OMIM: 123670,615188) PREDICTED: gamm ( 177) 1019 239.1 2.7e-63
NP_055432 (OMIM: 123660) gamma-crystallin A [Homo ( 174) 972 228.5 4.3e-60
NP_008822 (OMIM: 115700,123690) gamma-crystallin D ( 174) 920 216.7 1.5e-56
NP_060011 (OMIM: 116100,123730) beta-crystallin S ( 178) 698 166.4 2.1e-41
XP_011514138 (OMIM: 609603) PREDICTED: gamma-cryst ( 295) 464 113.6 2.9e-25
XP_005250009 (OMIM: 609603) PREDICTED: gamma-cryst ( 182) 448 109.8 2.4e-24
NP_004067 (OMIM: 123630,609741) beta-crystallin B3 ( 211) 400 99.0 5e-21
XP_011528204 (OMIM: 123630,609741) PREDICTED: beta ( 267) 400 99.0 6.1e-21
XP_011528202 (OMIM: 123620,601547) PREDICTED: beta ( 205) 388 96.2 3.2e-20
XP_006724204 (OMIM: 123620,601547) PREDICTED: beta ( 205) 388 96.2 3.2e-20
NP_000487 (OMIM: 123620,601547) beta-crystallin B2 ( 205) 388 96.2 3.2e-20
XP_011514139 (OMIM: 609603) PREDICTED: gamma-cryst ( 260) 384 95.4 7.3e-20
XP_011528201 (OMIM: 600929,611544) PREDICTED: beta ( 252) 382 94.9 9.8e-20
NP_001878 (OMIM: 600929,611544) beta-crystallin B1 ( 252) 382 94.9 9.8e-20
NP_005199 (OMIM: 123610,600881) beta-crystallin A3 ( 215) 371 92.4 4.8e-19
XP_016879687 (OMIM: 123610,600881) PREDICTED: beta ( 316) 371 92.5 6.6e-19
NP_001877 (OMIM: 123631,610425) beta-crystallin A4 ( 196) 351 87.9 1e-17
XP_006724203 (OMIM: 123631,610425) PREDICTED: beta ( 201) 351 87.9 1.1e-17
XP_016884087 (OMIM: 123631,610425) PREDICTED: beta ( 207) 351 87.9 1.1e-17
NP_476435 (OMIM: 115900,600836) beta-crystallin A2 ( 197) 330 83.1 2.8e-16
NP_476434 (OMIM: 115900,600836) beta-crystallin A2 ( 197) 330 83.1 2.8e-16
NP_653328 (OMIM: 609603) gamma-crystallin N isofor ( 182) 321 81.0 1.1e-15
NP_001615 (OMIM: 601797) absent in melanoma 1 prot (1723) 292 75.1 6.3e-13
XP_005266896 (OMIM: 601797) PREDICTED: absent in m (2131) 292 75.2 7.5e-13
NP_001295221 (OMIM: 609603) gamma-crystallin N iso ( 125) 275 70.5 1.1e-12
XP_016867262 (OMIM: 609603) PREDICTED: gamma-cryst ( 125) 275 70.5 1.1e-12
XP_016884088 (OMIM: 123630,609741) PREDICTED: beta ( 169) 205 54.7 8.3e-08
XP_016865822 (OMIM: 601797) PREDICTED: absent in m (1544) 162 45.6 0.00042
>>XP_011508964 (OMIM: 123680,604307) PREDICTED: gamma-cr (174 aa)
initn: 1251 init1: 1251 opt: 1251 Z-score: 1541.4 bits: 291.7 E(85289): 4.1e-79
Smith-Waterman score: 1251; 100.0% identity (100.0% similar) in 174 aa overlap (1-174:1-174)
10 20 30 40 50 60
pF1KE2 MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GEYPDYQQWMGLSDSIRSCCLIPQTVSHRLRLYEREDHKGLMMELSEDCPSIQDRFHLSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEYPDYQQWMGLSDSIRSCCLIPQTVSHRLRLYEREDHKGLMMELSEDCPSIQDRFHLSE
70 80 90 100 110 120
130 140 150 160 170
pF1KE2 IRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY
130 140 150 160 170
>>NP_066269 (OMIM: 123680,604307) gamma-crystallin C [Ho (174 aa)
initn: 1251 init1: 1251 opt: 1251 Z-score: 1541.4 bits: 291.7 E(85289): 4.1e-79
Smith-Waterman score: 1251; 100.0% identity (100.0% similar) in 174 aa overlap (1-174:1-174)
10 20 30 40 50 60
pF1KE2 MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GEYPDYQQWMGLSDSIRSCCLIPQTVSHRLRLYEREDHKGLMMELSEDCPSIQDRFHLSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 GEYPDYQQWMGLSDSIRSCCLIPQTVSHRLRLYEREDHKGLMMELSEDCPSIQDRFHLSE
70 80 90 100 110 120
130 140 150 160 170
pF1KE2 IRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 IRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY
130 140 150 160 170
>>NP_005201 (OMIM: 123670,615188) gamma-crystallin B [Ho (175 aa)
initn: 592 init1: 592 opt: 1020 Z-score: 1258.6 bits: 239.4 E(85289): 2.3e-63
Smith-Waterman score: 1020; 78.9% identity (93.1% similar) in 175 aa overlap (1-174:1-175)
10 20 30 40 50 60
pF1KE2 MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRR
:::::::::::::::::: :::::::::::::::::::::::::.::::::::.::.:::
NP_005 MGKITFYEDRAFQGRSYECTTDCPNLQPYFSRCNSIRVESGCWMIYERPNYQGHQYFLRR
10 20 30 40 50 60
70 80 90 100 110
pF1KE2 GEYPDYQQWMGLSDSIRSCCLIP-QTVSHRLRLYEREDHKGLMMELSEDCPSIQDRFHLS
::::::::::::::::::::::: .. ..:...:.:.. .: : ::..:: :.::::::.
NP_005 GEYPDYQQWMGLSDSIRSCCLIPPHSGAYRMKIYDRDELRGQMSELTDDCISVQDRFHLT
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 EIRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY
::.::.:::: :.:::.:::::::::::: :::: :::: .::.::::::.:::
NP_005 EIHSLNVLEGSWILYEMPNYRGRQYLLRPGEYRRFLDWGAPNAKVGSLRRVMDLY
130 140 150 160 170
>>XP_016858891 (OMIM: 123670,615188) PREDICTED: gamma-cr (177 aa)
initn: 593 init1: 593 opt: 1019 Z-score: 1257.3 bits: 239.1 E(85289): 2.7e-63
Smith-Waterman score: 1019; 79.2% identity (91.0% similar) in 178 aa overlap (1-174:1-177)
10 20 30 40 50 60
pF1KE2 MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRR
:::::::::::::::::: :::::::::::::::::::::::::.::::::::.::.:::
XP_016 MGKITFYEDRAFQGRSYECTTDCPNLQPYFSRCNSIRVESGCWMIYERPNYQGHQYFLRR
10 20 30 40 50 60
70 80 90 100 110
pF1KE2 GEYPDYQQWMGLSDSIRSCCLIPQTVSH----RLRLYEREDHKGLMMELSEDCPSIQDRF
::::::::::::::::::::::: ::: :...:.:.. .: : ::..:: :.::::
XP_016 GEYPDYQQWMGLSDSIRSCCLIPP-VSHSGAYRMKIYDRDELRGQMSELTDDCISVQDRF
70 80 90 100 110
120 130 140 150 160 170
pF1KE2 HLSEIRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY
::.::.::.:::: :.:::.:::::::::::: :::: :::: .::.::::::.:::
XP_016 HLTEIHSLNVLEGSWILYEMPNYRGRQYLLRPGEYRRFLDWGAPNAKVGSLRRVMDLY
120 130 140 150 160 170
>>NP_055432 (OMIM: 123660) gamma-crystallin A [Homo sapi (174 aa)
initn: 972 init1: 972 opt: 972 Z-score: 1199.9 bits: 228.5 E(85289): 4.3e-60
Smith-Waterman score: 972; 74.7% identity (90.2% similar) in 174 aa overlap (1-174:1-174)
10 20 30 40 50 60
pF1KE2 MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRR
:::::::::: :::: :. .:::::. ::::::::::.::::::::::::::.::.:::
NP_055 MGKITFYEDRDFQGRCYNCISDCPNLRVYFSRCNSIRVDSGCWMLYERPNYQGHQYFLRR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GEYPDYQQWMGLSDSIRSCCLIPQTVSHRLRLYEREDHKGLMMELSEDCPSIQDRFHLSE
:.:::::.:::::::..:: .::.: ::.::::::.:..::: ::..:: . . :.: :
NP_055 GKYPDYQHWMGLSDSVQSCRIIPHTSSHKLRLYERDDYRGLMSELTDDCACVPELFRLPE
70 80 90 100 110 120
130 140 150 160 170
pF1KE2 IRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY
: :::::::::::::.:::::::::::: .::: .:::. :::.::::::.:::
NP_055 IYSLHVLEGCWVLYEMPNYRGRQYLLRPGDYRRYHDWGGADAKVGSLRRVTDLY
130 140 150 160 170
>>NP_008822 (OMIM: 115700,123690) gamma-crystallin D [Ho (174 aa)
initn: 1060 init1: 920 opt: 920 Z-score: 1136.2 bits: 216.7 E(85289): 1.5e-56
Smith-Waterman score: 920; 71.7% identity (90.2% similar) in 173 aa overlap (1-173:1-173)
10 20 30 40 50 60
pF1KE2 MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRR
:::::.::::.:::: :: ..: ::::::.::::: ::.::::::::.:::.: ::.:::
NP_008 MGKITLYEDRGFQGRHYECSSDHPNLQPYLSRCNSARVDSGCWMLYEQPNYSGLQYFLRR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GEYPDYQQWMGLSDSIRSCCLIPQTVSHRLRLYEREDHKGLMMELSEDCPSIQDRFHLSE
:.: :.:::::::::.::: :::.. :::.:::::::..: :.:..::: .::::...:
NP_008 GDYADHQQWMGLSDSVRSCRLIPHSGSHRIRLYEREDYRGQMIEFTEDCSCLQDRFRFNE
70 80 90 100 110 120
130 140 150 160 170
pF1KE2 IRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY
:.::.:::: :::::: ::::::::: : .::: ::::: .:..::::::.:.
NP_008 IHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVIDFS
130 140 150 160 170
>>NP_060011 (OMIM: 116100,123730) beta-crystallin S [Hom (178 aa)
initn: 649 init1: 367 opt: 698 Z-score: 864.3 bits: 166.4 E(85289): 2.1e-41
Smith-Waterman score: 698; 53.5% identity (79.7% similar) in 172 aa overlap (3-172:7-178)
10 20 30 40 50
pF1KE2 MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQY
:::::::. :::: :. :: ... :.::::::.::.: : .:::::. : .:
NP_060 MSKTGTKITFYEDKNFQGRRYDCDCDCADFHTYLSRCNSIKVEGGTWAVYERPNFAGYMY
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 LLRRGEYPDYQQWMGLSDSIRSCCLI--PQTVSHRLRLYEREDHKGLMMELSEDCPSIQD
.: .::::.::.::::.: . :: . :. .......:. : .: :.: .::::::..
NP_060 ILPQGEYPEYQRWMGLNDRLSSCRAVHLPSGGQYKIQIFEKGDFSGQMYETTEDCPSIME
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 RFHLSEIRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY
.::. ::.: .:::: :..::::::::::::: .:::. :::: . . :.::.:.
NP_060 QFHMREIHSCKVLEGVWIFYELPNYRGRQYLLDKKEYRKPIDWGAASPAVQSFRRIVE
130 140 150 160 170
>>XP_011514138 (OMIM: 609603) PREDICTED: gamma-crystalli (295 aa)
initn: 583 init1: 195 opt: 464 Z-score: 574.7 bits: 113.6 E(85289): 2.9e-25
Smith-Waterman score: 464; 38.8% identity (72.5% similar) in 178 aa overlap (2-174:6-183)
10 20 30 40 50
pF1KE2 MGKITFYEDRAFQGRSYETTTDCPNLQP--YFSRCNSIRVESGCWMLYERPNYQGQ
::::.:: . : :.. :. :: :.: ...: :::.:::: :. ...:...::
XP_011 MAQRSGKITLYEGKHFTGQKLEVFGDCDNFQDRGFMNRVNSIHVESGAWVCFNHPDFRGQ
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 QYLLRRGEYPDYQQWMGLSDSIRSCCLIPQTVSH-RLRLYEREDHKGLMMELSEDCPSIQ
:..:..:.:::. .: . :: . :: . . : ::...: . : .:. :: : .:
XP_011 QFILEHGDYPDFFRWNSHSDHMGSCRPVGMHGEHFRLEIFEGCNFTGQCLEFLEDSPFLQ
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 DRFHLSE-IRSLHVL-EGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVV
.: ... . ...: .: ::::: :::.::.:... ..: .:: : .:.. ::..::
XP_011 SRGWVKNCVNTIKVYGDGAWVLYEEPNYHGRMYVVESGDFRSFSDWEAHSARVQSLHKVV
130 140 150 160 170 180
pF1KE2 DLY
...
XP_011 NFFQPSPPTGMAGRSSGDRGNPLRSHPDLGTLGDKSPQSQRAASECSLGSGHPSPGRSWM
190 200 210 220 230 240
>>XP_005250009 (OMIM: 609603) PREDICTED: gamma-crystalli (182 aa)
initn: 567 init1: 195 opt: 448 Z-score: 558.1 bits: 109.8 E(85289): 2.4e-24
Smith-Waterman score: 448; 38.1% identity (71.6% similar) in 176 aa overlap (2-172:6-181)
10 20 30 40 50
pF1KE2 MGKITFYEDRAFQGRSYETTTDCPNLQP--YFSRCNSIRVESGCWMLYERPNYQGQ
::::.:: . : :.. :. :: :.: ...: :::.:::: :. ...:...::
XP_005 MAQRSGKITLYEGKHFTGQKLEVFGDCDNFQDRGFMNRVNSIHVESGAWVCFNHPDFRGQ
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 QYLLRRGEYPDYQQWMGLSDSIRSCCLIPQTVSH-RLRLYEREDHKGLMMELSEDCPSIQ
:..:..:.:::. .: . :: . :: . . : ::...: . : .:. :: : .:
XP_005 QFILEHGDYPDFFRWNSHSDHMGSCRPVGMHGEHFRLEIFEGCNFTGQCLEFLEDSPFLQ
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 DRFHLSE-IRSLHVL-EGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVV
.: ... . ...: .: ::::: :::.::.:... ..: .:: : .:.. ::.. .
XP_005 SRGWVKNCVNTIKVYGDGAWVLYEEPNYHGRMYVVESGDFRSFSDWEAHSARVQSLHKSM
130 140 150 160 170 180
pF1KE2 DLY
.
XP_005 EP
>>NP_004067 (OMIM: 123630,609741) beta-crystallin B3 [Ho (211 aa)
initn: 347 init1: 168 opt: 400 Z-score: 498.5 bits: 99.0 E(85289): 5e-21
Smith-Waterman score: 400; 34.9% identity (68.0% similar) in 175 aa overlap (3-172:25-199)
10 20 30
pF1KE2 MGKITFYEDRAFQGRSYETTTDCPNL-QPYFSRCNSIR
:. .:: . :::. : ...::.: . . . .::.
NP_004 MAEQHGAPEQAAAGKSHGDLGGSYKVILYELENFQGKRCELSAECPSLTDSLLEKVGSIQ
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE2 VESGCWMLYERPNYQGQQYLLRRGEYPDYQQWMGLSDSIRSCCLIPQTVS---HRLRLYE
:::: :. .: ..:.:..:..:.:: .. : . :: : : ... :.:.:.:
NP_004 VESGPWLAFESRAFRGEQFVLEKGDYPRWDAWSNSRDSDSLLSLRPLNIDSPHHKLHLFE
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE2 REDHKGLMMEL-SEDCPSIQDRFHLSEIRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRR
.: ::. ..: ::. . ... :.....: :: ::.:.::::::... :::.
NP_004 NPAFSGRKMEIVDDDVPSLWAHGFQDRVASVRAINGTWVGYEFPGYRGRQYVFERGEYRH
130 140 150 160 170 180
160 170
pF1KE2 CQDWGAMDAKAGSLRRVVDLY
..: : . . :.::. :
NP_004 WNEWDASQPQLQSVRRIRDQKWHKRGRFPSS
190 200 210
174 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 18:05:05 2016 done: Sun Nov 6 18:05:06 2016
Total Scan time: 4.920 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]