Result of FASTA (omim) for
pFN21AE2216
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2216, 219 aa
1>>>pF1KE2216 219 - 219 aa - 219 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.4629+/-0.000297; mu= 18.2516+/- 0.019
mean_var=56.0406+/-11.304, 0's: 0 Z-trim(117.5): 18 B-trim: 0 in 0/52
Lambda= 0.171326
statistics sampled from 29535 (29554) to 29535 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.732), E-opt: 0.2 (0.347), width: 16
Scan time: 6.870
The best scores are: opt bits E(85289)
XP_011534961 (OMIM: 604441) PREDICTED: cell death ( 219) 1454 366.8 1.5e-101
XP_016876710 (OMIM: 604441) PREDICTED: cell death ( 219) 1454 366.8 1.5e-101
NP_055245 (OMIM: 604441) cell death activator CIDE ( 219) 1454 366.8 1.5e-101
NP_001305736 (OMIM: 604441) cell death activator C ( 219) 1454 366.8 1.5e-101
NP_001308071 (OMIM: 612120,615238) cell death acti ( 238) 545 142.2 7e-34
NP_071377 (OMIM: 612120,615238) cell death activat ( 238) 545 142.2 7e-34
NP_001186481 (OMIM: 612120,615238) cell death acti ( 238) 545 142.2 7e-34
NP_001186552 (OMIM: 612120,615238) cell death acti ( 251) 545 142.2 7.3e-34
NP_001270 (OMIM: 604440) cell death activator CIDE ( 219) 507 132.8 4.4e-31
NP_001305312 (OMIM: 604440) cell death activator C ( 253) 506 132.6 5.8e-31
NP_001186480 (OMIM: 612120,615238) cell death acti ( 248) 435 115.0 1.1e-25
NP_001308073 (OMIM: 612120,615238) cell death acti ( 164) 433 114.4 1.1e-25
NP_001308072 (OMIM: 612120,615238) cell death acti ( 164) 433 114.4 1.1e-25
NP_998731 (OMIM: 601882) DNA fragmentation factor ( 268) 144 43.1 0.00052
NP_004392 (OMIM: 601882) DNA fragmentation factor ( 331) 144 43.2 0.00062
>>XP_011534961 (OMIM: 604441) PREDICTED: cell death acti (219 aa)
initn: 1454 init1: 1454 opt: 1454 Z-score: 1944.0 bits: 366.8 E(85289): 1.5e-101
Smith-Waterman score: 1454; 100.0% identity (100.0% similar) in 219 aa overlap (1-219:1-219)
10 20 30 40 50 60
pF1KE2 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQRPFRVCDHKRTIRKGLTAATRQELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQRPFRVCDHKRTIRKGLTAATRQELL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 AKALETLLLNGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPTRSGVLSYGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKALETLLLNGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPTRSGVLSYGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 GRERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLGPKKVLRELLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLGPKKVLRELLR
130 140 150 160 170 180
190 200 210
pF1KE2 WTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQKGRLHSY
:::::::::::::::::::::::::::::::::::::::
XP_011 WTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQKGRLHSY
190 200 210
>>XP_016876710 (OMIM: 604441) PREDICTED: cell death acti (219 aa)
initn: 1454 init1: 1454 opt: 1454 Z-score: 1944.0 bits: 366.8 E(85289): 1.5e-101
Smith-Waterman score: 1454; 100.0% identity (100.0% similar) in 219 aa overlap (1-219:1-219)
10 20 30 40 50 60
pF1KE2 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQRPFRVCDHKRTIRKGLTAATRQELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQRPFRVCDHKRTIRKGLTAATRQELL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 AKALETLLLNGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPTRSGVLSYGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKALETLLLNGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPTRSGVLSYGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 GRERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLGPKKVLRELLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLGPKKVLRELLR
130 140 150 160 170 180
190 200 210
pF1KE2 WTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQKGRLHSY
:::::::::::::::::::::::::::::::::::::::
XP_016 WTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQKGRLHSY
190 200 210
>>NP_055245 (OMIM: 604441) cell death activator CIDE-B [ (219 aa)
initn: 1454 init1: 1454 opt: 1454 Z-score: 1944.0 bits: 366.8 E(85289): 1.5e-101
Smith-Waterman score: 1454; 100.0% identity (100.0% similar) in 219 aa overlap (1-219:1-219)
10 20 30 40 50 60
pF1KE2 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQRPFRVCDHKRTIRKGLTAATRQELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQRPFRVCDHKRTIRKGLTAATRQELL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 AKALETLLLNGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPTRSGVLSYGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AKALETLLLNGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPTRSGVLSYGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 GRERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLGPKKVLRELLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GRERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLGPKKVLRELLR
130 140 150 160 170 180
190 200 210
pF1KE2 WTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQKGRLHSY
:::::::::::::::::::::::::::::::::::::::
NP_055 WTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQKGRLHSY
190 200 210
>>NP_001305736 (OMIM: 604441) cell death activator CIDE- (219 aa)
initn: 1454 init1: 1454 opt: 1454 Z-score: 1944.0 bits: 366.8 E(85289): 1.5e-101
Smith-Waterman score: 1454; 100.0% identity (100.0% similar) in 219 aa overlap (1-219:1-219)
10 20 30 40 50 60
pF1KE2 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQRPFRVCDHKRTIRKGLTAATRQELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQRPFRVCDHKRTIRKGLTAATRQELL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 AKALETLLLNGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPTRSGVLSYGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKALETLLLNGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPTRSGVLSYGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 GRERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLGPKKVLRELLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLGPKKVLRELLR
130 140 150 160 170 180
190 200 210
pF1KE2 WTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQKGRLHSY
:::::::::::::::::::::::::::::::::::::::
NP_001 WTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQKGRLHSY
190 200 210
>>NP_001308071 (OMIM: 612120,615238) cell death activato (238 aa)
initn: 532 init1: 261 opt: 545 Z-score: 729.3 bits: 142.2 E(85289): 7e-34
Smith-Waterman score: 545; 42.2% identity (68.4% similar) in 225 aa overlap (1-218:5-228)
10 20 30 40 50
pF1KE2 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQ----RPFRVCDHKRTIRKGLT
:. :: : :..: : :: .: ... : : :. :: :: :..:::.
NP_001 MEYAMKSLSLLYPKSLSRHVSVRTSVVTQQL-LSEPSPKAPRARPCRVSTADRSVRKGIM
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 AATRQELLAKALETLLL-NGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPT
: . ..:: :. .::.: . . ::::::::.:..:..:: : :: .::::.::.:.:
NP_001 AYSLEDLLLKVRDTLMLADKPFFLVLEEDGTTVETEEYFQALAGDTVFMVLQKGQKWQPP
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 RSGVLSYGLG-RERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLG
. :. ..: .. :.:: :::.:: ::.:..: :::::::: ::.: :.. :
NP_001 SEQGTRHPLSLSHKPAKKIDVARVTFDLYKLNPQDFIGCLNVKATFYDTYSLSYDLHCCG
120 130 140 150 160 170
180 190 200 210
pF1KE2 PKKVLRELLRWTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQ-KGRLHSY
:....: .::. .:. ::.::: : :.. ....:. : ::. :
NP_001 AKRIMKEAFRWALFSMQATGHVLLGTSCYLQQLLDATEEGQPPKGKASSLIPTCLKILQ
180 190 200 210 220 230
>>NP_071377 (OMIM: 612120,615238) cell death activator C (238 aa)
initn: 532 init1: 261 opt: 545 Z-score: 729.3 bits: 142.2 E(85289): 7e-34
Smith-Waterman score: 545; 42.2% identity (68.4% similar) in 225 aa overlap (1-218:5-228)
10 20 30 40 50
pF1KE2 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQ----RPFRVCDHKRTIRKGLT
:. :: : :..: : :: .: ... : : :. :: :: :..:::.
NP_071 MEYAMKSLSLLYPKSLSRHVSVRTSVVTQQL-LSEPSPKAPRARPCRVSTADRSVRKGIM
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 AATRQELLAKALETLLL-NGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPT
: . ..:: :. .::.: . . ::::::::.:..:..:: : :: .::::.::.:.:
NP_071 AYSLEDLLLKVRDTLMLADKPFFLVLEEDGTTVETEEYFQALAGDTVFMVLQKGQKWQPP
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 RSGVLSYGLG-RERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLG
. :. ..: .. :.:: :::.:: ::.:..: :::::::: ::.: :.. :
NP_071 SEQGTRHPLSLSHKPAKKIDVARVTFDLYKLNPQDFIGCLNVKATFYDTYSLSYDLHCCG
120 130 140 150 160 170
180 190 200 210
pF1KE2 PKKVLRELLRWTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQ-KGRLHSY
:....: .::. .:. ::.::: : :.. ....:. : ::. :
NP_071 AKRIMKEAFRWALFSMQATGHVLLGTSCYLQQLLDATEEGQPPKGKASSLIPTCLKILQ
180 190 200 210 220 230
>>NP_001186481 (OMIM: 612120,615238) cell death activato (238 aa)
initn: 532 init1: 261 opt: 545 Z-score: 729.3 bits: 142.2 E(85289): 7e-34
Smith-Waterman score: 545; 42.2% identity (68.4% similar) in 225 aa overlap (1-218:5-228)
10 20 30 40 50
pF1KE2 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQ----RPFRVCDHKRTIRKGLT
:. :: : :..: : :: .: ... : : :. :: :: :..:::.
NP_001 MEYAMKSLSLLYPKSLSRHVSVRTSVVTQQL-LSEPSPKAPRARPCRVSTADRSVRKGIM
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 AATRQELLAKALETLLL-NGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPT
: . ..:: :. .::.: . . ::::::::.:..:..:: : :: .::::.::.:.:
NP_001 AYSLEDLLLKVRDTLMLADKPFFLVLEEDGTTVETEEYFQALAGDTVFMVLQKGQKWQPP
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 RSGVLSYGLG-RERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLG
. :. ..: .. :.:: :::.:: ::.:..: :::::::: ::.: :.. :
NP_001 SEQGTRHPLSLSHKPAKKIDVARVTFDLYKLNPQDFIGCLNVKATFYDTYSLSYDLHCCG
120 130 140 150 160 170
180 190 200 210
pF1KE2 PKKVLRELLRWTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQ-KGRLHSY
:....: .::. .:. ::.::: : :.. ....:. : ::. :
NP_001 AKRIMKEAFRWALFSMQATGHVLLGTSCYLQQLLDATEEGQPPKGKASSLIPTCLKILQ
180 190 200 210 220 230
>>NP_001186552 (OMIM: 612120,615238) cell death activato (251 aa)
initn: 532 init1: 261 opt: 545 Z-score: 729.0 bits: 142.2 E(85289): 7.3e-34
Smith-Waterman score: 545; 42.2% identity (68.4% similar) in 225 aa overlap (1-218:18-241)
10 20 30
pF1KE2 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQ----RPFR
:. :: : :..: : :: .: ... : : :. :: :
NP_001 MRNMESNAVQLTRMEYAMKSLSLLYPKSLSRHVSVRTSVVTQQL-LSEPSPKAPRARPCR
10 20 30 40 50
40 50 60 70 80 90
pF1KE2 VCDHKRTIRKGLTAATRQELLAKALETLLL-NGVLTLVLEEDGTAVDSEDFFQLLEDDTC
: :..:::. : . ..:: :. .::.: . . ::::::::.:..:..:: : ::
NP_001 VSTADRSVRKGIMAYSLEDLLLKVRDTLMLADKPFFLVLEEDGTTVETEEYFQALAGDTV
60 70 80 90 100 110
100 110 120 130 140 150
pF1KE2 LMVLQSGQSWSPTRSGVLSYGLG-RERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFY
.::::.::.:.: . :. ..: .. :.:: :::.:: ::.:..: ::::::::
NP_001 FMVLQKGQKWQPPSEQGTRHPLSLSHKPAKKIDVARVTFDLYKLNPQDFIGCLNVKATFY
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE2 GLYSMSCDFQGLGPKKVLRELLRWTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQ-KGRL
::.: :.. : :....: .::. .:. ::.::: : :.. ....:. : ::.
NP_001 DTYSLSYDLHCCGAKRIMKEAFRWALFSMQATGHVLLGTSCYLQQLLDATEEGQPPKGKA
180 190 200 210 220 230
pF1KE2 HSY
:
NP_001 SSLIPTCLKILQ
240 250
>>NP_001270 (OMIM: 604440) cell death activator CIDE-A i (219 aa)
initn: 353 init1: 187 opt: 507 Z-score: 679.0 bits: 132.8 E(85289): 4.4e-31
Smith-Waterman score: 507; 41.2% identity (71.1% similar) in 211 aa overlap (12-216:11-216)
10 20 30 40 50 60
pF1KE2 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQRPFRVCDHKRTIRKGLTAATRQELL
:.: .. ..:. : ..: : ::::: .: :. :.:. :.. :::.
NP_001 MEAARDYAGALIRPLTFMGSQTKRVLFTPLMHPARPFRVSNHDRSSRRGVMASSLQELI
10 20 30 40 50
70 80 90 100 110
pF1KE2 AKALETLLL-NGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPTRSGVLSYG
.:.:..:.. .:..:::::::::.::.:.::: : :.: .:.:..::.: : . : . .
NP_001 SKTLDALVIATGLVTLVLEEDGTVVDTEEFFQTLGDNTHFMILEKGQKWMPGSQHVPTCS
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 LGRERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLGPKKVLRELL
: . . ::: :::.:. ::.:..: ::::::.: .::.: :.. : : .:: ::
NP_001 -----PPKRSGIARVTFDLYRLNPKDFIGCLNVKATMYEMYSVSYDIRCTGLKGLLRSLL
120 130 140 150 160 170
180 190 200 210
pF1KE2 RWTSTLLQGLGHMLLGISSTLRHAVEGAEQW-----QQKGRLHSY
:. : : :..:. ... . .... :. : :::.
NP_001 RFLSYSAQVTGQFLIYLGTYMLRVLDDKEERPSLRSQAKGRFTCG
180 190 200 210
>>NP_001305312 (OMIM: 604440) cell death activator CIDE- (253 aa)
initn: 353 init1: 187 opt: 506 Z-score: 676.8 bits: 132.6 E(85289): 5.8e-31
Smith-Waterman score: 506; 40.7% identity (70.6% similar) in 214 aa overlap (9-216:42-250)
10 20 30
pF1KE2 MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQRPF
:.. : .. ..:. : ..: : :::
NP_001 NHNGSWAREGPRLGPSWKRGLWSPRGGPNRPAEPSRPLTFMGSQTKRVLFTPLMHPARPF
20 30 40 50 60 70
40 50 60 70 80 90
pF1KE2 RVCDHKRTIRKGLTAATRQELLAKALETLLL-NGVLTLVLEEDGTAVDSEDFFQLLEDDT
:: .: :. :.:. :.. :::..:.:..:.. .:..:::::::::.::.:.::: : :.:
NP_001 RVSNHDRSSRRGVMASSLQELISKTLDALVIATGLVTLVLEEDGTVVDTEEFFQTLGDNT
80 90 100 110 120 130
100 110 120 130 140 150
pF1KE2 CLMVLQSGQSWSPTRSGVLSYGLGRERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFY
.:.:..::.: : . : . . : . . ::: :::.:. ::.:..: ::::::.:
NP_001 HFMILEKGQKWMPGSQHVPTCS-----PPKRSGIARVTFDLYRLNPKDFIGCLNVKATMY
140 150 160 170 180
160 170 180 190 200 210
pF1KE2 GLYSMSCDFQGLGPKKVLRELLRWTSTLLQGLGHMLLGISSTLRHAVEGAEQW-----QQ
.::.: :.. : : .:: :::. : : :..:. ... . .... :. :
NP_001 EMYSVSYDIRCTGLKGLLRSLLRFLSYSAQVTGQFLIYLGTYMLRVLDDKEERPSLRSQA
190 200 210 220 230 240
pF1KE2 KGRLHSY
:::.
NP_001 KGRFTCG
250
219 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 12:24:00 2016 done: Sun Nov 6 12:24:01 2016
Total Scan time: 6.870 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]