Result of FASTA (ccds) for
pFN21AE2207
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2207, 319 aa
1>>>pF1KE2207 319 - 319 aa - 319 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.9297+/-0.000782; mu= 10.4375+/- 0.048
mean_var=146.6145+/-28.344, 0's: 0 Z-trim(114.2): 39 B-trim: 44 in 1/52
Lambda= 0.105922
statistics sampled from 14749 (14788) to 14749 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.79), E-opt: 0.2 (0.454), width: 16
Scan time: 2.650
The best scores are: opt bits E(32554)
CCDS3731.1 SPRY1 gene_id:10252|Hs108|chr4 ( 319) 2282 359.6 1.8e-99
CCDS9463.1 SPRY2 gene_id:10253|Hs108|chr13 ( 315) 1131 183.7 1.6e-46
CCDS47296.1 SPRY4 gene_id:81848|Hs108|chr5 ( 299) 825 137.0 1.8e-32
CCDS4274.1 SPRY4 gene_id:81848|Hs108|chr5 ( 322) 825 137.0 1.9e-32
CCDS14769.4 SPRY3 gene_id:10251|Hs108|chrY ( 288) 739 123.8 1.6e-28
CCDS14769.4 SPRY3 gene_id:10251|Hs108|chrX ( 288) 739 123.8 1.6e-28
>>CCDS3731.1 SPRY1 gene_id:10252|Hs108|chr4 (319 aa)
initn: 2282 init1: 2282 opt: 2282 Z-score: 1899.2 bits: 359.6 E(32554): 1.8e-99
Smith-Waterman score: 2282; 100.0% identity (100.0% similar) in 319 aa overlap (1-319:1-319)
10 20 30 40 50 60
pF1KE2 MDPQNQHGSGSSLVVIQQPSLDSRQRLDYEREIQPTAILSLDQIKAIRGSNEYTEGPSVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS37 MDPQNQHGSGSSLVVIQQPSLDSRQRLDYEREIQPTAILSLDQIKAIRGSNEYTEGPSVV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KRPAPRTAPRQEKHERTHEIIPINVNNNYEHRHTSHLGHAVLPSNARGPILSRSTSTGSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS37 KRPAPRTAPRQEKHERTHEIIPINVNNNYEHRHTSHLGHAVLPSNARGPILSRSTSTGSA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 ASSGSNSSASSEQGLLGRSPPTRPVPGHRSERAIRTQPKQLIVDDLKGSLKEDLTQHKFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS37 ASSGSNSSASSEQGLLGRSPPTRPVPGHRSERAIRTQPKQLIVDDLKGSLKEDLTQHKFI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 CEQCGKCKCGECTAPRTLPSCLACNRQCLCSAESMVEYGTCMCLVKGIFYHCSNDDEGDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS37 CEQCGKCKCGECTAPRTLPSCLACNRQCLCSAESMVEYGTCMCLVKGIFYHCSNDDEGDS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 YSDNPCSCSQSHCCSRYLCMGAMSLFLPCLLCYPPAKGCLKLCRRCYDWIHRPGCRCKNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS37 YSDNPCSCSQSHCCSRYLCMGAMSLFLPCLLCYPPAKGCLKLCRRCYDWIHRPGCRCKNS
250 260 270 280 290 300
310
pF1KE2 NTVYCKLESCPSRGQGKPS
:::::::::::::::::::
CCDS37 NTVYCKLESCPSRGQGKPS
310
>>CCDS9463.1 SPRY2 gene_id:10253|Hs108|chr13 (315 aa)
initn: 1013 init1: 461 opt: 1131 Z-score: 948.7 bits: 183.7 E(32554): 1.6e-46
Smith-Waterman score: 1152; 55.2% identity (73.0% similar) in 330 aa overlap (1-319:1-315)
10 20 30 40 50
pF1KE2 MDPQNQHGSGSSLVVIQQPSLDSRQRLDYE-REI--QPTAILSLDQIKAIRGSNEYTEGP
:. . : :.::. ..: : .::: . . :. : . .::::::.:::..:::::::
CCDS94 MEARAQSGNGSQ-PLLQTPRDGGRQRGEPDPRDALTQQVHVLSLDQIRAIRNTNEYTEGP
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 SVVKRPAPRTAPR---QEKHERTHEIIPINVNNNYEHRHTSHLGHAVLPSNARGPILSRS
.:: ::. . ::: :.:::: : . : :::. .: :. . :.::.: ::::
CCDS94 TVVPRPGLKPAPRPSTQHKHERLHGL-P-------EHRQPPRLQHSQVHSSARAP-LSRS
60 70 80 90 100 110
120 130 140 150 160
pF1KE2 TST---GSAASS-GSNSSASSEQGLLGRSPPTRPVPGHRSERAIRTQPK-QLIVDDLKGS
:: :: .:. :.::.:::: ::: : . :: .. ::.::: .: .::
CCDS94 ISTVSSGSRSSTRTSTSSSSSEQRLLGSSFSSGPV----ADGIIRVQPKSELKPGELKPL
120 130 140 150 160
170 180 190 200 210 220
pF1KE2 LKEDLTQHKFICEQCGKCKCGECTAPRTLPSCLACNRQCLCSAESMVEYGTCMCLVKGIF
:::: : . ::.:::::: ::: :: ::: :..::::::.....::::.: :::.:
CCDS94 SKEDLGLHAYRCEDCGKCKCKECTYPRPLPSDWICDKQCLCSAQNVIDYGTCVCCVKGLF
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE2 YHCSNDDEGDSYSDNPCSCSQSHCCSRYLCMGAMSLFLPCLLCYPPAKGCLKLCRRCYDW
:::::::: :. .::::::::::::.:. ::.:::::::: :: :::::::::. :::
CCDS94 YHCSNDDE-DNCADNPCSCSQSHCCTRWSAMGVMSLFLPCLWCYLPAKGCLKLCQGCYDR
230 240 250 260 270 280
290 300 310
pF1KE2 IHRPGCRCKNSNTVYCKLESCPSRGQGKPS
..:::::::::::: ::. . : :. ::.
CCDS94 VNRPGCRCKNSNTVCCKVPTVPPRNFEKPT
290 300 310
>>CCDS47296.1 SPRY4 gene_id:81848|Hs108|chr5 (299 aa)
initn: 889 init1: 726 opt: 825 Z-score: 696.3 bits: 137.0 E(32554): 1.8e-32
Smith-Waterman score: 894; 44.7% identity (68.8% similar) in 311 aa overlap (3-309:6-287)
10 20 30 40 50
pF1KE2 MDPQNQHGSGSSLVVIQQPSLDSRQRLDYEREIQPTAILSLDQIKAIRGSNEYTEGP
::. . .:..: :: ::: :... : .: .:: .::.:. . :.: ..:
CCDS47 MEPPIPQSAPLTPNSVMV--QPLLDS--RMSHSRLQHPLTILPIDQVKTSHVENDYIDNP
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 SVVKRPAPRTAPRQEKHERTHEIIPINVNNNYEHRHTSHLGHAVLPSNARGPILSRSTST
:. : :.:.. . . :. : . . . : : . . .
CCDS47 SL----ALTTGPKRTRGG-APELAPTPARCDQDVTH-----HWI-------------SFS
60 70 80 90
120 130 140 150 160 170
pF1KE2 GSAASSGSNSSASSEQGLLGR-SPPTRPVPGHRSERAIRTQPKQLIVD--DLKG-SLKED
: .: .:.::.::.: :: . .:: :: . : ::.: ::: . . :::: .. .
CCDS47 GRPSSVSSSSSTSSDQRLLDHMAPP--PVADQASPRAVRIQPKVVHCQPLDLKGPAVPPE
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE2 LTQHKFICEQCGKCKCGECTAPRTLPSCLACNRQCLCSAESMVEYGTCMCLVKGIFYHCS
: .: ..:: :::::: ::..::::::: .::..:::::...:.::::::::.::::::.
CCDS47 LDKHFLLCEACGKCKCKECASPRTLPSCWVCNQECLCSAQTLVNYGTCMCLVQGIFYHCT
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE2 NDDEGDSYSDNPCSCSQSHCCSRYLCMGAMSLFLPCLLCYPPAKGCLKLCRRCYDWIHRP
:.:. : .:.:::::.:.::.:. :::.:. ::::::: :: ::.:: .: :: ..::
CCDS47 NEDDEGSCADHPCSCSRSNCCARWSFMGALSVVLPCLLCYLPATGCVKLAQRGYDRLRRP
220 230 240 250 260 270
300 310
pF1KE2 GCRCKNSNTVYCKLESCPSRGQGKPS
:::::..:.: :: :
CCDS47 GCRCKHTNSVICKAASGDAKTSRPDKPF
280 290
>>CCDS4274.1 SPRY4 gene_id:81848|Hs108|chr5 (322 aa)
initn: 889 init1: 726 opt: 825 Z-score: 695.8 bits: 137.0 E(32554): 1.9e-32
Smith-Waterman score: 894; 44.7% identity (68.8% similar) in 311 aa overlap (3-309:29-310)
10 20 30
pF1KE2 MDPQNQHGSGSSLVVIQQPSLDSRQRLDYEREIQ
::. . .:..: :: ::: :... : .
CCDS42 MLSPLPTGPLEACFSVQSRTSSPMEPPIPQSAPLTPNSVMV--QPLLDS--RMSHSRLQH
10 20 30 40 50
40 50 60 70 80 90
pF1KE2 PTAILSLDQIKAIRGSNEYTEGPSVVKRPAPRTAPRQEKHERTHEIIPINVNNNYEHRHT
: .:: .::.:. . :.: ..::. : :.:.. . . :. : . . . :
CCDS42 PLTILPIDQVKTSHVENDYIDNPSL----ALTTGPKRTRGG-APELAPTPARCDQDVTH-
60 70 80 90 100 110
100 110 120 130 140 150
pF1KE2 SHLGHAVLPSNARGPILSRSTSTGSAASSGSNSSASSEQGLLGR-SPPTRPVPGHRSERA
: . . .: .: .:.::.::.: :: . .:: :: . : ::
CCDS42 ----HWI-------------SFSGRPSSVSSSSSTSSDQRLLDHMAPP--PVADQASPRA
120 130 140 150
160 170 180 190 200 210
pF1KE2 IRTQPKQLIVD--DLKG-SLKEDLTQHKFICEQCGKCKCGECTAPRTLPSCLACNRQCLC
.: ::: . . :::: .. .: .: ..:: :::::: ::..::::::: .::..:::
CCDS42 VRIQPKVVHCQPLDLKGPAVPPELDKHFLLCEACGKCKCKECASPRTLPSCWVCNQECLC
160 170 180 190 200 210
220 230 240 250 260 270
pF1KE2 SAESMVEYGTCMCLVKGIFYHCSNDDEGDSYSDNPCSCSQSHCCSRYLCMGAMSLFLPCL
::...:.::::::::.::::::.:.:. : .:.:::::.:.::.:. :::.:. ::::
CCDS42 SAQTLVNYGTCMCLVQGIFYHCTNEDDEGSCADHPCSCSRSNCCARWSFMGALSVVLPCL
220 230 240 250 260 270
280 290 300 310
pF1KE2 LCYPPAKGCLKLCRRCYDWIHRPGCRCKNSNTVYCKLESCPSRGQGKPS
::: :: ::.:: .: :: ..:::::::..:.: :: :
CCDS42 LCYLPATGCVKLAQRGYDRLRRPGCRCKHTNSVICKAASGDAKTSRPDKPF
280 290 300 310 320
>>CCDS14769.4 SPRY3 gene_id:10251|Hs108|chrY (288 aa)
initn: 665 init1: 369 opt: 739 Z-score: 625.4 bits: 123.8 E(32554): 1.6e-28
Smith-Waterman score: 746; 42.3% identity (64.5% similar) in 279 aa overlap (38-306:12-271)
10 20 30 40 50 60
pF1KE2 GSGSSLVVIQQPSLDSRQRLDYEREIQPTAILSLDQIKAIRGSNEYTEGPSVVKRPA---
:: ..:... ..::.:.: : . . :
CCDS14 MDAAVTDDFQQILPIEQLRSTHASNDYVERPPAPCKQALSS
10 20 30 40
70 80 90 100 110 120
pF1KE2 PRTAPRQEKHERTHEIIPINVNNNYEHRHTSHLGHAVLPSNARGPILSRSTSTGSAASSG
: . .: . . .: .. : :. : . : : . : .: :::
CCDS14 PSLIVQTHKSDWSLATMPTSLP-----RSLSQC-HQLQP-------LPQHLSQSSIASSM
50 60 70 80
130 140 150 160 170
pF1KE2 SNSSASSEQGLLGRSPPTRPVPGHRSERAIRTQPKQLIVDDLKGSLKEDLTQ-------H
:.:...:.: ::. :. :. .: ::::: . :.:: . : :
CCDS14 SHSTTASDQRLLASITPS---PSGQS--IIRTQPGAGVHPKADGALKGEAEQSAGHPSEH
90 100 110 120 130 140
180 190 200 210 220 230
pF1KE2 KFICEQCGKCKCGECTAPRTLPSCLACNRQCLCSAESMVEYGTCMCLVKGIFYHCSNDDE
::::.::.::: ::: : :::: ::..:::::::...::::.: :::.:::::.:::
CCDS14 LFICEECGRCKCVPCTAARPLPSCWLCNQRCLCSAESLLDYGTCLCCVKGLFYHCSTDDE
150 160 170 180 190 200
240 250 260 270 280 290
pF1KE2 GDSYSDNPCSCSQSHCCSRYLCMGAMSLFLPCLLCYPPAKGCLKLCRRCYDWIHRPGCRC
:. .:.::::. : : :. :. .::::::: :: :..:::.::.. :: ..::::::
CCDS14 -DNCADEPCSCGPSSCFVRWAAMSLISLFLPCLCCYLPTRGCLHLCQQGYDSLRRPGCRC
210 220 230 240 250 260
300 310
pF1KE2 KNSNTVYCKLESCPSRGQGKPS
: ... :.
CCDS14 KRHTNTVCRKISSGSAPFPKAQEKSV
270 280
>>CCDS14769.4 SPRY3 gene_id:10251|Hs108|chrX (288 aa)
initn: 665 init1: 369 opt: 739 Z-score: 625.4 bits: 123.8 E(32554): 1.6e-28
Smith-Waterman score: 746; 42.3% identity (64.5% similar) in 279 aa overlap (38-306:12-271)
10 20 30 40 50 60
pF1KE2 GSGSSLVVIQQPSLDSRQRLDYEREIQPTAILSLDQIKAIRGSNEYTEGPSVVKRPA---
:: ..:... ..::.:.: : . . :
CCDS14 MDAAVTDDFQQILPIEQLRSTHASNDYVERPPAPCKQALSS
10 20 30 40
70 80 90 100 110 120
pF1KE2 PRTAPRQEKHERTHEIIPINVNNNYEHRHTSHLGHAVLPSNARGPILSRSTSTGSAASSG
: . .: . . .: .. : :. : . : : . : .: :::
CCDS14 PSLIVQTHKSDWSLATMPTSLP-----RSLSQC-HQLQP-------LPQHLSQSSIASSM
50 60 70 80
130 140 150 160 170
pF1KE2 SNSSASSEQGLLGRSPPTRPVPGHRSERAIRTQPKQLIVDDLKGSLKEDLTQ-------H
:.:...:.: ::. :. :. .: ::::: . :.:: . : :
CCDS14 SHSTTASDQRLLASITPS---PSGQS--IIRTQPGAGVHPKADGALKGEAEQSAGHPSEH
90 100 110 120 130 140
180 190 200 210 220 230
pF1KE2 KFICEQCGKCKCGECTAPRTLPSCLACNRQCLCSAESMVEYGTCMCLVKGIFYHCSNDDE
::::.::.::: ::: : :::: ::..:::::::...::::.: :::.:::::.:::
CCDS14 LFICEECGRCKCVPCTAARPLPSCWLCNQRCLCSAESLLDYGTCLCCVKGLFYHCSTDDE
150 160 170 180 190 200
240 250 260 270 280 290
pF1KE2 GDSYSDNPCSCSQSHCCSRYLCMGAMSLFLPCLLCYPPAKGCLKLCRRCYDWIHRPGCRC
:. .:.::::. : : :. :. .::::::: :: :..:::.::.. :: ..::::::
CCDS14 -DNCADEPCSCGPSSCFVRWAAMSLISLFLPCLCCYLPTRGCLHLCQQGYDSLRRPGCRC
210 220 230 240 250 260
300 310
pF1KE2 KNSNTVYCKLESCPSRGQGKPS
: ... :.
CCDS14 KRHTNTVCRKISSGSAPFPKAQEKSV
270 280
319 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 10:00:56 2016 done: Sun Nov 6 10:00:57 2016
Total Scan time: 2.650 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]