Result of FASTA (omim) for
pFN21AE2179
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2179, 281 aa
1>>>pF1KE2179 281 - 281 aa - 281 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5266+/-0.000389; mu= 13.8952+/- 0.024
mean_var=69.7355+/-14.070, 0's: 0 Z-trim(112.1): 38 B-trim: 18 in 1/50
Lambda= 0.153584
statistics sampled from 20907 (20941) to 20907 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.631), E-opt: 0.2 (0.246), width: 16
Scan time: 6.680
The best scores are: opt bits E(85289)
NP_003801 (OMIM: 603598) tumor necrosis factor lig ( 281) 1876 424.8 8.8e-119
NP_001177871 (OMIM: 603598) tumor necrosis factor ( 101) 622 146.7 1.6e-35
NP_003692 (OMIM: 259710,602642) tumor necrosis fac ( 317) 318 79.6 8.1e-15
XP_016876292 (OMIM: 259710,602642) PREDICTED: tumo ( 244) 296 74.7 1.9e-13
XP_011533582 (OMIM: 259710,602642) PREDICTED: tumo ( 244) 296 74.7 1.9e-13
NP_143026 (OMIM: 259710,602642) tumor necrosis fac ( 244) 296 74.7 1.9e-13
XP_016876291 (OMIM: 259710,602642) PREDICTED: tumo ( 263) 296 74.7 2e-13
NP_001177872 (OMIM: 603598) tumor necrosis factor ( 65) 282 71.3 5.3e-13
NP_001191273 (OMIM: 604052) tumor necrosis factor ( 192) 222 58.3 1.3e-08
NP_005109 (OMIM: 604052) tumor necrosis factor lig ( 251) 217 57.2 3.6e-08
NP_000630 (OMIM: 134638,211980,601859) tumor necro ( 281) 209 55.5 1.4e-07
NP_742011 (OMIM: 604520) tumor necrosis factor lig ( 204) 189 51.0 2.2e-06
XP_016882906 (OMIM: 604520) PREDICTED: tumor necro ( 240) 189 51.0 2.6e-06
NP_003798 (OMIM: 604520) tumor necrosis factor lig ( 240) 189 51.0 2.6e-06
NP_000585 (OMIM: 157300,191160,600807,611162) tumo ( 233) 153 43.0 0.00063
NP_000065 (OMIM: 300386,308230) CD40 ligand [Homo ( 261) 139 39.9 0.006
>>NP_003801 (OMIM: 603598) tumor necrosis factor ligand (281 aa)
initn: 1876 init1: 1876 opt: 1876 Z-score: 2253.5 bits: 424.8 E(85289): 8.8e-119
Smith-Waterman score: 1876; 100.0% identity (100.0% similar) in 281 aa overlap (1-281:1-281)
10 20 30 40 50 60
pF1KE2 MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 DDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 RVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 FYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLY
190 200 210 220 230 240
250 260 270 280
pF1KE2 SIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
:::::::::::::::::::::::::::::::::::::::::
NP_003 SIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
250 260 270 280
>>NP_001177871 (OMIM: 603598) tumor necrosis factor liga (101 aa)
initn: 675 init1: 622 opt: 622 Z-score: 758.6 bits: 146.7 E(85289): 1.6e-35
Smith-Waterman score: 622; 100.0% identity (100.0% similar) in 90 aa overlap (1-90:1-90)
10 20 30 40 50 60
pF1KE2 MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 DDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQ
::::::::::::::::::::::::::::::
NP_001 DDSYWDPNDEESMNSPCWQVKWQLRQLVRKTPRMKRLWAAK
70 80 90 100
>>NP_003692 (OMIM: 259710,602642) tumor necrosis factor (317 aa)
initn: 269 init1: 179 opt: 318 Z-score: 387.0 bits: 79.6 E(85289): 8.1e-15
Smith-Waterman score: 328; 25.4% identity (58.5% similar) in 284 aa overlap (10-280:42-313)
10 20 30
pF1KE2 MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFT
:. ... . .. : : .: .. . ::
NP_003 LRGSEEMGGGPGAPHEGPLHAPPPPAPHQPPAASRSMFVALLGLGLGQVVCSVALFFYFR
20 30 40 50 60 70
40 50 60 70 80 90
pF1KE2 NELKQMQDKYSKSGIACF-----LKEDDSYWDPN----DEESMNSPCWQVKWQLRQLVRK
.. .. :..: :. :.:. .. : . : . . . : ..: .. :.:
NP_003 AQMDP--NRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQK
80 90 100 110 120
100 110 120 130 140
pF1KE2 MILRTSEETISTVQEKQQNISPL---VRERGPQRVAAHITGTRGRSNTLSSPNSKNEKAL
. . ... . . : : : . . ::.: :. . :..... .:
NP_003 ELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLT-----INATDIPSGSHKVSL
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE2 GRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMV
.:: .: : . .::. . ::.:.... ::::.:.. :: .: . . . :..
NP_003 ----SSWYHDR-GWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLM
190 200 210 220 230
210 220 230 240 250 260
pF1KE2 QYIYKYT-SYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLI
:. : . . :. :::.. .. :: ..:. .::: ::.:.:. ...: . :.: :.
NP_003 VYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLL
240 250 260 270 280 290
270 280
pF1KE2 DMDHEASFFGAFLVG
: :..:..:::: :
NP_003 DPDQDATYFGAFKVRDID
300 310
>>XP_016876292 (OMIM: 259710,602642) PREDICTED: tumor ne (244 aa)
initn: 269 init1: 179 opt: 296 Z-score: 362.4 bits: 74.7 E(85289): 1.9e-13
Smith-Waterman score: 302; 26.7% identity (59.5% similar) in 247 aa overlap (47-280:4-240)
20 30 40 50 60
pF1KE2 VLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACF-----LKEDDSYWDPN---
.. :..: :. :.:. .. : .
XP_016 MDPNRISEDGTHCIYRILRLHENADFQDTTLES
10 20 30
70 80 90 100 110 120
pF1KE2 -DEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPL---VRERGPQRVAA
: . . . : ..: .. :.: . . ... . . : : : . . :
XP_016 QDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFA
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 HITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYI
:.: :. . :..... .: .:: .: : . .::. . ::.:.... ::::.
XP_016 HLT-----INATDIPSGSHKVSL----SSWYHDR-GWAKISNMTFSNGKLIVNQDGFYYL
100 110 120 130 140
190 200 210 220 230 240
pF1KE2 YSQTYFRFQEEIKENTKNDKQMVQYIYKYT-SYPDPILLMKSARNSCWSKDAEYGLYSIY
:.. :: .: . . . :.. :. : . . :. :::.. .. :: ..:. .:::
XP_016 YANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSIN
150 160 170 180 190 200
250 260 270 280
pF1KE2 QGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
::.:.:. ...: . :.: :.: :..:..:::: :
XP_016 VGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
210 220 230 240
>>XP_011533582 (OMIM: 259710,602642) PREDICTED: tumor ne (244 aa)
initn: 269 init1: 179 opt: 296 Z-score: 362.4 bits: 74.7 E(85289): 1.9e-13
Smith-Waterman score: 302; 26.7% identity (59.5% similar) in 247 aa overlap (47-280:4-240)
20 30 40 50 60
pF1KE2 VLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACF-----LKEDDSYWDPN---
.. :..: :. :.:. .. : .
XP_011 MDPNRISEDGTHCIYRILRLHENADFQDTTLES
10 20 30
70 80 90 100 110 120
pF1KE2 -DEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPL---VRERGPQRVAA
: . . . : ..: .. :.: . . ... . . : : : . . :
XP_011 QDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFA
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 HITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYI
:.: :. . :..... .: .:: .: : . .::. . ::.:.... ::::.
XP_011 HLT-----INATDIPSGSHKVSL----SSWYHDR-GWAKISNMTFSNGKLIVNQDGFYYL
100 110 120 130 140
190 200 210 220 230 240
pF1KE2 YSQTYFRFQEEIKENTKNDKQMVQYIYKYT-SYPDPILLMKSARNSCWSKDAEYGLYSIY
:.. :: .: . . . :.. :. : . . :. :::.. .. :: ..:. .:::
XP_011 YANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSIN
150 160 170 180 190 200
250 260 270 280
pF1KE2 QGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
::.:.:. ...: . :.: :.: :..:..:::: :
XP_011 VGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
210 220 230 240
>>NP_143026 (OMIM: 259710,602642) tumor necrosis factor (244 aa)
initn: 269 init1: 179 opt: 296 Z-score: 362.4 bits: 74.7 E(85289): 1.9e-13
Smith-Waterman score: 302; 26.7% identity (59.5% similar) in 247 aa overlap (47-280:4-240)
20 30 40 50 60
pF1KE2 VLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACF-----LKEDDSYWDPN---
.. :..: :. :.:. .. : .
NP_143 MDPNRISEDGTHCIYRILRLHENADFQDTTLES
10 20 30
70 80 90 100 110 120
pF1KE2 -DEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPL---VRERGPQRVAA
: . . . : ..: .. :.: . . ... . . : : : . . :
NP_143 QDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFA
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 HITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYI
:.: :. . :..... .: .:: .: : . .::. . ::.:.... ::::.
NP_143 HLT-----INATDIPSGSHKVSL----SSWYHDR-GWAKISNMTFSNGKLIVNQDGFYYL
100 110 120 130 140
190 200 210 220 230 240
pF1KE2 YSQTYFRFQEEIKENTKNDKQMVQYIYKYT-SYPDPILLMKSARNSCWSKDAEYGLYSIY
:.. :: .: . . . :.. :. : . . :. :::.. .. :: ..:. .:::
NP_143 YANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSIN
150 160 170 180 190 200
250 260 270 280
pF1KE2 QGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
::.:.:. ...: . :.: :.: :..:..:::: :
NP_143 VGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
210 220 230 240
>>XP_016876291 (OMIM: 259710,602642) PREDICTED: tumor ne (263 aa)
initn: 269 init1: 179 opt: 296 Z-score: 361.9 bits: 74.7 E(85289): 2e-13
Smith-Waterman score: 303; 26.6% identity (59.5% similar) in 252 aa overlap (42-280:18-259)
20 30 40 50 60
pF1KE2 LGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACF-----LKEDDSYWD
:.. .. :..: :. :.:. .. :
XP_016 MRGSTKKTDDTSDFKFCLEMDPNRISEDGTHCIYRILRLHENADFQD
10 20 30 40
70 80 90 100 110
pF1KE2 PN----DEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPL---VRERGP
. : . . . : ..: .. :.: . . ... . . : : : .
XP_016 TTLESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLE
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE2 QRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEK
. ::.: :. . :..... .: .:: .: : . .::. . ::.:....
XP_016 AQPFAHLT-----INATDIPSGSHKVSL----SSWYHDR-GWAKISNMTFSNGKLIVNQD
110 120 130 140 150
180 190 200 210 220 230
pF1KE2 GFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYT-SYPDPILLMKSARNSCWSKDAEYG
::::.:.. :: .: . . . :.. :. : . . :. :::.. .. :: ..:.
XP_016 GFYYLYANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFH
160 170 180 190 200 210
240 250 260 270 280
pF1KE2 LYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
.::: ::.:.:. ...: . :.: :.: :..:..:::: :
XP_016 FYSINVGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
220 230 240 250 260
>>NP_001177872 (OMIM: 603598) tumor necrosis factor liga (65 aa)
initn: 318 init1: 282 opt: 282 Z-score: 354.4 bits: 71.3 E(85289): 5.3e-13
Smith-Waterman score: 282; 93.6% identity (97.9% similar) in 47 aa overlap (1-47:1-47)
10 20 30 40 50 60
pF1KE2 MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKE
::::::::::::::::::::::::::::::::::::::::::::. .
NP_001 MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQFAENDCQRLMSGQQTG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 DDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQ
NP_001 SLLPS
>>NP_001191273 (OMIM: 604052) tumor necrosis factor liga (192 aa)
initn: 158 init1: 74 opt: 222 Z-score: 275.4 bits: 58.3 E(85289): 1.3e-08
Smith-Waterman score: 222; 32.4% identity (59.6% similar) in 188 aa overlap (108-280:18-192)
80 90 100 110 120 130
pF1KE2 WQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVA-----AHITGTRGR
..:::.: . .: :. ::.: .:
NP_001 MQLTKGRLHFSHPLSHTKHISPFVTD-APLRADGDKPRAHLTVVR--
10 20 30 40
140 150 160 170 180 190
pF1KE2 SNTLSSPNSKNE-KALGRKINSWESSRSGHSFLSN-LHLRNGELVIHEKGFYYIYSQTYF
. . ::. :: :: . : .: .: .. : :.: :.: :.::::. :
NP_001 --QTPTQHFKNQFPAL-----HWEH-ELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTF
50 60 70 80 90
200 210 220 230 240
pF1KE2 RFQE----EIKENTKNDK--QMVQYIYKYT-SYPDPILLMKSARNSCWSKDAEYGLYSIY
: . ::.. . .: ... : : : :::.: :. .... : . . ::
NP_001 RGMTSECSEIRQAGRPNKPDSITVVITKVTDSYPEPTQLLMGTKSVCEVGSNWF--QPIY
100 110 120 130 140 150
250 260 270 280
pF1KE2 QGGIFELKENDRIFVSVTNEHLIDMDHE-ASFFGAFLVG
:..: :.:.:...:.:.. :.:. .: .::::::.
NP_001 LGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAFLL
160 170 180 190
>>NP_005109 (OMIM: 604052) tumor necrosis factor ligand (251 aa)
initn: 142 init1: 74 opt: 217 Z-score: 267.6 bits: 57.2 E(85289): 3.6e-08
Smith-Waterman score: 225; 31.6% identity (58.5% similar) in 212 aa overlap (79-280:58-251)
50 60 70 80 90 100
pF1KE2 YSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQ
:.. : . :. . :. .: . : .::
NP_005 ARSSSARWALTCCLVLLPFLAGLTTYLLVSQLRAQGEACVQFQALKGQEFAPS----HQQ
30 40 50 60 70 80
110 120 130 140 150 160
pF1KE2 NISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNE-KALGRKINSWESSRSGHSFLSN-
.:: : : .. ::.: .: . . ::. :: :: . : .: .:
NP_005 VYAPL-RADG-DKPRAHLTVVR----QTPTQHFKNQFPAL-----HWEH-ELGLAFTKNR
90 100 110 120 130
170 180 190 200 210
pF1KE2 LHLRNGELVIHEKGFYYIYSQTYFRFQE----EIKENTKNDK--QMVQYIYKYT-SYPDP
.. : :.: :.: :.::::. :: . ::.. . .: ... : : : :::.:
NP_005 MNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKVTDSYPEP
140 150 160 170 180 190
220 230 240 250 260 270
pF1KE2 ILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHE-ASFFGAF
:. .... : . . :: :..: :.:.:...:.:.. :.:. .: .:::::
NP_005 TQLLMGTKSVCEVGSNWF--QPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAF
200 210 220 230 240
280
pF1KE2 LVG
:.
NP_005 LL
250
281 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 00:03:16 2016 done: Mon Nov 7 00:03:17 2016
Total Scan time: 6.680 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]