Result of FASTA (omim) for
pFN21AE2158
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2158, 207 aa
1>>>pF1KE2158 207 - 207 aa - 207 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1634+/-0.000355; mu= 14.5259+/- 0.022
mean_var=65.0103+/-13.187, 0's: 0 Z-trim(113.5): 17 B-trim: 0 in 0/49
Lambda= 0.159068
statistics sampled from 22874 (22891) to 22874 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.649), E-opt: 0.2 (0.268), width: 16
Scan time: 5.650
The best scores are: opt bits E(85289)
NP_001172085 (OMIM: 604136) interleukin-24 isoform ( 207) 1373 323.6 1.5e-88
NP_006841 (OMIM: 604136) interleukin-24 isoform 1 ( 206) 1356 319.6 2.2e-87
XP_011507403 (OMIM: 604136) PREDICTED: interleukin ( 179) 1178 278.8 3.8e-75
XP_016855610 (OMIM: 604136) PREDICTED: interleukin ( 179) 1178 278.8 3.8e-75
NP_001172086 (OMIM: 604136) interleukin-24 isoform ( 154) 705 170.2 1.6e-42
XP_005273209 (OMIM: 605619) PREDICTED: interleukin ( 261) 296 76.5 4.5e-14
NP_061194 (OMIM: 605619) interleukin-20 precursor ( 176) 292 75.4 6.1e-14
NP_715639 (OMIM: 605687) interleukin-19 isoform 1 ( 215) 247 65.2 9.2e-11
NP_037503 (OMIM: 605687) interleukin-19 isoform 2 ( 177) 243 64.2 1.5e-10
NP_000563 (OMIM: 124092,180300,609423,614395) inte ( 178) 142 41.0 0.0014
XP_011507752 (OMIM: 605687) PREDICTED: interleukin ( 207) 141 40.8 0.0019
>>NP_001172085 (OMIM: 604136) interleukin-24 isoform 3 p (207 aa)
initn: 1373 init1: 1373 opt: 1373 Z-score: 1711.0 bits: 323.6 E(85289): 1.5e-88
Smith-Waterman score: 1373; 100.0% identity (100.0% similar) in 207 aa overlap (1-207:1-207)
10 20 30 40 50 60
pF1KE2 MNFQQRLQSLWTLASRPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNFQQRLQSLWTLASRPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 QVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQ
130 140 150 160 170 180
190 200
pF1KE2 LDVEAALTKALGEVDILLTWMQKFYKL
:::::::::::::::::::::::::::
NP_001 LDVEAALTKALGEVDILLTWMQKFYKL
190 200
>>NP_006841 (OMIM: 604136) interleukin-24 isoform 1 prec (206 aa)
initn: 1274 init1: 1274 opt: 1356 Z-score: 1689.9 bits: 319.6 E(85289): 2.2e-87
Smith-Waterman score: 1356; 99.5% identity (99.5% similar) in 207 aa overlap (1-207:1-206)
10 20 30 40 50 60
pF1KE2 MNFQQRLQSLWTLASRPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPC
:::::::::::::: :::::::::::::::::::::::::::::::::::::::::::::
NP_006 MNFQQRLQSLWTLA-RPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPC
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 QVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 QVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKT
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 VFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQ
120 130 140 150 160 170
190 200
pF1KE2 LDVEAALTKALGEVDILLTWMQKFYKL
:::::::::::::::::::::::::::
NP_006 LDVEAALTKALGEVDILLTWMQKFYKL
180 190 200
>>XP_011507403 (OMIM: 604136) PREDICTED: interleukin-24 (179 aa)
initn: 1178 init1: 1178 opt: 1178 Z-score: 1470.0 bits: 278.8 E(85289): 3.8e-75
Smith-Waterman score: 1178; 100.0% identity (100.0% similar) in 179 aa overlap (29-207:1-179)
10 20 30 40 50 60
pF1KE2 MNFQQRLQSLWTLASRPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPC
::::::::::::::::::::::::::::::::
XP_011 MQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPC
10 20 30
70 80 90 100 110 120
pF1KE2 QVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKT
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 VFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQ
100 110 120 130 140 150
190 200
pF1KE2 LDVEAALTKALGEVDILLTWMQKFYKL
:::::::::::::::::::::::::::
XP_011 LDVEAALTKALGEVDILLTWMQKFYKL
160 170
>>XP_016855610 (OMIM: 604136) PREDICTED: interleukin-24 (179 aa)
initn: 1178 init1: 1178 opt: 1178 Z-score: 1470.0 bits: 278.8 E(85289): 3.8e-75
Smith-Waterman score: 1178; 100.0% identity (100.0% similar) in 179 aa overlap (29-207:1-179)
10 20 30 40 50 60
pF1KE2 MNFQQRLQSLWTLASRPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPC
::::::::::::::::::::::::::::::::
XP_016 MQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPC
10 20 30
70 80 90 100 110 120
pF1KE2 QVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKT
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 VFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQ
100 110 120 130 140 150
190 200
pF1KE2 LDVEAALTKALGEVDILLTWMQKFYKL
:::::::::::::::::::::::::::
XP_016 LDVEAALTKALGEVDILLTWMQKFYKL
160 170
>>NP_001172086 (OMIM: 604136) interleukin-24 isoform 4 p (154 aa)
initn: 705 init1: 705 opt: 705 Z-score: 884.4 bits: 170.2 E(85289): 1.6e-42
Smith-Waterman score: 923; 74.4% identity (74.4% similar) in 207 aa overlap (1-207:1-154)
10 20 30 40 50 60
pF1KE2 MNFQQRLQSLWTLASRPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNFQQRLQSLWTLASRPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 QVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKT
::::::::::::::::::::::::::::::::::::::::::
NP_001 QVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVS------------------
70 80 90 100
130 140 150 160 170 180
pF1KE2 VFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQ
:::::::::::::::::::::::::
NP_001 -----------------------------------QENEMFSIRDSAHRRFLLFRRAFKQ
110 120
190 200
pF1KE2 LDVEAALTKALGEVDILLTWMQKFYKL
:::::::::::::::::::::::::::
NP_001 LDVEAALTKALGEVDILLTWMQKFYKL
130 140 150
>>XP_005273209 (OMIM: 605619) PREDICTED: interleukin-20 (261 aa)
initn: 278 init1: 149 opt: 296 Z-score: 373.7 bits: 76.5 E(85289): 4.5e-14
Smith-Waterman score: 296; 31.8% identity (64.1% similar) in 195 aa overlap (10-203:77-259)
10 20 30
pF1KE2 MNFQQRLQSLWTLASRPFCPPLLATASQMQMVVLPCLGF
:: : : : . ::.. . .: .
XP_005 ATTCATNSHSDSELRPEIFSSREAWQFFLLLW---SPDFRPKM--KASSLAFSLLSAAFY
50 60 70 80 90 100
40 50 60 70 80 90
pF1KE2 TLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQ-EVL
:::. .: . ...: : . . :.. ..: .. ..::.:. . :.:.. : :
XP_005 --LLWTPSTGLK--TLNLGSCVIATNL-QEIRNGFSEIRGSVQAKDGNIDIRILRRTESL
110 120 130 140 150
100 110 120 130 140 150
pF1KE2 QNVSDAESCYLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQEN
:... :. : :.. ::..:: ::::: .: . ::...:.:::.:. : ..:. . .
XP_005 QDTKPANRCCLLRHLLRLYLDRVFKNY--QTPDHYTLRKISSLANSFLTIKKDLRLCHAH
160 170 180 190 200 210
160 170 180 190 200
pF1KE2 EMFSIRDSAHRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKFYKL
. : ... . :..:. .::..:::::.:::: ::..
XP_005 MTCHCGEEAMKKYSQILSHFEKLEPQAAVVKALGELDILLQWMEETE
220 230 240 250 260
>>NP_061194 (OMIM: 605619) interleukin-20 precursor [Hom (176 aa)
initn: 251 init1: 149 opt: 292 Z-score: 371.3 bits: 75.4 E(85289): 6.1e-14
Smith-Waterman score: 292; 33.1% identity (68.1% similar) in 163 aa overlap (42-203:17-174)
20 30 40 50 60 70
pF1KE2 TLASRPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLW
:::. .: . ...: : . . :..
NP_061 MKASSLAFSLLSAAFYLLWTPSTGLK--TLNLGSCVIATNL-QEIR
10 20 30 40
80 90 100 110 120 130
pF1KE2 EAFWAVKDTMQAQDNITSARLLQQ-EVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTV
..: .. ..::.:. . :.:.. : ::... :. : :.. ::..:: ::::: .:
NP_061 NGFSEIRGSVQAKDGNIDIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNY--QTP
50 60 70 80 90 100
140 150 160 170 180 190
pF1KE2 EVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKA
. ::...:.:::.:. : ..:. . . . : ... . :..:. .::..::
NP_061 DHYTLRKISSLANSFLTIKKDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKA
110 120 130 140 150 160
200
pF1KE2 LGEVDILLTWMQKFYKL
:::.:::: ::..
NP_061 LGELDILLQWMEETE
170
>>NP_715639 (OMIM: 605687) interleukin-19 isoform 1 [Hom (215 aa)
initn: 216 init1: 127 opt: 247 Z-score: 314.2 bits: 65.2 E(85289): 9.2e-11
Smith-Waterman score: 247; 28.4% identity (65.8% similar) in 190 aa overlap (19-203:27-207)
10 20 30 40
pF1KE2 MNFQQRLQSLWTLASRPFCPPLL----ATASQMQMVVLPCLGFTLLLWSQVS
: :.: . ..: : : :: :.:. .:.
NP_715 MCTEGAFPHRSACSLPLTHVHTHIHVCVPVLWGSVPRGMKLQCVSLWLLG-TILILCSVD
10 20 30 40 50
50 60 70 80 90 100
pF1KE2 GAQGQEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQ-EVLQNVSDAESC
. .: . : .. . ... :.: .: ..::.:.. .. .:. :.:: .. . :
NP_715 N-HGLR----RCLISTDM-HHIEESFQEIKRAIQAKDTFPNVTILSTLETLQIIKPLDVC
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE2 YLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSA
....:: ::. :::.... . .. :...:..::.:. . . :. ::... :. :
NP_715 CVTKNLLAFYVDRVFKDHQEPNPKI--LRKISSIANSFLYMQKTLRQCQEQRQCHCRQEA
120 130 140 150 160 170
170 180 190 200
pF1KE2 HRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKFYKL
... . ::.:.:: :.:::.:..:.:..:
NP_715 TNATRVIHDNYDQLEVHAAAIKSLGELDVFLAWINKNHEVMFSA
180 190 200 210
>>NP_037503 (OMIM: 605687) interleukin-19 isoform 2 prec (177 aa)
initn: 216 init1: 127 opt: 243 Z-score: 310.5 bits: 64.2 E(85289): 1.5e-10
Smith-Waterman score: 243; 28.8% identity (67.8% similar) in 177 aa overlap (28-203:2-169)
10 20 30 40 50 60
pF1KE2 MNFQQRLQSLWTLASRPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPC
..: : : :: :.:. .:.. .: . :
NP_037 MKLQCVSLWLLG-TILILCSVDN-HGLRR----C
10 20
70 80 90 100 110
pF1KE2 QVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQ-EVLQNVSDAESCYLVHTLLEFYLK
.. . ... :.: .: ..::.:.. .. .:. :.:: .. . : ....:: ::.
NP_037 LISTDM-HHIEESFQEIKRAIQAKDTFPNVTILSTLETLQIIKPLDVCCVTKNLLAFYVD
30 40 50 60 70 80
120 130 140 150 160 170
pF1KE2 TVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFK
:::.... . .. :...:..::.:. . . :. ::... :. : ... .
NP_037 RVFKDHQEPNPKI--LRKISSIANSFLYMQKTLRQCQEQRQCHCRQEATNATRVIHDNYD
90 100 110 120 130 140
180 190 200
pF1KE2 QLDVEAALTKALGEVDILLTWMQKFYKL
::.:.:: :.:::.:..:.:..:
NP_037 QLEVHAAAIKSLGELDVFLAWINKNHEVMFSA
150 160 170
>>NP_000563 (OMIM: 124092,180300,609423,614395) interleu (178 aa)
initn: 87 init1: 46 opt: 142 Z-score: 185.2 bits: 41.0 E(85289): 0.0014
Smith-Waterman score: 142; 21.9% identity (59.6% similar) in 178 aa overlap (33-207:6-174)
10 20 30 40 50 60
pF1KE2 FQQRLQSLWTLASRPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQV
.: :: .:: ..: .:: . . . .
NP_000 MHSSALLCCL--VLLTGVRASPGQGTQSENSCTHF
10 20 30
70 80 90 100 110
pF1KE2 KGVVP---QKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLK
: .: . : .:: :: .: .:.. . ::.. .:.. . .: . ...:::.
NP_000 PGNLPNMLRDLRDAFSRVKTFFQMKDQLDNL-LLKESLLEDFKGYLGCQALSEMIQFYLE
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE2 TVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFK
:. . .:. .... ..:..:. . .:. .. : .. . . ::.
NP_000 EVMPQAENQDPDIKA--HVNSLGENLKTLRLRLRRCHR---FLPCENKSKAVEQVKNAFN
100 110 120 130 140
180 190 200
pF1KE2 QLDVEAALTKALGEVDILLTWMQKFYKL
.:. : .. ::..: ::...... .. .
NP_000 KLQ-EKGIYKAMSEFDIFINYIEAYMTMKIRN
150 160 170
207 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 23:06:19 2016 done: Sun Nov 6 23:06:20 2016
Total Scan time: 5.650 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]