Result of FASTA (omim) for
pFN21AE2134
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2134, 858 aa
1>>>pF1KE2134 858 - 858 aa - 858 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.2131+/-0.000543; mu= 15.9585+/- 0.033
mean_var=134.9191+/-28.899, 0's: 0 Z-trim(108.9): 373 B-trim: 219 in 1/50
Lambda= 0.110417
statistics sampled from 16580 (17042) to 16580 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.531), E-opt: 0.2 (0.2), width: 16
Scan time: 9.070
The best scores are: opt bits E(85289)
XP_016857697 (OMIM: 601744,603031,608556,615557) P ( 858) 5692 920.1 0
XP_006711568 (OMIM: 601744,603031,608556,615557) P ( 858) 5692 920.1 0
XP_005273300 (OMIM: 601744,603031,608556,615557) P ( 858) 5692 920.1 0
XP_005273298 (OMIM: 601744,603031,608556,615557) P ( 858) 5692 920.1 0
XP_005273299 (OMIM: 601744,603031,608556,615557) P ( 858) 5692 920.1 0
XP_011508239 (OMIM: 601744,603031,608556,615557) P ( 858) 5692 920.1 0
NP_003259 (OMIM: 601744,603031,608556,615557) toll ( 858) 5692 920.1 0
XP_006711569 (OMIM: 601744,603031,608556,615557) P ( 858) 5692 920.1 0
XP_006711567 (OMIM: 601744,603031,608556,615557) P ( 858) 5692 920.1 0
NP_619542 (OMIM: 300366) toll-like receptor 8 isof (1041) 653 117.5 3.2e-25
XP_011543831 (OMIM: 300366) PREDICTED: toll-like r (1059) 653 117.5 3.2e-25
XP_011543832 (OMIM: 300366) PREDICTED: toll-like r (1059) 653 117.5 3.2e-25
NP_057694 (OMIM: 300366) toll-like receptor 8 isof (1059) 653 117.5 3.2e-25
NP_057646 (OMIM: 300365) toll-like receptor 7 prec (1049) 626 113.2 6.3e-24
NP_059138 (OMIM: 605474) toll-like receptor 9 prec (1032) 521 96.5 6.8e-19
XP_016864066 (OMIM: 603029,609423) PREDICTED: toll ( 627) 498 92.6 6.1e-18
XP_011512046 (OMIM: 601194,613223) PREDICTED: toll ( 786) 449 84.9 1.6e-15
XP_011512044 (OMIM: 601194,613223) PREDICTED: toll ( 786) 449 84.9 1.6e-15
XP_005262719 (OMIM: 601194,613223) PREDICTED: toll ( 786) 449 84.9 1.6e-15
XP_016864061 (OMIM: 601194,613223) PREDICTED: toll ( 786) 449 84.9 1.6e-15
NP_003254 (OMIM: 601194,613223) toll-like receptor ( 786) 449 84.9 1.6e-15
XP_011512045 (OMIM: 601194,613223) PREDICTED: toll ( 786) 449 84.9 1.6e-15
XP_016864060 (OMIM: 601194,613223) PREDICTED: toll ( 786) 449 84.9 1.6e-15
XP_011512047 (OMIM: 601194,613223) PREDICTED: toll ( 786) 449 84.9 1.6e-15
NP_006059 (OMIM: 605403) toll-like receptor 6 prec ( 796) 401 77.3 3.2e-13
XP_011511915 (OMIM: 605403) PREDICTED: toll-like r ( 796) 401 77.3 3.2e-13
XP_011511914 (OMIM: 605403) PREDICTED: toll-like r ( 796) 401 77.3 3.2e-13
XP_011511916 (OMIM: 605403) PREDICTED: toll-like r ( 796) 401 77.3 3.2e-13
XP_005262694 (OMIM: 605403) PREDICTED: toll-like r ( 796) 401 77.3 3.2e-13
NP_003257 (OMIM: 603030,611488) toll-like receptor ( 799) 388 75.2 1.4e-12
NP_612564 (OMIM: 603030,611488) toll-like receptor ( 839) 388 75.2 1.4e-12
NP_004479 (OMIM: 173511) platelet glycoprotein V p ( 560) 356 69.9 3.6e-11
NP_001305722 (OMIM: 246300,603028,607948) toll-lik ( 784) 357 70.2 4.1e-11
XP_016864064 (OMIM: 246300,603028,607948) PREDICTE ( 784) 357 70.2 4.1e-11
NP_001305720 (OMIM: 246300,603028,607948) toll-lik ( 784) 357 70.2 4.1e-11
NP_001305719 (OMIM: 246300,603028,607948) toll-lik ( 784) 357 70.2 4.1e-11
XP_016864062 (OMIM: 246300,603028,607948) PREDICTE ( 784) 357 70.2 4.1e-11
NP_001305716 (OMIM: 246300,603028,607948) toll-lik ( 784) 357 70.2 4.1e-11
XP_011530517 (OMIM: 246300,603028,607948) PREDICTE ( 784) 357 70.2 4.1e-11
NP_003255 (OMIM: 246300,603028,607948) toll-like r ( 784) 357 70.2 4.1e-11
XP_011530518 (OMIM: 246300,603028,607948) PREDICTE ( 784) 357 70.2 4.1e-11
XP_016864065 (OMIM: 246300,603028,607948) PREDICTE ( 784) 357 70.2 4.1e-11
NP_001305724 (OMIM: 246300,603028,607948) toll-lik ( 784) 357 70.2 4.1e-11
NP_001305725 (OMIM: 246300,603028,607948) toll-lik ( 784) 357 70.2 4.1e-11
XP_016864063 (OMIM: 246300,603028,607948) PREDICTE ( 784) 357 70.2 4.1e-11
NP_001305718 (OMIM: 246300,603028,607948) toll-lik ( 784) 357 70.2 4.1e-11
NP_004961 (OMIM: 601489,615961) insulin-like growt ( 605) 328 65.5 8.4e-10
NP_001139478 (OMIM: 601489,615961) insulin-like gr ( 643) 328 65.5 8.8e-10
NP_001004432 (OMIM: 609794) leucine-rich repeat an ( 593) 323 64.7 1.4e-09
NP_612567 (OMIM: 603030,611488) toll-like receptor ( 639) 315 63.5 3.7e-09
>>XP_016857697 (OMIM: 601744,603031,608556,615557) PREDI (858 aa)
initn: 5692 init1: 5692 opt: 5692 Z-score: 4913.0 bits: 920.1 E(85289): 0
Smith-Waterman score: 5692; 99.8% identity (100.0% similar) in 858 aa overlap (1-858:1-858)
10 20 30 40 50 60
pF1KE2 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFISWLNHTNVT
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
XP_016 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 IAGPPADIYCVYPDSLSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV
:::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE
790 800 810 820 830 840
850
pF1KE2 KEKKKDNNIPLQTVATIS
::::::::::::::::::
XP_016 KEKKKDNNIPLQTVATIS
850
>>XP_006711568 (OMIM: 601744,603031,608556,615557) PREDI (858 aa)
initn: 5692 init1: 5692 opt: 5692 Z-score: 4913.0 bits: 920.1 E(85289): 0
Smith-Waterman score: 5692; 99.8% identity (100.0% similar) in 858 aa overlap (1-858:1-858)
10 20 30 40 50 60
pF1KE2 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFISWLNHTNVT
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
XP_006 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 IAGPPADIYCVYPDSLSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV
:::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::
XP_006 IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE
790 800 810 820 830 840
850
pF1KE2 KEKKKDNNIPLQTVATIS
::::::::::::::::::
XP_006 KEKKKDNNIPLQTVATIS
850
>>XP_005273300 (OMIM: 601744,603031,608556,615557) PREDI (858 aa)
initn: 5692 init1: 5692 opt: 5692 Z-score: 4913.0 bits: 920.1 E(85289): 0
Smith-Waterman score: 5692; 99.8% identity (100.0% similar) in 858 aa overlap (1-858:1-858)
10 20 30 40 50 60
pF1KE2 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFISWLNHTNVT
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
XP_005 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 IAGPPADIYCVYPDSLSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV
:::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::
XP_005 IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE
790 800 810 820 830 840
850
pF1KE2 KEKKKDNNIPLQTVATIS
::::::::::::::::::
XP_005 KEKKKDNNIPLQTVATIS
850
>>XP_005273298 (OMIM: 601744,603031,608556,615557) PREDI (858 aa)
initn: 5692 init1: 5692 opt: 5692 Z-score: 4913.0 bits: 920.1 E(85289): 0
Smith-Waterman score: 5692; 99.8% identity (100.0% similar) in 858 aa overlap (1-858:1-858)
10 20 30 40 50 60
pF1KE2 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFISWLNHTNVT
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
XP_005 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 IAGPPADIYCVYPDSLSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV
:::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::
XP_005 IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE
790 800 810 820 830 840
850
pF1KE2 KEKKKDNNIPLQTVATIS
::::::::::::::::::
XP_005 KEKKKDNNIPLQTVATIS
850
>>XP_005273299 (OMIM: 601744,603031,608556,615557) PREDI (858 aa)
initn: 5692 init1: 5692 opt: 5692 Z-score: 4913.0 bits: 920.1 E(85289): 0
Smith-Waterman score: 5692; 99.8% identity (100.0% similar) in 858 aa overlap (1-858:1-858)
10 20 30 40 50 60
pF1KE2 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFISWLNHTNVT
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
XP_005 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 IAGPPADIYCVYPDSLSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV
:::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::
XP_005 IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE
790 800 810 820 830 840
850
pF1KE2 KEKKKDNNIPLQTVATIS
::::::::::::::::::
XP_005 KEKKKDNNIPLQTVATIS
850
>>XP_011508239 (OMIM: 601744,603031,608556,615557) PREDI (858 aa)
initn: 5692 init1: 5692 opt: 5692 Z-score: 4913.0 bits: 920.1 E(85289): 0
Smith-Waterman score: 5692; 99.8% identity (100.0% similar) in 858 aa overlap (1-858:1-858)
10 20 30 40 50 60
pF1KE2 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFISWLNHTNVT
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
XP_011 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 IAGPPADIYCVYPDSLSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV
:::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::
XP_011 IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE
790 800 810 820 830 840
850
pF1KE2 KEKKKDNNIPLQTVATIS
::::::::::::::::::
XP_011 KEKKKDNNIPLQTVATIS
850
>>NP_003259 (OMIM: 601744,603031,608556,615557) toll-lik (858 aa)
initn: 5692 init1: 5692 opt: 5692 Z-score: 4913.0 bits: 920.1 E(85289): 0
Smith-Waterman score: 5692; 99.8% identity (100.0% similar) in 858 aa overlap (1-858:1-858)
10 20 30 40 50 60
pF1KE2 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFISWLNHTNVT
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
NP_003 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 IAGPPADIYCVYPDSLSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV
:::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::
NP_003 IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE
790 800 810 820 830 840
850
pF1KE2 KEKKKDNNIPLQTVATIS
::::::::::::::::::
NP_003 KEKKKDNNIPLQTVATIS
850
>>XP_006711569 (OMIM: 601744,603031,608556,615557) PREDI (858 aa)
initn: 5692 init1: 5692 opt: 5692 Z-score: 4913.0 bits: 920.1 E(85289): 0
Smith-Waterman score: 5692; 99.8% identity (100.0% similar) in 858 aa overlap (1-858:1-858)
10 20 30 40 50 60
pF1KE2 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFISWLNHTNVT
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
XP_006 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 IAGPPADIYCVYPDSLSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV
:::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::
XP_006 IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE
790 800 810 820 830 840
850
pF1KE2 KEKKKDNNIPLQTVATIS
::::::::::::::::::
XP_006 KEKKKDNNIPLQTVATIS
850
>>XP_006711567 (OMIM: 601744,603031,608556,615557) PREDI (858 aa)
initn: 5692 init1: 5692 opt: 5692 Z-score: 4913.0 bits: 920.1 E(85289): 0
Smith-Waterman score: 5692; 99.8% identity (100.0% similar) in 858 aa overlap (1-858:1-858)
10 20 30 40 50 60
pF1KE2 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFISWLNHTNVT
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
XP_006 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 IAGPPADIYCVYPDSLSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV
:::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::
XP_006 IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE
790 800 810 820 830 840
850
pF1KE2 KEKKKDNNIPLQTVATIS
::::::::::::::::::
XP_006 KEKKKDNNIPLQTVATIS
850
>>NP_619542 (OMIM: 300366) toll-like receptor 8 isoform (1041 aa)
initn: 303 init1: 134 opt: 653 Z-score: 573.8 bits: 117.5 E(85289): 3.2e-25
Smith-Waterman score: 699; 27.1% identity (56.5% similar) in 874 aa overlap (35-847:210-1032)
10 20 30 40 50 60
pF1KE2 LDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTER-LLLSFNYIRTVTA
: .:..:: : .. : :.:: . :. ..
NP_619 NCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISE
180 190 200 210 220 230
70 80 90 100
pF1KE2 SSFPFLEQLQLLELGSQ-----YTP-----------LTIDKEAFRNLPNLRILDLGSSKI
.: : .: ::.:... .: ..::. ::.:: .:: :.:.:...
NP_619 EDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSL
240 250 260 270 280 290
110 120 130 140 150 160
pF1KE2 YFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLY-----L
.. :... :: : : : : . . ... : : :::: : :.. : .
NP_619 RKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINI
300 310 320 330 340 350
170 180 190 200 210 220
pF1KE2 HPSFGKLNSLKSIDFSSNQIFLVCEHELEPL-QGKTLSFFSLAANSLYSRVSVDWGKCMN
.:.:: ::... . . . . : ...:: : .:: ..:. : . . .:. : ..
NP_619 SRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQ---IDF-KLFQ
360 370 380 390 400 410
230 240 250 260 270
pF1KE2 PFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIM---GAGFGFHNIKDPD
: : :::. .: : . .. . .. ..:..:. .:: .. : : ::
NP_619 NFSN--LEIIYLSENRIS-PLVKDTRQSYANSSSFQ----RHIRKRRSTDFEF----DPH
420 430 440 450 460
280 290 300 310 320 330
pF1KE2 QNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNL
.: : ..: .. ..: :.:.:. :.: :. . : .: ..
NP_619 SN-FYHFTRPLIKPQCAAYG----------------KALDLSLNSIFFIGPNQFENLPDI
470 480 490 500
340 350 360 370 380 390
pF1KE2 QVLNLSYNLLGELYS-SNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDN---
:::: : ... : ..: ..:.: :.:: .:.. . . ... : :..::: :
NP_619 ACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHY
510 520 530 540 550 560
400 410 420 430
pF1KE2 ---ALTTIH--FIPSIPDIF---LSGNKLVTLP-KINL-TANLIHL--SENRLENL----
: .: : :: .. .. :: :.. :: : :: . .:..: : :::. :
NP_619 FRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDD
570 580 590 600 610 620
440 450 460 470 480 490
pF1KE2 DILYFLLR--VPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWD
: :. . . .: : :. ::.. .. . :: .: ...:::.. . :
NP_619 DNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKF-----FNWT
630 640 650 660 670 680
500 510 520 530 540 550
pF1KE2 VFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLP--ANLEILD
... . .:..: : : : : .. . ..:: : :. ::.. : . : ..:. ::
NP_619 LLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLD
690 700 710 720 730 740
560 570 580 590 600
pF1KE2 ISRNQLLAPNPDVF-----VSLSVLDITHNKFICECELSTFISWLN-HTNVTIAGPP-AD
.: : : . : ... ..::.:.. : : : :... : :.. : :: : : .:
NP_619 LSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKI--PRLVD
750 760 770 780 790 800
610 620 630 640 650 660
pF1KE2 IYCVYPDSLSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFC
. :. : . : :. :: : . . : : :.. :. ... :. :
NP_619 VICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFI----TTMVMLAALAHHLFYWDV
810 820 830 840 850
670 680 690 700 710 720
pF1KE2 FICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFT---WVQNALLKHLDTQYSDQNR
.. :.. : : . . . . . ::::. ...:: . :: : : ::. . :.:
NP_619 WFIYNVCLAKV-KGYRSLSTSQTF-YDAYISYDTKDASVTDWVINELRYHLE-ESRDKNV
860 870 880 890 900 910
730 740 750 760 770 780
pF1KE2 FNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLE-AFSYAQGRCLSDL
. ::.::::. :: : :....: .:.: : ...... .. : .. :: : : ...
NP_619 L-LCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKS-WNFKTAFYLALQRLMDEN
920 930 940 950 960 970
790 800 810 820 830 840
pF1KE2 NSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKEKEK
...:.... . :.. .. .: . :.. :.::.. . : : . : . .: :...
NP_619 MDVIIFILLEPVLQHS--QYLRLRQRICKSSILQWPDNPKAEGLFWQTLRNVVLT-ENDS
980 990 1000 1010 1020
850
pF1KE2 KKDNNIPLQTVATIS
. .:
NP_619 RYNNMYVDSIKQY
1030 1040
858 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 10:47:35 2016 done: Tue Nov 8 10:47:36 2016
Total Scan time: 9.070 Total Display time: 0.270
Function used was FASTA [36.3.4 Apr, 2011]