Result of FASTA (omim) for
pFN21AE2118
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2118, 859 aa
1>>>pF1KE2118 859 - 859 aa - 859 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.5463+/-0.000456; mu= -8.0820+/- 0.029
mean_var=739.2528+/-154.009, 0's: 0 Z-trim(124.4): 1427 B-trim: 0 in 0/62
Lambda= 0.047171
statistics sampled from 44031 (46021) to 44031 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.811), E-opt: 0.2 (0.54), width: 16
Scan time: 17.500
The best scores are: opt bits E(85289)
XP_016875445 (OMIM: 600447) PREDICTED: mitogen-act ( 859) 5898 417.4 1.4e-115
NP_006292 (OMIM: 600447) mitogen-activated protein ( 859) 5898 417.4 1.4e-115
XP_011537027 (OMIM: 600447) PREDICTED: mitogen-act ( 892) 5582 395.9 4.4e-109
XP_005269195 (OMIM: 600447) PREDICTED: mitogen-act ( 892) 5582 395.9 4.4e-109
XP_006719651 (OMIM: 600447) PREDICTED: mitogen-act ( 892) 5582 395.9 4.4e-109
NP_001180440 (OMIM: 600447) mitogen-activated prot ( 892) 5582 395.9 4.4e-109
XP_011511612 (OMIM: 604915) PREDICTED: mitogen-act ( 966) 2630 195.0 1.4e-48
XP_016862945 (OMIM: 604915) PREDICTED: mitogen-act ( 966) 2630 195.0 1.4e-48
NP_004712 (OMIM: 604915) mitogen-activated protein ( 966) 2630 195.0 1.4e-48
NP_001229243 (OMIM: 604915) mitogen-activated prot ( 966) 2630 195.0 1.4e-48
XP_005269197 (OMIM: 600447) PREDICTED: mitogen-act ( 453) 2558 189.7 2.6e-47
XP_016862946 (OMIM: 604915) PREDICTED: mitogen-act ( 817) 2408 179.8 4.4e-44
NP_001229246 (OMIM: 604915) mitogen-activated prot ( 759) 2070 156.8 3.5e-37
XP_016862948 (OMIM: 604915) PREDICTED: mitogen-act ( 734) 1973 150.2 3.3e-35
XP_016862947 (OMIM: 604915) PREDICTED: mitogen-act ( 734) 1973 150.2 3.3e-35
XP_016859812 (OMIM: 609479,616890) PREDICTED: mito ( 455) 743 66.2 4e-10
XP_016859813 (OMIM: 609479,616890) PREDICTED: mito ( 455) 743 66.2 4e-10
NP_598407 (OMIM: 609479,616890) mitogen-activated ( 455) 743 66.2 4e-10
NP_057737 (OMIM: 609479,616890) mitogen-activated ( 800) 739 66.2 6.7e-10
XP_005246697 (OMIM: 609479,616890) PREDICTED: mito ( 800) 739 66.2 6.7e-10
NP_002437 (OMIM: 600137) mitogen-activated protein ( 954) 737 66.2 8.2e-10
NP_001271159 (OMIM: 600136) mitogen-activated prot (1104) 663 61.3 2.9e-08
NP_002410 (OMIM: 600050) mitogen-activated protein ( 847) 648 60.1 5.1e-08
XP_011542607 (OMIM: 614793) PREDICTED: mitogen-act ( 905) 640 59.6 7.7e-08
NP_115811 (OMIM: 614793) mitogen-activated protein (1036) 640 59.7 8.3e-08
XP_005267740 (OMIM: 600136) PREDICTED: mitogen-act (1081) 635 59.3 1.1e-07
NP_149132 (OMIM: 600136) mitogen-activated protein (1118) 635 59.4 1.1e-07
XP_011525284 (OMIM: 600137) PREDICTED: mitogen-act ( 860) 617 58.0 2.2e-07
XP_011525283 (OMIM: 600137) PREDICTED: mitogen-act ( 962) 617 58.1 2.4e-07
XP_011535090 (OMIM: 600136) PREDICTED: mitogen-act (1166) 608 57.6 4e-07
NP_001271160 (OMIM: 600136) mitogen-activated prot ( 880) 562 54.3 3e-06
NP_663306 (OMIM: 157800,602614,617137) mitogen-act ( 491) 535 52.1 7.6e-06
NP_663305 (OMIM: 157800,602614,617137) mitogen-act ( 518) 535 52.1 7.8e-06
NP_003179 (OMIM: 157800,602614,617137) mitogen-act ( 579) 535 52.2 8.3e-06
NP_663304 (OMIM: 157800,602614,617137) mitogen-act ( 606) 535 52.2 8.6e-06
NP_001120662 (OMIM: 124095) tyrosine-protein kinas ( 450) 508 50.2 2.6e-05
NP_004374 (OMIM: 124095) tyrosine-protein kinase C ( 450) 508 50.2 2.6e-05
XP_005254222 (OMIM: 124095) PREDICTED: tyrosine-pr ( 450) 508 50.2 2.6e-05
XP_016877414 (OMIM: 124095) PREDICTED: tyrosine-pr ( 450) 508 50.2 2.6e-05
XP_011535094 (OMIM: 600136) PREDICTED: mitogen-act ( 860) 514 51.0 2.8e-05
NP_647611 (OMIM: 600038) megakaryocyte-associated ( 466) 503 49.9 3.3e-05
XP_011526320 (OMIM: 600038) PREDICTED: megakaryocy ( 507) 503 49.9 3.5e-05
NP_647612 (OMIM: 600038) megakaryocyte-associated ( 507) 503 49.9 3.5e-05
NP_002369 (OMIM: 600038) megakaryocyte-associated ( 508) 503 49.9 3.5e-05
NP_001271161 (OMIM: 600136) mitogen-activated prot ( 837) 509 50.6 3.5e-05
NP_001317394 (OMIM: 191305,613375) tyrosine-protei ( 434) 490 48.9 5.9e-05
NP_001706 (OMIM: 191305,613375) tyrosine-protein k ( 505) 490 49.0 6.4e-05
XP_011533958 (OMIM: 606573) PREDICTED: tyrosine-pr ( 392) 463 47.0 0.0002
XP_005266937 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 463 47.2 0.00023
XP_011533956 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 463 47.2 0.00023
>>XP_016875445 (OMIM: 600447) PREDICTED: mitogen-activat (859 aa)
initn: 5898 init1: 5898 opt: 5898 Z-score: 2195.9 bits: 417.4 E(85289): 1.4e-115
Smith-Waterman score: 5898; 100.0% identity (100.0% similar) in 859 aa overlap (1-859:1-859)
10 20 30 40 50 60
pF1KE2 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 TQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 NMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 HALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 LHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 RRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 LLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 EEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNT
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 DERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDST
790 800 810 820 830 840
850
pF1KE2 ELDNSNSVDALRPPASLPP
:::::::::::::::::::
XP_016 ELDNSNSVDALRPPASLPP
850
>>NP_006292 (OMIM: 600447) mitogen-activated protein kin (859 aa)
initn: 5898 init1: 5898 opt: 5898 Z-score: 2195.9 bits: 417.4 E(85289): 1.4e-115
Smith-Waterman score: 5898; 100.0% identity (100.0% similar) in 859 aa overlap (1-859:1-859)
10 20 30 40 50 60
pF1KE2 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 TQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 NMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 NMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 HALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 HALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 LHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 RRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 LLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 EEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNT
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 DERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDST
790 800 810 820 830 840
850
pF1KE2 ELDNSNSVDALRPPASLPP
:::::::::::::::::::
NP_006 ELDNSNSVDALRPPASLPP
850
>>XP_011537027 (OMIM: 600447) PREDICTED: mitogen-activat (892 aa)
initn: 5580 init1: 5580 opt: 5582 Z-score: 2079.5 bits: 395.9 E(85289): 4.4e-109
Smith-Waterman score: 5806; 96.2% identity (96.3% similar) in 891 aa overlap (2-859:2-892)
10 20 30 40
pF1KE2 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTH--------------
::::::::::::::::::::::::::::::::::::::::::::.
XP_011 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTQCVLRDVVPLGGQGG
10 20 30 40 50 60
50 60 70 80
pF1KE2 -------------------VLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGF
:::::::::::::::::::::::::::::::::::::::::
XP_011 GGPSPSPGGEPPPEPFANSVLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGF
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE2 LEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGE
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE2 EVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRP
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE2 VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTK
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE2 MSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE2 HLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWR
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE2 EEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALM
430 440 450 460 470 480
450 460 470 480 490 500
pF1KE2 LQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPD
490 500 510 520 530 540
510 520 530 540 550 560
pF1KE2 ILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVP
550 560 570 580 590 600
570 580 590 600 610 620
pF1KE2 PHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATG
610 620 630 640 650 660
630 640 650 660 670 680
pF1KE2 GAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSG
670 680 690 700 710 720
690 700 710 720 730 740
pF1KE2 RGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQS
730 740 750 760 770 780
750 760 770 780 790 800
pF1KE2 LSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDPPPSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDPPPSEV
790 800 810 820 830 840
810 820 830 840 850
pF1KE2 IPGPEPSSLPIPHQELLRERGPPNSEDSDCDSTELDNSNSVDALRPPASLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IPGPEPSSLPIPHQELLRERGPPNSEDSDCDSTELDNSNSVDALRPPASLPP
850 860 870 880 890
>>XP_005269195 (OMIM: 600447) PREDICTED: mitogen-activat (892 aa)
initn: 5580 init1: 5580 opt: 5582 Z-score: 2079.5 bits: 395.9 E(85289): 4.4e-109
Smith-Waterman score: 5806; 96.2% identity (96.3% similar) in 891 aa overlap (2-859:2-892)
10 20 30 40
pF1KE2 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTH--------------
::::::::::::::::::::::::::::::::::::::::::::.
XP_005 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTQCVLRDVVPLGGQGG
10 20 30 40 50 60
50 60 70 80
pF1KE2 -------------------VLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGF
:::::::::::::::::::::::::::::::::::::::::
XP_005 GGPSPSPGGEPPPEPFANSVLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGF
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE2 LEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGE
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE2 EVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRP
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE2 VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTK
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE2 MSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE2 HLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWR
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE2 EEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALM
430 440 450 460 470 480
450 460 470 480 490 500
pF1KE2 LQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPD
490 500 510 520 530 540
510 520 530 540 550 560
pF1KE2 ILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVP
550 560 570 580 590 600
570 580 590 600 610 620
pF1KE2 PHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATG
610 620 630 640 650 660
630 640 650 660 670 680
pF1KE2 GAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSG
670 680 690 700 710 720
690 700 710 720 730 740
pF1KE2 RGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQS
730 740 750 760 770 780
750 760 770 780 790 800
pF1KE2 LSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDPPPSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDPPPSEV
790 800 810 820 830 840
810 820 830 840 850
pF1KE2 IPGPEPSSLPIPHQELLRERGPPNSEDSDCDSTELDNSNSVDALRPPASLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IPGPEPSSLPIPHQELLRERGPPNSEDSDCDSTELDNSNSVDALRPPASLPP
850 860 870 880 890
>>XP_006719651 (OMIM: 600447) PREDICTED: mitogen-activat (892 aa)
initn: 5580 init1: 5580 opt: 5582 Z-score: 2079.5 bits: 395.9 E(85289): 4.4e-109
Smith-Waterman score: 5806; 96.2% identity (96.3% similar) in 891 aa overlap (2-859:2-892)
10 20 30 40
pF1KE2 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTH--------------
::::::::::::::::::::::::::::::::::::::::::::.
XP_006 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTQCVLRDVVPLGGQGG
10 20 30 40 50 60
50 60 70 80
pF1KE2 -------------------VLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGF
:::::::::::::::::::::::::::::::::::::::::
XP_006 GGPSPSPGGEPPPEPFANSVLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGF
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE2 LEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGE
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE2 EVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRP
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE2 VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTK
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE2 MSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE2 HLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWR
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE2 EEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALM
430 440 450 460 470 480
450 460 470 480 490 500
pF1KE2 LQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPD
490 500 510 520 530 540
510 520 530 540 550 560
pF1KE2 ILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVP
550 560 570 580 590 600
570 580 590 600 610 620
pF1KE2 PHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATG
610 620 630 640 650 660
630 640 650 660 670 680
pF1KE2 GAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSG
670 680 690 700 710 720
690 700 710 720 730 740
pF1KE2 RGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQS
730 740 750 760 770 780
750 760 770 780 790 800
pF1KE2 LSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDPPPSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDPPPSEV
790 800 810 820 830 840
810 820 830 840 850
pF1KE2 IPGPEPSSLPIPHQELLRERGPPNSEDSDCDSTELDNSNSVDALRPPASLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IPGPEPSSLPIPHQELLRERGPPNSEDSDCDSTELDNSNSVDALRPPASLPP
850 860 870 880 890
>>NP_001180440 (OMIM: 600447) mitogen-activated protein (892 aa)
initn: 5580 init1: 5580 opt: 5582 Z-score: 2079.5 bits: 395.9 E(85289): 4.4e-109
Smith-Waterman score: 5806; 96.2% identity (96.3% similar) in 891 aa overlap (2-859:2-892)
10 20 30 40
pF1KE2 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTH--------------
::::::::::::::::::::::::::::::::::::::::::::.
NP_001 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTQCVLRDVVPLGGQGG
10 20 30 40 50 60
50 60 70 80
pF1KE2 -------------------VLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGF
:::::::::::::::::::::::::::::::::::::::::
NP_001 GGPSPSPGGEPPPEPFANSVLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGF
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE2 LEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGE
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE2 EVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRP
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE2 VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTK
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE2 MSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE2 HLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWR
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE2 EEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALM
430 440 450 460 470 480
450 460 470 480 490 500
pF1KE2 LQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPD
490 500 510 520 530 540
510 520 530 540 550 560
pF1KE2 ILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVP
550 560 570 580 590 600
570 580 590 600 610 620
pF1KE2 PHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATG
610 620 630 640 650 660
630 640 650 660 670 680
pF1KE2 GAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSG
670 680 690 700 710 720
690 700 710 720 730 740
pF1KE2 RGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQS
730 740 750 760 770 780
750 760 770 780 790 800
pF1KE2 LSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDPPPSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDPPPSEV
790 800 810 820 830 840
810 820 830 840 850
pF1KE2 IPGPEPSSLPIPHQELLRERGPPNSEDSDCDSTELDNSNSVDALRPPASLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPGPEPSSLPIPHQELLRERGPPNSEDSDCDSTELDNSNSVDALRPPASLPP
850 860 870 880 890
>>XP_011511612 (OMIM: 604915) PREDICTED: mitogen-activat (966 aa)
initn: 2872 init1: 2513 opt: 2630 Z-score: 993.4 bits: 195.0 E(85289): 1.4e-48
Smith-Waterman score: 2834; 56.7% identity (73.3% similar) in 836 aa overlap (33-801:70-898)
10 20 30 40 50 60
pF1KE2 CLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGGAA
:: .: . ::::.:.: . . .
XP_011 PKLLEDQQEKGMVRTELIESVHSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETAVSQ
40 50 60 70 80 90
70 80 90 100 110
pF1KE2 GSPESR--ASRVRADEVRLQ-CQSGSG---FLEGLFGCLRPVWTMIGKAYSTEHKQQQED
:. .. : ......: .:::: :::::::::::::..:::::::..: ::.:
XP_011 GNSNTVDGESTSGTEDIKIQFSRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQD
100 110 120 130 140 150
120 130 140 150 160 170
pF1KE2 LWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITF
:::::::: .:::.:::::::::::.:..::::.::::. .::::::::::::::::.:
XP_011 TWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAF
160 170 180 190 200 210
180 190 200 210 220 230
pF1KE2 KGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRD
::::::::::::.::.::.::::::::::: .:: :::::: :::.::::::::::::::
XP_011 KGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRD
220 230 240 250 260 270
240 250 260 270 280 290
pF1KE2 LKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSF
:::::.:.:. :.:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSF
280 290 300 310 320 330
300 310 320 330 340 350
pF1KE2 GVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPS
:::::::::::::::::::::::::::::::::::::.::::::::..: :.::::::::
XP_011 GVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPS
340 350 360 370 380 390
360 370 380 390 400 410
pF1KE2 FRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRR
::: :.::::::::::.:::::::::::::::::: :::::::::::.:::.:::. :::
XP_011 FRQTLMHLDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRR
400 410 420 430 440 450
420 430 440 450 460 470
pF1KE2 EELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHP
:::::::::::::::::::::::::::.:.:::::..:.::..::::.:.. :: : ::
XP_011 EELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHP
460 470 480 490 500 510
480 490 500 510 520 530
pF1KE2 SRGLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPS
: ..: :.::::.:...::.: . ..::::.:..:.. : ..: .. : : :: :
XP_011 VRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGI-PTTEVAPTASPLSGSPKMSTS
520 530 540 550 560 570
540 550 560 570 580
pF1KE2 PGRSR-RGKTRHRKASAKGSCGDLPGLRTAVPPHE--PGGPGSPGGLGGGPS--------
..:: :.: :::.....:: .:. .. : .: : . . ::
XP_011 SSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQ
580 590 600 610 620 630
590 600 610
pF1KE2 -AWEACPPALRGLHHDLL-------------------------------LRKMSSSSPDL
.. :::. :: : :.. .:::::
XP_011 QQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDL
640 650 660 670 680 690
620 630 640 650 660
pF1KE2 LSAALGS---------RGRGATGGAGDPGSPPPARGDTPPSEGS--APGSTSP--DSPGG
.:.:... .:... : . . : : . :: : :. : ::
XP_011 ISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIP-SAEPVGRSPDL
700 710 720 730 740 750
670 680 690 700 710
pF1KE2 AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHL-TPAALLYRAAVTRS-QKRGI-
.:. :. . . : .. :. : :..:: :: :: . :: :: :
XP_011 SKSPAHNPLLENAQSSEKTEENEFSGCRSESSLGTSHLGTPPALPRK---TRPLQKSGDD
760 770 780 790 800 810
720 730 740 750 760 770
pF1KE2 SSEEEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSEN--PSDGEEGTASEPSPSGTPEV
::::::::::::::. :: . .. :: ::::::: ::::::..:. : : :.
XP_011 SSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEEGNTSDHSNS--PDE
820 830 840 850 860 870
780 790 800 810 820 830
pF1KE2 GSTNTDERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDS
. . ..: :. ::. :: :::.:
XP_011 LADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGY
880 890 900 910 920 930
>>XP_016862945 (OMIM: 604915) PREDICTED: mitogen-activat (966 aa)
initn: 2872 init1: 2513 opt: 2630 Z-score: 993.4 bits: 195.0 E(85289): 1.4e-48
Smith-Waterman score: 2834; 56.7% identity (73.3% similar) in 836 aa overlap (33-801:70-898)
10 20 30 40 50 60
pF1KE2 CLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGGAA
:: .: . ::::.:.: . . .
XP_016 PKLLEDQQEKGMVRTELIESVHSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETAVSQ
40 50 60 70 80 90
70 80 90 100 110
pF1KE2 GSPESR--ASRVRADEVRLQ-CQSGSG---FLEGLFGCLRPVWTMIGKAYSTEHKQQQED
:. .. : ......: .:::: :::::::::::::..:::::::..: ::.:
XP_016 GNSNTVDGESTSGTEDIKIQFSRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQD
100 110 120 130 140 150
120 130 140 150 160 170
pF1KE2 LWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITF
:::::::: .:::.:::::::::::.:..::::.::::. .::::::::::::::::.:
XP_016 TWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAF
160 170 180 190 200 210
180 190 200 210 220 230
pF1KE2 KGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRD
::::::::::::.::.::.::::::::::: .:: :::::: :::.::::::::::::::
XP_016 KGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRD
220 230 240 250 260 270
240 250 260 270 280 290
pF1KE2 LKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSF
:::::.:.:. :.:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSF
280 290 300 310 320 330
300 310 320 330 340 350
pF1KE2 GVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPS
:::::::::::::::::::::::::::::::::::::.::::::::..: :.::::::::
XP_016 GVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPS
340 350 360 370 380 390
360 370 380 390 400 410
pF1KE2 FRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRR
::: :.::::::::::.:::::::::::::::::: :::::::::::.:::.:::. :::
XP_016 FRQTLMHLDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRR
400 410 420 430 440 450
420 430 440 450 460 470
pF1KE2 EELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHP
:::::::::::::::::::::::::::.:.:::::..:.::..::::.:.. :: : ::
XP_016 EELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHP
460 470 480 490 500 510
480 490 500 510 520 530
pF1KE2 SRGLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPS
: ..: :.::::.:...::.: . ..::::.:..:.. : ..: .. : : :: :
XP_016 VRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGI-PTTEVAPTASPLSGSPKMSTS
520 530 540 550 560 570
540 550 560 570 580
pF1KE2 PGRSR-RGKTRHRKASAKGSCGDLPGLRTAVPPHE--PGGPGSPGGLGGGPS--------
..:: :.: :::.....:: .:. .. : .: : . . ::
XP_016 SSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQ
580 590 600 610 620 630
590 600 610
pF1KE2 -AWEACPPALRGLHHDLL-------------------------------LRKMSSSSPDL
.. :::. :: : :.. .:::::
XP_016 QQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDL
640 650 660 670 680 690
620 630 640 650 660
pF1KE2 LSAALGS---------RGRGATGGAGDPGSPPPARGDTPPSEGS--APGSTSP--DSPGG
.:.:... .:... : . . : : . :: : :. : ::
XP_016 ISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIP-SAEPVGRSPDL
700 710 720 730 740 750
670 680 690 700 710
pF1KE2 AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHL-TPAALLYRAAVTRS-QKRGI-
.:. :. . . : .. :. : :..:: :: :: . :: :: :
XP_016 SKSPAHNPLLENAQSSEKTEENEFSGCRSESSLGTSHLGTPPALPRK---TRPLQKSGDD
760 770 780 790 800 810
720 730 740 750 760 770
pF1KE2 SSEEEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSEN--PSDGEEGTASEPSPSGTPEV
::::::::::::::. :: . .. :: ::::::: ::::::..:. : : :.
XP_016 SSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEEGNTSDHSNS--PDE
820 830 840 850 860 870
780 790 800 810 820 830
pF1KE2 GSTNTDERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDS
. . ..: :. ::. :: :::.:
XP_016 LADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGY
880 890 900 910 920 930
>>NP_004712 (OMIM: 604915) mitogen-activated protein kin (966 aa)
initn: 2872 init1: 2513 opt: 2630 Z-score: 993.4 bits: 195.0 E(85289): 1.4e-48
Smith-Waterman score: 2834; 56.7% identity (73.3% similar) in 836 aa overlap (33-801:70-898)
10 20 30 40 50 60
pF1KE2 CLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGGAA
:: .: . ::::.:.: . . .
NP_004 PKLLEDQQEKGMVRTELIESVHSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETAVSQ
40 50 60 70 80 90
70 80 90 100 110
pF1KE2 GSPESR--ASRVRADEVRLQ-CQSGSG---FLEGLFGCLRPVWTMIGKAYSTEHKQQQED
:. .. : ......: .:::: :::::::::::::..:::::::..: ::.:
NP_004 GNSNTVDGESTSGTEDIKIQFSRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQD
100 110 120 130 140 150
120 130 140 150 160 170
pF1KE2 LWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITF
:::::::: .:::.:::::::::::.:..::::.::::. .::::::::::::::::.:
NP_004 TWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAF
160 170 180 190 200 210
180 190 200 210 220 230
pF1KE2 KGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRD
::::::::::::.::.::.::::::::::: .:: :::::: :::.::::::::::::::
NP_004 KGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRD
220 230 240 250 260 270
240 250 260 270 280 290
pF1KE2 LKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSF
:::::.:.:. :.:::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSF
280 290 300 310 320 330
300 310 320 330 340 350
pF1KE2 GVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPS
:::::::::::::::::::::::::::::::::::::.::::::::..: :.::::::::
NP_004 GVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPS
340 350 360 370 380 390
360 370 380 390 400 410
pF1KE2 FRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRR
::: :.::::::::::.:::::::::::::::::: :::::::::::.:::.:::. :::
NP_004 FRQTLMHLDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRR
400 410 420 430 440 450
420 430 440 450 460 470
pF1KE2 EELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHP
:::::::::::::::::::::::::::.:.:::::..:.::..::::.:.. :: : ::
NP_004 EELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHP
460 470 480 490 500 510
480 490 500 510 520 530
pF1KE2 SRGLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPS
: ..: :.::::.:...::.: . ..::::.:..:.. : ..: .. : : :: :
NP_004 VRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGI-PTTEVAPTASPLSGSPKMSTS
520 530 540 550 560 570
540 550 560 570 580
pF1KE2 PGRSR-RGKTRHRKASAKGSCGDLPGLRTAVPPHE--PGGPGSPGGLGGGPS--------
..:: :.: :::.....:: .:. .. : .: : . . ::
NP_004 SSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQ
580 590 600 610 620 630
590 600 610
pF1KE2 -AWEACPPALRGLHHDLL-------------------------------LRKMSSSSPDL
.. :::. :: : :.. .:::::
NP_004 QQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDL
640 650 660 670 680 690
620 630 640 650 660
pF1KE2 LSAALGS---------RGRGATGGAGDPGSPPPARGDTPPSEGS--APGSTSP--DSPGG
.:.:... .:... : . . : : . :: : :. : ::
NP_004 ISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIP-SAEPVGRSPDL
700 710 720 730 740 750
670 680 690 700 710
pF1KE2 AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHL-TPAALLYRAAVTRS-QKRGI-
.:. :. . . : .. :. : :..:: :: :: . :: :: :
NP_004 SKSPAHNPLLENAQSSEKTEENEFSGCRSESSLGTSHLGTPPALPRK---TRPLQKSGDD
760 770 780 790 800 810
720 730 740 750 760 770
pF1KE2 SSEEEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSEN--PSDGEEGTASEPSPSGTPEV
::::::::::::::. :: . .. :: ::::::: ::::::..:. : : :.
NP_004 SSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEEGNTSDHSNS--PDE
820 830 840 850 860 870
780 790 800 810 820 830
pF1KE2 GSTNTDERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDS
. . ..: :. ::. :: :::.:
NP_004 LADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGY
880 890 900 910 920 930
>>NP_001229243 (OMIM: 604915) mitogen-activated protein (966 aa)
initn: 2872 init1: 2513 opt: 2630 Z-score: 993.4 bits: 195.0 E(85289): 1.4e-48
Smith-Waterman score: 2834; 56.7% identity (73.3% similar) in 836 aa overlap (33-801:70-898)
10 20 30 40 50 60
pF1KE2 CLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGGAA
:: .: . ::::.:.: . . .
NP_001 PKLLEDQQEKGMVRTELIESVHSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETAVSQ
40 50 60 70 80 90
70 80 90 100 110
pF1KE2 GSPESR--ASRVRADEVRLQ-CQSGSG---FLEGLFGCLRPVWTMIGKAYSTEHKQQQED
:. .. : ......: .:::: :::::::::::::..:::::::..: ::.:
NP_001 GNSNTVDGESTSGTEDIKIQFSRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQD
100 110 120 130 140 150
120 130 140 150 160 170
pF1KE2 LWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITF
:::::::: .:::.:::::::::::.:..::::.::::. .::::::::::::::::.:
NP_001 TWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAF
160 170 180 190 200 210
180 190 200 210 220 230
pF1KE2 KGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRD
::::::::::::.::.::.::::::::::: .:: :::::: :::.::::::::::::::
NP_001 KGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRD
220 230 240 250 260 270
240 250 260 270 280 290
pF1KE2 LKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSF
:::::.:.:. :.:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSF
280 290 300 310 320 330
300 310 320 330 340 350
pF1KE2 GVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPS
:::::::::::::::::::::::::::::::::::::.::::::::..: :.::::::::
NP_001 GVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPS
340 350 360 370 380 390
360 370 380 390 400 410
pF1KE2 FRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRR
::: :.::::::::::.:::::::::::::::::: :::::::::::.:::.:::. :::
NP_001 FRQTLMHLDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRR
400 410 420 430 440 450
420 430 440 450 460 470
pF1KE2 EELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHP
:::::::::::::::::::::::::::.:.:::::..:.::..::::.:.. :: : ::
NP_001 EELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHP
460 470 480 490 500 510
480 490 500 510 520 530
pF1KE2 SRGLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPS
: ..: :.::::.:...::.: . ..::::.:..:.. : ..: .. : : :: :
NP_001 VRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGI-PTTEVAPTASPLSGSPKMSTS
520 530 540 550 560 570
540 550 560 570 580
pF1KE2 PGRSR-RGKTRHRKASAKGSCGDLPGLRTAVPPHE--PGGPGSPGGLGGGPS--------
..:: :.: :::.....:: .:. .. : .: : . . ::
NP_001 SSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQ
580 590 600 610 620 630
590 600 610
pF1KE2 -AWEACPPALRGLHHDLL-------------------------------LRKMSSSSPDL
.. :::. :: : :.. .:::::
NP_001 QQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDL
640 650 660 670 680 690
620 630 640 650 660
pF1KE2 LSAALGS---------RGRGATGGAGDPGSPPPARGDTPPSEGS--APGSTSP--DSPGG
.:.:... .:... : . . : : . :: : :. : ::
NP_001 ISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIP-SAEPVGRSPDL
700 710 720 730 740 750
670 680 690 700 710
pF1KE2 AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHL-TPAALLYRAAVTRS-QKRGI-
.:. :. . . : .. :. : :..:: :: :: . :: :: :
NP_001 SKSPAHNPLLENAQSSEKTEENEFSGCRSESSLGTSHLGTPPALPRK---TRPLQKSGDD
760 770 780 790 800 810
720 730 740 750 760 770
pF1KE2 SSEEEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSEN--PSDGEEGTASEPSPSGTPEV
::::::::::::::. :: . .. :: ::::::: ::::::..:. : : :.
NP_001 SSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEEGNTSDHSNS--PDE
820 830 840 850 860 870
780 790 800 810 820 830
pF1KE2 GSTNTDERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDS
. . ..: :. ::. :: :::.:
NP_001 LADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGY
880 890 900 910 920 930
859 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 04:33:40 2016 done: Sun Nov 6 04:33:42 2016
Total Scan time: 17.500 Total Display time: 0.250
Function used was FASTA [36.3.4 Apr, 2011]