Result of FASTA (omim) for
pFN21AE2108
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2108, 845 aa
1>>>pF1KE2108 845 - 845 aa - 845 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.9712+/-0.000683; mu= 7.6631+/- 0.041
mean_var=267.1649+/-55.510, 0's: 0 Z-trim(112.3): 401 B-trim: 135 in 2/51
Lambda= 0.078467
statistics sampled from 20613 (21132) to 20613 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.593), E-opt: 0.2 (0.248), width: 16
Scan time: 11.670
The best scores are: opt bits E(85289)
NP_001018066 (OMIM: 192977,224050) very low-densit ( 845) 6114 707.5 6.5e-203
NP_003374 (OMIM: 192977,224050) very low-density l ( 873) 5506 638.7 3.5e-182
NP_001309155 (OMIM: 192977,224050) very low-densit ( 804) 5259 610.7 8.7e-174
NP_001309154 (OMIM: 192977,224050) very low-densit ( 832) 4651 541.8 4.6e-153
XP_011526312 (OMIM: 143890,606945) PREDICTED: low- ( 834) 2938 347.9 1.1e-94
NP_001182727 (OMIM: 143890,606945) low-density lip ( 858) 2938 347.9 1.1e-94
NP_000518 (OMIM: 143890,606945) low-density lipopr ( 860) 2938 347.9 1.1e-94
NP_001182728 (OMIM: 143890,606945) low-density lip ( 819) 2702 321.2 1.2e-86
NP_059992 (OMIM: 602600,608446) low-density lipopr ( 700) 2415 288.6 6.6e-77
XP_005271232 (OMIM: 602600,608446) PREDICTED: low- ( 834) 2187 262.9 4.3e-69
NP_001182732 (OMIM: 143890,606945) low-density lip ( 682) 2108 253.9 1.9e-66
NP_001182729 (OMIM: 143890,606945) low-density lip ( 692) 2086 251.4 1.1e-65
NP_001018064 (OMIM: 602600,608446) low-density lip ( 904) 2055 248.0 1.4e-64
NP_004622 (OMIM: 602600,608446) low-density lipopr ( 963) 2055 248.0 1.5e-64
XP_016857755 (OMIM: 602600,608446) PREDICTED: low- ( 842) 2041 246.4 4.1e-64
NP_150643 (OMIM: 602600,608446) low-density lipopr ( 793) 2038 246.0 5e-64
XP_006710945 (OMIM: 602600,608446) PREDICTED: low- ( 901) 2028 245.0 1.2e-63
XP_011540398 (OMIM: 602600,608446) PREDICTED: low- ( 762) 1813 220.5 2.3e-56
XP_006710944 (OMIM: 602600,608446) PREDICTED: low- ( 917) 1813 220.6 2.5e-56
XP_005271230 (OMIM: 602600,608446) PREDICTED: low- ( 976) 1813 220.7 2.6e-56
XP_005271231 (OMIM: 602600,608446) PREDICTED: low- ( 847) 1782 217.1 2.8e-55
XP_011540397 (OMIM: 602600,608446) PREDICTED: low- ( 804) 1750 213.4 3.3e-54
XP_016857754 (OMIM: 602600,608446) PREDICTED: low- ( 921) 1711 209.1 7.6e-53
XP_011540396 (OMIM: 602600,608446) PREDICTED: low- ( 934) 1543 190.1 4.1e-47
XP_016857756 (OMIM: 602600,608446) PREDICTED: low- ( 557) 1289 161.0 1.3e-38
XP_016857757 (OMIM: 602600,608446) PREDICTED: low- ( 557) 1289 161.0 1.3e-38
XP_011509485 (OMIM: 222448,600073) PREDICTED: low- (4612) 1304 163.9 1.5e-38
XP_016859831 (OMIM: 608766) PREDICTED: low-density (2883) 994 128.5 4.2e-28
XP_016859830 (OMIM: 608766) PREDICTED: low-density (4469) 994 128.8 5.6e-28
NP_061027 (OMIM: 608766) low-density lipoprotein r (4599) 994 128.8 5.7e-28
XP_011509486 (OMIM: 222448,600073) PREDICTED: low- (3892) 949 123.6 1.7e-26
NP_004516 (OMIM: 222448,600073) low-density lipopr (4655) 949 123.7 1.9e-26
XP_011543333 (OMIM: 133780,144750,166710,259770,60 (1600) 850 111.9 2.4e-23
XP_011543332 (OMIM: 133780,144750,166710,259770,60 (1624) 850 111.9 2.4e-23
XP_011543331 (OMIM: 133780,144750,166710,259770,60 (1662) 850 111.9 2.4e-23
NP_002326 (OMIM: 133780,144750,166710,259770,60181 (1615) 847 111.6 3e-23
XP_005274051 (OMIM: 133780,144750,166710,259770,60 (1653) 847 111.6 3.1e-23
XP_006719141 (OMIM: 603507,610947,616724) PREDICTE (1613) 819 108.4 2.7e-22
NP_002327 (OMIM: 603507,610947,616724) low-density (1613) 819 108.4 2.7e-22
XP_016863342 (OMIM: 131530,611718) PREDICTED: pro- ( 934) 787 104.5 2.4e-21
XP_016863340 (OMIM: 131530,611718) PREDICTED: pro- (1060) 787 104.6 2.6e-21
XP_016863339 (OMIM: 131530,611718) PREDICTED: pro- (1141) 787 104.6 2.7e-21
XP_016863338 (OMIM: 131530,611718) PREDICTED: pro- (1142) 787 104.6 2.7e-21
NP_001171601 (OMIM: 131530,611718) pro-epidermal g (1166) 787 104.6 2.7e-21
XP_011530009 (OMIM: 131530,611718) PREDICTED: pro- (1178) 787 104.6 2.7e-21
XP_016863336 (OMIM: 131530,611718) PREDICTED: pro- (1182) 787 104.6 2.7e-21
NP_001954 (OMIM: 131530,611718) pro-epidermal grow (1207) 787 104.6 2.8e-21
XP_005262853 (OMIM: 131530,611718) PREDICTED: pro- (1215) 787 104.6 2.8e-21
XP_016863335 (OMIM: 131530,611718) PREDICTED: pro- (1215) 787 104.6 2.8e-21
XP_016863334 (OMIM: 131530,611718) PREDICTED: pro- (1223) 787 104.6 2.8e-21
>>NP_001018066 (OMIM: 192977,224050) very low-density li (845 aa)
initn: 6114 init1: 6114 opt: 6114 Z-score: 3763.9 bits: 707.5 E(85289): 6.5e-203
Smith-Waterman score: 6114; 100.0% identity (100.0% similar) in 845 aa overlap (1-845:1-845)
10 20 30 40 50 60
pF1KE2 MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 PAPQINDHSPKYTCSCPSGYNVEENGRDCQRINVTTAVSEVSVPPKGTSAAWAILPLLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAPQINDHSPKYTCSCPSGYNVEENGRDCQRINVTTAVSEVSVPPKGTSAAWAILPLLLL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 VMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVST
790 800 810 820 830 840
pF1KE2 DDDLA
:::::
NP_001 DDDLA
>>NP_003374 (OMIM: 192977,224050) very low-density lipop (873 aa)
initn: 5503 init1: 5503 opt: 5506 Z-score: 3391.7 bits: 638.7 E(85289): 3.5e-182
Smith-Waterman score: 6040; 96.7% identity (96.7% similar) in 873 aa overlap (1-845:1-873)
10 20 30 40 50 60
pF1KE2 MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL
670 680 690 700 710 720
730 740 750
pF1KE2 PAPQINDHSPKYTCSCPSGYNVEENGRDCQR----------------------------I
:::::::::::::::::::::::::::::: :
NP_003 PAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISATSGLVPGGI
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE2 NVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKT
790 800 810 820 830 840
820 830 840
pF1KE2 TEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA
:::::::::::::::::::::::::::::::::
NP_003 TEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA
850 860 870
>>NP_001309155 (OMIM: 192977,224050) very low-density li (804 aa)
initn: 4979 init1: 4979 opt: 5259 Z-score: 3241.0 bits: 610.7 E(85289): 8.7e-174
Smith-Waterman score: 5691; 95.0% identity (95.1% similar) in 845 aa overlap (1-845:1-804)
10 20 30 40 50 60
pF1KE2 MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC
::::::::::::::::::::::::::::::::::::::::::::::::.
NP_001 GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCR-----------
70 80 90 100
130 140 150 160 170 180
pF1KE2 GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS
::::::::::::::::::::::::::::::
NP_001 ------------------------------NITCSPDEFTCSSGRCISRNFVCNGQDDCS
110 120 130
190 200 210 220 230 240
pF1KE2 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP
140 150 160 170 180 190
250 260 270 280 290 300
pF1KE2 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI
200 210 220 230 240 250
310 320 330 340 350 360
pF1KE2 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC
260 270 280 290 300 310
370 380 390 400 410 420
pF1KE2 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE
320 330 340 350 360 370
430 440 450 460 470 480
pF1KE2 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA
380 390 400 410 420 430
490 500 510 520 530 540
pF1KE2 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA
440 450 460 470 480 490
550 560 570 580 590 600
pF1KE2 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ
500 510 520 530 540 550
610 620 630 640 650 660
pF1KE2 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI
560 570 580 590 600 610
670 680 690 700 710 720
pF1KE2 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL
620 630 640 650 660 670
730 740 750 760 770 780
pF1KE2 PAPQINDHSPKYTCSCPSGYNVEENGRDCQRINVTTAVSEVSVPPKGTSAAWAILPLLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAPQINDHSPKYTCSCPSGYNVEENGRDCQRINVTTAVSEVSVPPKGTSAAWAILPLLLL
680 690 700 710 720 730
790 800 810 820 830 840
pF1KE2 VMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVST
740 750 760 770 780 790
pF1KE2 DDDLA
:::::
NP_001 DDDLA
800
>>NP_001309154 (OMIM: 192977,224050) very low-density li (832 aa)
initn: 4368 init1: 4368 opt: 4651 Z-score: 2868.9 bits: 541.8 E(85289): 4.6e-153
Smith-Waterman score: 5617; 91.9% identity (92.0% similar) in 873 aa overlap (1-845:1-832)
10 20 30 40 50 60
pF1KE2 MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC
::::::::::::::::::::::::::::::::::::::::::::::::.
NP_001 GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCR-----------
70 80 90 100
130 140 150 160 170 180
pF1KE2 GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS
::::::::::::::::::::::::::::::
NP_001 ------------------------------NITCSPDEFTCSSGRCISRNFVCNGQDDCS
110 120 130
190 200 210 220 230 240
pF1KE2 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP
140 150 160 170 180 190
250 260 270 280 290 300
pF1KE2 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI
200 210 220 230 240 250
310 320 330 340 350 360
pF1KE2 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC
260 270 280 290 300 310
370 380 390 400 410 420
pF1KE2 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE
320 330 340 350 360 370
430 440 450 460 470 480
pF1KE2 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA
380 390 400 410 420 430
490 500 510 520 530 540
pF1KE2 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA
440 450 460 470 480 490
550 560 570 580 590 600
pF1KE2 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ
500 510 520 530 540 550
610 620 630 640 650 660
pF1KE2 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI
560 570 580 590 600 610
670 680 690 700 710 720
pF1KE2 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL
620 630 640 650 660 670
730 740 750
pF1KE2 PAPQINDHSPKYTCSCPSGYNVEENGRDCQR----------------------------I
:::::::::::::::::::::::::::::: :
NP_001 PAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISATSGLVPGGI
680 690 700 710 720 730
760 770 780 790 800 810
pF1KE2 NVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKT
740 750 760 770 780 790
820 830 840
pF1KE2 TEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA
:::::::::::::::::::::::::::::::::
NP_001 TEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA
800 810 820 830
>>XP_011526312 (OMIM: 143890,606945) PREDICTED: low-dens (834 aa)
initn: 2755 init1: 1284 opt: 2938 Z-score: 1820.9 bits: 347.9 E(85289): 1.1e-94
Smith-Waterman score: 3086; 51.0% identity (75.1% similar) in 816 aa overlap (68-845:23-834)
40 50 60 70 80 90
pF1KE2 FQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDC
: : ...: :..:.:. .: :::. .:
XP_011 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAEC
10 20 30 40 50
100 110 120 130 140 150
pF1KE2 EDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPD
.:::::: : : ::. ..:::.. ..::: :::::. :::.: ::..: ::: :
XP_011 QDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQD
60 70 80 90 100 110
160 170 180 190 200 210
pF1KE2 EFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDAD
:: : .:.::::.:::... :: ::::: .: ::: :::..:.::: :.::.: :
XP_011 EFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPD
120 130 140 150 160 170
220 230 240 250 260 270
pF1KE2 CSDQSDESLEQCGRQPVIH---TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCP
: : ::: ..: :.. . : : :..: ::::::..::::: ::::: ::: ::
XP_011 CEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCA
180 190 200 210 220 230
280 290 300 310 320 330
pF1KE2 SRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDI
:::::.:.: ::.::::::::. :: : ::::.: ::. : ::.::::.::::: .
XP_011 VATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITL
240 250 260 270 280 290
340 350 360 370 380 390
pF1KE2 SKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTC
.::::. .:::::::::.::: :::: :::::::.:.:: ::::: : ::.:. .. :
XP_011 DKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRC
300 310 320 330 340 350
400 410 420 430 440 450
pF1KE2 GDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKI
::::::.: :::.:.::.:::::.: .:.:.: : .:::::. :.::::...::.
XP_011 EDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKM
360 370 380 390 400 410
460 470 480 490 500 510
pF1KE2 GLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDK--VGRHVKMID-N
:.:.:: .:. .:::.::::...:.....:.::::. : :...: :. . .:. .
XP_011 TLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRD
420 430 440 450 460 470
520 530 540 550 560 570
pF1KE2 VYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVY
. : ..::::....:::::.. :.::: :.::: :: . .: .:.:::. ::.:
XP_011 IQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMY
480 490 500 510 520 530
580 590 600 610 620 630
pF1KE2 WSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNG
:.::: ::::.:.:.:: : ::: .:::::::::::...::::.::::: .::.:.::
XP_011 WTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNG
540 550 560 570 580 590
640 650 660 670 680 690
pF1KE2 QDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDI
.:. .:.. . ::::..:..:::.:.: : :::...::..:::.. :..:: . .:.
XP_011 GNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDM
600 610 620 630 640 650
700 710 720 730 740 750
pF1KE2 IVYHELVQPSGKNWCEED-MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQ
...:.:.:: : ::::. . ::::.:::::::::: ::::.::.::.:. . .. :.:
XP_011 VLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCL
660 670 680 690 700 710
760 770
pF1KE2 ---------------RINVT-TAVSE---VSVPPKGTSAAWAILPLL------------L
:..:. ::: .. : :: . : : :
XP_011 TEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQVL
720 730 740 750 760 770
780 790 800 810 820 830
pF1KE2 LVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVS
::. .: .:.:.::. ::..:.::::::: ::::... : :. . :..::. ..::
XP_011 LVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHIC---HNQD-GYSYPSRQMVS
780 790 800 810 820
840
pF1KE2 TDDDLA
.::.:
XP_011 LEDDVA
830
>>NP_001182727 (OMIM: 143890,606945) low-density lipopro (858 aa)
initn: 2755 init1: 1284 opt: 2938 Z-score: 1820.7 bits: 347.9 E(85289): 1.1e-94
Smith-Waterman score: 3018; 50.2% identity (73.3% similar) in 815 aa overlap (68-816:23-835)
40 50 60 70 80 90
pF1KE2 FQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDC
: : ...: :..:.:. .: :::. .:
NP_001 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAEC
10 20 30 40 50
100 110 120 130 140 150
pF1KE2 EDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPD
.:::::: : : ::. ..:::.. ..::: :::::. :::.: ::..: ::: :
NP_001 QDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQD
60 70 80 90 100 110
160 170 180 190 200 210
pF1KE2 EFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDAD
:: : .:.::::.:::... :: ::::: .: ::: :::..:.::: :.::.: :
NP_001 EFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPD
120 130 140 150 160 170
220 230 240 250 260 270
pF1KE2 CSDQSDESLEQCGRQPVIH---TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCP
: : ::: ..: :.. . : : :..: ::::::..::::: ::::: ::: ::
NP_001 CEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCA
180 190 200 210 220 230
280 290 300 310 320 330
pF1KE2 SRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDI
:::::.:.: ::.::::::::. :: : ::::.: ::. : ::.::::.::::: .
NP_001 VATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITL
240 250 260 270 280 290
340 350 360 370 380 390
pF1KE2 SKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTC
.::::. .:::::::::.::: :::: :::::::.:.:: ::::: : ::.:. .. :
NP_001 DKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRC
300 310 320 330 340 350
400 410 420 430 440 450
pF1KE2 GDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKI
::::::.: :::.:.::.:::::.: .:.:.: : .:::::. :.::::...::.
NP_001 EDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKM
360 370 380 390 400 410
460 470 480 490 500 510
pF1KE2 GLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYN
:.:.:: .:. .:::.::::...:.....:.::::. : :...: : :. :.: .
NP_001 TLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHG--VSSYDTVIS
420 430 440 450 460 470
520 530 540 550 560
pF1KE2 -----PAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGF
: ..::::....:::::.. :.::: :.::: :: . .: .:.:::. ::
NP_001 RDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGF
480 490 500 510 520 530
570 580 590 600 610 620
pF1KE2 VYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDL
.::.::: ::::.:.:.:: : ::: .:::::::::::...::::.::::: .::.:.
NP_001 MYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDV
540 550 560 570 580 590
630 640 650 660 670 680
pF1KE2 NGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQ
:: .:. .:.. . ::::..:..:::.:.: : :::...::..:::.. :..:: . .
NP_001 NGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPE
600 610 620 630 640 650
690 700 710 720 730 740
pF1KE2 DIIVYHELVQPSGKNWCEED-MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRD
:....:.:.:: : ::::. . ::::.:::::::::: ::::.::.::.:. . .. :.
NP_001 DMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRS
660 670 680 690 700 710
750 760
pF1KE2 CQ---------------RINVT-TAV-----SEVSVP-----------------------
: :..:. ::: . ::
NP_001 CLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQ
720 730 740 750 760 770
770 780 790 800 810
pF1KE2 -------------PKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLK
:... : .::..:::. .: .:.:.::. ::..:.::::::: :
NP_001 ALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQK
780 790 800 810 820 830
820 830 840
pF1KE2 TTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA
:::..
NP_001 TTEDEVHICHNQDGYSYPSMVSLEDDVA
840 850
>>NP_000518 (OMIM: 143890,606945) low-density lipoprotei (860 aa)
initn: 2755 init1: 1284 opt: 2938 Z-score: 1820.7 bits: 347.9 E(85289): 1.1e-94
Smith-Waterman score: 3018; 50.2% identity (73.3% similar) in 815 aa overlap (68-816:23-835)
40 50 60 70 80 90
pF1KE2 FQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDC
: : ...: :..:.:. .: :::. .:
NP_000 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAEC
10 20 30 40 50
100 110 120 130 140 150
pF1KE2 EDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPD
.:::::: : : ::. ..:::.. ..::: :::::. :::.: ::..: ::: :
NP_000 QDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQD
60 70 80 90 100 110
160 170 180 190 200 210
pF1KE2 EFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDAD
:: : .:.::::.:::... :: ::::: .: ::: :::..:.::: :.::.: :
NP_000 EFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPD
120 130 140 150 160 170
220 230 240 250 260 270
pF1KE2 CSDQSDESLEQCGRQPVIH---TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCP
: : ::: ..: :.. . : : :..: ::::::..::::: ::::: ::: ::
NP_000 CEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCA
180 190 200 210 220 230
280 290 300 310 320 330
pF1KE2 SRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDI
:::::.:.: ::.::::::::. :: : ::::.: ::. : ::.::::.::::: .
NP_000 VATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITL
240 250 260 270 280 290
340 350 360 370 380 390
pF1KE2 SKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTC
.::::. .:::::::::.::: :::: :::::::.:.:: ::::: : ::.:. .. :
NP_000 DKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRC
300 310 320 330 340 350
400 410 420 430 440 450
pF1KE2 GDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKI
::::::.: :::.:.::.:::::.: .:.:.: : .:::::. :.::::...::.
NP_000 EDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKM
360 370 380 390 400 410
460 470 480 490 500 510
pF1KE2 GLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYN
:.:.:: .:. .:::.::::...:.....:.::::. : :...: : :. :.: .
NP_000 TLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHG--VSSYDTVIS
420 430 440 450 460 470
520 530 540 550 560
pF1KE2 -----PAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGF
: ..::::....:::::.. :.::: :.::: :: . .: .:.:::. ::
NP_000 RDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGF
480 490 500 510 520 530
570 580 590 600 610 620
pF1KE2 VYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDL
.::.::: ::::.:.:.:: : ::: .:::::::::::...::::.::::: .::.:.
NP_000 MYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDV
540 550 560 570 580 590
630 640 650 660 670 680
pF1KE2 NGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQ
:: .:. .:.. . ::::..:..:::.:.: : :::...::..:::.. :..:: . .
NP_000 NGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPE
600 610 620 630 640 650
690 700 710 720 730 740
pF1KE2 DIIVYHELVQPSGKNWCEED-MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRD
:....:.:.:: : ::::. . ::::.:::::::::: ::::.::.::.:. . .. :.
NP_000 DMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRS
660 670 680 690 700 710
750 760
pF1KE2 CQ---------------RINVT-TAV-----SEVSVP-----------------------
: :..:. ::: . ::
NP_000 CLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQ
720 730 740 750 760 770
770 780 790 800 810
pF1KE2 -------------PKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLK
:... : .::..:::. .: .:.:.::. ::..:.::::::: :
NP_000 ALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQK
780 790 800 810 820 830
820 830 840
pF1KE2 TTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA
:::..
NP_000 TTEDEVHICHNQDGYSYPSRQMVSLEDDVA
840 850 860
>>NP_001182728 (OMIM: 143890,606945) low-density lipopro (819 aa)
initn: 2595 init1: 1284 opt: 2702 Z-score: 1676.6 bits: 321.2 E(85289): 1.2e-86
Smith-Waterman score: 2782; 49.9% identity (73.1% similar) in 772 aa overlap (113-816:27-794)
90 100 110 120 130 140
pF1KE2 QCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDS
:. .:..: .. .:: .: ::: .:..
NP_001 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQC--QDGKCISYKWVCDGSAECQD
10 20 30 40 50
150 160 170 180 190 200
pF1KE2 GEDE--ENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQC
: :: :.:. ::: ::: : .:.::::.:::... :: ::::: .: ::: :::
NP_001 GSDESQETCSPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQC
60 70 80 90 100 110
210 220 230 240 250
pF1KE2 STSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIH---TKCPASEIQCGSGECIHKKWR
..:.::: :.::.: :: : ::: ..: :.. . : : :..: ::::::..::
NP_001 NSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWR
120 130 140 150 160 170
260 270 280 290 300 310
pF1KE2 CDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQ
::: ::::: ::: :: :::::.:.: ::.::::::::. :: : ::::.: ::.
NP_001 CDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTL
180 190 200 210 220 230
320 330 340 350 360 370
pF1KE2 CLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIG
: ::.::::.::::: ..::::. .:::::::::.::: :::: :::::::.:.:: ::
NP_001 CEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIG
240 250 260 270 280 290
380 390 400 410 420 430
pF1KE2 YECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV
::: : ::.:. .. : ::::::.: :::.:.::.:::::.: .:.:.: : .::::
NP_001 YECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAV
300 310 320 330 340 350
440 450 460 470 480 490
pF1KE2 GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSAS
:. :.::::...::. :.:.:: .:. .:::.::::...:.....:.::::. : :..
NP_001 GSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQ
360 370 380 390 400 410
500 510 520 530 540 550
pF1KE2 IDDKVGRHVKMIDNVYN-----PAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFN
.: : :. :.: . : ..::::....:::::.. :.::: :.::: ::
NP_001 LDRAHG--VSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFR
420 430 440 450 460 470
560 570 580 590 600 610
pF1KE2 SDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKS
. .: .:.:::. ::.::.::: ::::.:.:.:: : ::: .:::::::::::...
NP_001 ENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSG
480 490 500 510 520 530
620 630 640 650 660 670
pF1KE2 RLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANK
::::.::::: .::.:.:: .:. .:.. . ::::..:..:::.:.: : :::...::.
NP_001 RLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANR
540 550 560 570 580 590
680 690 700 710 720 730
pF1KE2 FTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEED-MENGGCEYLCLPAPQINDHSPK
.:::.. :..:: . .:....:.:.:: : ::::. . ::::.:::::::::: ::::
NP_001 LTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPK
600 610 620 630 640 650
740 750 760
pF1KE2 YTCSCPSGYNVEENGRDCQ---------------RINVT-TAV-----SEVSVP------
.::.::.:. . .. :.: :..:. ::: . ::
NP_001 FTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLP
660 670 680 690 700 710
770 780 790
pF1KE2 ------------------------------PKGTSAAWAILPLLLLVMAAVGGYLMWRNW
:... : .::..:::. .: .:.:.::
NP_001 GATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNW
720 730 740 750 760 770
800 810 820 830 840
pF1KE2 QHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA
. ::..:.::::::: ::::..
NP_001 RLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSRQMVSLEDDVA
780 790 800 810
>>NP_059992 (OMIM: 602600,608446) low-density lipoprotei (700 aa)
initn: 1635 init1: 859 opt: 2415 Z-score: 1501.7 bits: 288.6 E(85289): 6.6e-77
Smith-Waterman score: 2415; 49.8% identity (76.8% similar) in 664 aa overlap (193-843:47-697)
170 180 190 200 210 220
pF1KE2 SGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQS
: .::: . ::: : ::.: :: :.:
NP_059 LLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHS
20 30 40 50 60 70
230 240 250 260 270 280
pF1KE2 DESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDE--VNCPSRTCRP
:: ..: .. : :.. : .:.:::..:.:::. .: ::::: ..: ...:
NP_059 DE--DDCPKK-----TCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPA
80 90 100 110 120
290 300 310 320 330
pF1KE2 DQFECEDGS--CIHGSRQCNGIRDCVDGSDEVNCK-NVNQCLGPGKFKCRSGECIDISKV
... : : :. .: .:.: .:: :.::..: ... : : .:.: .: :. :
NP_059 EKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGD-EFQCGDGTCVLAIKH
130 140 150 160 170 180
340 350 360 370 380 390
pF1KE2 CNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDI
::::::: : ::: .:::: ::::::::: :: ::.:: : :::.:.:.::::::
NP_059 CNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDI
190 200 210 220 230 240
400 410 420 430 440 450
pF1KE2 DECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGL
:::..: :::::.: :: .:::: ::.::: : :::. :: ::::::::...:.: :
NP_059 DECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL
250 260 270 280 290 300
460 470 480 490 500 510
pF1KE2 ERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASID---DKVGRHVKMIDNVY
...: .:. .:.:.::::...:.....: ::: . :.:: .: : ..: . ....
NP_059 VKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH
310 320 330 340 350 360
520 530 540 550 560 570
pF1KE2 NPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWS
.: ..:::::.: :::::...:::::::.:: .:. ::. .: :: .:::::: ::.:::
NP_059 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS
370 380 390 400 410 420
580 590 600 610 620 630
pF1KE2 DWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQD
:::. :::::.:.:: ::. ::. .:.:::::::::...::::.:::::.:::.:..: .
NP_059 DWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGN
430 440 450 460 470 480
640 650 660 670 680 690
pF1KE2 RRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIV
:. ...: .::.::.....:::.:.: : ::::...::...: :.. :..:::. .::..
NP_059 RKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVI
490 500 510 520 530 540
700 710 720 730 740 750
pF1KE2 YHELVQPSGKNWCEEDME-NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRI
.::: :: . . :: ... ::::::::::::::..:::::::.::. . . . . : :
NP_059 FHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYR-
550 560 570 580 590 600
760 770 780 790 800 810
pF1KE2 NVTTAVSEVSVPPKGTSAAWAIL-PLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLK
: . .. :.:. .:. :...... ..:::.::::..:: :::::::::: :
NP_059 ---DANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRK
610 620 630 640 650 660
820 830 840
pF1KE2 TTEEDLS--IDIGRHSASVGHTYPAISVVSTDDDLA
::::. . ::: .:..::.::: ..: .::
NP_059 TTEEEDEDELHIGR-TAQIGHVYPARVALSLEDDGLP
670 680 690 700
>>XP_005271232 (OMIM: 602600,608446) PREDICTED: low-dens (834 aa)
initn: 1894 init1: 859 opt: 2187 Z-score: 1361.4 bits: 262.9 E(85289): 4.3e-69
Smith-Waterman score: 2194; 45.5% identity (70.5% similar) in 694 aa overlap (193-804:47-732)
170 180 190 200 210 220
pF1KE2 SGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQS
: .::: . ::: : ::.: :: :.:
XP_005 LLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHS
20 30 40 50 60 70
230 240 250 260 270 280
pF1KE2 DESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDE--VNCPSRTCRP
:: ..: .. : :.. : .:.:::..:.:::. .: ::::: ..: ...:
XP_005 DE--DDCPKKT-----CADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPA
80 90 100 110 120
290 300 310 320 330
pF1KE2 DQFECEDGS--CIHGSRQCNGIRDCVDGSDEVNCK-NVNQCLGPGKFKCRSGECIDISKV
... : : :. .: .:.: .:: :.::..: ... : : .:.: .: :. :
XP_005 EKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGD-EFQCGDGTCVLAIKH
130 140 150 160 170 180
340 350 360 370 380 390
pF1KE2 CNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDI
::::::: : ::: .:::: ::::::::: :: ::.:: : :::.:.:.::::::
XP_005 CNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDI
190 200 210 220 230 240
400 410 420 430 440 450
pF1KE2 DECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGL
:::..: :::::.: :: .:::: ::.::: : :::. :: ::::::::...:.: :
XP_005 DECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL
250 260 270 280 290 300
460 470 480 490 500 510
pF1KE2 ERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASID---DKVGRHVKMIDNVY
...: .:. .:.:.::::...:.....: ::: . :.:: .: : ..: . ....
XP_005 VKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH
310 320 330 340 350 360
520 530 540 550 560 570
pF1KE2 NPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWS
.: ..:::::.: :::::...:::::::.:: .:. ::. .: :: .:::::: ::.:::
XP_005 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS
370 380 390 400 410 420
580 590 600 610 620 630
pF1KE2 DWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQD
:::. :::::.:.:: ::. ::. .:.:::::::::...::::.:::::.:::.:..: .
XP_005 DWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGN
430 440 450 460 470 480
640 650 660 670 680 690
pF1KE2 RRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIV
:. ...: .::.::.....:::.:.: : ::::...::...: :.. :..:::. .::..
XP_005 RKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVI
490 500 510 520 530 540
700 710 720 730 740 750
pF1KE2 YHELVQPSGKNWCEEDME-NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRI
.::: :: . . :: ... ::::::::::::::..:::::::.::. . . . . : :
XP_005 FHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRA
550 560 570 580 590 600
760
pF1KE2 -----------------------------------------NVTTAV-SEVSVP--PK--
..:.:: : :::: :.
XP_005 PQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSIS
610 620 630 640 650 660
770 780 790 800
pF1KE2 ----------------------GTSAAWAIL----PLLLLVMAAVGGYLMWRNWQHKNMK
:.... :.. :...... ..:::.::::..:: :
XP_005 PSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTK
670 680 690 700 710 720
810 820 830 840
pF1KE2 SMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA
::::
XP_005 SMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRPLWAEPCLGETREPEDPA
730 740 750 760 770 780
845 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 20:39:01 2016 done: Sun Nov 6 20:39:03 2016
Total Scan time: 11.670 Total Display time: 0.290
Function used was FASTA [36.3.4 Apr, 2011]