Result of FASTA (omim) for
pFN21AE2101
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2101, 862 aa
1>>>pF1KE2101 862 - 862 aa - 862 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.6785+/-0.000426; mu= -8.4469+/- 0.027
mean_var=308.3795+/-62.817, 0's: 0 Z-trim(120.8): 296 B-trim: 0 in 0/58
Lambda= 0.073035
statistics sampled from 36149 (36449) to 36149 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.724), E-opt: 0.2 (0.427), width: 16
Scan time: 14.990
The best scores are: opt bits E(85289)
NP_113671 (OMIM: 606409,613385) E3 ubiquitin-prote ( 862) 5943 640.3 1.1e-182
NP_001311127 (OMIM: 606409,613385) E3 ubiquitin-pr ( 862) 5943 640.3 1.1e-182
XP_016883579 (OMIM: 606409,613385) PREDICTED: E3 u ( 900) 5798 625.1 4.5e-178
NP_001244067 (OMIM: 606409,613385) E3 ubiquitin-pr ( 752) 5227 564.9 5e-160
XP_016883580 (OMIM: 606409,613385) PREDICTED: E3 u ( 752) 5227 564.9 5e-160
XP_016883578 (OMIM: 606409,613385) PREDICTED: E3 u ( 903) 4932 533.8 1.3e-150
NP_001311126 (OMIM: 606409,613385) E3 ubiquitin-pr ( 903) 4932 533.8 1.3e-150
NP_001244066 (OMIM: 606409,613385) E3 ubiquitin-pr ( 903) 4932 533.8 1.3e-150
XP_011527381 (OMIM: 606409,613385) PREDICTED: E3 u ( 692) 4825 522.5 2.6e-147
XP_005260627 (OMIM: 606409,613385) PREDICTED: E3 u ( 692) 4825 522.5 2.6e-147
XP_016878369 (OMIM: 602308) PREDICTED: NEDD4-like ( 870) 3296 361.4 1e-98
XP_011521125 (OMIM: 602308) PREDICTED: NEDD4-like ( 870) 3296 361.4 1e-98
NP_008945 (OMIM: 602308) NEDD4-like E3 ubiquitin-p ( 870) 3296 361.4 1e-98
XP_016878370 (OMIM: 602308) PREDICTED: NEDD4-like ( 870) 3296 361.4 1e-98
XP_011521127 (OMIM: 602308) PREDICTED: NEDD4-like ( 870) 3296 361.4 1e-98
XP_016878368 (OMIM: 602308) PREDICTED: NEDD4-like ( 870) 3296 361.4 1e-98
NP_001257383 (OMIM: 602308) NEDD4-like E3 ubiquiti ( 870) 3296 361.4 1e-98
XP_016868484 (OMIM: 602307) PREDICTED: NEDD4-like ( 743) 3247 356.2 3.2e-97
XP_016868485 (OMIM: 602307) PREDICTED: NEDD4-like ( 743) 3247 356.2 3.2e-97
XP_016868482 (OMIM: 602307) PREDICTED: NEDD4-like ( 921) 3247 356.3 3.8e-97
XP_005250818 (OMIM: 602307) PREDICTED: NEDD4-like ( 921) 3247 356.3 3.8e-97
XP_005250817 (OMIM: 602307) PREDICTED: NEDD4-like ( 922) 3247 356.3 3.8e-97
NP_008944 (OMIM: 602307) NEDD4-like E3 ubiquitin-p ( 922) 3247 356.3 3.8e-97
XP_011521128 (OMIM: 602308) PREDICTED: NEDD4-like ( 754) 3131 344.0 1.5e-93
NP_001257382 (OMIM: 602308) NEDD4-like E3 ubiquiti ( 754) 3131 344.0 1.5e-93
XP_016883581 (OMIM: 606409,613385) PREDICTED: E3 u ( 442) 2600 287.9 6.8e-77
NP_955456 (OMIM: 602308) NEDD4-like E3 ubiquitin-p ( 431) 2284 254.6 7e-67
XP_016868486 (OMIM: 602307) PREDICTED: NEDD4-like ( 719) 2107 236.1 4.4e-61
XP_011515104 (OMIM: 602307) PREDICTED: NEDD4-like ( 898) 2107 236.2 5.4e-61
XP_016868483 (OMIM: 602307) PREDICTED: NEDD4-like ( 898) 2107 236.2 5.4e-61
NP_001316141 (OMIM: 602278) E3 ubiquitin-protein l ( 753) 1678 190.9 1.9e-47
XP_011519929 (OMIM: 602278) PREDICTED: E3 ubiquiti ( 827) 1678 190.9 2e-47
XP_011519928 (OMIM: 602278) PREDICTED: E3 ubiquiti ( 849) 1678 190.9 2.1e-47
XP_011519927 (OMIM: 602278) PREDICTED: E3 ubiquiti ( 849) 1678 190.9 2.1e-47
XP_011519926 (OMIM: 602278) PREDICTED: E3 ubiquiti ( 875) 1678 190.9 2.1e-47
NP_006145 (OMIM: 602278) E3 ubiquitin-protein liga ( 900) 1678 191.0 2.2e-47
NP_940682 (OMIM: 602278) E3 ubiquitin-protein liga (1247) 1678 191.0 2.9e-47
NP_001271269 (OMIM: 602278) E3 ubiquitin-protein l (1302) 1678 191.0 3e-47
NP_001271268 (OMIM: 602278) E3 ubiquitin-protein l (1303) 1678 191.0 3e-47
NP_001271267 (OMIM: 602278) E3 ubiquitin-protein l (1319) 1678 191.0 3e-47
XP_016881170 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 684) 1555 177.9 1.4e-43
XP_016881169 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 750) 1555 178.0 1.5e-43
XP_006722488 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 772) 1555 178.0 1.5e-43
NP_001138443 (OMIM: 606384) E3 ubiquitin-protein l ( 834) 1555 178.0 1.6e-43
NP_001138442 (OMIM: 606384) E3 ubiquitin-protein l ( 834) 1555 178.0 1.6e-43
XP_016881166 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 838) 1555 178.0 1.6e-43
XP_016881168 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 854) 1555 178.0 1.7e-43
NP_001138436 (OMIM: 606384) E3 ubiquitin-protein l ( 854) 1555 178.0 1.7e-43
NP_001138437 (OMIM: 606384) E3 ubiquitin-protein l ( 854) 1555 178.0 1.7e-43
NP_001138438 (OMIM: 606384) E3 ubiquitin-protein l ( 854) 1555 178.0 1.7e-43
>>NP_113671 (OMIM: 606409,613385) E3 ubiquitin-protein l (862 aa)
initn: 5943 init1: 5943 opt: 5943 Z-score: 3400.7 bits: 640.3 E(85289): 1.1e-182
Smith-Waterman score: 5943; 100.0% identity (100.0% similar) in 862 aa overlap (1-862:1-862)
10 20 30 40 50 60
pF1KE2 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_113 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_113 NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_113 QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 DDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_113 DDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 GSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_113 GSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 VYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_113 VYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_113 LQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_113 RITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 IAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_113 IAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 PGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_113 PGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 GRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_113 GRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 EMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_113 EMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGF
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 NEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_113 NEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 EKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_113 EKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYK
790 800 810 820 830 840
850 860
pF1KE2 SYEQLKEKLLFAIEETEGFGQE
::::::::::::::::::::::
NP_113 SYEQLKEKLLFAIEETEGFGQE
850 860
>>NP_001311127 (OMIM: 606409,613385) E3 ubiquitin-protei (862 aa)
initn: 5943 init1: 5943 opt: 5943 Z-score: 3400.7 bits: 640.3 E(85289): 1.1e-182
Smith-Waterman score: 5943; 100.0% identity (100.0% similar) in 862 aa overlap (1-862:1-862)
10 20 30 40 50 60
pF1KE2 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 DDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 GSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 VYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 IAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 PGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 GRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 EMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGF
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 NEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 EKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYK
790 800 810 820 830 840
850 860
pF1KE2 SYEQLKEKLLFAIEETEGFGQE
::::::::::::::::::::::
NP_001 SYEQLKEKLLFAIEETEGFGQE
850 860
>>XP_016883579 (OMIM: 606409,613385) PREDICTED: E3 ubiqu (900 aa)
initn: 5924 init1: 5798 opt: 5798 Z-score: 3317.9 bits: 625.1 E(85289): 4.5e-178
Smith-Waterman score: 5813; 95.6% identity (95.6% similar) in 894 aa overlap (7-862:7-900)
10 20
pF1KE2 MSDSGSQLGSMGSLTMKSQLQIT-------------------------------------
:::::::::::::::::
XP_016 MSDSGSQLGSMGSLTMKSQLQITETRFHHLDQAGLELLTSGSTHLGLPKYRDYRREPPRP
10 20 30 40 50 60
30 40 50 60 70 80
pF1KE2 -VISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNTNSPKWKQPLTVIVTPVSKLHFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNTNSPKWKQPLTVIVTPVSKLHFR
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE2 VWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLSICLDGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLSICLDGL
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE2 QLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSL
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE2 SNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATS
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE2 GLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPG
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE2 WERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQ
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE2 DLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEG
430 440 450 460 470 480
450 460 470 480 490 500
pF1KE2 WEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLA
490 500 510 520 530 540
510 520 530 540 550 560
pF1KE2 MPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHE
550 560 570 580 590 600
570 580 590 600 610 620
pF1KE2 VLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPF
610 620 630 640 650 660
630 640 650 660 670 680
pF1KE2 YKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPN
670 680 690 700 710 720
690 700 710 720 730 740
pF1KE2 GGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLC
730 740 750 760 770 780
750 760 770 780 790 800
pF1KE2 GMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFA
790 800 810 820 830 840
810 820 830 840 850 860
pF1KE2 DLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE
850 860 870 880 890 900
>>NP_001244067 (OMIM: 606409,613385) E3 ubiquitin-protei (752 aa)
initn: 5227 init1: 5227 opt: 5227 Z-score: 2993.9 bits: 564.9 E(85289): 5e-160
Smith-Waterman score: 5227; 100.0% identity (100.0% similar) in 752 aa overlap (111-862:1-752)
90 100 110 120 130 140
pF1KE2 FRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLSICLD
::::::::::::::::::::::::::::::
NP_001 MKLEEVVVTLQLGGDKEPTETIGDLSICLD
10 20 30
150 160 170 180 190 200
pF1KE2 GLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSP
40 50 60 70 80 90
210 220 230 240 250 260
pF1KE2 SLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGA
100 110 120 130 140 150
270 280 290 300 310 320
pF1KE2 TSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLP
160 170 180 190 200 210
330 340 350 360 370 380
pF1KE2 PGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYG
220 230 240 250 260 270
390 400 410 420 430 440
pF1KE2 NQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLP
280 290 300 310 320 330
450 460 470 480 490 500
pF1KE2 EGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQ
340 350 360 370 380 390
510 520 530 540 550 560
pF1KE2 LAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLS
400 410 420 430 440 450
570 580 590 600 610 620
pF1KE2 HEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSL
460 470 480 490 500 510
630 640 650 660 670 680
pF1KE2 PFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLK
520 530 540 550 560 570
690 700 710 720 730 740
pF1KE2 PNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVL
580 590 600 610 620 630
750 760 770 780 790 800
pF1KE2 LCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGG
640 650 660 670 680 690
810 820 830 840 850 860
pF1KE2 FADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFG
700 710 720 730 740 750
pF1KE2 QE
::
NP_001 QE
>>XP_016883580 (OMIM: 606409,613385) PREDICTED: E3 ubiqu (752 aa)
initn: 5227 init1: 5227 opt: 5227 Z-score: 2993.9 bits: 564.9 E(85289): 5e-160
Smith-Waterman score: 5227; 100.0% identity (100.0% similar) in 752 aa overlap (111-862:1-752)
90 100 110 120 130 140
pF1KE2 FRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLSICLD
::::::::::::::::::::::::::::::
XP_016 MKLEEVVVTLQLGGDKEPTETIGDLSICLD
10 20 30
150 160 170 180 190 200
pF1KE2 GLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSP
40 50 60 70 80 90
210 220 230 240 250 260
pF1KE2 SLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGA
100 110 120 130 140 150
270 280 290 300 310 320
pF1KE2 TSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLP
160 170 180 190 200 210
330 340 350 360 370 380
pF1KE2 PGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYG
220 230 240 250 260 270
390 400 410 420 430 440
pF1KE2 NQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLP
280 290 300 310 320 330
450 460 470 480 490 500
pF1KE2 EGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQ
340 350 360 370 380 390
510 520 530 540 550 560
pF1KE2 LAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLS
400 410 420 430 440 450
570 580 590 600 610 620
pF1KE2 HEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSL
460 470 480 490 500 510
630 640 650 660 670 680
pF1KE2 PFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLK
520 530 540 550 560 570
690 700 710 720 730 740
pF1KE2 PNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVL
580 590 600 610 620 630
750 760 770 780 790 800
pF1KE2 LCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGG
640 650 660 670 680 690
810 820 830 840 850 860
pF1KE2 FADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFG
700 710 720 730 740 750
pF1KE2 QE
::
XP_016 QE
>>XP_016883578 (OMIM: 606409,613385) PREDICTED: E3 ubiqu (903 aa)
initn: 5925 init1: 4919 opt: 4932 Z-score: 2824.7 bits: 533.8 E(85289): 1.3e-150
Smith-Waterman score: 5789; 95.3% identity (95.4% similar) in 894 aa overlap (10-862:10-903)
10 20 30 40 50 60
pF1KE2 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL
70 80 90 100 110 120
130 140 150
pF1KE2 QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSES---------------------
::::::::::::::::::::::::::::::::::::::.
XP_016 QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSENGVSLCLPRLECNSAISAHCNL
130 140 150 160 170 180
160 170 180 190
pF1KE2 --------------------ASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNS
::::::::::::::::::::::::::::::::::::::::
XP_016 CLPGLSDSPISASRVAGFTGASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNS
190 200 210 220 230 240
200 210 220 230 240 250
pF1KE2 PSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEG
250 260 270 280 290 300
260 270 280 290 300 310
pF1KE2 ATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPL
310 320 330 340 350 360
320 330 340 350 360 370
pF1KE2 PPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIY
370 380 390 400 410 420
380 390 400 410 420 430
pF1KE2 GNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPL
430 440 450 460 470 480
440 450 460 470 480 490
pF1KE2 PEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQ
490 500 510 520 530 540
500 510 520 530 540 550
pF1KE2 QLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLL
550 560 570 580 590 600
560 570 580 590 600 610
pF1KE2 SHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFS
610 620 630 640 650 660
620 630 640 650 660 670
pF1KE2 LPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDL
670 680 690 700 710 720
680 690 700 710 720 730
pF1KE2 KPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEV
730 740 750 760 770 780
740 750 760 770 780 790
pF1KE2 LLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVG
790 800 810 820 830 840
800 810 820 830 840 850
pF1KE2 GFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF
850 860 870 880 890 900
860
pF1KE2 GQE
:::
XP_016 GQE
>>NP_001311126 (OMIM: 606409,613385) E3 ubiquitin-protei (903 aa)
initn: 5925 init1: 4919 opt: 4932 Z-score: 2824.7 bits: 533.8 E(85289): 1.3e-150
Smith-Waterman score: 5789; 95.3% identity (95.4% similar) in 894 aa overlap (10-862:10-903)
10 20 30 40 50 60
pF1KE2 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL
70 80 90 100 110 120
130 140 150
pF1KE2 QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSES---------------------
::::::::::::::::::::::::::::::::::::::.
NP_001 QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSENGVSLCLPRLECNSAISAHCNL
130 140 150 160 170 180
160 170 180 190
pF1KE2 --------------------ASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNS
::::::::::::::::::::::::::::::::::::::::
NP_001 CLPGLSDSPISASRVAGFTGASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNS
190 200 210 220 230 240
200 210 220 230 240 250
pF1KE2 PSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEG
250 260 270 280 290 300
260 270 280 290 300 310
pF1KE2 ATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPL
310 320 330 340 350 360
320 330 340 350 360 370
pF1KE2 PPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIY
370 380 390 400 410 420
380 390 400 410 420 430
pF1KE2 GNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPL
430 440 450 460 470 480
440 450 460 470 480 490
pF1KE2 PEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQ
490 500 510 520 530 540
500 510 520 530 540 550
pF1KE2 QLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLL
550 560 570 580 590 600
560 570 580 590 600 610
pF1KE2 SHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFS
610 620 630 640 650 660
620 630 640 650 660 670
pF1KE2 LPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDL
670 680 690 700 710 720
680 690 700 710 720 730
pF1KE2 KPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEV
730 740 750 760 770 780
740 750 760 770 780 790
pF1KE2 LLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVG
790 800 810 820 830 840
800 810 820 830 840 850
pF1KE2 GFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF
850 860 870 880 890 900
860
pF1KE2 GQE
:::
NP_001 GQE
>>NP_001244066 (OMIM: 606409,613385) E3 ubiquitin-protei (903 aa)
initn: 5925 init1: 4919 opt: 4932 Z-score: 2824.7 bits: 533.8 E(85289): 1.3e-150
Smith-Waterman score: 5789; 95.3% identity (95.4% similar) in 894 aa overlap (10-862:10-903)
10 20 30 40 50 60
pF1KE2 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL
70 80 90 100 110 120
130 140 150
pF1KE2 QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSES---------------------
::::::::::::::::::::::::::::::::::::::.
NP_001 QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSENGVSLCLPRLECNSAISAHCNL
130 140 150 160 170 180
160 170 180 190
pF1KE2 --------------------ASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNS
::::::::::::::::::::::::::::::::::::::::
NP_001 CLPGLSDSPISASRVAGFTGASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNS
190 200 210 220 230 240
200 210 220 230 240 250
pF1KE2 PSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEG
250 260 270 280 290 300
260 270 280 290 300 310
pF1KE2 ATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPL
310 320 330 340 350 360
320 330 340 350 360 370
pF1KE2 PPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIY
370 380 390 400 410 420
380 390 400 410 420 430
pF1KE2 GNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPL
430 440 450 460 470 480
440 450 460 470 480 490
pF1KE2 PEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQ
490 500 510 520 530 540
500 510 520 530 540 550
pF1KE2 QLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLL
550 560 570 580 590 600
560 570 580 590 600 610
pF1KE2 SHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFS
610 620 630 640 650 660
620 630 640 650 660 670
pF1KE2 LPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDL
670 680 690 700 710 720
680 690 700 710 720 730
pF1KE2 KPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEV
730 740 750 760 770 780
740 750 760 770 780 790
pF1KE2 LLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVG
790 800 810 820 830 840
800 810 820 830 840 850
pF1KE2 GFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF
850 860 870 880 890 900
860
pF1KE2 GQE
:::
NP_001 GQE
>>XP_011527381 (OMIM: 606409,613385) PREDICTED: E3 ubiqu (692 aa)
initn: 4825 init1: 4825 opt: 4825 Z-score: 2765.6 bits: 522.5 E(85289): 2.6e-147
Smith-Waterman score: 4825; 99.9% identity (100.0% similar) in 689 aa overlap (174-862:4-692)
150 160 170 180 190 200
pF1KE2 LESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSLS
.:::::::::::::::::::::::::::::
XP_011 MIYKVSTNGSDDPEDAGAGENRRVSGNNSPSLS
10 20 30
210 220 230 240 250 260
pF1KE2 NGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSG
40 50 60 70 80 90
270 280 290 300 310 320
pF1KE2 LIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGW
100 110 120 130 140 150
330 340 350 360 370 380
pF1KE2 ERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQD
160 170 180 190 200 210
390 400 410 420 430 440
pF1KE2 LFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGW
220 230 240 250 260 270
450 460 470 480 490 500
pF1KE2 EMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAM
280 290 300 310 320 330
510 520 530 540 550 560
pF1KE2 PQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEV
340 350 360 370 380 390
570 580 590 600 610 620
pF1KE2 LNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFY
400 410 420 430 440 450
630 640 650 660 670 680
pF1KE2 KRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNG
460 470 480 490 500 510
690 700 710 720 730 740
pF1KE2 GNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCG
520 530 540 550 560 570
750 760 770 780 790 800
pF1KE2 MQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFAD
580 590 600 610 620 630
810 820 830 840 850 860
pF1KE2 LMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE
640 650 660 670 680 690
>>XP_005260627 (OMIM: 606409,613385) PREDICTED: E3 ubiqu (692 aa)
initn: 4825 init1: 4825 opt: 4825 Z-score: 2765.6 bits: 522.5 E(85289): 2.6e-147
Smith-Waterman score: 4825; 99.9% identity (100.0% similar) in 689 aa overlap (174-862:4-692)
150 160 170 180 190 200
pF1KE2 LESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSLS
.:::::::::::::::::::::::::::::
XP_005 MFRKVSTNGSDDPEDAGAGENRRVSGNNSPSLS
10 20 30
210 220 230 240 250 260
pF1KE2 NGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSG
40 50 60 70 80 90
270 280 290 300 310 320
pF1KE2 LIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGW
100 110 120 130 140 150
330 340 350 360 370 380
pF1KE2 ERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQD
160 170 180 190 200 210
390 400 410 420 430 440
pF1KE2 LFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGW
220 230 240 250 260 270
450 460 470 480 490 500
pF1KE2 EMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAM
280 290 300 310 320 330
510 520 530 540 550 560
pF1KE2 PQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEV
340 350 360 370 380 390
570 580 590 600 610 620
pF1KE2 LNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFY
400 410 420 430 440 450
630 640 650 660 670 680
pF1KE2 KRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNG
460 470 480 490 500 510
690 700 710 720 730 740
pF1KE2 GNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCG
520 530 540 550 560 570
750 760 770 780 790 800
pF1KE2 MQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFAD
580 590 600 610 620 630
810 820 830 840 850 860
pF1KE2 LMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE
640 650 660 670 680 690
862 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 20:42:03 2016 done: Sun Nov 6 20:42:05 2016
Total Scan time: 14.990 Total Display time: 0.310
Function used was FASTA [36.3.4 Apr, 2011]