Result of FASTA (omim) for
pFN21AE2086
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2086, 760 aa
1>>>pF1KE2086 760 - 760 aa - 760 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3101+/-0.000481; mu= 20.6652+/- 0.030
mean_var=74.4405+/-15.083, 0's: 0 Z-trim(109.4): 57 B-trim: 705 in 1/52
Lambda= 0.148652
statistics sampled from 17491 (17548) to 17491 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.55), E-opt: 0.2 (0.206), width: 16
Scan time: 11.680
The best scores are: opt bits E(85289)
NP_000391 (OMIM: 126340,278730,601675,610756) TFII ( 760) 4988 1080.0 0
XP_016881956 (OMIM: 126340,278730,601675,610756) P ( 719) 4711 1020.6 0
XP_011524913 (OMIM: 126340,278730,601675,610756) P ( 734) 4591 994.8 0
NP_001124339 (OMIM: 126340,278730,601675,610756) T ( 405) 2556 558.2 2.4e-158
XP_016880689 (OMIM: 114480,189960,605882,609054) P (1088) 594 137.8 2.4e-31
NP_114432 (OMIM: 114480,189960,605882,609054) Fanc (1249) 594 137.8 2.7e-31
XP_011523637 (OMIM: 114480,189960,605882,609054) P (1249) 576 133.9 3.9e-30
NP_116575 (OMIM: 608833,615190,616373) regulator o (1243) 532 124.5 2.7e-27
NP_057518 (OMIM: 608833,615190,616373) regulator o (1219) 517 121.3 2.4e-26
NP_001269938 (OMIM: 608833,615190,616373) regulato (1300) 517 121.3 2.6e-26
XP_016874420 (OMIM: 601150,613398) PREDICTED: prob ( 931) 414 99.1 8.8e-20
XP_006719113 (OMIM: 601150,613398) PREDICTED: prob ( 967) 414 99.1 9.1e-20
NP_001244074 (OMIM: 601150,613398) probable ATP-de ( 880) 409 98.0 1.8e-19
NP_085911 (OMIM: 601150,613398) probable ATP-depen ( 906) 409 98.0 1.8e-19
XP_016874421 (OMIM: 601150,613398) PREDICTED: prob ( 906) 409 98.0 1.8e-19
XP_005253390 (OMIM: 601150,613398) PREDICTED: prob ( 942) 409 98.0 1.9e-19
XP_016874417 (OMIM: 601150,613398) PREDICTED: prob (1027) 409 98.1 2e-19
XP_016874419 (OMIM: 601150,613398) PREDICTED: prob (1002) 404 97.0 4.1e-19
NP_001269939 (OMIM: 608833,615190,616373) regulato ( 996) 377 91.2 2.3e-17
XP_016874418 (OMIM: 601150,613398) PREDICTED: prob (1014) 343 83.9 3.6e-15
XP_016880691 (OMIM: 114480,189960,605882,609054) P ( 631) 338 82.7 5.2e-15
XP_016880692 (OMIM: 114480,189960,605882,609054) P ( 631) 338 82.7 5.2e-15
XP_016880690 (OMIM: 114480,189960,605882,609054) P (1088) 338 82.9 8e-15
XP_011523640 (OMIM: 114480,189960,605882,609054) P (1108) 338 82.9 8.1e-15
XP_011523639 (OMIM: 114480,189960,605882,609054) P (1202) 338 82.9 8.7e-15
XP_011523636 (OMIM: 114480,189960,605882,609054) P (1269) 338 82.9 9e-15
XP_011523635 (OMIM: 114480,189960,605882,609054) P (1269) 338 82.9 9e-15
XP_011523634 (OMIM: 114480,189960,605882,609054) P (1269) 338 82.9 9e-15
XP_011523638 (OMIM: 114480,189960,605882,609054) P (1229) 320 79.0 1.3e-13
XP_016874423 (OMIM: 601150,613398) PREDICTED: prob ( 831) 309 76.6 4.8e-13
NP_001244073 (OMIM: 601150,613398) probable ATP-de ( 970) 309 76.6 5.5e-13
NP_689651 (OMIM: 601150,613398) probable ATP-depen ( 970) 309 76.6 5.5e-13
XP_005253388 (OMIM: 601150,613398) PREDICTED: prob (1006) 309 76.6 5.6e-13
XP_011518894 (OMIM: 601150,613398) PREDICTED: prob (1031) 309 76.6 5.7e-13
XP_016874425 (OMIM: 601150,613398) PREDICTED: prob ( 768) 304 75.5 9.5e-13
XP_016874426 (OMIM: 601150,613398) PREDICTED: prob ( 768) 304 75.5 9.5e-13
XP_016874424 (OMIM: 601150,613398) PREDICTED: prob ( 768) 304 75.5 9.5e-13
XP_016874422 (OMIM: 601150,613398) PREDICTED: prob ( 847) 304 75.5 1e-12
XP_016874414 (OMIM: 601150,613398) PREDICTED: prob (1055) 304 75.6 1.2e-12
XP_016874411 (OMIM: 601150,613398) PREDICTED: prob (1055) 304 75.6 1.2e-12
XP_016874412 (OMIM: 601150,613398) PREDICTED: prob (1055) 304 75.6 1.2e-12
XP_016874413 (OMIM: 601150,613398) PREDICTED: prob (1055) 304 75.6 1.2e-12
XP_016874410 (OMIM: 601150,613398) PREDICTED: prob (1066) 304 75.6 1.2e-12
XP_016874408 (OMIM: 601150,613398) PREDICTED: prob (1091) 304 75.6 1.3e-12
XP_016874407 (OMIM: 601150,613398) PREDICTED: prob (1091) 304 75.6 1.3e-12
NP_004390 (OMIM: 601150,613398) probable ATP-depen ( 856) 280 70.4 3.7e-11
XP_011518897 (OMIM: 601150,613398) PREDICTED: prob ( 892) 280 70.4 3.8e-11
XP_011523642 (OMIM: 114480,189960,605882,609054) P ( 853) 261 66.3 6.2e-10
XP_011523641 (OMIM: 114480,189960,605882,609054) P ( 872) 252 64.4 2.4e-09
XP_016874409 (OMIM: 601150,613398) PREDICTED: prob (1078) 247 63.3 6e-09
>>NP_000391 (OMIM: 126340,278730,601675,610756) TFIIH ba (760 aa)
initn: 4988 init1: 4988 opt: 4988 Z-score: 5778.8 bits: 1080.0 E(85289): 0
Smith-Waterman score: 4988; 99.7% identity (100.0% similar) in 760 aa overlap (1-760:1-760)
10 20 30 40 50 60
pF1KE2 MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 KALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 TDAHLANPVLPNEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSG
:::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 FDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMAT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 FTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 SYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 RGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 AQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYF
670 680 690 700 710 720
730 740 750 760
pF1KE2 LRQMAQPFHREDQLGLSLLSLEQLESEETLQRIEQIAQQL
::::::::::::::::::::::::::::::.:::::::::
NP_000 LRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQQL
730 740 750 760
>>XP_016881956 (OMIM: 126340,278730,601675,610756) PREDI (719 aa)
initn: 4711 init1: 4711 opt: 4711 Z-score: 5458.1 bits: 1020.6 E(85289): 0
Smith-Waterman score: 4711; 99.7% identity (100.0% similar) in 719 aa overlap (42-760:1-719)
20 30 40 50 60 70
pF1KE2 FPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLI
::::::::::::::::::::::::::::::
XP_016 MPSGTGKTVSLLALIMAYQRAYPLEVTKLI
10 20 30
80 90 100 110 120 130
pF1KE2 YCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVD
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE2 GKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCP
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE2 YFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNL
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE2 TRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLP
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE2 NEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKP
.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKP
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE2 LRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANP
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE2 ILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLC
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE2 PMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVAS
460 470 480 490 500 510
560 570 580 590 600 610
pF1KE2 WYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFV
520 530 540 550 560 570
620 630 640 650 660 670
pF1KE2 HHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGK
580 590 600 610 620 630
680 690 700 710 720 730
pF1KE2 TDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHRE
640 650 660 670 680 690
740 750 760
pF1KE2 DQLGLSLLSLEQLESEETLQRIEQIAQQL
:::::::::::::::::::.:::::::::
XP_016 DQLGLSLLSLEQLESEETLKRIEQIAQQL
700 710
>>XP_011524913 (OMIM: 126340,278730,601675,610756) PREDI (734 aa)
initn: 4591 init1: 4591 opt: 4591 Z-score: 5318.9 bits: 994.8 E(85289): 0
Smith-Waterman score: 4761; 96.3% identity (96.6% similar) in 760 aa overlap (1-760:1-734)
10 20 30 40 50 60
pF1KE2 MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQ
:::::::::::::::::::::::::::::::::::
XP_011 MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAK-------------------------
10 20 30
70 80 90 100 110 120
pF1KE2 RAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 -AYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPE
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 VTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDL
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 KALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARE
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 TDAHLANPVLPNEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSG
:::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSG
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 LAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEP
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE2 FDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMAT
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE2 FTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFT
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE2 SYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVA
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE2 RGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHA
580 590 600 610 620 630
670 680 690 700 710 720
pF1KE2 AQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYF
640 650 660 670 680 690
730 740 750 760
pF1KE2 LRQMAQPFHREDQLGLSLLSLEQLESEETLQRIEQIAQQL
::::::::::::::::::::::::::::::.:::::::::
XP_011 LRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQQL
700 710 720 730
>>NP_001124339 (OMIM: 126340,278730,601675,610756) TFIIH (405 aa)
initn: 2556 init1: 2556 opt: 2556 Z-score: 2963.9 bits: 558.2 E(85289): 2.4e-158
Smith-Waterman score: 2556; 99.7% identity (100.0% similar) in 389 aa overlap (25-413:1-389)
10 20 30 40 50 60
pF1KE2 MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQ
::::::::::::::::::::::::::::::::::::
NP_001 MRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQ
10 20 30
70 80 90 100 110 120
pF1KE2 RAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPE
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 VTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDL
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 KALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARE
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 TDAHLANPVLPNEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSG
:::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSG
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 LAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEP
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGQAQHCGS
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE2 FDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMAT
NP_001 SRNQKRSHP
400
>>XP_016880689 (OMIM: 114480,189960,605882,609054) PREDI (1088 aa)
initn: 506 init1: 133 opt: 594 Z-score: 683.8 bits: 137.8 E(85289): 2.4e-31
Smith-Waterman score: 638; 26.5% identity (54.2% similar) in 672 aa overlap (66-701:81-707)
40 50 60 70 80 90
pF1KE2 GHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYE
.. :. . .:: .: .. .:::.
XP_016 GHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRR-----T
60 70 80 90 100
100 110 120 130 140 150
pF1KE2 KQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHC
: .:. :::: . :.::::. :... :: : . .. : :
XP_016 AYSG--VPM--TILSSRDHTCVHPEVVG-NFNRNE--KCMELLDG------KNGKS---C
110 120 130 140
160 170 180 190 200 210
pF1KE2 RFYEEFDAHGREVPLPA--GI---YNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYH
::. . . : . :. .....: .::.. :::. :: : :... :.
XP_016 YFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYN
150 160 170 180 190 200
220 230 240 250 260 270
pF1KE2 YLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTV
:::: .: . .. .: .. ::..::::::.. .: : ..:. : . .:... ..
XP_016 YLLDAQIRESMDLNL-KEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNN
210 220 230 240 250 260
280 290 300 310 320
pF1KE2 LRIKETDEQRLRDEYRRLVEGLREASAAR--ETDAHLANPVLP-NEVLQEAVPGSIRTAE
.: : :.. :: :.. : ::.: : : . : . ::.: .: ::
XP_016 IRKK--DHEPLRAVCCSLINWL-EANAEYLVERDYESACKIWSGNEMLLTLHKMGITTAT
270 280 290 300 310 320
330 340 350 360 370
pF1KE2 ------HFLGFLRRLLE----YVKWRLRVQHVVQESPPAFLSGLAQRV-CIQRKPLRFCA
:: . :.. . : : . : :.. : .:.:: . . . :. ::
XP_016 FPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFAD
330 340 350 360 370 380
380 390 400 410 420 430
pF1KE2 ERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFS
. .. .: :. :.: .:. .. . : .:.:
XP_016 DYKIAIQQTYSWTNQIDISD--------------KNGLLVLPKNKKRSRQKTAVHVLNFW
390 400 410 420 430
440 450 460 470 480 490
pF1KE2 CMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLA--RVCLCPMI
:.. ..:.. . . :....:::::::. . . : .:::. : .. ..
XP_016 CLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELG------VTFTIQLEANHIIKNSQV
440 450 460 470 480
500 510 520 530 540 550
pF1KE2 ----IGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVA
:: : . . :.. : . . : ::: . .: .::. :. ::. .:.
XP_016 WVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKE
490 500 510 520 530 540
560 570 580 590 600
pF1KE2 SWYEQGILENIQRNKLLFIETQDGAETSVA--LEKYQEACE-NGR--GAILLSVARGKVS
: :. .:.. : ...: : : .:. :. : .: . .:. ::.:..: :::::
XP_016 RWLSTGLWHNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 EGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRE----NDFLTFDAMRHAA
::.:: .:::: .:.:. ... .. . .: . ..: .. ..:.:
XP_016 EGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALN
610 620 630 640 650 660
670 680 690 700 710
pF1KE2 QCVGRAIRGKTDYGLMVFADKRFARGDKR--GKLPRWIQEHLTDANLNLTVDEGVQVAKY
: .:: :: ..:.: ....: :: . .: . : .:.....
XP_016 QALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSK
670 680 690 700 710 720
720 730 740 750 760
pF1KE2 FLRQMAQPFHREDQLGLSLLSLEQLESEETLQRIEQIAQQL
XP_016 KHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQEL
730 740 750 760 770 780
>>NP_114432 (OMIM: 114480,189960,605882,609054) Fanconi (1249 aa)
initn: 544 init1: 133 opt: 594 Z-score: 683.0 bits: 137.8 E(85289): 2.7e-31
Smith-Waterman score: 638; 26.5% identity (54.2% similar) in 672 aa overlap (66-701:242-868)
40 50 60 70 80 90
pF1KE2 GHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYE
.. :. . .:: .: .. .:::.
NP_114 GHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRR-----T
220 230 240 250 260
100 110 120 130 140 150
pF1KE2 KQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHC
: .:. :::: . :.::::. :... :: : . .. : :
NP_114 AYSG--VPM--TILSSRDHTCVHPEVVG-NFNRNE--KCMELLDG------KNGKS---C
270 280 290 300 310
160 170 180 190 200 210
pF1KE2 RFYEEFDAHGREVPLPA--GI---YNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYH
::. . . : . :. .....: .::.. :::. :: : :... :.
NP_114 YFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYN
320 330 340 350 360 370
220 230 240 250 260 270
pF1KE2 YLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTV
:::: .: . .. .: .. ::..::::::.. .: : ..:. : . .:... ..
NP_114 YLLDAQIRESMDLNL-KEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNN
380 390 400 410 420
280 290 300 310 320
pF1KE2 LRIKETDEQRLRDEYRRLVEGLREASAAR--ETDAHLANPVLP-NEVLQEAVPGSIRTAE
.: : :.. :: :.. : ::.: : : . : . ::.: .: ::
NP_114 IRKK--DHEPLRAVCCSLINWL-EANAEYLVERDYESACKIWSGNEMLLTLHKMGITTAT
430 440 450 460 470 480
330 340 350 360 370
pF1KE2 ------HFLGFLRRLLE----YVKWRLRVQHVVQESPPAFLSGLAQRV-CIQRKPLRFCA
:: . :.. . : : . : :.. : .:.:: . . . :. ::
NP_114 FPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFAD
490 500 510 520 530 540
380 390 400 410 420 430
pF1KE2 ERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFS
. .. .: :. :.: .:. .. . : .:.:
NP_114 DYKIAIQQTYSWTNQIDISD--------------KNGLLVLPKNKKRSRQKTAVHVLNFW
550 560 570 580 590
440 450 460 470 480 490
pF1KE2 CMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLA--RVCLCPMI
:.. ..:.. . . :....:::::::. . . : .:::. : .. ..
NP_114 CLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELG------VTFTIQLEANHIIKNSQV
600 610 620 630 640
500 510 520 530 540 550
pF1KE2 ----IGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVA
:: : . . :.. : . . : ::: . .: .::. :. ::. .:.
NP_114 WVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKE
650 660 670 680 690 700
560 570 580 590 600
pF1KE2 SWYEQGILENIQRNKLLFIETQDGAETSVA--LEKYQEACE-NGR--GAILLSVARGKVS
: :. .:.. : ...: : : .:. :. : .: . .:. ::.:..: :::::
NP_114 RWLSTGLWHNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVS
710 720 730 740 750 760
610 620 630 640 650 660
pF1KE2 EGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRE----NDFLTFDAMRHAA
::.:: .:::: .:.:. ... .. . .: . ..: .. ..:.:
NP_114 EGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALN
770 780 790 800 810 820
670 680 690 700 710
pF1KE2 QCVGRAIRGKTDYGLMVFADKRFARGDKR--GKLPRWIQEHLTDANLNLTVDEGVQVAKY
: .:: :: ..:.: ....: :: . .: . : .:.....
NP_114 QALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSK
830 840 850 860 870 880
720 730 740 750 760
pF1KE2 FLRQMAQPFHREDQLGLSLLSLEQLESEETLQRIEQIAQQL
NP_114 KHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQEL
890 900 910 920 930 940
>>XP_011523637 (OMIM: 114480,189960,605882,609054) PREDI (1249 aa)
initn: 516 init1: 133 opt: 576 Z-score: 662.1 bits: 133.9 E(85289): 3.9e-30
Smith-Waterman score: 619; 26.3% identity (54.2% similar) in 668 aa overlap (66-701:242-868)
40 50 60 70 80 90
pF1KE2 GHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYE
.. :. . .:: .: .. .:::.
XP_011 GHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRR-----T
220 230 240 250 260
100 110 120 130 140 150
pF1KE2 KQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHC
: .:. :::: . :.::::. :... :: : . .. : :
XP_011 AYSG--VPM--TILSSRDHTCVHPEVVG-NFNRNE--KCMELLDG------KNGKS---C
270 280 290 300 310
160 170 180 190 200 210
pF1KE2 RFYEEFDAHGREVPLPA--GI---YNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYH
::. . . : . :. .....: .::.. :::. :: : :... :.
XP_011 YFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYN
320 330 340 350 360 370
220 230 240 250 260 270
pF1KE2 YLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTV
:::: .: . .. .: .. ::..::::::.. .: : ..:. : . .:... ..
XP_011 YLLDAQIRESMDLNL-KEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNN
380 390 400 410 420
280 290 300 310 320
pF1KE2 LRIKETDEQRLRDEYRRLVEGLREASAAR--ETDAHLANPVLP-NEVLQEAVPGSIRTAE
.: : :.. :: :.. : ::.: : : . : . ::.: .: ::
XP_011 IRKK--DHEPLRAVCCSLINWL-EANAEYLVERDYESACKIWSGNEMLLTLHKMGITTAT
430 440 450 460 470 480
330 340 350 360 370
pF1KE2 ------HFLGFLRRLLE----YVKWRLRVQHVVQESPPAFLSGLAQRV-CIQRKPLRFCA
:: . :.. . : : . : :.. : .:.:: . . . :. ::
XP_011 FPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFAD
490 500 510 520 530 540
380 390 400 410 420 430
pF1KE2 ERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFS
. .. .: :. :.: .:. .. . : .:.:
XP_011 DYKIAIQQTYSWTNQIDISD--------------KNGLLVLPKNKKRSRQKTAVHVLNFW
550 560 570 580 590
440 450 460 470 480 490
pF1KE2 CMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILD--FHPVTMATFTMTLARVCLCPMI
:.. ..:.. . . :....:::::::. . . : : :. . ... .:
XP_011 CLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQIMSSKFI
600 610 620 630 640 650
500 510 520 530 540 550
pF1KE2 IGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYE
: : :.... : . . : ::: . .: .::. :. ::. .:. :
XP_011 IYVVA--CARVSSLKNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLS
660 670 680 690 700 710
560 570 580 590 600
pF1KE2 QGILENIQRNKLLFIETQDGAETSVA--LEKYQEACE-NGR--GAILLSVARGKVSEGID
:. .:.. : ...: : : .:. :. : .: . .:. ::.:..: :::::::.:
XP_011 TGLWHNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLD
720 730 740 750 760 770
610 620 630 640 650 660
pF1KE2 FVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRE----NDFLTFDAMRHAAQCVG
: .:::: .:.:. ... .. . .: . ..: .. ..:.: : .:
XP_011 FSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQALG
780 790 800 810 820 830
670 680 690 700 710 720
pF1KE2 RAIRGKTDYGLMVFADKRFARGDKR--GKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQ
: :: ..:.: ....: :: . .: . : .:.....
XP_011 RCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQK
840 850 860 870 880 890
730 740 750 760
pF1KE2 MAQPFHREDQLGLSLLSLEQLESEETLQRIEQIAQQL
XP_011 VLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPK
900 910 920 930 940 950
>>NP_116575 (OMIM: 608833,615190,616373) regulator of te (1243 aa)
initn: 790 init1: 154 opt: 532 Z-score: 611.1 bits: 124.5 E(85289): 2.7e-27
Smith-Waterman score: 688; 25.4% identity (52.7% similar) in 792 aa overlap (18-730:18-786)
10 20 30 40 50
pF1KE2 MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAY-
: : :: .. . :. : .:.:: :.:::::. :: .:.
NP_116 MPKIVLNGVTVDFPFQPYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAWR
10 20 30 40 50 60
60 70 80
pF1KE2 -------------QRA----YP---------------------LEVTKLIYCSRTVPEIE
.:: .: .. :.:: ::: ..
NP_116 EHLRDGISARKIAERAQGELFPDRALSSWGNAAAAAGDPIACYTDIPKIIYASRTHSQLT
70 80 90 100 110 120
90 100 110 120
pF1KE2 KVIEELRKLLNFYEKQEGEKLPFLGLA----------------LSSRKNLCIHPEVTPLR
.::.:::. . :... : : : :.::..::::::: .
NP_116 QVINELRN--TSYRSRCRATLWVLETAPPRPTVLSPTRPKVCVLGSREQLCIHPEVKKQE
130 140 150 160 170
130 140 150 160 170 180
pF1KE2 FGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGR
.. :.. .:: :. :.::.. . .. : : . : ...:: :
NP_116 SNHLQIHLCRKKVAS--RS----------CHFYNNVEEKSLEQELASPILDIEDLVKSGS
180 190 200 210 220
190 200 210 220 230 240
pF1KE2 RQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCID
.. :::.:.: .:... . :.:::: : . .: . .::.::::::....: .
NP_116 KHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHNIDL-KGTVVIFDEAHNVEKMCEE
230 240 250 260 270 280
250 260 270 280 290 300
pF1KE2 SMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHL
: : .:: . : .. . . . . : . . :: . : :.:
NP_116 SASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFSADSPSPGL---NMELEDIAKL
290 300 310 320 330 340
310 320 330 340 350 360
pF1KE2 ANPVLPNEVLQEAV--PGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQ
.: : .:: ::. . . ... .:. .. .... . .: ... ::
NP_116 KMILLRLEGAIDAVELPGDDSGVTKPGSYIFELFAEAQITFQTKGCILDSLDQIIQHLAG
350 360 370 380 390 400
370 380 390 400 410
pF1KE2 RVCIQRKPLRFCAERLRSLLHTLEITDLADFSP-----LTLLANFATLVSTYAKGFTIII
:. . . . ..: .... . .: .. :: : : .. . . : :
NP_116 RAGVFTNTAGL--QKLADIIQIVFSVDPSEGSPGSPAGLGALQSYKVHIHPDA-GHRRTA
410 420 430 440 450
420 430 440 450 460 470
pF1KE2 EPFDDRTPTIA---NPILHFSCMDASLAIKPVFER-FQSVIITSGTLSPLDIYPKILDF-
. : . : : . .: . :.. . ... . .. .:.:.:::::.:.. . ...
NP_116 QRSDAWSTTAARKRGKVLSYWCFSPGHSMHELVRQGVRSLILTSGTLAPVSSFALEMQIP
460 470 480 490 500 510
480 490 500 510 520 530
pF1KE2 HPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPD
:: . . . . . .. :: : . .:: :. : . . . :. : ... :::
NP_116 FPVCLEN-PHIIDKHQIWVGVVPRGPDGAQLSSAFDRRFSEECLSSLGKALGNIARVVPY
520 530 540 550 560 570
540 550 560 570 580 590
pF1KE2 GIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQE--ACENG
:.. :: :: ::... : . . .... : ::.: .. . : .. : : ..
NP_116 GLLIFFPSYPVMEKSLEFWRARDLARKMEALKPLFVEPRSKGSFSETISAYYARVAAPGS
580 590 600 610 620 630
600 610 620 630 640
pF1KE2 RGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRD---------
:: .:.: :::.:::.:: ::.::. :.:: .. . ....: .
NP_116 TGATFLAVCRGKASEGLDFSDTNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMKGQGGAGG
640 650 660 670 680 690
650 660 670 680 690 700
pF1KE2 QFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHL-
:: . ... .: : . : .::.:: . ::: . . :.::: .: :..:: :.. :.
NP_116 QF-LSGQEWYRQQASRAVNQAIGRVIRHRQDYGAVFLCDHRFAFADARAQLPSWVRPHVR
700 710 720 730 740 750
710 720 730 740 750 760
pF1KE2 TDANLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLQRIEQIAQQL
. :.. .. . .: . : : : :
NP_116 VYDNFGHVIRDVAQFFRVAERTMPAPAPRATAPSVRGEDAVSEAKSPGPFFSTRKAKSLD
760 770 780 790 800 810
>>NP_057518 (OMIM: 608833,615190,616373) regulator of te (1219 aa)
initn: 790 init1: 154 opt: 517 Z-score: 593.9 bits: 121.3 E(85289): 2.4e-26
Smith-Waterman score: 729; 25.9% identity (53.7% similar) in 792 aa overlap (2-730:3-762)
10 20 30 40 50
pF1KE2 MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAY
:. ..:. : ::.. : : :: .. . :. : .:.:: :.:::::. :: .:.
NP_057 MPKIVLNGVTVDFPFQP-YKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAW
10 20 30 40 50
60 70 80
pF1KE2 --------------QRA----YP---------------------LEVTKLIYCSRTVPEI
.:: .: .. :.:: ::: ..
NP_057 REHLRDGISARKIAERAQGELFPDRALSSWGNAAAAAGDPIACYTDIPKIIYASRTHSQL
60 70 80 90 100 110
90 100 110 120 130 140
pF1KE2 EKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTAS
.::.:::. . :. :. :: ::..::::::: . .. :.. .::
NP_057 TQVINELRN--TSYRP----KVCVLG----SREQLCIHPEVKKQESNHLQIHLCRKKVAS
120 130 140 150 160
150 160 170 180 190 200
pF1KE2 YVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSIL
:. :.::.. . .. : : . : ...:: : .. :::.:.:
NP_057 --RS----------CHFYNNVEEKSLEQELASPILDIEDLVKSGSKHRVCPYYLSRNLKQ
170 180 190 200 210
210 220 230 240 250 260
pF1KE2 HANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQ
.:... . :.:::: : . .: . .::.::::::....: .: : .:: . :
NP_057 QADIIFMPYNYLLDAKSRRAHNIDL-KGTVVIFDEAHNVEKMCEESASFDLTPHDLASGL
220 230 240 250 260 270
270 280 290 300 310
pF1KE2 GNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPNEVLQEAV-
.. . . . . : . . :: . : :.: .: : .::
NP_057 DVIDQVLEEQTKAAQQGEPHPEFSADSPSPGL---NMELEDIAKLKMILLRLEGAIDAVE
280 290 300 310 320 330
320 330 340 350 360 370
pF1KE2 -PGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAER
::. . . ... .:. .. .... . .: ... :: :. . . . ..
NP_057 LPGDDSGVTKPGSYIFELFAEAQITFQTKGCILDSLDQIIQHLAGRAGVFTNTAGL--QK
340 350 360 370 380 390
380 390 400 410 420 430
pF1KE2 LRSLLHTLEITDLADFSP-----LTLLANFATLVSTYAKGFTIIIEPFDDRTPTIA---N
: .... . .: .. :: : : .. . . : : . : . : : .
NP_057 LADIIQIVFSVDPSEGSPGSPAGLGALQSYKVHIHPDA-GHRRTAQRSDAWSTTAARKRG
400 410 420 430 440 450
440 450 460 470 480
pF1KE2 PILHFSCMDASLAIKPVFER-FQSVIITSGTLSPLDIYPKILDF-HPVTMATFTMTLARV
.: . :.. . ... . .. .:.:.:::::.:.. . ... :: . . . .
NP_057 KVLSYWCFSPGHSMHELVRQGVRSLILTSGTLAPVSSFALEMQIPFPVCLEN-PHIIDKH
460 470 480 490 500
490 500 510 520 530 540
pF1KE2 CLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMEST
. .. :: : . .:: :. : . . . :. : ... ::: :.. :: :: ::..
NP_057 QIWVGVVPRGPDGAQLSSAFDRRFSEECLSSLGKALGNIARVVPYGLLIFFPSYPVMEKS
510 520 530 540 550 560
550 560 570 580 590 600
pF1KE2 VASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQE--ACENGRGAILLSVARGKVSE
. : . . .... : ::.: .. . : .. : : .. :: .:.: :::.::
NP_057 LEFWRARDLARKMEALKPLFVEPRSKGSFSETISAYYARVAAPGSTGATFLAVCRGKASE
570 580 590 600 610 620
610 620 630 640 650
pF1KE2 GIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRD---------QFQIRENDFLTFDAM
:.:: ::.::. :.:: .. . ....: . :: . ... .:
NP_057 GLDFSDTNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMKGQGGAGGQF-LSGQEWYRQQAS
630 640 650 660 670 680
660 670 680 690 700 710
pF1KE2 RHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHL-TDANLNLTVDEGVQV
: . : .::.:: . ::: . . :.::: .: :..:: :.. :. . :.. .. . .:
NP_057 RAVNQAIGRVIRHRQDYGAVFLCDHRFAFADARAQLPSWVRPHVRVYDNFGHVIRDVAQF
690 700 710 720 730 740
720 730 740 750 760
pF1KE2 AKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLQRIEQIAQQL
. : : : :
NP_057 FRVAERTMPAPAPRATAPSVRGEDAVSEAKSPGPFFSTRKAKSLDLHVPSLKQRSSGSPA
750 760 770 780 790 800
>>NP_001269938 (OMIM: 608833,615190,616373) regulator of (1300 aa)
initn: 790 init1: 154 opt: 517 Z-score: 593.5 bits: 121.3 E(85289): 2.6e-26
Smith-Waterman score: 729; 25.9% identity (53.7% similar) in 792 aa overlap (2-730:3-762)
10 20 30 40 50
pF1KE2 MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAY
:. ..:. : ::.. : : :: .. . :. : .:.:: :.:::::. :: .:.
NP_001 MPKIVLNGVTVDFPFQP-YKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAW
10 20 30 40 50
60 70 80
pF1KE2 --------------QRA----YP---------------------LEVTKLIYCSRTVPEI
.:: .: .. :.:: ::: ..
NP_001 REHLRDGISARKIAERAQGELFPDRALSSWGNAAAAAGDPIACYTDIPKIIYASRTHSQL
60 70 80 90 100 110
90 100 110 120 130 140
pF1KE2 EKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTAS
.::.:::. . :. :. :: ::..::::::: . .. :.. .::
NP_001 TQVINELRN--TSYRP----KVCVLG----SREQLCIHPEVKKQESNHLQIHLCRKKVAS
120 130 140 150 160
150 160 170 180 190 200
pF1KE2 YVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSIL
:. :.::.. . .. : : . : ...:: : .. :::.:.:
NP_001 --RS----------CHFYNNVEEKSLEQELASPILDIEDLVKSGSKHRVCPYYLSRNLKQ
170 180 190 200 210
210 220 230 240 250 260
pF1KE2 HANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQ
.:... . :.:::: : . .: . .::.::::::....: .: : .:: . :
NP_001 QADIIFMPYNYLLDAKSRRAHNIDL-KGTVVIFDEAHNVEKMCEESASFDLTPHDLASGL
220 230 240 250 260 270
270 280 290 300 310
pF1KE2 GNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPNEVLQEAV-
.. . . . . : . . :: . : :.: .: : .::
NP_001 DVIDQVLEEQTKAAQQGEPHPEFSADSPSPGL---NMELEDIAKLKMILLRLEGAIDAVE
280 290 300 310 320 330
320 330 340 350 360 370
pF1KE2 -PGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAER
::. . . ... .:. .. .... . .: ... :: :. . . . ..
NP_001 LPGDDSGVTKPGSYIFELFAEAQITFQTKGCILDSLDQIIQHLAGRAGVFTNTAGL--QK
340 350 360 370 380 390
380 390 400 410 420 430
pF1KE2 LRSLLHTLEITDLADFSP-----LTLLANFATLVSTYAKGFTIIIEPFDDRTPTIA---N
: .... . .: .. :: : : .. . . : : . : . : : .
NP_001 LADIIQIVFSVDPSEGSPGSPAGLGALQSYKVHIHPDA-GHRRTAQRSDAWSTTAARKRG
400 410 420 430 440 450
440 450 460 470 480
pF1KE2 PILHFSCMDASLAIKPVFER-FQSVIITSGTLSPLDIYPKILDF-HPVTMATFTMTLARV
.: . :.. . ... . .. .:.:.:::::.:.. . ... :: . . . .
NP_001 KVLSYWCFSPGHSMHELVRQGVRSLILTSGTLAPVSSFALEMQIPFPVCLEN-PHIIDKH
460 470 480 490 500
490 500 510 520 530 540
pF1KE2 CLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMEST
. .. :: : . .:: :. : . . . :. : ... ::: :.. :: :: ::..
NP_001 QIWVGVVPRGPDGAQLSSAFDRRFSEECLSSLGKALGNIARVVPYGLLIFFPSYPVMEKS
510 520 530 540 550 560
550 560 570 580 590 600
pF1KE2 VASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQE--ACENGRGAILLSVARGKVSE
. : . . .... : ::.: .. . : .. : : .. :: .:.: :::.::
NP_001 LEFWRARDLARKMEALKPLFVEPRSKGSFSETISAYYARVAAPGSTGATFLAVCRGKASE
570 580 590 600 610 620
610 620 630 640 650
pF1KE2 GIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRD---------QFQIRENDFLTFDAM
:.:: ::.::. :.:: .. . ....: . :: . ... .:
NP_001 GLDFSDTNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMKGQGGAGGQF-LSGQEWYRQQAS
630 640 650 660 670 680
660 670 680 690 700 710
pF1KE2 RHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHL-TDANLNLTVDEGVQV
: . : .::.:: . ::: . . :.::: .: :..:: :.. :. . :.. .. . .:
NP_001 RAVNQAIGRVIRHRQDYGAVFLCDHRFAFADARAQLPSWVRPHVRVYDNFGHVIRDVAQF
690 700 710 720 730 740
720 730 740 750 760
pF1KE2 AKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLQRIEQIAQQL
. : : : :
NP_001 FRVAERTMPAPAPRATAPSVRGEDAVSEAKSPGPFFSTRKAKSLDLHVPSLKQRSSGSPA
750 760 770 780 790 800
760 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 12:10:30 2016 done: Sun Nov 6 12:10:32 2016
Total Scan time: 11.680 Total Display time: 0.220
Function used was FASTA [36.3.4 Apr, 2011]