Result of FASTA (omim) for
pFN21AE2022
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2022, 599 aa
1>>>pF1KE2022 599 - 599 aa - 599 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.9280+/-0.000437; mu= 15.9284+/- 0.027
mean_var=89.3041+/-18.101, 0's: 0 Z-trim(111.0): 141 B-trim: 127 in 1/57
Lambda= 0.135718
statistics sampled from 19307 (19461) to 19307 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.593), E-opt: 0.2 (0.228), width: 16
Scan time: 9.620
The best scores are: opt bits E(85289)
NP_003844 (OMIM: 604509) interleukin-18 receptor a ( 599) 4040 801.9 0
XP_011510390 (OMIM: 604509) PREDICTED: interleukin ( 457) 3006 599.4 8.7e-171
XP_011510389 (OMIM: 604509) PREDICTED: interleukin ( 457) 3006 599.4 8.7e-171
XP_016860662 (OMIM: 604509) PREDICTED: interleukin ( 313) 1906 383.9 4.4e-106
NP_059112 (OMIM: 300277) X-linked interleukin-1 re ( 686) 749 157.6 1.3e-37
XP_016884892 (OMIM: 300277) PREDICTED: X-linked in ( 686) 749 157.6 1.3e-37
XP_011529207 (OMIM: 300277) PREDICTED: X-linked in ( 562) 712 150.3 1.7e-35
NP_055086 (OMIM: 300143,300206) interleukin-1 rece ( 696) 687 145.4 5.9e-34
XP_016884729 (OMIM: 300143,300206) PREDICTED: inte ( 696) 687 145.4 5.9e-34
XP_016884730 (OMIM: 300143,300206) PREDICTED: inte ( 570) 644 137.0 1.7e-31
XP_005264096 (OMIM: 604494) PREDICTED: interleukin ( 540) 563 121.1 9.8e-27
NP_003846 (OMIM: 604494) interleukin-18 receptor 1 ( 541) 561 120.7 1.3e-26
NP_002173 (OMIM: 602626) interleukin-1 receptor ac ( 570) 544 117.4 1.3e-25
NP_001161401 (OMIM: 602626) interleukin-1 receptor ( 570) 544 117.4 1.3e-25
NP_001161400 (OMIM: 602626) interleukin-1 receptor ( 570) 544 117.4 1.3e-25
NP_001269328 (OMIM: 604494) interleukin-18 recepto ( 385) 540 116.5 1.7e-25
XP_016860670 (OMIM: 604494) PREDICTED: interleukin ( 386) 538 116.1 2.2e-25
NP_001307907 (OMIM: 147810) interleukin-1 receptor ( 569) 521 112.9 3.1e-24
NP_001307911 (OMIM: 147810) interleukin-1 receptor ( 569) 521 112.9 3.1e-24
NP_001307910 (OMIM: 147810) interleukin-1 receptor ( 569) 521 112.9 3.1e-24
NP_000868 (OMIM: 147810) interleukin-1 receptor ty ( 569) 521 112.9 3.1e-24
XP_011509419 (OMIM: 147810) PREDICTED: interleukin ( 569) 521 112.9 3.1e-24
XP_005263991 (OMIM: 147810) PREDICTED: interleukin ( 569) 521 112.9 3.1e-24
XP_016859478 (OMIM: 147810) PREDICTED: interleukin ( 569) 521 112.9 3.1e-24
XP_005263987 (OMIM: 147810) PREDICTED: interleukin ( 569) 521 112.9 3.1e-24
XP_011509418 (OMIM: 147810) PREDICTED: interleukin ( 569) 521 112.9 3.1e-24
XP_011509420 (OMIM: 147810) PREDICTED: interleukin ( 569) 521 112.9 3.1e-24
NP_001307909 (OMIM: 147810) interleukin-1 receptor ( 569) 521 112.9 3.1e-24
XP_011509417 (OMIM: 147810) PREDICTED: interleukin ( 569) 521 112.9 3.1e-24
NP_001161403 (OMIM: 602626) interleukin-1 receptor ( 687) 512 111.2 1.2e-23
XP_016860663 (OMIM: 604512) PREDICTED: interleukin ( 606) 483 105.5 5.6e-22
NP_003845 (OMIM: 604512) interleukin-1 receptor-li ( 575) 480 104.8 8e-22
XP_005264093 (OMIM: 604512) PREDICTED: interleukin ( 575) 480 104.8 8e-22
XP_011510396 (OMIM: 604512) PREDICTED: interleukin ( 595) 480 104.9 8.3e-22
XP_005264092 (OMIM: 604512) PREDICTED: interleukin ( 603) 480 104.9 8.4e-22
XP_011510394 (OMIM: 604512) PREDICTED: interleukin ( 617) 480 104.9 8.5e-22
XP_011510393 (OMIM: 604512) PREDICTED: interleukin ( 622) 478 104.5 1.1e-21
XP_016860673 (OMIM: 604494) PREDICTED: interleukin ( 291) 468 102.3 2.4e-21
XP_016860672 (OMIM: 604494) PREDICTED: interleukin ( 291) 468 102.3 2.4e-21
XP_016860671 (OMIM: 604494) PREDICTED: interleukin ( 292) 466 101.9 3.1e-21
XP_016861837 (OMIM: 602626) PREDICTED: interleukin ( 376) 466 102.0 3.8e-21
NP_057316 (OMIM: 601203) interleukin-1 receptor-li ( 556) 460 100.9 1.2e-20
XP_006712902 (OMIM: 601203) PREDICTED: interleukin ( 556) 460 100.9 1.2e-20
NP_001307912 (OMIM: 147810) interleukin-1 receptor ( 425) 435 96.0 2.8e-19
NP_001307913 (OMIM: 147810) interleukin-1 receptor ( 386) 398 88.7 4e-17
XP_006712883 (OMIM: 604512) PREDICTED: interleukin ( 529) 399 89.0 4.5e-17
XP_016860668 (OMIM: 604512) PREDICTED: interleukin ( 424) 380 85.2 4.9e-16
XP_016860667 (OMIM: 604512) PREDICTED: interleukin ( 424) 380 85.2 4.9e-16
XP_006712885 (OMIM: 604512) PREDICTED: interleukin ( 444) 380 85.2 5.1e-16
XP_016860664 (OMIM: 604512) PREDICTED: interleukin ( 508) 380 85.2 5.7e-16
>>NP_003844 (OMIM: 604509) interleukin-18 receptor acces (599 aa)
initn: 4040 init1: 4040 opt: 4040 Z-score: 4279.6 bits: 801.9 E(85289): 0
Smith-Waterman score: 4040; 100.0% identity (100.0% similar) in 599 aa overlap (1-599:1-599)
10 20 30 40 50 60
pF1KE2 MLCLGWIFLWLVAGERIKGFNISGCSTKKLLWTYSTRSEEEFVLFCDLPEPQKSHFCHRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MLCLGWIFLWLVAGERIKGFNISGCSTKKLLWTYSTRSEEEFVLFCDLPEPQKSHFCHRN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RLSPKQVPEHLPFMGSNDLSDVQWYQQPSNGDPLEDIRKSYPHIIQDKCTLHFLTPGVNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RLSPKQVPEHLPFMGSNDLSDVQWYQQPSNGDPLEDIRKSYPHIIQDKCTLHFLTPGVNN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 SGSYICRPKMIKSPYDVACCVKMILEVKPQTNASCEYSASHKQDLLLGSTGSISCPSLSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SGSYICRPKMIKSPYDVACCVKMILEVKPQTNASCEYSASHKQDLLLGSTGSISCPSLSC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QSDAQSPAVTWYKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSWTVRAVVQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QSDAQSPAVTWYKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSWTVRAVVQV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 RTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIKDSDLEWEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIKDSDLEWEV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 SVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 PSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 LSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALRVLPTVTWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALRVLPTVTWR
490 500 510 520 530 540
550 560 570 580 590
pF1KE2 GLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGRSSQPKEW
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGRSSQPKEW
550 560 570 580 590
>>XP_011510390 (OMIM: 604509) PREDICTED: interleukin-18 (457 aa)
initn: 3006 init1: 3006 opt: 3006 Z-score: 3187.2 bits: 599.4 E(85289): 8.7e-171
Smith-Waterman score: 3006; 100.0% identity (100.0% similar) in 457 aa overlap (143-599:1-457)
120 130 140 150 160 170
pF1KE2 FLTPGVNNSGSYICRPKMIKSPYDVACCVKMILEVKPQTNASCEYSASHKQDLLLGSTGS
::::::::::::::::::::::::::::::
XP_011 MILEVKPQTNASCEYSASHKQDLLLGSTGS
10 20 30
180 190 200 210 220 230
pF1KE2 ISCPSLSCQSDAQSPAVTWYKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISCPSLSCQSDAQSPAVTWYKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSW
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE2 TVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIK
100 110 120 130 140 150
300 310 320 330 340 350
pF1KE2 DSDLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSDLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQL
160 170 180 190 200 210
360 370 380 390 400 410
pF1KE2 KEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFV
220 230 240 250 260 270
420 430 440 450 460 470
pF1KE2 SYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIK
280 290 300 310 320 330
480 490 500 510 520 530
pF1KE2 RSRRGIFILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSRRGIFILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALR
340 350 360 370 380 390
540 550 560 570 580 590
pF1KE2 VLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGR
400 410 420 430 440 450
pF1KE2 SSQPKEW
:::::::
XP_011 SSQPKEW
>>XP_011510389 (OMIM: 604509) PREDICTED: interleukin-18 (457 aa)
initn: 3006 init1: 3006 opt: 3006 Z-score: 3187.2 bits: 599.4 E(85289): 8.7e-171
Smith-Waterman score: 3006; 100.0% identity (100.0% similar) in 457 aa overlap (143-599:1-457)
120 130 140 150 160 170
pF1KE2 FLTPGVNNSGSYICRPKMIKSPYDVACCVKMILEVKPQTNASCEYSASHKQDLLLGSTGS
::::::::::::::::::::::::::::::
XP_011 MILEVKPQTNASCEYSASHKQDLLLGSTGS
10 20 30
180 190 200 210 220 230
pF1KE2 ISCPSLSCQSDAQSPAVTWYKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISCPSLSCQSDAQSPAVTWYKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSW
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE2 TVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIK
100 110 120 130 140 150
300 310 320 330 340 350
pF1KE2 DSDLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSDLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQL
160 170 180 190 200 210
360 370 380 390 400 410
pF1KE2 KEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFV
220 230 240 250 260 270
420 430 440 450 460 470
pF1KE2 SYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIK
280 290 300 310 320 330
480 490 500 510 520 530
pF1KE2 RSRRGIFILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSRRGIFILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALR
340 350 360 370 380 390
540 550 560 570 580 590
pF1KE2 VLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGR
400 410 420 430 440 450
pF1KE2 SSQPKEW
:::::::
XP_011 SSQPKEW
>>XP_016860662 (OMIM: 604509) PREDICTED: interleukin-18 (313 aa)
initn: 1906 init1: 1906 opt: 1906 Z-score: 2025.5 bits: 383.9 E(85289): 4.4e-106
Smith-Waterman score: 1906; 100.0% identity (100.0% similar) in 292 aa overlap (308-599:22-313)
280 290 300 310 320 330
pF1KE2 GFERVFNPVIKWYIKDSDLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVC
::::::::::::::::::::::::::::::
XP_016 MSNQMCLQRMHSLIFRRCDPDIKSTLKDEIIERNIILEKVTQRDLRRKFVC
10 20 30 40 50
340 350 360 370 380 390
pF1KE2 FVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQS
60 70 80 90 100 110
400 410 420 430 440 450
pF1KE2 KDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDV
120 130 140 150 160 170
460 470 480 490 500 510
pF1KE2 APGGVYAEDIVSIIKRSRRGIFILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APGGVYAEDIVSIIKRSRRGIFILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYF
180 190 200 210 220 230
520 530 540 550 560 570
pF1KE2 QEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSR
240 250 260 270 280 290
580 590
pF1KE2 IFQWKGLSRTETTGRSSQPKEW
::::::::::::::::::::::
XP_016 IFQWKGLSRTETTGRSSQPKEW
300 310
>>NP_059112 (OMIM: 300277) X-linked interleukin-1 recept (686 aa)
initn: 469 init1: 205 opt: 749 Z-score: 796.3 bits: 157.6 E(85289): 1.3e-37
Smith-Waterman score: 749; 30.7% identity (62.4% similar) in 508 aa overlap (82-565:74-562)
60 70 80 90 100 110
pF1KE2 QKSHFCHRNRLSPKQVPEHLPFMGSNDLSDVQWYQQPSNGDPLEDIRKSYPHIIQDKCTL
..::. ..:: : : : .. ... ..
NP_059 LAGEPVRVKCALFYSYIRTNYSTAQSTGLRLMWYK--NKGDLEEPIIFSEVRMSKEEDSI
50 60 70 80 90 100
120 130 140 150 160
pF1KE2 HFLTPGVNNSGSYICRPKMIKSPYDVACCVK--MILEVKPQTNASCEYS-ASHKQDLLLG
: . ...:: : : . .: : :.: : : : . .. : : . . .
NP_059 WFHSAEAQDSGFYTCVLR--NSTY----CMKVSMSLTVAENESGLCYNSRIRYLEKSEVT
110 120 130 140 150
170 180 190 200 210 220
pF1KE2 STGSISCPSLS-CQSDAQSPAVTWYKNGK-----LLSVERSNRIVVDEVYDYHQGTYVCD
. ::::... ... : : :.:::. : . ....: ....:: . :.:.:.
NP_059 KRKEISCPDMDDFKKSDQEPDVVWYKECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCE
160 170 180 190 200 210
230 240 250 260 270
pF1KE2 YTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVED---TLEVELGKPLTISCKARFGF
. :.. ..: ... : :: : :.:. ...:.:::::.: ::: :::
NP_059 LKYEGKLVRRTTE--LKVTALLTDKPPKP--LFPMENQPSVIDVQLGKPLNIPCKAFFGF
220 230 240 250 260 270
280 290 300 310 320 330
pF1KE2 ERVFNPVIKWYIKDS---DLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFV
.:.: :. .. .: .. : . .: : .. .: .:...:.. :: ...
NP_059 SGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLA-NYT
280 290 300 310 320 330
340 350 360 370 380 390
pF1KE2 CFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHW-IEIVLLYRTY
: :.: : :: :. :. .. : : .:.. .:. ...:. . ::..:.:: .
NP_059 CHVENRNGRKHASVLLR-KKDLIYKIELAGGLGAIFLLLVLLVVIYKCYNIELMLFYRQH
340 350 360 370 380
400 410 420 430 440 450
pF1KE2 QSKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLER
. :.: :.:..::..::.: .. . .. ::..:: ..:::::..:::.: . ::
NP_059 FGADETNDDNKEYDAYLSYTKVDQ-DTLDCDNPEEEQFALEVLPDVLEKHYGYKLFIPER
390 400 410 420 430 440
460 470 480 490 500 510
pF1KE2 DVAPGGVYAEDIVSIIKRSRRGIFILSPNYV--NGPSIFELQAAVNLALDDQTLKLILIK
:. :.:.: ::.. ...::: :..:.:.:. : :::::.. .. : . .:.:::.
NP_059 DLIPSGTYMEDLTRYVEQSRRLIIVLTPDYILRRGWSIFELESRLHNMLVSGEIKVILIE
450 460 470 480 490 500
520 530 540 550 560
pF1KE2 FCYF------QEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGF
. :: ::: :.....: . :.: :: ::.:: .. :.::.:...
NP_059 CTELKGKVNCQEVESL----KRSIKLLSLIKWKGSKSSKLNSKFWKHLVYEMPIKKKEML
510 520 530 540 550 560
570 580 590
pF1KE2 TWNQLRITSRIFQWKGLSRTETTGRSSQPKEW
NP_059 PRCHVLDSAEQGLFGELQPIPSIAMTSTSATLVSSQADLPEFHPSDSMQIRHCCRGYKHE
570 580 590 600 610 620
>>XP_016884892 (OMIM: 300277) PREDICTED: X-linked interl (686 aa)
initn: 469 init1: 205 opt: 749 Z-score: 796.3 bits: 157.6 E(85289): 1.3e-37
Smith-Waterman score: 749; 30.7% identity (62.4% similar) in 508 aa overlap (82-565:74-562)
60 70 80 90 100 110
pF1KE2 QKSHFCHRNRLSPKQVPEHLPFMGSNDLSDVQWYQQPSNGDPLEDIRKSYPHIIQDKCTL
..::. ..:: : : : .. ... ..
XP_016 LAGEPVRVKCALFYSYIRTNYSTAQSTGLRLMWYK--NKGDLEEPIIFSEVRMSKEEDSI
50 60 70 80 90 100
120 130 140 150 160
pF1KE2 HFLTPGVNNSGSYICRPKMIKSPYDVACCVK--MILEVKPQTNASCEYS-ASHKQDLLLG
: . ...:: : : . .: : :.: : : : . .. : : . . .
XP_016 WFHSAEAQDSGFYTCVLR--NSTY----CMKVSMSLTVAENESGLCYNSRIRYLEKSEVT
110 120 130 140 150
170 180 190 200 210 220
pF1KE2 STGSISCPSLS-CQSDAQSPAVTWYKNGK-----LLSVERSNRIVVDEVYDYHQGTYVCD
. ::::... ... : : :.:::. : . ....: ....:: . :.:.:.
XP_016 KRKEISCPDMDDFKKSDQEPDVVWYKECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCE
160 170 180 190 200 210
230 240 250 260 270
pF1KE2 YTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVED---TLEVELGKPLTISCKARFGF
. :.. ..: ... : :: : :.:. ...:.:::::.: ::: :::
XP_016 LKYEGKLVRRTTE--LKVTALLTDKPPKP--LFPMENQPSVIDVQLGKPLNIPCKAFFGF
220 230 240 250 260 270
280 290 300 310 320 330
pF1KE2 ERVFNPVIKWYIKDS---DLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFV
.:.: :. .. .: .. : . .: : .. .: .:...:.. :: ...
XP_016 SGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLA-NYT
280 290 300 310 320 330
340 350 360 370 380 390
pF1KE2 CFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHW-IEIVLLYRTY
: :.: : :: :. :. .. : : .:.. .:. ...:. . ::..:.:: .
XP_016 CHVENRNGRKHASVLLR-KKDLIYKIELAGGLGAIFLLLVLLVVIYKCYNIELMLFYRQH
340 350 360 370 380
400 410 420 430 440 450
pF1KE2 QSKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLER
. :.: :.:..::..::.: .. . .. ::..:: ..:::::..:::.: . ::
XP_016 FGADETNDDNKEYDAYLSYTKVDQ-DTLDCDNPEEEQFALEVLPDVLEKHYGYKLFIPER
390 400 410 420 430 440
460 470 480 490 500 510
pF1KE2 DVAPGGVYAEDIVSIIKRSRRGIFILSPNYV--NGPSIFELQAAVNLALDDQTLKLILIK
:. :.:.: ::.. ...::: :..:.:.:. : :::::.. .. : . .:.:::.
XP_016 DLIPSGTYMEDLTRYVEQSRRLIIVLTPDYILRRGWSIFELESRLHNMLVSGEIKVILIE
450 460 470 480 490 500
520 530 540 550 560
pF1KE2 FCYF------QEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGF
. :: ::: :.....: . :.: :: ::.:: .. :.::.:...
XP_016 CTELKGKVNCQEVESL----KRSIKLLSLIKWKGSKSSKLNSKFWKHLVYEMPIKKKEML
510 520 530 540 550 560
570 580 590
pF1KE2 TWNQLRITSRIFQWKGLSRTETTGRSSQPKEW
XP_016 PRCHVLDSAEQGLFGELQPIPSIAMTSTSATLVSSQADLPEFHPSDSMQIRHCCRGYKHE
570 580 590 600 610 620
>>XP_011529207 (OMIM: 300277) PREDICTED: X-linked interl (562 aa)
initn: 469 init1: 205 opt: 712 Z-score: 758.4 bits: 150.3 E(85289): 1.7e-35
Smith-Waterman score: 712; 31.5% identity (63.5% similar) in 447 aa overlap (141-565:3-438)
120 130 140 150 160
pF1KE2 LHFLTPGVNNSGSYICRPKMIKSPYDVACCVKMILEVKPQTNASCEYS-ASHKQDLLLGS
:.: : : . .. : : . . . .
XP_011 MKVSMSLTVAENESGLCYNSRIRYLEKSEVTK
10 20 30
170 180 190 200 210 220
pF1KE2 TGSISCPSLS-CQSDAQSPAVTWYKNGK-----LLSVERSNRIVVDEVYDYHQGTYVCDY
::::... ... : : :.:::. : . ....: ....:: . :.:.:.
XP_011 RKEISCPDMDDFKKSDQEPDVVWYKECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCEL
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE2 TQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVED---TLEVELGKPLTISCKARFGFE
. :.. ..: ... : :: : :.:. ...:.:::::.: ::: :::
XP_011 KYEGKLVRRTTE--LKVTALLTDKPPKP--LFPMENQPSVIDVQLGKPLNIPCKAFFGFS
100 110 120 130 140
290 300 310 320 330
pF1KE2 RVFNPVIKWYIKDS---DLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVC
.:.: :. .. .: .. : . .: : .. .: .:...:.. :: ...:
XP_011 GESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLA-NYTC
150 160 170 180 190 200
340 350 360 370 380 390
pF1KE2 FVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHW-IEIVLLYRTYQ
:.: : :: :. :. .. : : .:.. .:. ...:. . ::..:.:: .
XP_011 HVENRNGRKHASVLLR-KKDLIYKIELAGGLGAIFLLLVLLVVIYKCYNIELMLFYRQHF
210 220 230 240 250 260
400 410 420 430 440 450
pF1KE2 SKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERD
. :.: :.:..::..::.: .. . .. ::..:: ..:::::..:::.: . :::
XP_011 GADETNDDNKEYDAYLSYTKVDQ-DTLDCDNPEEEQFALEVLPDVLEKHYGYKLFIPERD
270 280 290 300 310 320
460 470 480 490 500 510
pF1KE2 VAPGGVYAEDIVSIIKRSRRGIFILSPNYV--NGPSIFELQAAVNLALDDQTLKLILIKF
. :.:.: ::.. ...::: :..:.:.:. : :::::.. .. : . .:.:::.
XP_011 LIPSGTYMEDLTRYVEQSRRLIIVLTPDYILRRGWSIFELESRLHNMLVSGEIKVILIEC
330 340 350 360 370 380
520 530 540 550 560
pF1KE2 CYF------QEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFT
. :: ::: :.....: . :.: :: ::.:: .. :.::.:...
XP_011 TELKGKVNCQEVESL----KRSIKLLSLIKWKGSKSSKLNSKFWKHLVYEMPIKKKEMLP
390 400 410 420 430 440
570 580 590
pF1KE2 WNQLRITSRIFQWKGLSRTETTGRSSQPKEW
XP_011 RCHVLDSAEQGLFGELQPIPSIAMTSTSATLVSSQADLPEFHPSDSMQIRHCCRGYKHEI
450 460 470 480 490 500
>>NP_055086 (OMIM: 300143,300206) interleukin-1 receptor (696 aa)
initn: 497 init1: 194 opt: 687 Z-score: 730.6 bits: 145.4 E(85289): 5.9e-34
Smith-Waterman score: 691; 29.4% identity (60.0% similar) in 527 aa overlap (76-571:69-571)
50 60 70 80 90 100
pF1KE2 CDLPEPQKSHFCHRNRLSPKQVPEHLPFMGSNDLSDVQWYQQPSNGDPLEDIRKSYPHII
: :: ..::.. . :: : : . ..
NP_055 KKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLS-LMWYKSSGPGDFEEPIAFDGSRMS
40 50 60 70 80 90
110 120 130 140 150 160
pF1KE2 QDKCTLHFLTPGVNNSGSYICRPKMIKSPYDVACCVK--MILEVKPQTNASCEYSASHK-
... .. : ...:: : : . .: : :.: . : : . .. : :... :
NP_055 KEEDSIWFRPTLLQDSGLYACVIR--NSTY----CMKVSISLTVGENDTGLC-YNSKMKY
100 110 120 130 140 150
170 180 190 200 210
pF1KE2 -QDLLLGSTGSISCPSL-SCQSDAQSPAVTWYKNGKLLS-----VERSNRIVVDEVYDYH
. :... ::: .. . .. : . :::. . . : . . ... :: .
NP_055 FEKAELSKSKEISCRDIEDFLLPTREPEILWYKECRTKTWRPSIVFKRDTLLIREVREDD
160 170 180 190 200 210
220 230 240 250 260 270
pF1KE2 QGTYVCDYTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVEDTL---EVELGKPLTIS
:.:.:. . : :: .... . . : : .: :.:. : :..:: ...
NP_055 IGNYTCELKYGGFV----VRRTTELTVTAPLTDKPPKLLYPMESKLTIQETQLGDSANLT
220 230 240 250 260
280 290 300 310 320
pF1KE2 CKARFGFERVFNPVIKW-----YIKDSDLE--WEVSVPEAKSIKSTLKDEIIERNIILEK
:.: ::. .:.: : .:.: : . :: .. . .: : .. . ..:...
NP_055 CRAFFGYSGDVSPLIYWMKGEKFIEDLDENRVWESDI---RILKEHLGEQEVSISLIVDS
270 280 290 300 310 320
330 340 350 360 370 380
pF1KE2 VTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHW
: . :: .. :.:.:. : :: :. :: .. : : .:... .:. . .:. .
NP_055 VEEGDLG-NYSCYVENGNGRRHASVLLH-KRELMYTVELAGGLGAILLLLVCLVTIYKCY
330 340 350 360 370 380
390 400 410 420 430 440
pF1KE2 -IEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEH-LALSLFPDVLE
:::.:.::.. . .. ::.::.::..::.: . :.. .. .::. .:: ..::.::
NP_055 KIEIMLFYRNHFGAEELDGDNKDYDAYLSYTKVD--PDQWNQETGEEERFALEILPDMLE
390 400 410 420 430
450 460 470 480 490 500
pF1KE2 NKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYV--NGPSIFELQAAVNLA
..:::.: . .::. : :.: ::.. . .:.: :....:::: : :::::.. .
NP_055 KHYGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYVVRRGWSIFELETRLRNM
440 450 460 470 480 490
510 520 530 540 550
pF1KE2 LDDQTLKLILIKFCY-------FQEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAK
: .:.:::. : .:: :.: : .: .: .. :.: : ::.:: .
NP_055 LVTGEIKVILIE-CSELRGIMNYQEVEALKHTIK----LLTVIKWHGPKCNKLNSKFWKR
500 510 520 530 540 550
560 570 580 590
pF1KE2 MRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGRSSQPKEW
..:.:: : . .: .:
NP_055 LQYEMPFKRIEPITHEQALDVSEQGPFGELQTVSAISMAAATSTALATAHPDLRSTFHNT
560 570 580 590 600 610
>>XP_016884729 (OMIM: 300143,300206) PREDICTED: interleu (696 aa)
initn: 497 init1: 194 opt: 687 Z-score: 730.6 bits: 145.4 E(85289): 5.9e-34
Smith-Waterman score: 691; 29.4% identity (60.0% similar) in 527 aa overlap (76-571:69-571)
50 60 70 80 90 100
pF1KE2 CDLPEPQKSHFCHRNRLSPKQVPEHLPFMGSNDLSDVQWYQQPSNGDPLEDIRKSYPHII
: :: ..::.. . :: : : . ..
XP_016 KKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLS-LMWYKSSGPGDFEEPIAFDGSRMS
40 50 60 70 80 90
110 120 130 140 150 160
pF1KE2 QDKCTLHFLTPGVNNSGSYICRPKMIKSPYDVACCVK--MILEVKPQTNASCEYSASHK-
... .. : ...:: : : . .: : :.: . : : . .. : :... :
XP_016 KEEDSIWFRPTLLQDSGLYACVIR--NSTY----CMKVSISLTVGENDTGLC-YNSKMKY
100 110 120 130 140 150
170 180 190 200 210
pF1KE2 -QDLLLGSTGSISCPSL-SCQSDAQSPAVTWYKNGKLLS-----VERSNRIVVDEVYDYH
. :... ::: .. . .. : . :::. . . : . . ... :: .
XP_016 FEKAELSKSKEISCRDIEDFLLPTREPEILWYKECRTKTWRPSIVFKRDTLLIREVREDD
160 170 180 190 200 210
220 230 240 250 260 270
pF1KE2 QGTYVCDYTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVEDTL---EVELGKPLTIS
:.:.:. . : :: .... . . : : .: :.:. : :..:: ...
XP_016 IGNYTCELKYGGFV----VRRTTELTVTAPLTDKPPKLLYPMESKLTIQETQLGDSANLT
220 230 240 250 260
280 290 300 310 320
pF1KE2 CKARFGFERVFNPVIKW-----YIKDSDLE--WEVSVPEAKSIKSTLKDEIIERNIILEK
:.: ::. .:.: : .:.: : . :: .. . .: : .. . ..:...
XP_016 CRAFFGYSGDVSPLIYWMKGEKFIEDLDENRVWESDI---RILKEHLGEQEVSISLIVDS
270 280 290 300 310 320
330 340 350 360 370 380
pF1KE2 VTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHW
: . :: .. :.:.:. : :: :. :: .. : : .:... .:. . .:. .
XP_016 VEEGDLG-NYSCYVENGNGRRHASVLLH-KRELMYTVELAGGLGAILLLLVCLVTIYKCY
330 340 350 360 370 380
390 400 410 420 430 440
pF1KE2 -IEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEH-LALSLFPDVLE
:::.:.::.. . .. ::.::.::..::.: . :.. .. .::. .:: ..::.::
XP_016 KIEIMLFYRNHFGAEELDGDNKDYDAYLSYTKVD--PDQWNQETGEEERFALEILPDMLE
390 400 410 420 430
450 460 470 480 490 500
pF1KE2 NKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYV--NGPSIFELQAAVNLA
..:::.: . .::. : :.: ::.. . .:.: :....:::: : :::::.. .
XP_016 KHYGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYVVRRGWSIFELETRLRNM
440 450 460 470 480 490
510 520 530 540 550
pF1KE2 LDDQTLKLILIKFCY-------FQEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAK
: .:.:::. : .:: :.: : .: .: .. :.: : ::.:: .
XP_016 LVTGEIKVILIE-CSELRGIMNYQEVEALKHTIK----LLTVIKWHGPKCNKLNSKFWKR
500 510 520 530 540 550
560 570 580 590
pF1KE2 MRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGRSSQPKEW
..:.:: : . .: .:
XP_016 LQYEMPFKRIEPITHEQALDVSEQGPFGELQTVSAISMAAATSTALATAHPDLRSTFHNT
560 570 580 590 600 610
>>XP_016884730 (OMIM: 300143,300206) PREDICTED: interleu (570 aa)
initn: 474 init1: 194 opt: 644 Z-score: 686.3 bits: 137.0 E(85289): 1.7e-31
Smith-Waterman score: 647; 30.0% identity (61.1% similar) in 460 aa overlap (141-571:3-445)
120 130 140 150 160
pF1KE2 LHFLTPGVNNSGSYICRPKMIKSPYDVACCVKMILEVKPQTNASCEYSASHK--QDLLLG
:.. : : . .. : :... : . :.
XP_016 MKVSISLTVGENDTGLC-YNSKMKYFEKAELS
10 20 30
170 180 190 200 210 220
pF1KE2 STGSISCPSL-SCQSDAQSPAVTWYKNGKLLS-----VERSNRIVVDEVYDYHQGTYVCD
.. ::: .. . .. : . :::. . . : . . ... :: . :.:.:.
XP_016 KSKEISCRDIEDFLLPTREPEILWYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCE
40 50 60 70 80 90
230 240 250 260 270
pF1KE2 YTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVEDTL---EVELGKPLTISCKARFGF
. : :: .... . . : : .: :.:. : :..:: ...:.: ::.
XP_016 LKYGGFV----VRRTTELTVTAPLTDKPPKLLYPMESKLTIQETQLGDSANLTCRAFFGY
100 110 120 130 140
280 290 300 310 320 330
pF1KE2 ERVFNPVIKW-----YIKDSDLE--WEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLR
.:.: : .:.: : . :: .. . .: : .. . ..:...: . ::
XP_016 SGDVSPLIYWMKGEKFIEDLDENRVWESDI---RILKEHLGEQEVSISLIVDSVEEGDLG
150 160 170 180 190 200
340 350 360 370 380 390
pF1KE2 RKFVCFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHW-IEIVLL
.. :.:.:. : :: :. :: .. : : .:... .:. . .:. . :::.:.
XP_016 -NYSCYVENGNGRRHASVLLH-KRELMYTVELAGGLGAILLLLVCLVTIYKCYKIEIMLF
210 220 230 240 250 260
400 410 420 430 440 450
pF1KE2 YRTYQSKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEH-LALSLFPDVLENKYGYSL
::.. . .. ::.::.::..::.: . :.. .. .::. .:: ..::.::..:::.:
XP_016 YRNHFGAEELDGDNKDYDAYLSYTKVD--PDQWNQETGEEERFALEILPDMLEKHYGYKL
270 280 290 300 310 320
460 470 480 490 500
pF1KE2 CLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYV--NGPSIFELQAAVNLALDDQTLK
. .::. : :.: ::.. . .:.: :....:::: : :::::.. . : .:
XP_016 FIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYVVRRGWSIFELETRLRNMLVTGEIK
330 340 350 360 370 380
510 520 530 540 550 560
pF1KE2 LILIKFCY-------FQEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPV
.:::. : .:: :.: : .: .: .. :.: : ::.:: ...:.::
XP_016 VILIE-CSELRGIMNYQEVEALKHTIK----LLTVIKWHGPKCNKLNSKFWKRLQYEMPF
390 400 410 420 430
570 580 590
pF1KE2 KNSQGFTWNQLRITSRIFQWKGLSRTETTGRSSQPKEW
: . .: .:
XP_016 KRIEPITHEQALDVSEQGPFGELQTVSAISMAAATSTALATAHPDLRSTFHNTYHSQMRQ
440 450 460 470 480 490
599 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 18:22:02 2016 done: Sun Nov 6 18:22:03 2016
Total Scan time: 9.620 Total Display time: 0.110
Function used was FASTA [36.3.4 Apr, 2011]