Result of FASTA (ccds) for
pFN21AE2007
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2007, 583 aa
1>>>pF1KE2007 583 - 583 aa - 583 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.2293+/-0.00124; mu= 15.2771+/- 0.074
mean_var=133.1308+/-26.957, 0's: 0 Z-trim(105.9): 201 B-trim: 2 in 1/50
Lambda= 0.111157
statistics sampled from 8484 (8703) to 8484 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.621), E-opt: 0.2 (0.267), width: 16
Scan time: 3.070
The best scores are: opt bits E(32554)
CCDS34049.1 CFI gene_id:3426|Hs108|chr4 ( 583) 4168 680.7 1.4e-195
CCDS82946.1 CFI gene_id:3426|Hs108|chr4 ( 591) 4142 676.5 2.5e-194
CCDS82945.1 CFI gene_id:3426|Hs108|chr4 ( 576) 4106 670.8 1.3e-192
CCDS43129.2 TMPRSS7 gene_id:344805|Hs108|chr3 ( 717) 698 124.3 5.1e-28
CCDS74856.1 TMPRSS6 gene_id:164656|Hs108|chr22 ( 802) 660 118.3 3.8e-26
CCDS13941.1 TMPRSS6 gene_id:164656|Hs108|chr22 ( 811) 660 118.3 3.8e-26
CCDS3518.1 TMPRSS11D gene_id:9407|Hs108|chr4 ( 418) 605 109.2 1.1e-23
CCDS32993.1 HPN gene_id:3249|Hs108|chr19 ( 417) 536 98.1 2.3e-20
CCDS34120.1 KLKB1 gene_id:3818|Hs108|chr4 ( 638) 537 98.5 2.8e-20
CCDS33564.1 TMPRSS2 gene_id:7113|Hs108|chr21 ( 492) 533 97.7 3.6e-20
CCDS54486.1 TMPRSS2 gene_id:7113|Hs108|chr21 ( 529) 533 97.7 3.8e-20
CCDS3520.1 TMPRSS11F gene_id:389208|Hs108|chr4 ( 438) 526 96.5 7.3e-20
CCDS3847.1 F11 gene_id:2160|Hs108|chr4 ( 625) 528 97.0 7.5e-20
CCDS73391.1 TMPRSS5 gene_id:80975|Hs108|chr11 ( 413) 524 96.2 8.7e-20
CCDS33993.1 TMPRSS11E gene_id:28983|Hs108|chr4 ( 423) 524 96.2 8.9e-20
CCDS73392.1 TMPRSS5 gene_id:80975|Hs108|chr11 ( 448) 524 96.2 9.3e-20
CCDS44735.1 TMPRSS5 gene_id:80975|Hs108|chr11 ( 457) 524 96.2 9.4e-20
CCDS3521.1 TMPRSS11B gene_id:132724|Hs108|chr4 ( 416) 520 95.5 1.4e-19
CCDS5976.1 PRSS55 gene_id:203074|Hs108|chr8 ( 352) 517 95.0 1.7e-19
CCDS44881.1 TMPRSS12 gene_id:283471|Hs108|chr12 ( 348) 516 94.8 1.9e-19
CCDS3369.1 HGFAC gene_id:3083|Hs108|chr4 ( 655) 517 95.3 2.6e-19
CCDS75098.1 HGFAC gene_id:3083|Hs108|chr4 ( 662) 517 95.3 2.6e-19
CCDS12088.1 TMPRSS9 gene_id:360200|Hs108|chr19 (1059) 513 94.8 5.7e-19
CCDS8487.1 ST14 gene_id:6768|Hs108|chr11 ( 855) 509 94.1 7.7e-19
CCDS47065.1 TMPRSS11A gene_id:339967|Hs108|chr4 ( 418) 503 92.8 9.1e-19
CCDS3519.1 TMPRSS11A gene_id:339967|Hs108|chr4 ( 421) 503 92.8 9.2e-19
CCDS74669.1 PRSS56 gene_id:646960|Hs108|chr2 ( 603) 495 91.7 2.9e-18
CCDS14666.1 F9 gene_id:2158|Hs108|chrX ( 461) 489 90.6 4.6e-18
CCDS55788.1 TMPRSS13 gene_id:84000|Hs108|chr11 ( 532) 488 90.5 5.7e-18
CCDS58185.1 TMPRSS13 gene_id:84000|Hs108|chr11 ( 563) 488 90.5 5.9e-18
CCDS41721.1 TMPRSS13 gene_id:84000|Hs108|chr11 ( 567) 488 90.5 6e-18
CCDS10430.1 TPSG1 gene_id:25823|Hs108|chr16 ( 321) 484 89.7 6.3e-18
CCDS156.1 CTRC gene_id:11330|Hs108|chr1 ( 268) 482 89.3 6.9e-18
CCDS13571.1 TMPRSS15 gene_id:5651|Hs108|chr21 (1019) 488 90.8 8.9e-18
CCDS34302.1 F12 gene_id:2161|Hs108|chr5 ( 615) 479 89.1 1.7e-17
CCDS2145.1 PROC gene_id:5624|Hs108|chr2 ( 461) 475 88.4 2.2e-17
CCDS45469.1 PRSS8 gene_id:5652|Hs108|chr16 ( 343) 472 87.8 2.5e-17
CCDS5279.1 PLG gene_id:5340|Hs108|chr6 ( 810) 474 88.5 3.6e-17
CCDS83495.1 F9 gene_id:2158|Hs108|chrX ( 423) 469 87.4 4e-17
CCDS58790.1 TMPRSS3 gene_id:64699|Hs108|chr21 ( 453) 465 86.8 6.6e-17
CCDS13686.1 TMPRSS3 gene_id:64699|Hs108|chr21 ( 454) 465 86.8 6.6e-17
CCDS157.1 CELA2A gene_id:63036|Hs108|chr1 ( 269) 461 85.9 7.1e-17
CCDS53579.1 HABP2 gene_id:3026|Hs108|chr10 ( 534) 463 86.5 9.2e-17
CCDS7577.1 HABP2 gene_id:3026|Hs108|chr10 ( 560) 463 86.5 9.5e-17
CCDS47145.1 PRSS48 gene_id:345062|Hs108|chr4 ( 328) 452 84.5 2.2e-16
CCDS10852.1 CTRL gene_id:1506|Hs108|chr16 ( 264) 449 84.0 2.7e-16
CCDS14101.1 ACR gene_id:49|Hs108|chr22 ( 421) 442 83.0 8.1e-16
CCDS3709.1 PRSS12 gene_id:8492|Hs108|chr4 ( 875) 446 84.0 8.6e-16
CCDS12808.1 KLK2 gene_id:3817|Hs108|chr19 ( 261) 437 82.0 1e-15
CCDS9530.1 F10 gene_id:2159|Hs108|chr13 ( 488) 439 82.6 1.2e-15
>>CCDS34049.1 CFI gene_id:3426|Hs108|chr4 (583 aa)
initn: 4168 init1: 4168 opt: 4168 Z-score: 3625.0 bits: 680.7 E(32554): 1.4e-195
Smith-Waterman score: 4168; 99.8% identity (100.0% similar) in 583 aa overlap (1-583:1-583)
10 20 30 40 50 60
pF1KE2 MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQPWQRCIEGTCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS34 MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQPWQRCIEGTCV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 CKLPYQCPKNGTAVCATNRRSFPTYCQQKSLECLHPGTKFLNNGTCTAEGKFSVSLKHGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS34 CKLPYQCPKNGTAVCATNRRSFPTYCQQKSLECLHPGTKFLNNGTCTAEGKFSVSLKHGN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 TDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINSTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS34 TDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINSTE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 CLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS34 CLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 CDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCAGFASVA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.
CCDS34 CDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCAGFASVT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 QEETEILTADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS34 QEETEILTADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 SGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS34 SGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHEN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 YNAGTYQNDIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS34 YNAGTYQNDIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNER
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 VFSLQWGEVKLISNCSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS34 VFSLQWGEVKLISNCSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYV
490 500 510 520 530 540
550 560 570 580
pF1KE2 WGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV
:::::::::::::::::::::::::::::::::::::::::::
CCDS34 WGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV
550 560 570 580
>>CCDS82946.1 CFI gene_id:3426|Hs108|chr4 (591 aa)
initn: 4154 init1: 2121 opt: 4142 Z-score: 3602.4 bits: 676.5 E(32554): 2.5e-194
Smith-Waterman score: 4142; 98.5% identity (98.6% similar) in 591 aa overlap (1-583:1-591)
10 20 30 40 50 60
pF1KE2 MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQPWQRCIEGTCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQPWQRCIEGTCV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 CKLPYQCPKNGTAVCATNRRSFPTYCQQKSLECLHPGTKFLNNGTCTAEGKFSVSLKHGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 CKLPYQCPKNGTAVCATNRRSFPTYCQQKSLECLHPGTKFLNNGTCTAEGKFSVSLKHGN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 TDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINSTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 TDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINSTE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 CLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 CLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKA
190 200 210 220 230 240
250 260 270 280 290
pF1KE2 CDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCA------
::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 CDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCAAARHPT
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE2 --GFASVAQEETEILTADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLP
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 IQGFASVTQEETEILTADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLP
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE2 WQVAIKDASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVIEYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 WQVAIKDASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVIEYV
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE2 DRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 DRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGW
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE2 GREKDNERVFSLQWGEVKLISNCSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 GREKDNERVFSLQWGEVKLISNCSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCM
490 500 510 520 530 540
540 550 560 570 580
pF1KE2 DANNVTYVWGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV
:::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 DANNVTYVWGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV
550 560 570 580 590
>>CCDS82945.1 CFI gene_id:3426|Hs108|chr4 (576 aa)
initn: 4116 init1: 2121 opt: 4106 Z-score: 3571.3 bits: 670.8 E(32554): 1.3e-192
Smith-Waterman score: 4106; 98.8% identity (98.8% similar) in 583 aa overlap (1-583:1-576)
10 20 30 40 50 60
pF1KE2 MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQPWQRCIEGTCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQPWQRCIEGTCV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 CKLPYQCPKNGTAVCATNRRSFPTYCQQKSLECLHPGTKFLNNGTCTAEGKFSVSLKHGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 CKLPYQCPKNGTAVCATNRRSFPTYCQQKSLECLHPGTKFLNNGTCTAEGKFSVSLKHGN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 TDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINSTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 TDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINSTE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 CLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 CLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 CDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCAGFASVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 CDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCA------
250 260 270 280 290
310 320 330 340 350 360
pF1KE2 QEETEILTADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 -EETEILTADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDA
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE2 SGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 SGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHEN
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE2 YNAGTYQNDIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 YNAGTYQNDIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNER
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE2 VFSLQWGEVKLISNCSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 VFSLQWGEVKLISNCSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYV
480 490 500 510 520 530
550 560 570 580
pF1KE2 WGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV
:::::::::::::::::::::::::::::::::::::::::::
CCDS82 WGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV
540 550 560 570
>>CCDS43129.2 TMPRSS7 gene_id:344805|Hs108|chr3 (717 aa)
initn: 579 init1: 185 opt: 698 Z-score: 616.5 bits: 124.3 E(32554): 5.1e-28
Smith-Waterman score: 698; 33.2% identity (59.8% similar) in 383 aa overlap (209-573:346-713)
180 190 200 210 220 230
pF1KE2 TECLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYISQM
.:. :. . :. .: .: .: . :
CCDS43 YMDHQTIFRVPSPLVHIQLQCSSRLSDKPLLAEYGSYNISQPCPVGSF-RCSSGLCVPQA
320 330 340 350 360 370
240 250 260 270 280 290
pF1KE2 KACDGINDCGDQSDELCC----KACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCA
. :::.::: :.:::: : ::. ..:. . : : :.: :: .:.:: .:.
CCDS43 QRCDGVNDCFDESDELFCVSPQPACNTSSFR-QHGPLI-----CDGFRDCENGRDEQNCT
380 390 400 410 420
300 310 320 330 340
pF1KE2 GFASVAQEETEILTADMDAERRRIKSLLPKLSC-------GVK-NRMHIRRKRIVGGKRA
:. .. . .. :.. . ..: : .: .::.:: .
CCDS43 --QSIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGCTCSRSSSALHRIIGGTDT
430 440 450 460 470 480
350 360 370 380 390 400
pF1KE2 QLGDLPWQVAIKDASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVD-WIHPDLK
: ::::... ... ::. :. :.:.::::..... ::. . ... . :
CCDS43 LEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWTAHLGMYVQGNAK
490 500 510 520 530 540
410 420 430 440 450 460
pF1KE2 RIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPND
. : ::. :: ::. :.. ::::.... . .: . : :.: . . ..
CCDS43 --FVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQ--PICIPPTGQRVRSGE
550 560 570 580 590 600
470 480 490 500 510 520
pF1KE2 TCIVSGWGR--EKDNERVFSLQWGEVKLISN--CSKFYGNRFYEKEMECAGTYDGSIDAC
: :.:::: : ::. . :: .::.::.. : . :: . ..: ::: ..:. :::
CCDS43 KCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVSTYG--IITSRMLCAGIMSGKRDAC
610 620 630 640 650 660
530 540 550 560 570 580
pF1KE2 KGDSGGPLVCMDANNVTYVW-GVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQ
:::::::: : .. .. :.::::.. :.:.::::::.:.:. :: .:
CCDS43 KGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVPWIHKYVPSLL
670 680 690 700 710
pF1KE2 YNV
>>CCDS74856.1 TMPRSS6 gene_id:164656|Hs108|chr22 (802 aa)
initn: 395 init1: 272 opt: 660 Z-score: 583.0 bits: 118.3 E(32554): 3.8e-26
Smith-Waterman score: 660; 31.4% identity (59.2% similar) in 373 aa overlap (215-569:443-797)
190 200 210 220 230 240
pF1KE2 HCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKACDGI
:.:. : .:. ::: . ::::.
CCDS74 IPVVATAGITINFTSQISLTGPGVRVHYGLYNQSDPCP-GEFLCSVNGLCVP---ACDGV
420 430 440 450 460
250 260 270 280 290
pF1KE2 NDCGDQSDELCCKACQGKGFHCK-SGVCIPSQYQCNGEVDCITGEDE------VGCAGFA
.:: . :: : .:.. :.:: ...:: :.:. ::..: :: : :. :.
CCDS74 KDCPNGLDERNC-VCRAT-FQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFT
470 480 490 500 510 520
300 310 320 330 340 350
pF1KE2 SVAQEETEILTADMDAERR---RIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLPWQ
.... . . . . : : : . .::... .::::: .. :. :::
CCDS74 FQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDCGLQG----PSSRIVGGAVSSEGEWPWQ
530 540 550 560 570 580
360 370 380 390 400 410
pF1KE2 VAIKDASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVD--WIHPDLKRIVIEYV
.... . ::: :. :..:::::.. .. .::. . : . : :
CCDS74 ASLQVRGRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFKV
590 600 610 620 630 640
420 430 440 450 460
pF1KE2 DRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSI---PACVPWSPYLFQPNDTCIV
.:...: .. ... :.::... : . :: :.:.: ..:.:. : .
CCDS74 SRLLLHPYHEEDSHDYDVALLQL-------DHPVVRSAAVRPVCLPARSHFFEPGLHCWI
650 660 670 680 690
470 480 490 500 510 520
pF1KE2 SGWGREKDNERVFS-LQWGEVKLISN--CSKFYGNRFYEKEMECAGTYDGSIDACKGDSG
.::: ... . . :: .:.:: . ::. : . . : ::: :. :::.::::
CCDS74 TGWGALREGGPISNALQKVDVQLIPQDLCSEVYRYQVTPR-MLCAGYRKGKKDACQGDSG
700 710 720 730 740 750
530 540 550 560 570 580
pF1KE2 GPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV
::::: .. .. :.:::: .::.:.. ::::.... ..::
CCDS74 GPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWIQQVVT
760 770 780 790 800
>>CCDS13941.1 TMPRSS6 gene_id:164656|Hs108|chr22 (811 aa)
initn: 395 init1: 272 opt: 660 Z-score: 582.9 bits: 118.3 E(32554): 3.8e-26
Smith-Waterman score: 660; 31.4% identity (59.2% similar) in 373 aa overlap (215-569:452-806)
190 200 210 220 230 240
pF1KE2 HCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKACDGI
:.:. : .:. ::: . ::::.
CCDS13 IPVVATAGITINFTSQISLTGPGVRVHYGLYNQSDPCP-GEFLCSVNGLCVP---ACDGV
430 440 450 460 470
250 260 270 280 290
pF1KE2 NDCGDQSDELCCKACQGKGFHCK-SGVCIPSQYQCNGEVDCITGEDE------VGCAGFA
.:: . :: : .:.. :.:: ...:: :.:. ::..: :: : :. :.
CCDS13 KDCPNGLDERNC-VCRAT-FQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFT
480 490 500 510 520 530
300 310 320 330 340 350
pF1KE2 SVAQEETEILTADMDAERR---RIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLPWQ
.... . . . . : : : . .::... .::::: .. :. :::
CCDS13 FQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDCGLQG----PSSRIVGGAVSSEGEWPWQ
540 550 560 570 580 590
360 370 380 390 400 410
pF1KE2 VAIKDASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVD--WIHPDLKRIVIEYV
.... . ::: :. :..:::::.. .. .::. . : . : :
CCDS13 ASLQVRGRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFKV
600 610 620 630 640 650
420 430 440 450 460
pF1KE2 DRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSI---PACVPWSPYLFQPNDTCIV
.:...: .. ... :.::... : . :: :.:.: ..:.:. : .
CCDS13 SRLLLHPYHEEDSHDYDVALLQL-------DHPVVRSAAVRPVCLPARSHFFEPGLHCWI
660 670 680 690 700
470 480 490 500 510 520
pF1KE2 SGWGREKDNERVFS-LQWGEVKLISN--CSKFYGNRFYEKEMECAGTYDGSIDACKGDSG
.::: ... . . :: .:.:: . ::. : . . : ::: :. :::.::::
CCDS13 TGWGALREGGPISNALQKVDVQLIPQDLCSEVYRYQVTPR-MLCAGYRKGKKDACQGDSG
710 720 730 740 750 760
530 540 550 560 570 580
pF1KE2 GPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV
::::: .. .. :.:::: .::.:.. ::::.... ..::
CCDS13 GPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWIQQVVT
770 780 790 800 810
>>CCDS3518.1 TMPRSS11D gene_id:9407|Hs108|chr4 (418 aa)
initn: 472 init1: 289 opt: 605 Z-score: 538.8 bits: 109.2 E(32554): 1.1e-23
Smith-Waterman score: 605; 38.6% identity (69.3% similar) in 254 aa overlap (327-574:173-417)
300 310 320 330 340 350
pF1KE2 ASVAQEETEILTADMDAERRRIKSLLPKLSCGV-KNRMHIRRKRIVGGKRAQLGDLPWQV
::. . . . ..::.:: .:. :. ::::
CCDS35 LNNSGNLEINPSTEITSLTDQAAANWLINECGAGPDLITLSEQRILGGTEAEEGSWPWQV
150 160 170 180 190 200
360 370 380 390 400 410
pF1KE2 AIKDASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVIEYVDRI
... .. ::: :.. ::::::::.:.... : : :. .. : :. : :
CCDS35 SLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRM----RVRNI
210 220 230 240 250
420 430 440 450 460 470
pF1KE2 IFHENYNAGTYQNDIALIEMKKDGN-KKDCELPRSIPACVPWSPYLFQPNDTCIVSGWG-
..:.::...:..:::::...... . :: . :. :.: . . :..: :.:::
CCDS35 LIHNNYKSATHENDIALVRLENSVTFTKDIH---SV--CLPAATQNIPPGSTAYVTGWGA
260 270 280 290 300 310
480 490 500 510 520 530
pF1KE2 REKDNERVFSLQWGEVKLISN--CSKFYG-NRFYEKEMECAGTYDGSIDACKGDSGGPLV
.: .. : :. :.:..::: :. .. : . : :::. .:..:::.::::::::
CCDS35 QEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLV
320 330 340 350 360 370
540 550 560 570 580
pF1KE2 CMDANNVTYVWGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV
:. . .. :.::::..:: :. :::::.:. :.::: ..:
CCDS35 QEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI
380 390 400 410
>>CCDS32993.1 HPN gene_id:3249|Hs108|chr19 (417 aa)
initn: 444 init1: 170 opt: 536 Z-score: 479.0 bits: 98.1 E(32554): 2.3e-20
Smith-Waterman score: 536; 34.4% identity (60.3% similar) in 302 aa overlap (292-569:113-400)
270 280 290 300 310
pF1KE2 KGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCAGFASV-------AQEETEILTADMDAE
: .:: : .:. :.... :
CCDS32 ARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCVDEGRLPHTQRLLEVISV-CDCP
90 100 110 120 130 140
320 330 340 350 360 370
pF1KE2 RRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCW
: :. . . . .:: : .. :::::. ..:: ::::... .. ::: ..: :
CCDS32 RGRFLAAICQ-DCG---RRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDW
150 160 170 180 190
380 390 400 410 420
pF1KE2 ILTAAHCL--RASKTHRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHENY------NAGTY
.::::::. : :..... .: : .. .. : ..: .: :.
CCDS32 VLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAV---VYHGGYLPFRDPNSEEN
200 210 220 230 240 250
430 440 450 460 470 480
pF1KE2 QNDIALIEMKKDGNKKDCELPRSI-PACVPWSPYLFQPNDTCIVSGWGREKD-NERVFSL
.:::::..... : . : :.:.: . . . : :.::: . .... :
CCDS32 SNDIALVHLSSP-----LPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVL
260 270 280 290 300
490 500 510 520 530 540
pF1KE2 QWGEVKLISN--CS--KFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYV
: ..: .::: :. ::::.. : : ::: .:.::::.::::::.:: :. . :
CCDS32 QEARVPIISNDVCNGADFYGNQIKPK-MFCAGYPEGGIDACQGDSGGPFVCEDSISRTPR
310 320 330 340 350 360
550 560 570 580
pF1KE2 W---GVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV
: :.:::: .:. . :::::::... .::
CCDS32 WRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL
370 380 390 400 410
>>CCDS34120.1 KLKB1 gene_id:3818|Hs108|chr4 (638 aa)
initn: 459 init1: 149 opt: 537 Z-score: 477.6 bits: 98.5 E(32554): 2.8e-20
Smith-Waterman score: 537; 37.8% identity (64.3% similar) in 238 aa overlap (339-569:390-621)
310 320 330 340 350 360
pF1KE2 ADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIK---DASGITC
::::: .. :. ::::... :. :
CCDS34 IAYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLC
360 370 380 390 400 410
370 380 390 400 410 420
pF1KE2 GGIYIGGCWILTAAHCLRASKTHR-YQIWTTVVDWIHPDLKRIVIEYVDRIIFHENYNAG
:: :: :.::::::. . . ..:.. ... . : . . .::.:.::...
CCDS34 GGSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILN-LSDITKDTPFSQIKEIIIHQNYKVS
420 430 440 450 460 470
430 440 450 460 470 480
pF1KE2 TYQNDIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNERVFS-
..:::::... : . . : :.: . .: :.::: :.. .. .
CCDS34 EGNHDIALIKLQAPLNYTEFQ----KPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNI
480 490 500 510 520 530
490 500 510 520 530 540
pF1KE2 LQWGEVKLISN--CSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVW
:: .. :..: :.: : . ..: ::: .:. ::::::::::::: :.. .
CCDS34 LQKVNIPLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVC-KHNGMWRLV
540 550 560 570 580 590
550 560 570 580
pF1KE2 GVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV
:..::::.:.. : ::::::::.:.:::
CCDS34 GITSWGEGCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
600 610 620 630
>>CCDS33564.1 TMPRSS2 gene_id:7113|Hs108|chr21 (492 aa)
initn: 440 init1: 271 opt: 533 Z-score: 475.5 bits: 97.7 E(32554): 3.6e-20
Smith-Waterman score: 564; 31.6% identity (56.3% similar) in 373 aa overlap (228-569:119-484)
200 210 220 230 240 250
pF1KE2 FTKRRTMGYQDFADVVCYTQKADSPMDDFFQC-VNGKYISQMKACDGINDCGDQSDELCC
.: .: :. . :::.. : :: :
CCDS33 LTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRC
90 100 110 120 130 140
260 270 280 290
pF1KE2 KACQGKGF-------HCKS--GVCIPSQYQCNGEVDC---------ITGEDEVGCAGFAS
: .: . :: :: . . :.. : ... : .: .:
CCDS33 VRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTS
150 160 170 180 190 200
300 310 320 330 340 350
pF1KE2 VAQEETEILTADM-------DAERRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDL
. .: ..:. :: . : ..::: : :..:::::. : :
CCDS33 FMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGV-NLNSSRQSRIVGGESALPGAW
210 220 230 240 250 260
360 370 380 390 400 410
pF1KE2 PWQVAIKDASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVIEY
::::... . .::: : ::.:::::.. .. .. ::. . .. .. :
CCDS33 PWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWH-WTAFAGILRQSFMFYGAGY
270 280 290 300 310 320
420 430 440 450 460 470
pF1KE2 -VDRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVS
:...: : ::.. : .:::::....: . .: : . :.:.: ...::.. : .:
CCDS33 QVEKVISHPNYDSKTKNNDIALMKLQKPLTFND--LVK--PVCLPNPGMMLQPEQLCWIS
330 340 350 360 370 380
480 490 500 510 520
pF1KE2 GWG-REKDNERVFSLQWGEVKLISN--C-SKFYGNRFYEKEMECAGTYDGSIDACKGDSG
::: :. .. :. ..: :: . : :.. . . : ::: .:..:.:.::::
CCDS33 GWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSG
390 400 410 420 430 440
530 540 550 560 570 580
pF1KE2 GPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV
:::: . ::. .. : .::: .:.: :::: .: . :::
CCDS33 GPLVT-SKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG
450 460 470 480 490
583 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 11:23:25 2016 done: Sun Nov 6 11:23:26 2016
Total Scan time: 3.070 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]