Result of FASTA (omim) for
pFN21AE1995
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1995, 575 aa
1>>>pF1KE1995 575 - 575 aa - 575 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.0002+/-0.000349; mu= 4.3612+/- 0.022
mean_var=270.0362+/-56.571, 0's: 0 Z-trim(123.7): 40 B-trim: 808 in 1/57
Lambda= 0.078048
statistics sampled from 43941 (43994) to 43941 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.804), E-opt: 0.2 (0.516), width: 16
Scan time: 11.860
The best scores are: opt bits E(85289)
NP_005466 (OMIM: 133100,187950,254450,605093) SH2B ( 575) 3991 462.6 1.6e-129
XP_005253876 (OMIM: 133100,187950,254450,605093) P ( 576) 3979 461.2 4.1e-129
NP_001278353 (OMIM: 133100,187950,254450,605093) S ( 373) 2298 271.8 2.8e-72
XP_011536023 (OMIM: 133100,187950,254450,605093) P ( 374) 2286 270.4 7.3e-72
XP_005253875 (OMIM: 133100,187950,254450,605093) P ( 615) 2284 270.4 1.2e-71
XP_011536022 (OMIM: 133100,187950,254450,605093) P ( 616) 2272 269.0 3.1e-71
XP_011536021 (OMIM: 133100,187950,254450,605093) P ( 616) 2272 269.0 3.1e-71
XP_006719243 (OMIM: 133100,187950,254450,605093) P ( 309) 2129 252.7 1.3e-66
XP_016867170 (OMIM: 605300) PREDICTED: SH2B adapte ( 631) 585 79.1 4.8e-14
XP_016867169 (OMIM: 605300) PREDICTED: SH2B adapte ( 631) 585 79.1 4.8e-14
XP_005277036 (OMIM: 605300) PREDICTED: SH2B adapte ( 632) 585 79.1 4.8e-14
XP_005277034 (OMIM: 605300) PREDICTED: SH2B adapte ( 632) 585 79.1 4.8e-14
XP_011514042 (OMIM: 605300) PREDICTED: SH2B adapte ( 645) 585 79.1 4.8e-14
XP_005277033 (OMIM: 605300) PREDICTED: SH2B adapte ( 673) 585 79.1 5e-14
XP_005277032 (OMIM: 605300) PREDICTED: SH2B adapte ( 674) 585 79.1 5e-14
NP_066189 (OMIM: 605300) SH2B adapter protein 2 [H ( 675) 585 79.1 5e-14
NP_001139269 (OMIM: 608937) SH2B adapter protein 1 ( 683) 552 75.4 6.6e-13
XP_016878609 (OMIM: 608937) PREDICTED: SH2B adapte ( 391) 542 74.1 9.8e-13
XP_016878608 (OMIM: 608937) PREDICTED: SH2B adapte ( 420) 542 74.1 1e-12
XP_016878607 (OMIM: 608937) PREDICTED: SH2B adapte ( 420) 542 74.1 1e-12
XP_016878606 (OMIM: 608937) PREDICTED: SH2B adapte ( 688) 545 74.6 1.1e-12
XP_016878604 (OMIM: 608937) PREDICTED: SH2B adapte ( 756) 542 74.3 1.6e-12
XP_016878603 (OMIM: 608937) PREDICTED: SH2B adapte ( 756) 542 74.3 1.6e-12
XP_016878605 (OMIM: 608937) PREDICTED: SH2B adapte ( 756) 542 74.3 1.6e-12
NP_001295222 (OMIM: 608937) SH2B adapter protein 1 ( 756) 542 74.3 1.6e-12
NP_001139267 (OMIM: 608937) SH2B adapter protein 1 ( 756) 542 74.3 1.6e-12
NP_001295223 (OMIM: 608937) SH2B adapter protein 1 ( 335) 528 72.4 2.6e-12
NP_001139268 (OMIM: 608937) SH2B adapter protein 1 ( 671) 528 72.7 4.3e-12
NP_001139284 (OMIM: 608937) SH2B adapter protein 1 ( 671) 528 72.7 4.3e-12
NP_056318 (OMIM: 608937) SH2B adapter protein 1 is ( 671) 528 72.7 4.3e-12
>>NP_005466 (OMIM: 133100,187950,254450,605093) SH2B ada (575 aa)
initn: 3991 init1: 3991 opt: 3991 Z-score: 2446.4 bits: 462.6 E(85289): 1.6e-129
Smith-Waterman score: 3991; 99.5% identity (99.8% similar) in 575 aa overlap (1-575:1-575)
10 20 30 40 50 60
pF1KE1 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGSPGEAAETPARPGLAK
::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::
NP_005 SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 KLLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 DPPKSSRPKLQAACSSIQEVRRCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMA
::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::
NP_005 DPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 ELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 CYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 CYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 RGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 LPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQ
490 500 510 520 530 540
550 560 570
pF1KE1 HLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL
:::::::::::::::::::::::::::::::::::
NP_005 HLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL
550 560 570
>>XP_005253876 (OMIM: 133100,187950,254450,605093) PREDI (576 aa)
initn: 3977 init1: 2135 opt: 3979 Z-score: 2439.1 bits: 461.2 E(85289): 4.1e-129
Smith-Waterman score: 3979; 99.3% identity (99.7% similar) in 576 aa overlap (1-575:1-576)
10 20 30 40 50 60
pF1KE1 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGSPGEAAETPARPGLAK
::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::
XP_005 SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 KLLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 DPPKSSRPKLQAACSSIQEVRRCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMA
::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::
XP_005 DPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMA
250 260 270 280 290 300
310 320 330 340 350
pF1KE1 ELSECTGRG-LESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFL
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELSECTGRGRLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFL
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE1 SCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLT
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE1 ERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPF
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE1 SLPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSL
490 500 510 520 530 540
540 550 560 570
pF1KE1 QHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL
::::::::::::::::::::::::::::::::::::
XP_005 QHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL
550 560 570
>>NP_001278353 (OMIM: 133100,187950,254450,605093) SH2B (373 aa)
initn: 2288 init1: 2288 opt: 2298 Z-score: 1418.5 bits: 271.8 E(85289): 2.8e-72
Smith-Waterman score: 2298; 93.1% identity (94.5% similar) in 364 aa overlap (217-575:10-373)
190 200 210 220 230 240
pF1KE1 LAREPPPEALKEAVLRYSLADEASMDSGARWQR---GRLALRRAPGPDGP--DRVLELFD
:.: : . :: :. : . .:
NP_001 MGFPVLCRGWRRTWPGCASWLGAPPPQKPLLSPLLLNHR
10 20 30
250 260 270 280 290 300
pF1KE1 PPKSSRPKLQAACSSIQEVRRCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAE
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::
NP_001 SSKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAE
40 50 60 70 80 90
310 320 330 340 350 360
pF1KE1 LSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSC
100 110 120 130 140 150
370 380 390 400 410 420
pF1KE1 YPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTER
160 170 180 190 200 210
430 440 450 460 470 480
pF1KE1 GQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSL
220 230 240 250 260 270
490 500 510 520 530 540
pF1KE1 PHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQH
280 290 300 310 320 330
550 560 570
pF1KE1 LEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL
::::::::::::::::::::::::::::::::::
NP_001 LEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL
340 350 360 370
>>XP_011536023 (OMIM: 133100,187950,254450,605093) PREDI (374 aa)
initn: 2274 init1: 1856 opt: 2286 Z-score: 1411.2 bits: 270.4 E(85289): 7.3e-72
Smith-Waterman score: 2286; 92.9% identity (94.2% similar) in 365 aa overlap (217-575:10-374)
190 200 210 220 230 240
pF1KE1 LAREPPPEALKEAVLRYSLADEASMDSGARWQR---GRLALRRAPGPDGP--DRVLELFD
:.: : . :: :. : . .:
XP_011 MGFPVLCRGWRRTWPGCASWLGAPPPQKPLLSPLLLNHR
10 20 30
250 260 270 280 290 300
pF1KE1 PPKSSRPKLQAACSSIQEVRRCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAE
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::
XP_011 SSKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAE
40 50 60 70 80 90
310 320 330 340 350 360
pF1KE1 LSECTGRG-LESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLS
:::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSECTGRGRLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLS
100 110 120 130 140 150
370 380 390 400 410 420
pF1KE1 CYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTE
160 170 180 190 200 210
430 440 450 460 470 480
pF1KE1 RGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFS
220 230 240 250 260 270
490 500 510 520 530 540
pF1KE1 LPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQ
280 290 300 310 320 330
550 560 570
pF1KE1 HLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL
:::::::::::::::::::::::::::::::::::
XP_011 HLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL
340 350 360 370
>>XP_005253875 (OMIM: 133100,187950,254450,605093) PREDI (615 aa)
initn: 2284 init1: 2284 opt: 2284 Z-score: 1407.2 bits: 270.4 E(85289): 1.2e-71
Smith-Waterman score: 3842; 92.9% identity (93.2% similar) in 607 aa overlap (9-575:9-615)
10 20 30 40 50 60
pF1KE1 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGSPGEAAETPARPGLAK
::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::
XP_005 SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 KLLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF
190 200 210 220 230 240
250 260
pF1KE1 DPPK----------------------------------------SSRPKLQAACSSIQEV
:::: ::::::::::::::::
XP_005 DPPKWPEPELSRLRFRLKQGLSCAHVPTRCNLAGASGIGHPYHQSSRPKLQAACSSIQEV
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE1 RRCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAELSECTGRGLESTEAEMHIP
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAELSECTGRGLESTEAEMHIP
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE1 SALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQL
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE1 QGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLHH
430 440 450 460 470 480
450 460 470 480 490 500
pF1KE1 FQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSELGLPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSELGLPH
490 500 510 520 530 540
510 520 530 540 550 560
pF1KE1 LSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDSS
550 560 570 580 590 600
570
pF1KE1 SRSHLRAIDNQYTPL
:::::::::::::::
XP_005 SRSHLRAIDNQYTPL
610
>>XP_011536022 (OMIM: 133100,187950,254450,605093) PREDI (616 aa)
initn: 3565 init1: 1856 opt: 2272 Z-score: 1399.9 bits: 269.0 E(85289): 3.1e-71
Smith-Waterman score: 3825; 92.8% identity (93.1% similar) in 607 aa overlap (10-575:10-616)
10 20 30 40 50 60
pF1KE1 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGSPGEAAETPARPGLAK
::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::
XP_011 SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 KLLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF
190 200 210 220 230 240
250 260
pF1KE1 DPPK----------------------------------------SSRPKLQAACSSIQEV
:::: ::::::::::::::::
XP_011 DPPKWPEPELSRLRFRLKQGLSCAHVPTRCNLAGASGIGHPYHQSSRPKLQAACSSIQEV
250 260 270 280 290 300
270 280 290 300 310
pF1KE1 RRCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAELSECTGRG-LESTEAEMHI
: ::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::
XP_011 RWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAELSECTGRGRLESTEAEMHI
310 320 330 340 350 360
320 330 340 350 360 370
pF1KE1 PSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQ
370 380 390 400 410 420
380 390 400 410 420 430
pF1KE1 LQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLH
430 440 450 460 470 480
440 450 460 470 480 490
pF1KE1 HFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSELGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSELGLP
490 500 510 520 530 540
500 510 520 530 540 550
pF1KE1 HLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDS
550 560 570 580 590 600
560 570
pF1KE1 SSRSHLRAIDNQYTPL
::::::::::::::::
XP_011 SSRSHLRAIDNQYTPL
610
>>XP_011536021 (OMIM: 133100,187950,254450,605093) PREDI (616 aa)
initn: 3565 init1: 1856 opt: 2272 Z-score: 1399.9 bits: 269.0 E(85289): 3.1e-71
Smith-Waterman score: 3825; 92.8% identity (93.1% similar) in 607 aa overlap (10-575:10-616)
10 20 30 40 50 60
pF1KE1 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGSPGEAAETPARPGLAK
::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::
XP_011 SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 KLLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF
190 200 210 220 230 240
250 260
pF1KE1 DPPK----------------------------------------SSRPKLQAACSSIQEV
:::: ::::::::::::::::
XP_011 DPPKWPEPELSRLRFRLKQGLSCAHVPTRCNLAGASGIGHPYHQSSRPKLQAACSSIQEV
250 260 270 280 290 300
270 280 290 300 310
pF1KE1 RRCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAELSECTGRG-LESTEAEMHI
: ::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::
XP_011 RWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAELSECTGRGRLESTEAEMHI
310 320 330 340 350 360
320 330 340 350 360 370
pF1KE1 PSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQ
370 380 390 400 410 420
380 390 400 410 420 430
pF1KE1 LQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLH
430 440 450 460 470 480
440 450 460 470 480 490
pF1KE1 HFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSELGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSELGLP
490 500 510 520 530 540
500 510 520 530 540 550
pF1KE1 HLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDS
550 560 570 580 590 600
560 570
pF1KE1 SSRSHLRAIDNQYTPL
::::::::::::::::
XP_011 SSRSHLRAIDNQYTPL
610
>>XP_006719243 (OMIM: 133100,187950,254450,605093) PREDI (309 aa)
initn: 2127 init1: 1856 opt: 2129 Z-score: 1316.7 bits: 252.7 E(85289): 1.3e-66
Smith-Waterman score: 2129; 99.7% identity (99.7% similar) in 309 aa overlap (268-575:1-309)
240 250 260 270 280 290
pF1KE1 ELFDPPKSSRPKLQAACSSIQEVRRCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNS
::::::::::::::::::::::::::::::
XP_006 MPDNLYTFVLKVKDRTDIIFEVGDEQQLNS
10 20 30
300 310 320 330 340 350
pF1KE1 WMAELSECTGRG-LESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTD
:::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WMAELSECTGRGRLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTD
40 50 60 70 80 90
360 370 380 390 400 410
pF1KE1 HFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRL
100 110 120 130 140 150
420 430 440 450 460 470
pF1KE1 SLTERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SLTERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVL
160 170 180 190 200 210
480 490 500 510 520 530
pF1KE1 FPFSLPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FPFSLPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELA
220 230 240 250 260 270
540 550 560 570
pF1KE1 NSLQHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL
:::::::::::::::::::::::::::::::::::::::
XP_006 NSLQHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL
280 290 300
>>XP_016867170 (OMIM: 605300) PREDICTED: SH2B adapter pr (631 aa)
initn: 824 init1: 504 opt: 585 Z-score: 373.2 bits: 79.1 E(85289): 4.8e-14
Smith-Waterman score: 894; 35.8% identity (54.5% similar) in 628 aa overlap (26-573:23-629)
10 20 30 40 50
pF1KE1 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQH-APLR
: .:::::: ::: ..:... : :..: . .:
XP_016 MNGAGPGPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDA
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 AELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEA-SPEPGPGPAAPGLP--
. : .:. : : .::: . : : :: ..::: :: . : . :
XP_016 GASFSRHFAANFLDVFGEEVRRVLVAG----PTTRGAAVSAEAMEPELADTSALKAAPYG
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 KARSSEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGSPGEAAETPARP
..::::... . : :::.. : : :.: . :: :.:
XP_016 HSRSSEDVSTHAATKARVRKGF--SLRNMSLCVVDGVRDMWHRRASPEPDAAAAPRTAEP
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 --GLAKKL-LPWSLAREPP-PEALKEAVLRYSLADEASMDSG--ARWQRGRLALRRAPGP
...: : .:: . . .:..::. .::.:. :: :.::. :: :::: .
XP_016 RDKWTRRLRLSRTLAAKVELVDIQREGALRFMVADDAAAGSGGSAQWQKCRLLLRRAVAE
180 190 200 210 220 230
240 250 260 270 280
pF1KE1 DGPDRV-LELFDPPKSSRPKLQAACSSIQEVRRCTRLEMPDNLYTFVLKVKDRTDIIFEV
. : ::.: :::.::::.. :.: ::: ::::.. ::::::.. .. :.:.
XP_016 E---RFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILET
240 250 260 270 280
290 300
pF1KE1 GDEQQLNSWMAELSECT-------------------------------------------
: : .::.:... :.
XP_016 IDSLQKHSWVADIQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDVDLPRPPETT
290 300 310 320 330 340
310 320 330 340 350
pF1KE1 ----------GRGLEST-EAEMHIPSALEPSTSSSPRGS-TDSLNQGASPGGLLDPACQK
.:: ... :. .:.: .: :: :: .:: : : . :. :: .
XP_016 AVGAVVTAPHSRGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQ-GAETDPEAEP
350 360 370 380 390 400
360 370 380 390 400 410
pF1KE1 TDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHL
. :: :::::: .::::::::: :: ::.:..:::::: ::::::::::: ::::
XP_016 -ELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHL
410 420 430 440 450 460
420 430 440 450 460 470
pF1KE1 RLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNT
::::. .:::.:::: : ::.:::.::. ::::: :.. :. : ::: . . :: :
XP_016 RLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQDPPPEPGPT
470 480 490 500 510 520
480 490 500 510 520
pF1KE1 V-LFPFSLPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSS-------------
: : :.. :. : : ....:: . :: : ::
XP_016 PPAAPASPACWSDSPGQHYFSSL-----AAAACPPA-SPSDAAGASSSSASSSSAASGPA
530 540 550 560 570 580
530 540 550 560 570
pF1KE1 PPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL
::. . . : . .:: ..: : : : . : .. .. ::..:::.
XP_016 PPRPVEGQL-SARSRSNSAERLL-EAV--AATAAEEPPEAAPGRARAVENQYSFY
590 600 610 620 630
>>XP_016867169 (OMIM: 605300) PREDICTED: SH2B adapter pr (631 aa)
initn: 824 init1: 504 opt: 585 Z-score: 373.2 bits: 79.1 E(85289): 4.8e-14
Smith-Waterman score: 894; 35.8% identity (54.5% similar) in 628 aa overlap (26-573:23-629)
10 20 30 40 50
pF1KE1 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQH-APLR
: .:::::: ::: ..:... : :..: . .:
XP_016 MNGAGPGPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDA
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 AELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEA-SPEPGPGPAAPGLP--
. : .:. : : .::: . : : :: ..::: :: . : . :
XP_016 GASFSRHFAANFLDVFGEEVRRVLVAG----PTTRGAAVSAEAMEPELADTSALKAAPYG
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 KARSSEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGSPGEAAETPARP
..::::... . : :::.. : : :.: . :: :.:
XP_016 HSRSSEDVSTHAATKARVRKGF--SLRNMSLCVVDGVRDMWHRRASPEPDAAAAPRTAEP
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 --GLAKKL-LPWSLAREPP-PEALKEAVLRYSLADEASMDSG--ARWQRGRLALRRAPGP
...: : .:: . . .:..::. .::.:. :: :.::. :: :::: .
XP_016 RDKWTRRLRLSRTLAAKVELVDIQREGALRFMVADDAAAGSGGSAQWQKCRLLLRRAVAE
180 190 200 210 220 230
240 250 260 270 280
pF1KE1 DGPDRV-LELFDPPKSSRPKLQAACSSIQEVRRCTRLEMPDNLYTFVLKVKDRTDIIFEV
. : ::.: :::.::::.. :.: ::: ::::.. ::::::.. .. :.:.
XP_016 E---RFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILET
240 250 260 270 280
290 300
pF1KE1 GDEQQLNSWMAELSECT-------------------------------------------
: : .::.:... :.
XP_016 IDSLQKHSWVADIQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDVDLPRPPETT
290 300 310 320 330 340
310 320 330 340 350
pF1KE1 ----------GRGLEST-EAEMHIPSALEPSTSSSPRGS-TDSLNQGASPGGLLDPACQK
.:: ... :. .:.: .: :: :: .:: : : . :. :: .
XP_016 AVGAVVTAPHSRGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQ-GAETDPEAEP
350 360 370 380 390 400
360 370 380 390 400 410
pF1KE1 TDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHL
. :: :::::: .::::::::: :: ::.:..:::::: ::::::::::: ::::
XP_016 -ELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHL
410 420 430 440 450 460
420 430 440 450 460 470
pF1KE1 RLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNT
::::. .:::.:::: : ::.:::.::. ::::: :.. :. : ::: . . :: :
XP_016 RLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQDPPPEPGPT
470 480 490 500 510 520
480 490 500 510 520
pF1KE1 V-LFPFSLPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSS-------------
: : :.. :. : : ....:: . :: : ::
XP_016 PPAAPASPACWSDSPGQHYFSSL-----AAAACPPA-SPSDAAGASSSSASSSSAASGPA
530 540 550 560 570 580
530 540 550 560 570
pF1KE1 PPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL
::. . . : . .:: ..: : : : . : .. .. ::..:::.
XP_016 PPRPVEGQL-SARSRSNSAERLL-EAV--AATAAEEPPEAAPGRARAVENQYSFY
590 600 610 620 630
575 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 16:00:18 2016 done: Mon Nov 7 16:00:20 2016
Total Scan time: 11.860 Total Display time: 0.120
Function used was FASTA [36.3.4 Apr, 2011]