Result of FASTA (omim) for
pFN21AE1951
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1951, 508 aa
1>>>pF1KE1951 508 - 508 aa - 508 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.3881+/-0.000384; mu= 0.7343+/- 0.024
mean_var=249.1519+/-51.685, 0's: 0 Z-trim(121.0): 183 B-trim: 1558 in 1/58
Lambda= 0.081254
statistics sampled from 36750 (36937) to 36750 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.761), E-opt: 0.2 (0.433), width: 16
Scan time: 9.920
The best scores are: opt bits E(85289)
NP_114143 (OMIM: 610020) TBC1 domain family member ( 508) 3493 422.5 1.4e-117
NP_001191169 (OMIM: 610020) TBC1 domain family mem ( 515) 3469 419.7 9.9e-117
NP_056342 (OMIM: 613620) TBC1 domain family member ( 808) 1952 242.1 4.8e-63
NP_940919 (OMIM: 610831) carabin isoform 1 [Homo s ( 446) 1384 175.3 3.4e-43
XP_006718601 (OMIM: 610831) PREDICTED: carabin iso ( 446) 1384 175.3 3.4e-43
XP_006718603 (OMIM: 610831) PREDICTED: carabin iso ( 446) 1384 175.3 3.4e-43
XP_006718602 (OMIM: 610831) PREDICTED: carabin iso ( 446) 1384 175.3 3.4e-43
XP_011544091 (OMIM: 613620) PREDICTED: TBC1 domain ( 703) 1228 157.1 1.5e-37
XP_011543304 (OMIM: 610831) PREDICTED: carabin iso ( 313) 1135 146.0 1.6e-34
XP_011544092 (OMIM: 613620) PREDICTED: TBC1 domain ( 536) 1115 143.8 1.2e-33
XP_006718605 (OMIM: 610831) PREDICTED: carabin iso ( 345) 859 113.6 9.3e-25
XP_006718604 (OMIM: 610831) PREDICTED: carabin iso ( 345) 859 113.6 9.3e-25
XP_006718606 (OMIM: 610831) PREDICTED: carabin iso ( 345) 859 113.6 9.3e-25
XP_006718607 (OMIM: 610831) PREDICTED: carabin iso ( 345) 859 113.6 9.3e-25
XP_011543303 (OMIM: 610831) PREDICTED: carabin iso ( 345) 859 113.6 9.3e-25
XP_016858483 (OMIM: 609238) PREDICTED: rab GTPase- ( 778) 542 76.8 2.6e-13
NP_055672 (OMIM: 609238) rab GTPase-activating pro ( 815) 542 76.8 2.7e-13
XP_006711756 (OMIM: 609238) PREDICTED: rab GTPase- ( 985) 542 76.8 3.2e-13
XP_005245738 (OMIM: 609238) PREDICTED: rab GTPase- (1014) 542 76.8 3.2e-13
XP_011508525 (OMIM: 609238) PREDICTED: rab GTPase- (1051) 542 76.9 3.3e-13
XP_005245737 (OMIM: 609238) PREDICTED: rab GTPase- (1051) 542 76.9 3.3e-13
NP_001243437 (OMIM: 610831) carabin isoform 2 [Hom ( 310) 529 74.9 3.8e-13
NP_055503 (OMIM: 605405) USP6 N-terminal-like prot ( 828) 504 72.3 6.1e-12
NP_001073960 (OMIM: 605405) USP6 N-terminal-like p ( 845) 504 72.3 6.2e-12
XP_016872460 (OMIM: 605405) PREDICTED: USP6 N-term ( 846) 504 72.3 6.2e-12
XP_016872462 (OMIM: 605405) PREDICTED: USP6 N-term ( 851) 504 72.3 6.2e-12
XP_006717605 (OMIM: 605405) PREDICTED: USP6 N-term ( 856) 504 72.3 6.2e-12
XP_011518064 (OMIM: 605405) PREDICTED: USP6 N-term ( 856) 504 72.3 6.2e-12
XP_016870059 (OMIM: 615882) PREDICTED: rab GTPase- ( 900) 493 71.1 1.6e-11
XP_011516744 (OMIM: 615882) PREDICTED: rab GTPase- ( 900) 493 71.1 1.6e-11
XP_011516743 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 493 71.1 1.8e-11
XP_016870056 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 493 71.1 1.8e-11
XP_016870057 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 493 71.1 1.8e-11
NP_036329 (OMIM: 615882) rab GTPase-activating pro (1069) 493 71.1 1.8e-11
XP_016870058 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 493 71.1 1.8e-11
XP_011516742 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 493 71.1 1.8e-11
NP_001254501 (OMIM: 609871) TBC1 domain family mem ( 468) 461 67.1 1.3e-10
XP_011517145 (OMIM: 609871) PREDICTED: TBC1 domain ( 468) 461 67.1 1.3e-10
XP_016870388 (OMIM: 609871) PREDICTED: TBC1 domain ( 483) 461 67.1 1.3e-10
NP_001254500 (OMIM: 609871) TBC1 domain family mem ( 928) 461 67.3 2.2e-10
XP_016857774 (OMIM: 602942) PREDICTED: ecotropic v ( 741) 456 66.7 2.8e-10
XP_016857773 (OMIM: 602942) PREDICTED: ecotropic v ( 777) 456 66.7 2.9e-10
XP_016857772 (OMIM: 602942) PREDICTED: ecotropic v ( 785) 456 66.7 2.9e-10
NP_005656 (OMIM: 602942) ecotropic viral integrati ( 810) 456 66.7 3e-10
XP_016857770 (OMIM: 602942) PREDICTED: ecotropic v ( 818) 456 66.7 3e-10
NP_001295177 (OMIM: 602942) ecotropic viral integr ( 821) 456 66.7 3e-10
XP_016857769 (OMIM: 602942) PREDICTED: ecotropic v ( 826) 456 66.7 3e-10
XP_016857766 (OMIM: 602942) PREDICTED: ecotropic v ( 854) 456 66.7 3.1e-10
XP_016857765 (OMIM: 602942) PREDICTED: ecotropic v ( 859) 456 66.7 3.1e-10
XP_016857760 (OMIM: 602942) PREDICTED: ecotropic v ( 903) 456 66.7 3.2e-10
>>NP_114143 (OMIM: 610020) TBC1 domain family member 10A (508 aa)
initn: 3493 init1: 3493 opt: 3493 Z-score: 2231.9 bits: 422.5 E(85289): 1.4e-117
Smith-Waterman score: 3493; 100.0% identity (100.0% similar) in 508 aa overlap (1-508:1-508)
10 20 30 40 50 60
pF1KE1 MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 IVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 IVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 WQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 WQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 RVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 RVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 DGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 DGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 KIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTERQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 KIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTERQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 IEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEPGPRPALQPSPSIRLPLDAPLPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 IEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEPGPRPALQPSPSIRLPLDAPLPG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 SKAKPKPPKQAQKEQRKQMKGRGQLEKPPAPNQAMVVAAAGDACPPQHVPPKDSAPKDSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 SKAKPKPPKQAQKEQRKQMKGRGQLEKPPAPNQAMVVAAAGDACPPQHVPPKDSAPKDSA
430 440 450 460 470 480
490 500
pF1KE1 PQDLAPQVSAHHRSQESLTSQESEDTYL
::::::::::::::::::::::::::::
NP_114 PQDLAPQVSAHHRSQESLTSQESEDTYL
490 500
>>NP_001191169 (OMIM: 610020) TBC1 domain family member (515 aa)
initn: 3479 init1: 3045 opt: 3469 Z-score: 2216.6 bits: 419.7 E(85289): 9.9e-117
Smith-Waterman score: 3469; 98.6% identity (98.6% similar) in 515 aa overlap (1-508:1-515)
10 20 30 40 50 60
pF1KE1 MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGF
10 20 30 40 50 60
70 80 90 100 110
pF1KE1 IVGSQGAEGA-------LEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIP
:::::::::: :::::::::::::::::::::::::::::::::::::::::::
NP_001 IVGSQGAEGAPCPLLHRLEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIP
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 PSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGG
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE1 HGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSE
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE1 KLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWD
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE1 MFFCEGVKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MFFCEGVKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVE
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE1 LPVTERQIEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEPGPRPALQPSPSIRLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPVTERQIEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEPGPRPALQPSPSIRLP
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE1 LDAPLPGSKAKPKPPKQAQKEQRKQMKGRGQLEKPPAPNQAMVVAAAGDACPPQHVPPKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDAPLPGSKAKPKPPKQAQKEQRKQMKGRGQLEKPPAPNQAMVVAAAGDACPPQHVPPKD
430 440 450 460 470 480
480 490 500
pF1KE1 SAPKDSAPQDLAPQVSAHHRSQESLTSQESEDTYL
:::::::::::::::::::::::::::::::::::
NP_001 SAPKDSAPQDLAPQVSAHHRSQESLTSQESEDTYL
490 500 510
>>NP_056342 (OMIM: 613620) TBC1 domain family member 10B (808 aa)
initn: 1965 init1: 1922 opt: 1952 Z-score: 1252.9 bits: 242.1 E(85289): 4.8e-63
Smith-Waterman score: 1969; 59.0% identity (79.0% similar) in 505 aa overlap (6-504:255-741)
10 20 30
pF1KE1 MAKSNGENGPRAPAAGESLSGTRE-SLAQGPDAAT
: .:::. : ..:: :: .: .
NP_056 EAPVAVVTVTPAPEPAENSQDLGSTSSLGPGISGPRGQAP-DTLSYLDSVSLMSGTLESL
230 240 250 260 270 280
40 50 60 70 80 90
pF1KE1 TDELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGALEE-VPLEVLRQRESKWLDMLNNW
.:..::.::::: ::.: :. ::.::. ::: . :.:: .:..: :::: :::::..::
NP_056 ADDVSSMGSDSEINGLALRKTDKYGFLGGSQYS-GSLESSIPVDVARQRELKWLDMFSNW
290 300 310 320 330 340
100 110 120 130 140 150
pF1KE1 DKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDV
:::.... .:..:::.:::: :::..::::::..: :.::::::.::. .:::::::::
NP_056 DKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWLDV
350 360 370 380 390 400
160 170 180 190 200 210
pF1KE1 IERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAE
::.::::::::::::..:::::::::.:.:::::.:::.:::::::::.:::::::::::
NP_056 IEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAE
410 420 430 440 450 460
220 230 240 250 260 270
pF1KE1 QAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTE
::::::::::.:::::::: ::::::::::.:.::...::.::.:: ::.:::.:::::
NP_056 QAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTE
470 480 490 500 510 520
280 290 300 310 320 330
pF1KE1 WFMCAFSRTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLKHALGSPEKVKACQGQYETIER
:::: :.:::::.::::::::::::::::::::.::::.:.::: ::...:::.:::.:.
NP_056 WFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQ
530 540 550 560 570 580
340 350 360 370 380 390
pF1KE1 LRSLSPKIMQEAFLVQEVVELPVTERQIEREHLIQLRRWQETRGELQCRSPPRLHGAKAI
::.: . ::: :::.::..::::: ::::. ::..:.::::::: : ::::..::
NP_056 LRNLPQQCMQEDFLVHEVTNLPVTEALIERENAAQLKKWRETRGELQYRPSRRLHGSRAI
590 600 610 620 630 640
400 410 420 430 440
pF1KE1 LDAEPGPRPALQPSPSI-RLPLDAPLPGSKAK---PKPPKQAQKEQRKQMKGRGQLEKPP
. . .: : :: :. :: ::.: :.:: . :. : :
NP_056 HEERRRQQPPLGPSSSLLSLP-GLKSRGSRAAGGAPSPPPPV----RRASAG-------P
650 660 670 680 690
450 460 470 480 490 500
pF1KE1 APNQAMVVAAAGDACPPQHVPPKDSAPKDSAPQDLAPQVSAHHRSQESLTSQESEDTYL
::. ::.: : : : .:.: :. .. : . ...... .::.:
NP_056 APGP--VVTAEG-LHPSLPSPTGNSTPLGSS-KETRKQEKERQKQEKERQKQEKEREKER
700 710 720 730 740
NP_056 QKQEKEREKQEKEREKQEKERQKQEKKAQGRKLSLRRKADGPPGPHDGGDRPSAEARQDA
750 760 770 780 790 800
>>NP_940919 (OMIM: 610831) carabin isoform 1 [Homo sapie (446 aa)
initn: 1320 init1: 1291 opt: 1384 Z-score: 896.6 bits: 175.3 E(85289): 3.4e-43
Smith-Waterman score: 1384; 46.6% identity (74.1% similar) in 440 aa overlap (24-453:7-436)
10 20 30 40 50
pF1KE1 MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAE-RRIDKFG
:.:.: :. :. :::::::: .: . :. :..:
NP_940 MAQALGEDLVQPPE--LQDDSSSLGSDSELSGPGPYRQADRYG
10 20 30 40
60 70 80 90 100 110
pF1KE1 FIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGR
:: ::.. : . : ...:::: ::..: ..:.: :....::....:.:::: .::.:
NP_940 FIGGSSAEPGPGHP-PADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRAR
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE1 AWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDL
: : :..: ...:: ..:: .::::.:...: ::::::::.:::::: ::::: :
NP_940 CWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGL
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE1 FRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQ
..:::::::::::.::::::.:.:::::::.: :.:::::::::: ::::::. ..::..
NP_940 LQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVR
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE1 LDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEG
::.:....::... : .::::.. . ::::. :::.: :.:.::. .:::::: :. ::
NP_940 LDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEG
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE1 VKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTER
....:::::.:.. :::. :. :: : ::. ::.. : .:: ....: . ..::
NP_940 ARVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQLQEEAFMSQVHSVVLSER
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE1 QIEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEP--GPRPALQPS-PSIRLPLDA
...:: :: . .. : :: ::.::..:. : : . .: : :. ..
NP_940 DLQREIKAQLAQLPDSAPGPPPRPQVRLAGAQAIFEAQQLAGVRRGAKPEVP--RIVVQP
350 360 370 380 390
420 430 440 450 460 470
pF1KE1 PLPGSKAKPKPPKQAQKEQRKQMKG-----RGQ-LEKPPAPNQAMVVAAAGDACPPQHVP
: .:.::.. . . : ..: :: .: :: :..
NP_940 P-----EEPRPPRRKPQTRGKTFHGLLTRARGPPIEGPPRPQRGSTSFLDTRF
400 410 420 430 440
480 490 500
pF1KE1 PKDSAPKDSAPQDLAPQVSAHHRSQESLTSQESEDTYL
>>XP_006718601 (OMIM: 610831) PREDICTED: carabin isoform (446 aa)
initn: 1320 init1: 1291 opt: 1384 Z-score: 896.6 bits: 175.3 E(85289): 3.4e-43
Smith-Waterman score: 1384; 46.6% identity (74.1% similar) in 440 aa overlap (24-453:7-436)
10 20 30 40 50
pF1KE1 MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAE-RRIDKFG
:.:.: :. :. :::::::: .: . :. :..:
XP_006 MAQALGEDLVQPPE--LQDDSSSLGSDSELSGPGPYRQADRYG
10 20 30 40
60 70 80 90 100 110
pF1KE1 FIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGR
:: ::.. : . : ...:::: ::..: ..:.: :....::....:.:::: .::.:
XP_006 FIGGSSAEPGPGHP-PADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRAR
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE1 AWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDL
: : :..: ...:: ..:: .::::.:...: ::::::::.:::::: ::::: :
XP_006 CWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGL
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE1 FRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQ
..:::::::::::.::::::.:.:::::::.: :.:::::::::: ::::::. ..::..
XP_006 LQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVR
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE1 LDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEG
::.:....::... : .::::.. . ::::. :::.: :.:.::. .:::::: :. ::
XP_006 LDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEG
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE1 VKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTER
....:::::.:.. :::. :. :: : ::. ::.. : .:: ....: . ..::
XP_006 ARVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQLQEEAFMSQVHSVVLSER
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE1 QIEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEP--GPRPALQPS-PSIRLPLDA
...:: :: . .. : :: ::.::..:. : : . .: : :. ..
XP_006 DLQREIKAQLAQLPDSAPGPPPRPQVRLAGAQAIFEAQQLAGVRRGAKPEVP--RIVVQP
350 360 370 380 390
420 430 440 450 460 470
pF1KE1 PLPGSKAKPKPPKQAQKEQRKQMKG-----RGQ-LEKPPAPNQAMVVAAAGDACPPQHVP
: .:.::.. . . : ..: :: .: :: :..
XP_006 P-----EEPRPPRRKPQTRGKTFHGLLTRARGPPIEGPPRPQRGSTSFLDTRF
400 410 420 430 440
480 490 500
pF1KE1 PKDSAPKDSAPQDLAPQVSAHHRSQESLTSQESEDTYL
>>XP_006718603 (OMIM: 610831) PREDICTED: carabin isoform (446 aa)
initn: 1320 init1: 1291 opt: 1384 Z-score: 896.6 bits: 175.3 E(85289): 3.4e-43
Smith-Waterman score: 1384; 46.6% identity (74.1% similar) in 440 aa overlap (24-453:7-436)
10 20 30 40 50
pF1KE1 MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAE-RRIDKFG
:.:.: :. :. :::::::: .: . :. :..:
XP_006 MAQALGEDLVQPPE--LQDDSSSLGSDSELSGPGPYRQADRYG
10 20 30 40
60 70 80 90 100 110
pF1KE1 FIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGR
:: ::.. : . : ...:::: ::..: ..:.: :....::....:.:::: .::.:
XP_006 FIGGSSAEPGPGHP-PADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRAR
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE1 AWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDL
: : :..: ...:: ..:: .::::.:...: ::::::::.:::::: ::::: :
XP_006 CWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGL
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE1 FRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQ
..:::::::::::.::::::.:.:::::::.: :.:::::::::: ::::::. ..::..
XP_006 LQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVR
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE1 LDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEG
::.:....::... : .::::.. . ::::. :::.: :.:.::. .:::::: :. ::
XP_006 LDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEG
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE1 VKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTER
....:::::.:.. :::. :. :: : ::. ::.. : .:: ....: . ..::
XP_006 ARVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQLQEEAFMSQVHSVVLSER
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE1 QIEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEP--GPRPALQPS-PSIRLPLDA
...:: :: . .. : :: ::.::..:. : : . .: : :. ..
XP_006 DLQREIKAQLAQLPDSAPGPPPRPQVRLAGAQAIFEAQQLAGVRRGAKPEVP--RIVVQP
350 360 370 380 390
420 430 440 450 460 470
pF1KE1 PLPGSKAKPKPPKQAQKEQRKQMKG-----RGQ-LEKPPAPNQAMVVAAAGDACPPQHVP
: .:.::.. . . : ..: :: .: :: :..
XP_006 P-----EEPRPPRRKPQTRGKTFHGLLTRARGPPIEGPPRPQRGSTSFLDTRF
400 410 420 430 440
480 490 500
pF1KE1 PKDSAPKDSAPQDLAPQVSAHHRSQESLTSQESEDTYL
>>XP_006718602 (OMIM: 610831) PREDICTED: carabin isoform (446 aa)
initn: 1320 init1: 1291 opt: 1384 Z-score: 896.6 bits: 175.3 E(85289): 3.4e-43
Smith-Waterman score: 1384; 46.6% identity (74.1% similar) in 440 aa overlap (24-453:7-436)
10 20 30 40 50
pF1KE1 MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAE-RRIDKFG
:.:.: :. :. :::::::: .: . :. :..:
XP_006 MAQALGEDLVQPPE--LQDDSSSLGSDSELSGPGPYRQADRYG
10 20 30 40
60 70 80 90 100 110
pF1KE1 FIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGR
:: ::.. : . : ...:::: ::..: ..:.: :....::....:.:::: .::.:
XP_006 FIGGSSAEPGPGHP-PADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRAR
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE1 AWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDL
: : :..: ...:: ..:: .::::.:...: ::::::::.:::::: ::::: :
XP_006 CWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGL
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE1 FRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQ
..:::::::::::.::::::.:.:::::::.: :.:::::::::: ::::::. ..::..
XP_006 LQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVR
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE1 LDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEG
::.:....::... : .::::.. . ::::. :::.: :.:.::. .:::::: :. ::
XP_006 LDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEG
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE1 VKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTER
....:::::.:.. :::. :. :: : ::. ::.. : .:: ....: . ..::
XP_006 ARVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQLQEEAFMSQVHSVVLSER
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE1 QIEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEP--GPRPALQPS-PSIRLPLDA
...:: :: . .. : :: ::.::..:. : : . .: : :. ..
XP_006 DLQREIKAQLAQLPDSAPGPPPRPQVRLAGAQAIFEAQQLAGVRRGAKPEVP--RIVVQP
350 360 370 380 390
420 430 440 450 460 470
pF1KE1 PLPGSKAKPKPPKQAQKEQRKQMKG-----RGQ-LEKPPAPNQAMVVAAAGDACPPQHVP
: .:.::.. . . : ..: :: .: :: :..
XP_006 P-----EEPRPPRRKPQTRGKTFHGLLTRARGPPIEGPPRPQRGSTSFLDTRF
400 410 420 430 440
480 490 500
pF1KE1 PKDSAPKDSAPQDLAPQVSAHHRSQESLTSQESEDTYL
>>XP_011544091 (OMIM: 613620) PREDICTED: TBC1 domain fam (703 aa)
initn: 1390 init1: 1202 opt: 1228 Z-score: 795.0 bits: 157.1 E(85289): 1.5e-37
Smith-Waterman score: 1245; 58.3% identity (76.5% similar) in 336 aa overlap (173-504:317-636)
150 160 170 180 190 200
pF1KE1 MSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPI
: ::::.:.:::::.:::.:::::::::.
XP_011 VSSMGSDSEINGLALRKTDKYGFLGGSQYSGSLQQDLYRILKAYTIYRPDEGYCQAQAPV
290 300 310 320 330 340
210 220 230 240 250 260
pF1KE1 AAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSR
:::::::::::::::::::::.:::::::: ::::::::::.:.::...::.::.:: :
XP_011 AAVLLMHMPAEQAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRR
350 360 370 380 390 400
270 280 290 300 310 320
pF1KE1 QKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLKHALGSPEKVK
:.:::.::::::::: :.:::::.::::::::::::::::::::.::::.:.::: ::..
XP_011 QRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLR
410 420 430 440 450 460
330 340 350 360 370 380
pF1KE1 ACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTERQIEREHLIQLRRWQETRGELQCR
.:::.:::.:.::.: . ::: :::.::..::::: ::::. ::..:.::::::: :
XP_011 SCQGMYETMEQLRNLPQQCMQEDFLVHEVTNLPVTEALIERENAAQLKKWRETRGELQYR
470 480 490 500 510 520
390 400 410 420 430
pF1KE1 SPPRLHGAKAILDAEPGPRPALQPSPSI-RLPLDAPLPGSKAK---PKPPKQAQKEQRKQ
::::..:: . . .: : :: :. :: ::.: :.:: . :.
XP_011 PSRRLHGSRAIHEERRRQQPPLGPSSSLLSLP-GLKSRGSRAAGGAPSPPPPV----RRA
530 540 550 560 570 580
440 450 460 470 480 490
pF1KE1 MKGRGQLEKPPAPNQAMVVAAAGDACPPQHVPPKDSAPKDSAPQDLAPQVSAHHRSQESL
: :::. ::.: : : : .:.: :. .. : . ......
XP_011 SAG-------PAPGP--VVTAEG-LHPSLPSPTGNSTPLGSS-KETRKQEKERQKQEKER
590 600 610 620 630
500
pF1KE1 TSQESEDTYL
.::.:
XP_011 QKQEKEREKERQKQEKEREKQEKEREKQEKERQKQEKKAQGRKLSLRRKADGPPGPHDGG
640 650 660 670 680 690
>>XP_011543304 (OMIM: 610831) PREDICTED: carabin isoform (313 aa)
initn: 1096 init1: 1096 opt: 1135 Z-score: 740.9 bits: 146.0 E(85289): 1.6e-34
Smith-Waterman score: 1135; 55.2% identity (82.3% similar) in 277 aa overlap (24-299:7-280)
10 20 30 40 50
pF1KE1 MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAE-RRIDKFG
:.:.: :. :. :::::::: .: . :. :..:
XP_011 MAQALGEDLVQPPE--LQDDSSSLGSDSELSGPGPYRQADRYG
10 20 30 40
60 70 80 90 100 110
pF1KE1 FIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGR
:: ::.. : . : ...:::: ::..: ..:.: :....::....:.:::: .::.:
XP_011 FIGGSSAEPGPGHP-PADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRAR
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE1 AWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDL
: : :..: ...:: ..:: .::::.:...: ::::::::.:::::: ::::: :
XP_011 CWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGL
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE1 FRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQ
..:::::::::::.::::::.:.:::::::.: :.:::::::::: ::::::. ..::..
XP_011 LQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVR
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE1 LDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEG
::.:....::... : .::::.. . ::::. :::.: :.:.::. .:::::: :. ::
XP_011 LDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEG
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE1 VKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTER
XP_011 GGLTGVAVEAWGQRGHCPQGPGYSLRSREGLEP
290 300 310
>>XP_011544092 (OMIM: 613620) PREDICTED: TBC1 domain fam (536 aa)
initn: 1103 init1: 1103 opt: 1115 Z-score: 725.1 bits: 143.8 E(85289): 1.2e-33
Smith-Waterman score: 1115; 66.8% identity (86.6% similar) in 232 aa overlap (6-235:255-484)
10 20 30
pF1KE1 MAKSNGENGPRAPAAGESLSGTRE-SLAQGPDAAT
: .:::. : ..:: :: .: .
XP_011 EAPVAVVTVTPAPEPAENSQDLGSTSSLGPGISGPRGQAP-DTLSYLDSVSLMSGTLESL
230 240 250 260 270 280
40 50 60 70 80 90
pF1KE1 TDELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGALEE-VPLEVLRQRESKWLDMLNNW
.:..::.::::: ::.: :. ::.::. ::: . :.:: .:..: :::: :::::..::
XP_011 ADDVSSMGSDSEINGLALRKTDKYGFLGGSQYS-GSLESSIPVDVARQRELKWLDMFSNW
290 300 310 320 330 340
100 110 120 130 140 150
pF1KE1 DKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDV
:::.... .:..:::.:::: :::..::::::..: :.::::::.::. .:::::::::
XP_011 DKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWLDV
350 360 370 380 390 400
160 170 180 190 200 210
pF1KE1 IERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAE
::.::::::::::::..:::::::::.:.:::::.:::.:::::::::.:::::::::::
XP_011 IEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAE
410 420 430 440 450 460
220 230 240 250 260 270
pF1KE1 QAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTE
::::::::::.:::::::: :
XP_011 QAFWCLVQICDKYLPGYYSAGLALRSSSGWPWSCCATRWAQWRSCAPAKACMRPWSSCVT
470 480 490 500 510 520
508 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 21:58:02 2016 done: Sun Nov 6 21:58:04 2016
Total Scan time: 9.920 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]