Result of FASTA (omim) for
pFN21AE1935
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1935, 474 aa
1>>>pF1KE1935 474 - 474 aa - 474 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.7775+/-0.000374; mu= 15.7325+/- 0.023
mean_var=77.1275+/-15.105, 0's: 0 Z-trim(113.2): 38 B-trim: 0 in 0/53
Lambda= 0.146039
statistics sampled from 22466 (22490) to 22466 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.639), E-opt: 0.2 (0.264), width: 16
Scan time: 9.610
The best scores are: opt bits E(85289)
NP_001191235 (OMIM: 139200) vitamin D-binding prot ( 474) 3171 677.8 1.7e-194
NP_000574 (OMIM: 139200) vitamin D-binding protein ( 474) 3171 677.8 1.7e-194
NP_001191236 (OMIM: 139200) vitamin D-binding prot ( 493) 3171 677.8 1.8e-194
XP_006714240 (OMIM: 139200) PREDICTED: vitamin D-b ( 425) 2841 608.3 1.3e-173
NP_000468 (OMIM: 103600,615999,616000) serum album ( 609) 595 135.1 5.1e-31
XP_016863331 (OMIM: 104145) PREDICTED: afamin isof ( 494) 299 72.7 2.6e-12
XP_016863333 (OMIM: 104145) PREDICTED: afamin isof ( 423) 233 58.8 3.4e-08
XP_016863332 (OMIM: 104145) PREDICTED: afamin isof ( 425) 233 58.8 3.5e-08
NP_001124 (OMIM: 104145) afamin precursor [Homo sa ( 599) 229 58.0 8.3e-08
NP_001125 (OMIM: 104150,615969,615970) alpha-fetop ( 609) 220 56.1 3.1e-07
>>NP_001191235 (OMIM: 139200) vitamin D-binding protein (474 aa)
initn: 3171 init1: 3171 opt: 3171 Z-score: 3612.6 bits: 677.8 E(85289): 1.7e-194
Smith-Waterman score: 3171; 99.6% identity (100.0% similar) in 474 aa overlap (1-474:1-474)
10 20 30 40 50 60
pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 SQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 LCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 SYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 QKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 QEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 LSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKK
370 380 390 400 410 420
430 440 450 460 470
pF1KE1 KLAERLKAKLPEATPTELAKLVNKRSDFASNCCSINSPPLYCDSEIDAELKNIL
:::::::::::.::::::::::::.:::::::::::::::::::::::::::::
NP_001 KLAERLKAKLPDATPTELAKLVNKHSDFASNCCSINSPPLYCDSEIDAELKNIL
430 440 450 460 470
>>NP_000574 (OMIM: 139200) vitamin D-binding protein iso (474 aa)
initn: 3171 init1: 3171 opt: 3171 Z-score: 3612.6 bits: 677.8 E(85289): 1.7e-194
Smith-Waterman score: 3171; 99.6% identity (100.0% similar) in 474 aa overlap (1-474:1-474)
10 20 30 40 50 60
pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 SQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 LCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 SYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 QKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 QEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 LSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKK
370 380 390 400 410 420
430 440 450 460 470
pF1KE1 KLAERLKAKLPEATPTELAKLVNKRSDFASNCCSINSPPLYCDSEIDAELKNIL
:::::::::::.::::::::::::.:::::::::::::::::::::::::::::
NP_000 KLAERLKAKLPDATPTELAKLVNKHSDFASNCCSINSPPLYCDSEIDAELKNIL
430 440 450 460 470
>>NP_001191236 (OMIM: 139200) vitamin D-binding protein (493 aa)
initn: 3171 init1: 3171 opt: 3171 Z-score: 3612.4 bits: 677.8 E(85289): 1.8e-194
Smith-Waterman score: 3171; 99.6% identity (100.0% similar) in 474 aa overlap (1-474:20-493)
10 20 30 40
pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFT
:::::::::::::::::::::::::::::::::::::::::
NP_001 MLWSWSEERGGAARLSGRKMKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFT
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 SLSLVLYSRKFPSGTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLSLVLYSRKFPSGTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSP
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE1 FPVHPGTAECCTKEGLERKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FPVHPGTAECCTKEGLERKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMW
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE1 EYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCS
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE1 QYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEH
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE1 TVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTK
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE1 VMDKYTFELSRRTHLPEVFLSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMDKYTFELSRRTHLPEVFLSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFID
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE1 KGQELCADYSENTFTEYKKKLAERLKAKLPEATPTELAKLVNKRSDFASNCCSINSPPLY
::::::::::::::::::::::::::::::.::::::::::::.::::::::::::::::
NP_001 KGQELCADYSENTFTEYKKKLAERLKAKLPDATPTELAKLVNKHSDFASNCCSINSPPLY
430 440 450 460 470 480
470
pF1KE1 CDSEIDAELKNIL
:::::::::::::
NP_001 CDSEIDAELKNIL
490
>>XP_006714240 (OMIM: 139200) PREDICTED: vitamin D-bindi (425 aa)
initn: 2841 init1: 2841 opt: 2841 Z-score: 3237.6 bits: 608.3 E(85289): 1.3e-173
Smith-Waterman score: 2841; 100.0% identity (100.0% similar) in 422 aa overlap (1-422:1-422)
10 20 30 40 50 60
pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 SQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 LCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 SYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 QKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 QEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 LSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKK
370 380 390 400 410 420
430 440 450 460 470
pF1KE1 KLAERLKAKLPEATPTELAKLVNKRSDFASNCCSINSPPLYCDSEIDAELKNIL
::
XP_006 KLMLN
>>NP_000468 (OMIM: 103600,615999,616000) serum albumin p (609 aa)
initn: 424 init1: 302 opt: 595 Z-score: 677.8 bits: 135.1 E(85289): 5.1e-31
Smith-Waterman score: 598; 24.9% identity (58.1% similar) in 470 aa overlap (1-453:1-462)
10 20 30 40 50
pF1KE1 MKRVLVLLLAVAFGHALERG---RDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTF
:: : . : :. : :: :: .:..: ..:. ::.:.: .: :. ... . . :
NP_000 MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 EQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGL
:. .::.::. ....: :. . .: . . .. : : . .. :.::.:.
NP_000 EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 ERKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVS
::. :. : . ..: :.: : .: ::. . . . .....: . . :.
NP_000 ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE1 YTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRV-CSQYAAYGEKKSRLSNL
..: : . :: .:. ..:.: . .:. . .. ..:. :.. .::. . .
NP_000 FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE1 IKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKF
.:.:. : :.. .: :. :.:.. ..::.. .: : . . . .:.: .. .::.
NP_000 ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLEC-ADDRADLAKYICENQDSISSKL
250 260 270 280 290
300 310 320 330 340 350
pF1KE1 EDCCQEKTAMDVFVCTYFMPAAQLP-ELPDV--ELPTNKDVC-DPGNTK--VMDKYTFEL
..:: :: .. : . ..: .::.. .. .:::: . ...: . . .:
NP_000 KECC-EKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEY
300 310 320 330 340 350
360 370 380 390 400
pF1KE1 SRRTHLPE---VFLSKVLEPTLKSLGECCDVEDSTTC----FNAKGPLLKKELSSFIDKG
.:: : :. :.: .. . .: .:: . : : :. ::.. : ...: ..
NP_000 ARR-H-PDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVE-EPQNLIKQN
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE1 QELCADYSENTFTEYKKKLAERLKAKLPEATPTELAKLVNKRSDFASNCCSINSPPLYCD
:: . .: : .. : : :.:... :... . . .:.::
NP_000 CELFEQLGEYKF---QNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPC
420 430 440 450 460 470
470
pF1KE1 SEIDAELKNIL
NP_000 AEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFT
480 490 500 510 520 530
>>XP_016863331 (OMIM: 104145) PREDICTED: afamin isoform (494 aa)
initn: 230 init1: 147 opt: 299 Z-score: 342.1 bits: 72.7 E(85289): 2.6e-12
Smith-Waterman score: 299; 21.0% identity (55.8% similar) in 267 aa overlap (10-271:206-467)
10 20 30
pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKED
:. . :. .:.:. :: . ..: .
XP_016 PTLLTVAVHFEEVAKSCCEEQNKVNCLQTRAIPVTQYLKAFSSYQKH-VCGALLKFGTKV
180 190 200 210 220 230
40 50 60 70 80 90
pF1KE1 FTSLSLVLYSRKFPSGTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESN
. ... :.:::. :... .::..: : ..:: :: .: ..... ...
XP_016 VHFIYIAILSQKFPKIEFKELISLVEDVSSNYDGCC-EGDVVQCIRDTSKVMNHICSKQD
240 250 260 270 280 290
100 110 120 130 140 150
pF1KE1 SPFPVHPGTAECCTKEGLERKLCMAALKH--QPQEFPTYVEPTND--EICEAFRKDPKEY
: . ::: :. :: :. .. .:... .: ..:. :: .
XP_016 S---ISSKIKECCEKKIPERGQCIINSNKDDRPKDLSLREGKFTDSENVCQERDADPDTF
300 310 320 330 340 350
160 170 180 190 200 210
pF1KE1 ANQFMWEYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTT-
.: .::: . . . :. .. : ... .::.. .: :. . .... . .
XP_016 FAKFTFEYSRRHPDLSIPELLRIVQIYKDLLRNCCNTENPPGCYRYAEDKFNETTEKSLK
360 370 380 390 400 410
220 230 240 250 260 270
pF1KE1 LSNRVCSQYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCM
. .. :... :. . ::.:.. .: . :... :.: ... .. :: . :
XP_016 MVQQECKHFQNLGKDGLKYHYLIRLTKIAPQLSTEELVSLGEKMVTAFTTCCTLSEEFAC
420 430 440 450 460 470
280 290 300 310 320 330
pF1KE1 AKELPEHTVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDV
XP_016 VDNLTCVNLRMRSFRGRQTGFLST
480 490
>--
initn: 127 init1: 62 opt: 222 Z-score: 254.5 bits: 56.5 E(85289): 2e-07
Smith-Waterman score: 222; 23.1% identity (57.7% similar) in 182 aa overlap (21-199:27-202)
10 20 30 40 50
pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPS
:: :. . ..: .... .... ...
XP_016 MKLLKLTGFIFFLFFLTESLTLPTQPRDIENFNSTQKFI---EDNIEYITIIAFAQYVQE
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 GTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTK
.:::.. .:::..: . : :. . :.: ...:. : : .. .: . . ..::.:
XP_016 ATFEEMEKLVKDMVEYKDRCMADKTLPECSKLPNNVLQEKICAMEG-LPQKHNFSHCCSK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 EGLERKLCMAALKHQPQEF-PTYVEPTND--EICEAFRKDPKEYANQFMWEYSTNYGQAP
.:.::. :.. : : . :: : : :.:.... . :.:..: . .
XP_016 VDAQRRLCFFYNKKSDVGFLPPF--PTLDPEEKCQAYESNRESLLNHFLYEVARRNPFVF
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 LSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKS
:.. . . .. ::: . . :.
XP_016 APTLLTVAVHFEEVAKSCCEEQNKVNCLQTRAIPVTQYLKAFSSYQKHVCGALLKFGTKV
180 190 200 210 220 230
>>XP_016863333 (OMIM: 104145) PREDICTED: afamin isoform (423 aa)
initn: 298 init1: 133 opt: 233 Z-score: 268.0 bits: 58.8 E(85289): 3.4e-08
Smith-Waterman score: 257; 23.0% identity (55.3% similar) in 226 aa overlap (170-385:175-394)
140 150 160 170 180 190
pF1KE1 TNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCF
:: : :. . .. ::: . . :.
XP_016 EEKCQAYESNRESLLNHFLYEVARRNPFVFAPTLLTVAV--HFEEVAKSCCEEQNKVNCL
150 160 170 180 190 200
200 210 220 230 240 250
pF1KE1 LKERLQL-KHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDI
. . . ..:. ... ...::. .: : .. . :.:: : ...... :.::.
XP_016 QTRAIPVTQYLKAFSSYQKHVCGALLKFGTKVVHFIYIAILSQKFPKIEFKELISLVEDV
210 220 230 240 250 260
260 270 280 290 300 310
pF1KE1 TNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAA
.. . :::. .:. .. . ..:.. .. .::...:: :: . :
XP_016 SSNYDGCCEGDVVQCI-RDTSKVMNHICSKQDSISSKIKECC-EKKIPERGQCIINSNKD
270 280 290 300 310 320
320 330 340 350 360
pF1KE1 QLPE---LPDVELPTNKDVC---DPGNTKVMDKYTFELSRR---THLPEVFLSKVLEPTL
. :. : . .. ...:: : . :.::: ::: .:: : ....
XP_016 DRPKDLSLREGKFTDSENVCQERDADPDTFFAKFTFEYSRRHPDLSIPE--LLRIVQIYK
330 340 350 360 370
370 380 390 400 410 420
pF1KE1 KSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKKKLAERLKAK
: .::..:. :.
XP_016 DLLRNCCNTENPPGCYRYAEDKFNETTEKSLKMVQQEFTSSGSRR
380 390 400 410 420
>--
initn: 111 init1: 62 opt: 199 Z-score: 229.3 bits: 51.6 E(85289): 4.9e-06
Smith-Waterman score: 199; 25.5% identity (61.4% similar) in 145 aa overlap (21-162:27-165)
10 20 30 40 50
pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPS
:: :. . ..: .... .... ...
XP_016 MKLLKLTGFIFFLFFLTESLTLPTQPRDIENFNSTQKFI---EDNIEYITIIAFAQYVQE
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 GTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTK
.:::.. .:::..: . : :. . :.: ...:. : : .. .: . . ..::.:
XP_016 ATFEEMEKLVKDMVEYKDRCMADKTLPECSKLPNNVLQEKICAMEG-LPQKHNFSHCCSK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 EGLERKLCMAALKHQPQEF-PTYVEPTND--EICEAFRKDPKEYANQFMWEYSTNYGQAP
.:.::. :.. : : . :: : : :.:.... . :.:..:
XP_016 VDAQRRLCFFYNKKSDVGFLPPF--PTLDPEEKCQAYESNRESLLNHFLYEVARRNPFVF
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 LSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKS
XP_016 APTLLTVAVHFEEVAKSCCEEQNKVNCLQTRAIPVTQYLKAFSSYQKHVCGALLKFGTKV
180 190 200 210 220 230
>>XP_016863332 (OMIM: 104145) PREDICTED: afamin isoform (425 aa)
initn: 298 init1: 133 opt: 233 Z-score: 268.0 bits: 58.8 E(85289): 3.5e-08
Smith-Waterman score: 257; 23.0% identity (55.3% similar) in 226 aa overlap (170-385:175-394)
140 150 160 170 180 190
pF1KE1 TNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCF
:: : :. . .. ::: . . :.
XP_016 EEKCQAYESNRESLLNHFLYEVARRNPFVFAPTLLTVAV--HFEEVAKSCCEEQNKVNCL
150 160 170 180 190 200
200 210 220 230 240 250
pF1KE1 LKERLQL-KHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDI
. . . ..:. ... ...::. .: : .. . :.:: : ...... :.::.
XP_016 QTRAIPVTQYLKAFSSYQKHVCGALLKFGTKVVHFIYIAILSQKFPKIEFKELISLVEDV
210 220 230 240 250 260
260 270 280 290 300 310
pF1KE1 TNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAA
.. . :::. .:. .. . ..:.. .. .::...:: :: . :
XP_016 SSNYDGCCEGDVVQCI-RDTSKVMNHICSKQDSISSKIKECC-EKKIPERGQCIINSNKD
270 280 290 300 310 320
320 330 340 350 360
pF1KE1 QLPE---LPDVELPTNKDVC---DPGNTKVMDKYTFELSRR---THLPEVFLSKVLEPTL
. :. : . .. ...:: : . :.::: ::: .:: : ....
XP_016 DRPKDLSLREGKFTDSENVCQERDADPDTFFAKFTFEYSRRHPDLSIPE--LLRIVQIYK
330 340 350 360 370
370 380 390 400 410 420
pF1KE1 KSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKKKLAERLKAK
: .::..:. :.
XP_016 DLLRNCCNTENPPGCYRYAEDKFNETTEKSLKMLPHQAHEDSSPTLH
380 390 400 410 420
>--
initn: 111 init1: 62 opt: 199 Z-score: 229.3 bits: 51.6 E(85289): 5e-06
Smith-Waterman score: 199; 25.5% identity (61.4% similar) in 145 aa overlap (21-162:27-165)
10 20 30 40 50
pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPS
:: :. . ..: .... .... ...
XP_016 MKLLKLTGFIFFLFFLTESLTLPTQPRDIENFNSTQKFI---EDNIEYITIIAFAQYVQE
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 GTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTK
.:::.. .:::..: . : :. . :.: ...:. : : .. .: . . ..::.:
XP_016 ATFEEMEKLVKDMVEYKDRCMADKTLPECSKLPNNVLQEKICAMEG-LPQKHNFSHCCSK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 EGLERKLCMAALKHQPQEF-PTYVEPTND--EICEAFRKDPKEYANQFMWEYSTNYGQAP
.:.::. :.. : : . :: : : :.:.... . :.:..:
XP_016 VDAQRRLCFFYNKKSDVGFLPPF--PTLDPEEKCQAYESNRESLLNHFLYEVARRNPFVF
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 LSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKS
XP_016 APTLLTVAVHFEEVAKSCCEEQNKVNCLQTRAIPVTQYLKAFSSYQKHVCGALLKFGTKV
180 190 200 210 220 230
>>NP_001124 (OMIM: 104145) afamin precursor [Homo sapien (599 aa)
initn: 266 init1: 159 opt: 229 Z-score: 261.2 bits: 58.0 E(85289): 8.3e-08
Smith-Waterman score: 257; 23.0% identity (55.3% similar) in 226 aa overlap (170-385:175-394)
140 150 160 170 180 190
pF1KE1 TNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCF
:: : :. . .. ::: . . :.
NP_001 EEKCQAYESNRESLLNHFLYEVARRNPFVFAPTLLTVAV--HFEEVAKSCCEEQNKVNCL
150 160 170 180 190 200
200 210 220 230 240 250
pF1KE1 LKERLQL-KHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDI
. . . ..:. ... ...::. .: : .. . :.:: : ...... :.::.
NP_001 QTRAIPVTQYLKAFSSYQKHVCGALLKFGTKVVHFIYIAILSQKFPKIEFKELISLVEDV
210 220 230 240 250 260
260 270 280 290 300 310
pF1KE1 TNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAA
.. . :::. .:. .. . ..:.. .. .::...:: :: . :
NP_001 SSNYDGCCEGDVVQCI-RDTSKVMNHICSKQDSISSKIKECC-EKKIPERGQCIINSNKD
270 280 290 300 310 320
320 330 340 350 360
pF1KE1 QLPE---LPDVELPTNKDVC---DPGNTKVMDKYTFELSRR---THLPEVFLSKVLEPTL
. :. : . .. ...:: : . :.::: ::: .:: : ....
NP_001 DRPKDLSLREGKFTDSENVCQERDADPDTFFAKFTFEYSRRHPDLSIPE--LLRIVQIYK
330 340 350 360 370
370 380 390 400 410 420
pF1KE1 KSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKKKLAERLKAK
: .::..:. :.
NP_001 DLLRNCCNTENPPGCYRYAEDKFNETTEKSLKMVQQECKHFQNLGKDGLKYHYLIRLTKI
380 390 400 410 420 430
>--
initn: 266 init1: 159 opt: 229 Z-score: 261.2 bits: 58.0 E(85289): 8.3e-08
Smith-Waterman score: 229; 21.9% identity (55.6% similar) in 178 aa overlap (29-202:416-593)
10 20 30 40 50
pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFE
::.:..:::. . :. .. :. . :
NP_001 NTENPPGCYRYAEDKFNETTEKSLKMVQQECKHFQNLGKDGLKYHYLIRLTKIAPQLSTE
390 400 410 420 430 440
60 70 80 90 100 110
pF1KE1 QVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLE
.. .: ...:. .::. . . : :. .. . .. : : ..:.. .:: .
NP_001 ELVSLGEKMVTAFTTCCTLSEEFACVDNLADLVFGELCGVNENRTINPAVDHCCKTNFAF
450 460 470 480 490 500
120 130 140 150 160 170
pF1KE1 RKLCMAALK----HQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSL
:. :. .:: . : : . . ..:.. .. .. ...:. . .
NP_001 RRPCFESLKADKTYVPPPFSQDLFTFHADMCQSQNEELQRKTDRFLVNLVKLKHELTDEE
510 520 530 540 550 560
180 190 200 210 220 230
pF1KE1 LVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLS
: : .. ..: .:: . :: ::: .:
NP_001 LQSLFTNFANVVDKCCKAESPEVCFNEESPKIGN
570 580 590
>--
initn: 111 init1: 62 opt: 199 Z-score: 227.0 bits: 51.7 E(85289): 6.6e-06
Smith-Waterman score: 199; 25.5% identity (61.4% similar) in 145 aa overlap (21-162:27-165)
10 20 30 40 50
pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPS
:: :. . ..: .... .... ...
NP_001 MKLLKLTGFIFFLFFLTESLTLPTQPRDIENFNSTQKFI---EDNIEYITIIAFAQYVQE
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 GTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTK
.:::.. .:::..: . : :. . :.: ...:. : : .. .: . . ..::.:
NP_001 ATFEEMEKLVKDMVEYKDRCMADKTLPECSKLPNNVLQEKICAMEG-LPQKHNFSHCCSK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 EGLERKLCMAALKHQPQEF-PTYVEPTND--EICEAFRKDPKEYANQFMWEYSTNYGQAP
.:.::. :.. : : . :: : : :.:.... . :.:..:
NP_001 VDAQRRLCFFYNKKSDVGFLPPF--PTLDPEEKCQAYESNRESLLNHFLYEVARRNPFVF
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 LSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKS
NP_001 APTLLTVAVHFEEVAKSCCEEQNKVNCLQTRAIPVTQYLKAFSSYQKHVCGALLKFGTKV
180 190 200 210 220 230
>>NP_001125 (OMIM: 104150,615969,615970) alpha-fetoprote (609 aa)
initn: 216 init1: 124 opt: 220 Z-score: 250.8 bits: 56.1 E(85289): 3.1e-07
Smith-Waterman score: 360; 21.4% identity (58.6% similar) in 304 aa overlap (5-304:9-307)
10 20 30 40 50
pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGT
:..:: . ...:.:. .: .. .. .. ....:. ..... .:
NP_001 MKWVESIFLIFLLNFTESRTLHRN-EYGIASILDSYQCTAEISLADLATIFFAQFVQEAT
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 FEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEG
...::..::.... : .. . : ... :. . :. . . . : ..::..
NP_001 YKEVSKMVKDALTAIEKPTGDEQSSGCLENQLPAFLEELCHEKEILEKY-GHSDCCSQSE
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 LERKLC-MAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYG--QAPLS
:. : .: : : .: . : :::...: . . :.:..: . . ::
NP_001 EGRHNCFLAHKKPTPASIPLFQVPEPVTSCEAYEEDRETFMNKFIYEIARRHPFLYAPTI
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 LLVSYTKSYLSMVGSCCTSASPTVCF-LKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSR
:: .. : ... ::: . . . :: : :.: . :....:. . .: . .
NP_001 LL--WAARYDKIIPSCCKAENAVECFQTKAATVTKELRESSLLNQHACAVMKNFGTRTFQ
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE1 LSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTK
.. ::.:: ... .. :. :.... .::.. ::. .. . .:.. .:
NP_001 AITVTKLSQKFTKVNFTEIQKLVLDVAHVHEHCCRGDVLDCL-QDGEKIMSYICSQQDTL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE1 NSKFEDCCQEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSR
..:. .::. :
NP_001 SNKITECCKLTTLERGQCIIHAENDEKPEGLSPNLNRFLGDRDFNQFSSGEKNIFLASFV
300 310 320 330 340 350
>--
initn: 181 init1: 67 opt: 209 Z-score: 238.3 bits: 53.8 E(85289): 1.6e-06
Smith-Waterman score: 209; 21.0% identity (53.2% similar) in 186 aa overlap (27-206:414-599)
10 20 30 40 50
pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGT
. : :..::. . . :: :..: :. :
NP_001 CFQTENPLECQDKGEEELQKYIQESQALAKRSCGLFQKLGEYYLQNAFLVAYTKKAPQLT
390 400 410 420 430 440
60 70 80 90 100 110
pF1KE1 FEQVSQLVKEVVSLTEACCAEGADP--DCYDTRTSALSAKSCESNSPFPVHPGTAECCTK
.. ....... . .:: . : : . .. . .. : . ::.::...:::.
NP_001 SSELMAITRKMAATAATCCQLSEDKLLACGEGAADIIIGHLCIRHEMTPVNPGVGQCCTS
450 460 470 480 490 500
120 130 140 150 160 170
pF1KE1 EGLERKLCMAAL----KHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQA
.:. :...: . : : . ..:.: . . ..:. . . :
NP_001 SYANRRPCFSSLVVDETYVPPAFSDDKFIFHKDLCQAQGVALQTMKQEFLINLVKQKPQI
510 520 530 540 550 560
180 190 200 210 220 230
pF1KE1 PLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKK
: . .. ... .:: . ::: .: .:
NP_001 TEEQLEAVIADFSGLLEKCCQGQEQEVCFAEEGQKLISKTRAALGV
570 580 590 600
240 250 260 270 280 290
pF1KE1 SRLSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLS
474 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 10:02:12 2016 done: Sun Nov 6 10:02:13 2016
Total Scan time: 9.610 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]