Result of FASTA (omim) for
pFN21AE1893
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1893, 422 aa
1>>>pF1KE1893 422 - 422 aa - 422 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.0241+/-0.000449; mu= 13.6317+/- 0.028
mean_var=75.5860+/-14.623, 0's: 0 Z-trim(109.6): 48 B-trim: 28 in 1/54
Lambda= 0.147521
statistics sampled from 17844 (17859) to 17844 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.562), E-opt: 0.2 (0.209), width: 16
Scan time: 8.260
The best scores are: opt bits E(85289)
NP_002806 (OMIM: 604449) 26S proteasome non-ATPase ( 422) 2637 571.1 1.8e-162
NP_001257411 (OMIM: 604449) 26S proteasome non-ATP ( 422) 2637 571.1 1.8e-162
NP_004227 (OMIM: 604508) COP9 signalosome complex ( 443) 395 94.0 8.3e-19
NP_001137359 (OMIM: 604508) COP9 signalosome compl ( 450) 386 92.0 3.2e-18
>>NP_002806 (OMIM: 604449) 26S proteasome non-ATPase reg (422 aa)
initn: 2637 init1: 2637 opt: 2637 Z-score: 3037.7 bits: 571.1 E(85289): 1.8e-162
Smith-Waterman score: 2637; 100.0% identity (100.0% similar) in 422 aa overlap (1-422:1-422)
10 20 30 40 50 60
pF1KE1 MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDEEAVQVKEQSILELGSLLAKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDEEAVQVKEQSILELGSLLAKT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKSE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 KRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHAL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 SNLPKARAALTSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SNLPKARAALTSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 SIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 DFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKAD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 VERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKK
370 380 390 400 410 420
pF1KE1 LT
::
NP_002 LT
>>NP_001257411 (OMIM: 604449) 26S proteasome non-ATPase (422 aa)
initn: 2637 init1: 2637 opt: 2637 Z-score: 3037.7 bits: 571.1 E(85289): 1.8e-162
Smith-Waterman score: 2637; 100.0% identity (100.0% similar) in 422 aa overlap (1-422:1-422)
10 20 30 40 50 60
pF1KE1 MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDEEAVQVKEQSILELGSLLAKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDEEAVQVKEQSILELGSLLAKT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKSE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 KRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHAL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 SNLPKARAALTSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNLPKARAALTSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 SIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 DFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKAD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 VERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKK
370 380 390 400 410 420
pF1KE1 LT
::
NP_001 LT
>>NP_004227 (OMIM: 604508) COP9 signalosome complex subu (443 aa)
initn: 302 init1: 229 opt: 395 Z-score: 458.6 bits: 94.0 E(85289): 8.3e-19
Smith-Waterman score: 395; 26.0% identity (57.9% similar) in 385 aa overlap (8-380:35-404)
10 20 30
pF1KE1 MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQE
.. ...: : .:... ...... . :
NP_004 EDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELE-GE
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE1 NDEEAVQVKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLF-
. : . .. .: : .: . . :: :.: ..... . . . :.:: .
NP_004 KGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIR---SAVTRNYSEKSINSILDYIS
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE1 LDMEAATGQEV-ELCLECIEWAKSEKRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLR
. . :: : :: .. ::... : ...: .::.. ..: . .. :: .
NP_004 TSKQMDLLQEFYETTLEALKDAKNDRLWF---KTNTKLGKLYLEREEYGKLQKILRQLHQ
130 140 150 160 170
160 170 180 190 200
pF1KE1 ELKKMDDK------ALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCP-PKLQA
. : . . :.:. :: . : : .: : .: .. .:: : : ...
NP_004 SCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAI--PHPLIMG
180 190 200 210 220 230
210 220 230 240 250 260
pF1KE1 TLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPKAITSLKYMLLCKIMLNT---PE
.. .: .: .: ... :.. :.:::..:: ::. : :::..: ...... :
NP_004 VIRECGGKMHL-REGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPF
240 250 260 270 280 290
270 280 290 300 310 320
pF1KE1 DVQALVSGKLALRYAGRQTEALKCVAQASKNRSLADFEKALTDYRAELRDDPIISTHLAK
: : : . :. ...: .: ....::: : .... :::.: :. .
NP_004 DSQEAKPYK-----NDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEE
300 310 320 330 340
330 340 350 360 370 380
pF1KE1 LYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGEGVL
: :. : ::..:.:..:..: ::. .... :::: : : :::. .:: .::
NP_004 LLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLL
350 360 370 380 390 400
390 400 410 420
pF1KE1 IIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKKLT
NP_004 ELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA
410 420 430 440
>>NP_001137359 (OMIM: 604508) COP9 signalosome complex s (450 aa)
initn: 302 init1: 229 opt: 386 Z-score: 448.2 bits: 92.0 E(85289): 3.2e-18
Smith-Waterman score: 396; 26.5% identity (57.7% similar) in 388 aa overlap (4-380:49-411)
10 20 30
pF1KE1 MAAAAVVEFQRAQSLLSTDREASIDILHSIVKR
::. ::.. : . : .. :....:
NP_001 EYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELEGEKGEWGFKALKQMIKI
20 30 40 50 60 70
40 50 60 70 80 90
pF1KE1 DIQ-ENDEEAVQVKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSL
... : : .. .: . . : .... . ....: :. : :: .. : .
NP_001 NFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYI-----STSKQNSDFLCQ--
80 90 100 110 120 130
100 110 120 130 140 150
pF1KE1 LDLFLDMEAATGQEVELCLECIEWAKSEKRTFLRQALEARLVSLYFDTKRYQEALHLGSQ
.::. .. : :: .. ::... : ...: .::.. ..: . .. :
NP_001 MDLLQEF-------YETTLEALKDAKNDRLWF---KTNTKLGKLYLEREEYGKLQKILRQ
140 150 160 170 180
160 170 180 190 200
pF1KE1 LLRELKKMDDK------ALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCP-PK
: . . : . . :.:. :: . : : .: : .: .. .:: : :
NP_001 LHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAI--PHPL
190 200 210 220 230
210 220 230 240 250 260
pF1KE1 LQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPKAITSLKYMLLCKIMLNT--
..... .: .: .: ... :.. :.:::..:: ::. : :::..: ......
NP_001 IMGVIRECGGKMHL-REGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGI
240 250 260 270 280 290
270 280 290 300 310 320
pF1KE1 -PEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLADFEKALTDYRAELRDDPIISTH
: : : : . :. ...: .: ....::: : .... :::.: :
NP_001 NPFDSQEAKPYK-----NDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREH
300 310 320 330 340 350
330 340 350 360 370 380
pF1KE1 LAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGE
. .: :. : ::..:.:..:..: ::. .... :::: : : :::. .:: .::
NP_001 IEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVN
360 370 380 390 400 410
390 400 410 420
pF1KE1 GVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKKLT
NP_001 QLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA
420 430 440 450
422 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 13:53:33 2016 done: Sun Nov 6 13:53:34 2016
Total Scan time: 8.260 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]