Result of FASTA (omim) for
pFN21AE1890
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1890, 418 aa
1>>>pF1KE1890 418 - 418 aa - 418 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.3516+/-0.000356; mu= 12.7710+/- 0.022
mean_var=99.7606+/-19.941, 0's: 0 Z-trim(116.5): 68 B-trim: 0 in 0/54
Lambda= 0.128409
statistics sampled from 27706 (27774) to 27706 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.69), E-opt: 0.2 (0.326), width: 16
Scan time: 8.910
The best scores are: opt bits E(85289)
NP_861449 (OMIM: 609292) sprouty-related, EVH1 dom ( 418) 3006 567.3 2.6e-161
NP_001121682 (OMIM: 609292) sprouty-related, EVH1 ( 415) 2950 556.9 3.4e-158
XP_016859065 (OMIM: 609292) PREDICTED: sprouty-rel ( 295) 2149 408.4 1.2e-113
XP_005264258 (OMIM: 609292) PREDICTED: sprouty-rel ( 221) 1661 317.9 1.5e-86
XP_005264257 (OMIM: 609292) PREDICTED: sprouty-rel ( 248) 1338 258.1 1.7e-68
XP_005264259 (OMIM: 609292) PREDICTED: sprouty-rel ( 218) 1336 257.7 2e-68
XP_006723282 (OMIM: 609293) PREDICTED: sprouty-rel ( 410) 990 193.8 6.7e-49
NP_001035987 (OMIM: 609293) sprouty-related, EVH1 ( 410) 990 193.8 6.7e-49
XP_011519591 (OMIM: 609291,611431) PREDICTED: spro ( 423) 937 184.0 6.2e-46
NP_689807 (OMIM: 609291,611431) sprouty-related, E ( 444) 937 184.0 6.5e-46
XP_005254259 (OMIM: 609291,611431) PREDICTED: spro ( 456) 937 184.0 6.6e-46
XP_011525280 (OMIM: 609293) PREDICTED: sprouty-rel ( 379) 753 149.9 1e-35
NP_001291919 (OMIM: 300531) protein sprouty homolo ( 288) 256 57.7 4.3e-08
NP_005831 (OMIM: 300531) protein sprouty homolog 3 ( 288) 256 57.7 4.3e-08
XP_016857242 (OMIM: 609061) PREDICTED: protein ena ( 628) 247 56.3 2.6e-07
XP_016857243 (OMIM: 609061) PREDICTED: protein ena ( 614) 245 55.9 3.3e-07
XP_016857239 (OMIM: 609061) PREDICTED: protein ena ( 839) 245 56.0 4.2e-07
XP_016857236 (OMIM: 609061) PREDICTED: protein ena ( 855) 245 56.0 4.3e-07
XP_016857235 (OMIM: 609061) PREDICTED: protein ena ( 876) 245 56.0 4.4e-07
XP_016857238 (OMIM: 609061) PREDICTED: protein ena ( 851) 243 55.6 5.5e-07
XP_011542531 (OMIM: 609061) PREDICTED: protein ena ( 872) 243 55.6 5.6e-07
XP_005273244 (OMIM: 609061) PREDICTED: protein ena ( 605) 232 53.5 1.7e-06
NP_060682 (OMIM: 609061) protein enabled homolog i ( 570) 230 53.1 2.1e-06
NP_001008493 (OMIM: 609061) protein enabled homolo ( 591) 230 53.1 2.2e-06
NP_001305465 (OMIM: 602466,616818) protein sprouty ( 315) 225 52.0 2.5e-06
NP_001305467 (OMIM: 602466,616818) protein sprouty ( 315) 225 52.0 2.5e-06
NP_005833 (OMIM: 602466,616818) protein sprouty ho ( 315) 225 52.0 2.5e-06
NP_001305466 (OMIM: 602466,616818) protein sprouty ( 315) 225 52.0 2.5e-06
XP_016857241 (OMIM: 609061) PREDICTED: protein ena ( 795) 230 53.2 2.8e-06
XP_016857240 (OMIM: 609061) PREDICTED: protein ena ( 832) 230 53.2 2.9e-06
XP_016857237 (OMIM: 609061) PREDICTED: protein ena ( 853) 230 53.2 2.9e-06
XP_016857244 (OMIM: 609061) PREDICTED: protein ena ( 601) 227 52.5 3.3e-06
NP_005832 (OMIM: 602465) protein sprouty homolog 1 ( 319) 218 50.7 6.2e-06
NP_001244967 (OMIM: 602465) protein sprouty homolo ( 319) 218 50.7 6.2e-06
NP_955359 (OMIM: 602465) protein sprouty homolog 1 ( 319) 218 50.7 6.2e-06
XP_005262743 (OMIM: 602465) PREDICTED: protein spr ( 319) 218 50.7 6.2e-06
NP_001244968 (OMIM: 602465) protein sprouty homolo ( 319) 218 50.7 6.2e-06
XP_016863124 (OMIM: 602465) PREDICTED: protein spr ( 319) 218 50.7 6.2e-06
XP_011535130 (OMIM: 616912) PREDICTED: ena/VASP-li ( 370) 216 50.4 9e-06
NP_001317150 (OMIM: 616912) ena/VASP-like protein ( 416) 216 50.4 9.9e-06
NP_057421 (OMIM: 616912) ena/VASP-like protein iso ( 418) 216 50.4 9.9e-06
XP_005267806 (OMIM: 616912) PREDICTED: ena/VASP-li ( 422) 216 50.4 1e-05
XP_016876852 (OMIM: 616912) PREDICTED: ena/VASP-li ( 429) 216 50.4 1e-05
XP_016882689 (OMIM: 601703) PREDICTED: vasodilator ( 378) 213 49.8 1.3e-05
XP_005259257 (OMIM: 601703) PREDICTED: vasodilator ( 379) 213 49.8 1.3e-05
XP_005259256 (OMIM: 601703) PREDICTED: vasodilator ( 379) 213 49.8 1.3e-05
NP_003361 (OMIM: 601703) vasodilator-stimulated ph ( 380) 213 49.8 1.4e-05
XP_016857246 (OMIM: 609061) PREDICTED: protein ena ( 578) 212 49.8 2.2e-05
XP_016857245 (OMIM: 609061) PREDICTED: protein ena ( 578) 212 49.8 2.2e-05
NP_001280218 (OMIM: 607984,615266) protein sprouty ( 299) 200 47.4 5.9e-05
>>NP_861449 (OMIM: 609292) sprouty-related, EVH1 domain- (418 aa)
initn: 3006 init1: 3006 opt: 3006 Z-score: 3017.2 bits: 567.3 E(85289): 2.6e-161
Smith-Waterman score: 3006; 100.0% identity (100.0% similar) in 418 aa overlap (1-418:1-418)
10 20 30 40 50 60
pF1KE1 MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_861 MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_861 GERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 DLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKREQPTRTISSPTSCEHRRIYTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_861 DLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKREQPTRTISSPTSCEHRRIYTL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 GHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEIVRINPREKIWMTGYEDYRHAPVRGKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_861 GHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEIVRINPREKIWMTGYEDYRHAPVRGKY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 PDPSEDADSSYVRFAKGEVPKHDYNYPYVDSSDFGLGEDPKGRGGSVIKTQPSRGKSRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_861 PDPSEDADSSYVRFAKGEVPKHDYNYPYVDSSDFGLGEDPKGRGGSVIKTQPSRGKSRRR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 KEDGERSRCVYCRDMFNHEENRRGHCQDAPDSVRTCIRRVSCMWCADSMLYHCMSDPEGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_861 KEDGERSRCVYCRDMFNHEENRRGHCQDAPDSVRTCIRRVSCMWCADSMLYHCMSDPEGD
310 320 330 340 350 360
370 380 390 400 410
pF1KE1 YTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACYHCGVMCRCCGGKHKAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_861 YTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACYHCGVMCRCCGGKHKAAA
370 380 390 400 410
>>NP_001121682 (OMIM: 609292) sprouty-related, EVH1 doma (415 aa)
initn: 2950 init1: 2950 opt: 2950 Z-score: 2961.2 bits: 556.9 E(85289): 3.4e-158
Smith-Waterman score: 2950; 99.5% identity (99.8% similar) in 412 aa overlap (7-418:4-415)
10 20 30 40 50 60
pF1KE1 MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIH
: .:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MASPGSDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIH
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 GERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIE
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE1 DLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKREQPTRTISSPTSCEHRRIYTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKREQPTRTISSPTSCEHRRIYTL
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE1 GHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEIVRINPREKIWMTGYEDYRHAPVRGKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEIVRINPREKIWMTGYEDYRHAPVRGKY
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE1 PDPSEDADSSYVRFAKGEVPKHDYNYPYVDSSDFGLGEDPKGRGGSVIKTQPSRGKSRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDPSEDADSSYVRFAKGEVPKHDYNYPYVDSSDFGLGEDPKGRGGSVIKTQPSRGKSRRR
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE1 KEDGERSRCVYCRDMFNHEENRRGHCQDAPDSVRTCIRRVSCMWCADSMLYHCMSDPEGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KEDGERSRCVYCRDMFNHEENRRGHCQDAPDSVRTCIRRVSCMWCADSMLYHCMSDPEGD
300 310 320 330 340 350
370 380 390 400 410
pF1KE1 YTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACYHCGVMCRCCGGKHKAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACYHCGVMCRCCGGKHKAAA
360 370 380 390 400 410
>>XP_016859065 (OMIM: 609292) PREDICTED: sprouty-related (295 aa)
initn: 2149 init1: 2149 opt: 2149 Z-score: 2161.4 bits: 408.4 E(85289): 1.2e-113
Smith-Waterman score: 2149; 100.0% identity (100.0% similar) in 294 aa overlap (125-418:2-295)
100 110 120 130 140 150
pF1KE1 NRKFGLTFQSPADARAFDRGVRKAIEDLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSN
::::::::::::::::::::::::::::::
XP_016 MGSTTSSSTIHNEAELGDDDVFTTATDSSSN
10 20 30
160 170 180 190 200 210
pF1KE1 SSQKREQPTRTISSPTSCEHRRIYTLGHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSQKREQPTRTISSPTSCEHRRIYTLGHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEI
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE1 VRINPREKIWMTGYEDYRHAPVRGKYPDPSEDADSSYVRFAKGEVPKHDYNYPYVDSSDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRINPREKIWMTGYEDYRHAPVRGKYPDPSEDADSSYVRFAKGEVPKHDYNYPYVDSSDF
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE1 GLGEDPKGRGGSVIKTQPSRGKSRRRKEDGERSRCVYCRDMFNHEENRRGHCQDAPDSVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLGEDPKGRGGSVIKTQPSRGKSRRRKEDGERSRCVYCRDMFNHEENRRGHCQDAPDSVR
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE1 TCIRRVSCMWCADSMLYHCMSDPEGDYTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TCIRRVSCMWCADSMLYHCMSDPEGDYTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCY
220 230 240 250 260 270
400 410
pF1KE1 LPLRACYHCGVMCRCCGGKHKAAA
::::::::::::::::::::::::
XP_016 LPLRACYHCGVMCRCCGGKHKAAA
280 290
>>XP_005264258 (OMIM: 609292) PREDICTED: sprouty-related (221 aa)
initn: 1661 init1: 1661 opt: 1661 Z-score: 1674.6 bits: 317.9 E(85289): 1.5e-86
Smith-Waterman score: 1661; 100.0% identity (100.0% similar) in 221 aa overlap (198-418:1-221)
170 180 190 200 210 220
pF1KE1 SPTSCEHRRIYTLGHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEIVRINPREKIWMTG
::::::::::::::::::::::::::::::
XP_005 MPRPYRQVSFPDDDEEIVRINPREKIWMTG
10 20 30
230 240 250 260 270 280
pF1KE1 YEDYRHAPVRGKYPDPSEDADSSYVRFAKGEVPKHDYNYPYVDSSDFGLGEDPKGRGGSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YEDYRHAPVRGKYPDPSEDADSSYVRFAKGEVPKHDYNYPYVDSSDFGLGEDPKGRGGSV
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE1 IKTQPSRGKSRRRKEDGERSRCVYCRDMFNHEENRRGHCQDAPDSVRTCIRRVSCMWCAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IKTQPSRGKSRRRKEDGERSRCVYCRDMFNHEENRRGHCQDAPDSVRTCIRRVSCMWCAD
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE1 SMLYHCMSDPEGDYTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACYHCGVMC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SMLYHCMSDPEGDYTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACYHCGVMC
160 170 180 190 200 210
410
pF1KE1 RCCGGKHKAAA
:::::::::::
XP_005 RCCGGKHKAAA
220
>>XP_005264257 (OMIM: 609292) PREDICTED: sprouty-related (248 aa)
initn: 1337 init1: 1337 opt: 1338 Z-score: 1350.5 bits: 258.1 E(85289): 1.7e-68
Smith-Waterman score: 1338; 92.6% identity (94.4% similar) in 216 aa overlap (1-213:1-216)
10 20 30 40 50 60
pF1KE1 MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 DLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKREQPTRTISSPTSCEHRRIYTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKREQPTRTISSPTSCEHRRIYTL
130 140 150 160 170 180
190 200 210 220 230
pF1KE1 GHLHDSYPTDHYHLDQPMPRPY---RQVSFPDDDEEIVRINPREKIWMTGYEDYRHAPVR
:::::::::::::::: . . : .:: . :
XP_005 GHLHDSYPTDHYHLDQALRKHQELERTTSFKAQKAEAHYQYFVCSQLQGRLQKCTKLAGF
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE1 GKYPDPSEDADSSYVRFAKGEVPKHDYNYPYVDSSDFGLGEDPKGRGGSVIKTQPSRGKS
XP_005 LGANASNW
>>XP_005264259 (OMIM: 609292) PREDICTED: sprouty-related (218 aa)
initn: 1335 init1: 1335 opt: 1336 Z-score: 1349.3 bits: 257.7 E(85289): 2e-68
Smith-Waterman score: 1336; 98.5% identity (99.0% similar) in 200 aa overlap (1-200:1-200)
10 20 30 40 50 60
pF1KE1 MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 DLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKREQPTRTISSPTSCEHRRIYTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKREQPTRTISSPTSCEHRRIYTL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 GHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEIVRINPREKIWMTGYEDYRHAPVRGKY
:::::::::::::::: . :
XP_005 GHLHDSYPTDHYHLDQLQGRLQKCTKLAGFLGANASNW
190 200 210
>>XP_006723282 (OMIM: 609293) PREDICTED: sprouty-related (410 aa)
initn: 909 init1: 368 opt: 990 Z-score: 998.9 bits: 193.8 E(85289): 6.7e-49
Smith-Waterman score: 990; 39.4% identity (63.2% similar) in 419 aa overlap (13-418:1-409)
10 20 30 40 50
pF1KE1 MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKV--MHPEGNGRSG-F
.:::.::::.::::::::.: :::.:.:.::.: .:::..:.: .
XP_006 MVRVRAVVMARDDSSGGWLPVGGGGLSQVSVCRVRGARPEGGARQGHY
10 20 30 40
60 70 80 90 100 110
pF1KE1 LIHGERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRK
.::::: .:. ..::: .. :::.:.:: ::::.. . ::::::::::.: :....
XP_006 VIHGERLRDQKTTLECTLKPGLVYNKVNPIFHHWSLGDCKFGLTFQSPAEADEFQKSLLA
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE1 AIEDLIEGSTTSSSTIHNEAELGDDDV----FTTATDSSSNSSQKR-EQPTRTISSPTSC
:. : .:: : ::. . . : .:. .::.:.::..: : : . ..:
XP_006 ALAALGRGSLTPSSSSSSSSPSQDTAETPCPLTSHVDSDSSSSHSRQETPPSAAAAPIIT
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE1 EHRRIYTLGHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEIVRINPREKIWM-TGYEDY
. . : . : . : .: ...:. .: .. . : :::::
XP_006 MES---ASGFGPTTPPQRRRSSAQSYPPLLPFTGIPEPSEPLAGAGGLG--WGGRGYEDY
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE1 RHAPVRGKYPDPSEDADSSYVRFAK-GEVPKHDYNYPYVDSSDFGLGEDPKGRGGSVIKT
: :. : : .. ::::: : . . : . . . . : .
XP_006 R----RSGPPAPLA-LSTCVVRFAKTGALRGAALGPPAALPAPLTEAAPPAPPARPPPGP
230 240 250 260 270
300 310 320 330 340
pF1KE1 QPSRGKSRRRKEDGERSRCVYCRDMFNHE-ENRRGHCQDAPDSVRTCIRRVSCMWCADSM
:: . .. : : .:::.:: .: .. ..: :.: .::: : .::.::.:::.:.
XP_006 GPSSAPAKASPEAEEAARCVHCRALFRRRADGRGGRCAEAPDPGRLLVRRLSCLWCAESL
280 290 300 310 320 330
350 360 370 380 390 400
pF1KE1 LYHCMSDPEGDYTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACYHCGVMCRC
::::.:: :::..:::.:. . . :: :: :::. .::.::: :::::. .. : :
XP_006 LYHCLSDAEGDFSDPCACEPGHPRPAARWAALAALSLAVPCLCCYAPLRACHWVAARCGC
340 350 360 370 380 390
410
pF1KE1 --CGGKHKAAA
:::.:. ::
XP_006 AGCGGRHEEAAR
400 410
>>NP_001035987 (OMIM: 609293) sprouty-related, EVH1 doma (410 aa)
initn: 909 init1: 368 opt: 990 Z-score: 998.9 bits: 193.8 E(85289): 6.7e-49
Smith-Waterman score: 990; 39.4% identity (63.2% similar) in 419 aa overlap (13-418:1-409)
10 20 30 40 50
pF1KE1 MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKV--MHPEGNGRSG-F
.:::.::::.::::::::.: :::.:.:.::.: .:::..:.: .
NP_001 MVRVRAVVMARDDSSGGWLPVGGGGLSQVSVCRVRGARPEGGARQGHY
10 20 30 40
60 70 80 90 100 110
pF1KE1 LIHGERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRK
.::::: .:. ..::: .. :::.:.:: ::::.. . ::::::::::.: :....
NP_001 VIHGERLRDQKTTLECTLKPGLVYNKVNPIFHHWSLGDCKFGLTFQSPAEADEFQKSLLA
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE1 AIEDLIEGSTTSSSTIHNEAELGDDDV----FTTATDSSSNSSQKR-EQPTRTISSPTSC
:. : .:: : ::. . . : .:. .::.:.::..: : : . ..:
NP_001 ALAALGRGSLTPSSSSSSSSPSQDTAETPCPLTSHVDSDSSSSHSRQETPPSAAAAPIIT
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE1 EHRRIYTLGHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEIVRINPREKIWM-TGYEDY
. . : . : . : .: ...:. .: .. . : :::::
NP_001 MES---ASGFGPTTPPQRRRSSAQSYPPLLPFTGIPEPSEPLAGAGGLG--WGGRGYEDY
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE1 RHAPVRGKYPDPSEDADSSYVRFAK-GEVPKHDYNYPYVDSSDFGLGEDPKGRGGSVIKT
: :. : : .. ::::: : . . : . . . . : .
NP_001 R----RSGPPAPLA-LSTCVVRFAKTGALRGAALGPPAALPAPLTEAAPPAPPARPPPGP
230 240 250 260 270
300 310 320 330 340
pF1KE1 QPSRGKSRRRKEDGERSRCVYCRDMFNHE-ENRRGHCQDAPDSVRTCIRRVSCMWCADSM
:: . .. : : .:::.:: .: .. ..: :.: .::: : .::.::.:::.:.
NP_001 GPSSAPAKASPEAEEAARCVHCRALFRRRADGRGGRCAEAPDPGRLLVRRLSCLWCAESL
280 290 300 310 320 330
350 360 370 380 390 400
pF1KE1 LYHCMSDPEGDYTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACYHCGVMCRC
::::.:: :::..:::.:. . . :: :: :::. .::.::: :::::. .. : :
NP_001 LYHCLSDAEGDFSDPCACEPGHPRPAARWAALAALSLAVPCLCCYAPLRACHWVAARCGC
340 350 360 370 380 390
410
pF1KE1 --CGGKHKAAA
:::.:. ::
NP_001 AGCGGRHEEAAR
400 410
>>XP_011519591 (OMIM: 609291,611431) PREDICTED: sprouty- (423 aa)
initn: 1320 init1: 769 opt: 937 Z-score: 945.6 bits: 184.0 E(85289): 6.2e-46
Smith-Waterman score: 1427; 53.1% identity (70.3% similar) in 437 aa overlap (21-417:1-422)
10 20 30 40 50 60
pF1KE1 MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIH
::::::::::.: :.:.: : : :: : : :: . :.:.
XP_011 MTRDDSSGGWLPLGGSGLSSVTVFKVPHQEENGCADFFIR
10 20 30 40
70 80 90 100 110 120
pF1KE1 GERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIE
::: .::.:::::...:::.:.:..:::::::.:..::::::::::::::::::.:.:::
XP_011 GERLRDKMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAIE
50 60 70 80 90 100
130 140 150 160 170
pF1KE1 DLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQ----KRE-----QPTRTIS-SPT
:. .: :. :::: : ::. .. ::::. . ..: .: :. . :.
XP_011 DISQGCPESK----NEAE-GADDLQANEEDSSSSLVKDHLFQQETVVTSEPYRSSNIRPS
110 120 130 140 150
180 190 200
pF1KE1 SCEH---RRIY--------TLGH--LHDSYPTDHYHLDQ--------------PMPRPYR
: ::.: :.:. : . . .: : :. . :
XP_011 PFEDLNARRVYMQSQANQITFGQPGLDIQSRSMEYVQRQISKECGSLKSQNRVPL-KSIR
160 170 180 190 200 210
210 220 230 240 250 260
pF1KE1 QVSFPDDDEEIVRINPREKIWMTGYEDYRHAPVRGKYPDPSEDADSSYVRFAKGEVPKHD
.::: :.:: :::::::. : . : :::: : : .::::: ..:.: . : :
XP_011 HVSFQDEDE-IVRINPRD-ILIRRYADYRH-PDMWKNDLERDDADSS-IQFSKPDSKKSD
220 230 240 250 260 270
270 280 290 300 310 320
pF1KE1 YNYPYVDSSDFGLGEDPKGRGGSVIKTQPSR---GKSRRRKEDGERSRCVYCRDMFNHEE
: : : . .. .:: . :.::::: ::.::::::::::::::.. :::::
XP_011 YLYSCGDETKLS---SPKD--SVVFKTQPSSLKIKKSKRRKEDGERSRCVYCQERFNHEE
280 290 300 310 320
330 340 350 360 370 380
pF1KE1 NRRGHCQDAPDSVRTCIRRVSCMWCADSMLYHCMSDPEGDYTDPCSCDTSDEKFCLRWMA
: ::.:::::: .. :: .:::: ::.::::::::: :::..:::::::::.::::::.:
XP_011 NVRGKCQDAPDPIKRCIYQVSCMLCAESMLYHCMSDSEGDFSDPCSCDTSDDKFCLRWLA
330 340 350 360 370 380
390 400 410
pF1KE1 LIALSFLAPCMCCYLPLRACYHCGVMCRCCGGKHKAAA
:.::::..::::::.::: :..:: : :::::::::
XP_011 LVALSFIVPCMCCYVPLRMCHRCGEACGCCGGKHKAAG
390 400 410 420
>>NP_689807 (OMIM: 609291,611431) sprouty-related, EVH1 (444 aa)
initn: 1368 init1: 769 opt: 937 Z-score: 945.3 bits: 184.0 E(85289): 6.5e-46
Smith-Waterman score: 1484; 53.1% identity (70.5% similar) in 458 aa overlap (1-417:1-443)
10 20 30 40 50
pF1KE1 MTEETHP-DDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLI
:.::: :.:. .::.:::::::::::::.: :.:.: : : :: : : :: . :.:
NP_689 MSEETATSDNDNSYARVRAVVMTRDDSSGGWLPLGGSGLSSVTVFKVPHQEENGCADFFI
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 HGERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAI
.::: .::.:::::...:::.:.:..:::::::.:..::::::::::::::::::.:.::
NP_689 RGERLRDKMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAI
70 80 90 100 110 120
120 130 140 150 160
pF1KE1 EDLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQ----KRE-----QPTRTIS-SP
::. .: :. :::: : ::. .. ::::. . ..: .: :. . :
NP_689 EDISQGCPESK----NEAE-GADDLQANEEDSSSSLVKDHLFQQETVVTSEPYRSSNIRP
130 140 150 160 170
170 180 190 200
pF1KE1 TSCEH---RRIY--------TLGH--LHDSYPTDHYHLDQ--------------PMPRPY
. : ::.: :.:. : . . .: : :. .
NP_689 SPFEDLNARRVYMQSQANQITFGQPGLDIQSRSMEYVQRQISKECGSLKSQNRVPL-KSI
180 190 200 210 220 230
210 220 230 240 250 260
pF1KE1 RQVSFPDDDEEIVRINPREKIWMTGYEDYRHAPVRGKYPDPSEDADSSYVRFAKGEVPKH
:.::: :.:: :::::::. : . : :::: : : .::::: ..:.: . :
NP_689 RHVSFQDEDE-IVRINPRD-ILIRRYADYRH-PDMWKNDLERDDADSS-IQFSKPDSKKS
240 250 260 270 280 290
270 280 290 300 310
pF1KE1 DYNYPYVDSSDFGLGEDPKGRGGSVIKTQPSR---GKSRRRKEDGERSRCVYCRDMFNHE
:: : : . .. .:: . :.::::: ::.::::::::::::::.. ::::
NP_689 DYLYSCGDETKLS---SPKD--SVVFKTQPSSLKIKKSKRRKEDGERSRCVYCQERFNHE
300 310 320 330 340
320 330 340 350 360 370
pF1KE1 ENRRGHCQDAPDSVRTCIRRVSCMWCADSMLYHCMSDPEGDYTDPCSCDTSDEKFCLRWM
:: ::.:::::: .. :: .:::: ::.::::::::: :::..:::::::::.::::::.
NP_689 ENVRGKCQDAPDPIKRCIYQVSCMLCAESMLYHCMSDSEGDFSDPCSCDTSDDKFCLRWL
350 360 370 380 390 400
380 390 400 410
pF1KE1 ALIALSFLAPCMCCYLPLRACYHCGVMCRCCGGKHKAAA
::.::::..::::::.::: :..:: : :::::::::
NP_689 ALVALSFIVPCMCCYVPLRMCHRCGEACGCCGGKHKAAG
410 420 430 440
418 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 12:07:47 2016 done: Sun Nov 6 12:07:49 2016
Total Scan time: 8.910 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]