Result of FASTA (omim) for
pFN21AE1869
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1869, 390 aa
1>>>pF1KE1869 390 - 390 aa - 390 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1922+/-0.000287; mu= 18.5981+/- 0.018
mean_var=76.2215+/-15.262, 0's: 0 Z-trim(118.5): 68 B-trim: 1655 in 1/55
Lambda= 0.146905
statistics sampled from 31466 (31550) to 31466 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.727), E-opt: 0.2 (0.37), width: 16
Scan time: 9.470
The best scores are: opt bits E(85289)
NP_000651 (OMIM: 131300,190180,219700) transformin ( 390) 2658 572.3 6.8e-163
XP_011525544 (OMIM: 131300,190180,219700) PREDICTE ( 391) 2646 569.8 4e-162
NP_003230 (OMIM: 107970,190230,615582) transformin ( 412) 700 157.4 5.9e-38
NP_001316868 (OMIM: 107970,190230,615582) transfor ( 412) 700 157.4 5.9e-38
NP_003229 (OMIM: 190220,614816) transforming growt ( 414) 699 157.1 6.8e-38
NP_001129071 (OMIM: 190220,614816) transforming gr ( 442) 699 157.2 7.2e-38
NP_001191 (OMIM: 112261,112600,235200) bone morpho ( 396) 327 78.3 3.6e-14
NP_002183 (OMIM: 147290) inhibin beta A chain prep ( 426) 317 76.2 1.6e-13
XP_016867665 (OMIM: 147290) PREDICTED: inhibin bet ( 426) 317 76.2 1.6e-13
XP_016867664 (OMIM: 147290) PREDICTED: inhibin bet ( 483) 317 76.2 1.8e-13
XP_016867663 (OMIM: 147290) PREDICTED: inhibin bet ( 548) 317 76.3 2e-13
NP_001316867 (OMIM: 107970,190230,615582) transfor ( 309) 304 73.3 8.7e-13
NP_005802 (OMIM: 603936) growth/differentiation fa ( 407) 293 71.1 5.4e-12
XP_006719257 (OMIM: 603936) PREDICTED: growth/diff ( 407) 293 71.1 5.4e-12
NP_113667 (OMIM: 612031) inhibin beta E chain prep ( 350) 290 70.4 7.5e-12
NP_005250 (OMIM: 601788,614160) growth/differentia ( 375) 290 70.4 7.9e-12
XP_011527625 (OMIM: 112261,112600,235200) PREDICTE ( 240) 275 67.1 5.1e-11
NP_005529 (OMIM: 601233) inhibin beta C chain prep ( 352) 262 64.5 4.6e-10
NP_002184 (OMIM: 147390) inhibin beta B chain prep ( 407) 261 64.3 5.9e-10
XP_016866687 (OMIM: 112265) PREDICTED: bone morpho ( 239) 256 63.1 8.2e-10
NP_066551 (OMIM: 112265) bone morphogenetic protei ( 454) 259 63.9 8.7e-10
XP_016877094 (OMIM: 112262,600625,607932) PREDICTE ( 345) 255 63.0 1.3e-09
XP_016877093 (OMIM: 112262,600625,607932) PREDICTE ( 345) 255 63.0 1.3e-09
XP_005268072 (OMIM: 112262,600625,607932) PREDICTE ( 408) 255 63.0 1.4e-09
NP_570911 (OMIM: 112262,600625,607932) bone morpho ( 408) 255 63.0 1.4e-09
NP_001193 (OMIM: 112262,600625,607932) bone morpho ( 408) 255 63.0 1.4e-09
XP_016877092 (OMIM: 112262,600625,607932) PREDICTE ( 408) 255 63.0 1.4e-09
NP_001709 (OMIM: 112266) bone morphogenetic protei ( 513) 251 62.3 3.1e-09
NP_065685 (OMIM: 606522,613702,613703,613704) grow ( 364) 241 60.0 1e-08
NP_001483 (OMIM: 187500,208530,217095,602880,61385 ( 372) 239 59.6 1.4e-08
NP_001710 (OMIM: 112267) bone morphogenetic protei ( 431) 236 59.0 2.4e-08
NP_001001557 (OMIM: 118100,601147,613094,613703,61 ( 455) 232 58.2 4.6e-08
NP_004855 (OMIM: 605312) growth/differentiation fa ( 308) 219 55.3 2.3e-07
NP_878248 (OMIM: 604651) growth/differentiation fa ( 450) 219 55.4 3.1e-07
NP_055297 (OMIM: 608748) bone morphogenetic protei ( 424) 215 54.6 5.3e-07
NP_001192 (OMIM: 112263) bone morphogenetic protei ( 472) 210 53.5 1.2e-06
NP_000548 (OMIM: 112600,113100,200700,201250,22890 ( 501) 208 53.1 1.7e-06
XP_011527377 (OMIM: 112600,113100,200700,201250,22 ( 501) 208 53.1 1.7e-06
NP_001306067 (OMIM: 112600,113100,200700,201250,22 ( 501) 208 53.1 1.7e-06
NP_001316835 (OMIM: 270100,601265) nodal homolog i ( 214) 201 51.4 2.4e-06
NP_060525 (OMIM: 270100,601265) nodal homolog isof ( 347) 201 51.5 3.5e-06
NP_004953 (OMIM: 601361) growth/differentiation fa ( 478) 175 46.1 0.00021
NP_057288 (OMIM: 605120,615506) growth/differentia ( 429) 172 45.5 0.00029
NP_005439 (OMIM: 300247,300510) bone morphogenetic ( 392) 163 43.5 0.001
NP_000470 (OMIM: 261550,600957) muellerian-inhibit ( 560) 158 42.6 0.0028
NP_001165896 (OMIM: 601877) left-right determinati ( 332) 148 40.3 0.0082
NP_003231 (OMIM: 601877) left-right determination ( 366) 148 40.3 0.0089
>>NP_000651 (OMIM: 131300,190180,219700) transforming gr (390 aa)
initn: 2658 init1: 2658 opt: 2658 Z-score: 3045.5 bits: 572.3 E(85289): 6.8e-163
Smith-Waterman score: 2658; 99.7% identity (99.7% similar) in 390 aa overlap (1-390:1-390)
10 20 30 40 50 60
pF1KE1 MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 YDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 TGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 DFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQA
310 320 330 340 350 360
370 380 390
pF1KE1 LEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
::::::::::::::::::::::::::::::
NP_000 LEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
370 380 390
>>XP_011525544 (OMIM: 131300,190180,219700) PREDICTED: t (391 aa)
initn: 1580 init1: 1557 opt: 2646 Z-score: 3031.7 bits: 569.8 E(85289): 4e-162
Smith-Waterman score: 2646; 99.5% identity (99.5% similar) in 391 aa overlap (1-390:1-391)
10 20 30 40 50 60
pF1KE1 MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 YDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWR
130 140 150 160 170 180
190 200 210 220 230
pF1KE1 YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDIN-GF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
XP_011 YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINAGF
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE1 TTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLY
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE1 IDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQ
310 320 330 340 350 360
360 370 380 390
pF1KE1 ALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
:::::::::::::::::::::::::::::::
XP_011 ALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
370 380 390
>>NP_003230 (OMIM: 107970,190230,615582) transforming gr (412 aa)
initn: 1022 init1: 669 opt: 700 Z-score: 802.4 bits: 157.4 E(85289): 5.9e-38
Smith-Waterman score: 1093; 46.3% identity (67.6% similar) in 410 aa overlap (15-390:9-412)
10 20 30 40 50 60
pF1KE1 MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA
:. : .:. . . .:::: :.:. .:.::.:::::::::::::.
NP_003 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLT
10 20 30 40 50
70 80 90 100 110
pF1KE1 SPPSQGEVPPGPLPEAVLALYNSTRD---RVAGESAE--PEPEPEADYYAKEVTRVLMVE
::: . .: :::::::::. .. :: : . . :..:::::. . :..
NP_003 SPPEPTVMTH--VPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQ
60 70 80 90 100 110
120 130 140 150 160
pF1KE1 ---THNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRL----KLKVEQHV
:::. : : ... : :.: ... . : :::.:.::. . . ::..
NP_003 GLAEHNELAVCPKGITSKVFRF-NVSSVEKNRTN---LFRAEFRVLRVPNPSSKRNEQRI
120 130 140 150 160
170 180 190 200 210 220
pF1KE1 ELYQKYSNN----SWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCS
::.: . . ::.... : . :::::::: .::.:: : :...: ::
NP_003 ELFQILRPDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCP
170 180 190 200 210 220
230 240 250 260
pF1KE1 C-------DSRDN---TLQVDINGFTTGR---RGDLATIHGM---NRPFLLLMATPLERA
: : .: .... ..: . ::::. .. . . : :.:: : .:
NP_003 CHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRL
230 240 250 260 270 280
270 280 290 300 310 320
pF1KE1 QH--LQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPC
.. ..:..::::::::: . :.::::: ::::::.::::::.::::::.:::: :::
NP_003 DNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPC
290 300 310 320 330 340
330 340 350 360 370 380
pF1KE1 PYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRS
::. : :: .: ::.::: :: :::.:::::: :::: :.::::: :::::::::.:.:
NP_003 PYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKS
350 360 370 380 390 400
390
pF1KE1 CKCS
::::
NP_003 CKCS
410
>>NP_001316868 (OMIM: 107970,190230,615582) transforming (412 aa)
initn: 1022 init1: 669 opt: 700 Z-score: 802.4 bits: 157.4 E(85289): 5.9e-38
Smith-Waterman score: 1093; 46.3% identity (67.6% similar) in 410 aa overlap (15-390:9-412)
10 20 30 40 50 60
pF1KE1 MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA
:. : .:. . . .:::: :.:. .:.::.:::::::::::::.
NP_001 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLT
10 20 30 40 50
70 80 90 100 110
pF1KE1 SPPSQGEVPPGPLPEAVLALYNSTRD---RVAGESAE--PEPEPEADYYAKEVTRVLMVE
::: . .: :::::::::. .. :: : . . :..:::::. . :..
NP_001 SPPEPTVMTH--VPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQ
60 70 80 90 100 110
120 130 140 150 160
pF1KE1 ---THNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRL----KLKVEQHV
:::. : : ... : :.: ... . : :::.:.::. . . ::..
NP_001 GLAEHNELAVCPKGITSKVFRF-NVSSVEKNRTN---LFRAEFRVLRVPNPSSKRNEQRI
120 130 140 150 160
170 180 190 200 210 220
pF1KE1 ELYQKYSNN----SWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCS
::.: . . ::.... : . :::::::: .::.:: : :...: ::
NP_001 ELFQILRPDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCP
170 180 190 200 210 220
230 240 250 260
pF1KE1 C-------DSRDN---TLQVDINGFTTGR---RGDLATIHGM---NRPFLLLMATPLERA
: : .: .... ..: . ::::. .. . . : :.:: : .:
NP_001 CHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRL
230 240 250 260 270 280
270 280 290 300 310 320
pF1KE1 QH--LQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPC
.. ..:..::::::::: . :.::::: ::::::.::::::.::::::.:::: :::
NP_001 DNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPC
290 300 310 320 330 340
330 340 350 360 370 380
pF1KE1 PYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRS
::. : :: .: ::.::: :: :::.:::::: :::: :.::::: :::::::::.:.:
NP_001 PYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKS
350 360 370 380 390 400
390
pF1KE1 CKCS
::::
NP_001 CKCS
410
>>NP_003229 (OMIM: 190220,614816) transforming growth fa (414 aa)
initn: 1019 init1: 653 opt: 699 Z-score: 801.3 bits: 157.1 E(85289): 6.8e-38
Smith-Waterman score: 1086; 45.1% identity (67.0% similar) in 412 aa overlap (18-390:9-414)
10 20 30 40 50 60
pF1KE1 MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA
.:.: : .::::.:.::. :::::::::::::::.:.
NP_003 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLT
10 20 30 40 50
70 80 90 100 110
pF1KE1 SPPSQGEVP-PGPLPEAVLALYNSTRD----RVAGESAEPEPE-PEADYYAKEVTRVLM-
::: . : : .: :...:::::: ... ..: : : . .:::::: .. :
NP_003 SPPE--DYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMP
60 70 80 90 100
120 130 140 150 160
pF1KE1 --VETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRL---KLKV-EQH
..: : : . : . :..: ... . . : .::.:..:: : .: ::.
NP_003 PFFPSENAIPPTFYRPYFRI-VRFDVSAMEKNASN---LVKAEFRVFRLQNPKARVPEQR
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE1 VELYQ-----KYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAH
.:::: .. . ::...... :::::::: .:..:: . . ::..: :
NP_003 IELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLH
170 180 190 200 210 220
230 240 250 260
pF1KE1 CSC-----------DSRDNTLQV---DINGFTTGRRGDLATIHGMNR------PFLLLMA
: : .... :.. :.: .: :: ::.. . : ::::
NP_003 CPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLML
230 240 250 260 270 280
270 280 290 300 310 320
pF1KE1 TPLERAQHLQSSRHR-RALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANF
: : . :..:.. ::::. ::: ... :::.: :::::..:::::::::::::.:::
NP_003 LPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANF
290 300 310 320 330 340
330 340 350 360 370 380
pF1KE1 CLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSN
: : :::.:: :::.:.::.::: :: :::.:::: : :::: :.::.:. ::.:::::
NP_003 CAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSN
350 360 370 380 390 400
390
pF1KE1 MIVRSCKCS
:::.:::::
NP_003 MIVKSCKCS
410
>>NP_001129071 (OMIM: 190220,614816) transforming growth (442 aa)
initn: 1040 init1: 653 opt: 699 Z-score: 800.9 bits: 157.2 E(85289): 7.2e-38
Smith-Waterman score: 1025; 43.4% identity (63.7% similar) in 424 aa overlap (30-390:21-442)
10 20 30 40 50 60
pF1KE1 MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA
::::.:.::. :::::::::::::::.:.
NP_001 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLT
10 20 30 40 50
70 80 90 100 110
pF1KE1 SPPSQGEVP-PGPLPEAVLALYNSTRD----RVAGESAEPEPE-PEADYYAKEVTRVLM-
::: . : : .: :...:::::: ... ..: : : . .:::::: .. :
NP_001 SPPE--DYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMP
60 70 80 90 100
120 130 140
pF1KE1 ----VETHNEIYDKFKQSTHSI----------YM----------FFNTSELREAVPEPVL
:: . . :. :. :. .: .. .. :
NP_001 PFFPSETVCPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNA
110 120 130 140 150 160
150 160 170 180 190
pF1KE1 --LSRAELRLLRL---KLKV-EQHVELYQ-----KYSNNSWRYLSNRLLAPSDSPEWLSF
: .::.:..:: : .: ::..:::: .. . ::...... :::::
NP_001 SNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSF
170 180 190 200 210 220
200 210 220 230 240
pF1KE1 DVTGVVRQWLSRGGEIEGFRLSAHCSC-----------DSRDNTLQV---DINGFTTGRR
::: .:..:: . . ::..: :: : .... :.. :.: .:
NP_001 DVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTS
230 240 250 260 270 280
250 260 270 280 290
pF1KE1 GDLATIHGMNR------PFLLLMATPLERAQHLQSSRHR-RALDTNYCFSSTEKNCCVRQ
:: ::.. . : :::: : : . :..:.. ::::. ::: ... :::.:
NP_001 GDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRP
290 300 310 320 330 340
300 310 320 330 340 350
pF1KE1 LYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCV
:::::..:::::::::::::.:::: : :::.:: :::.:.::.::: :: :::.::::
NP_001 LYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCV
350 360 370 380 390 400
360 370 380 390
pF1KE1 PQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
: :::: :.::.:. ::.::::::::.:::::
NP_001 SQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS
410 420 430 440
>>NP_001191 (OMIM: 112261,112600,235200) bone morphogene (396 aa)
initn: 269 init1: 114 opt: 327 Z-score: 375.4 bits: 78.3 E(85289): 3.6e-14
Smith-Waterman score: 339; 27.9% identity (53.4% similar) in 427 aa overlap (4-389:3-395)
10 20 30 40 50
pF1KE1 MPPSGLRLLL-LLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRG--------
.: : :: :::: :: : :::: :: .:: : :
NP_001 MVAGTRCLLALLLPQ----VLLGG--AAGLVP------ELGRRKFAAASSGRPSSQPSD
10 20 30 40
60 70 80 90 100
pF1KE1 QILSK--LRLASPPSQGEVPPGPLPEAVLALYN-STRDRVAGESAEPEPEPEADYYAKEV
..::. ::: : . . : : .::. : . : .:. . : :. . . :...
NP_001 EVLSEFELRLLSMFGLKQRPT-PSRDAVVPPYMLDLYRRHSGQPGSPAPDHRLERAASRA
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE1 TRVLMVETHNEIYDKFKQSTHSI--YMFFNTSELREAVPEPVLLSRAELRLLRLKLK---
. : . :.: ... ... . .::: : ..: ... :::...: ...
NP_001 NTVRSFH-HEESLEELPETSGKTTRRFFFNLS----SIPTEEFITSAELQVFREQMQDAL
110 120 130 140 150 160
170 180 190 200 210
pF1KE1 -----VEQHVELYQ---KYSNNSW----RYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRG
......:. . :: : :..::. . : .: ::::: .: .: ..:
NP_001 GNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLVNQNAS-RWESFDVTPAVMRWTAQG
170 180 190 200 210 220
220 230 240 250 260
pF1KE1 GEIEGFRLS-AHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMAT-----PL
.:: . :: . . .: :. . . . : ::.:. .. ::
NP_001 HANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQI----RPLLVTFGHDGKGHPL
230 240 250 260 270
270 280 290 300 310 320
pF1KE1 ERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQ-LYIDFRKDLGWK-WIHEPKGYHANFCL
.. .. :.....: . :. : :. ::.:: .:.::. :: : :::: .:
NP_001 HKREKRQAKHKQR---------KRLKSSCKRHPLYVDF-SDVGWNDWIVAPPGYHAFYCH
280 290 300 310 320
330 340 350 360 370
pF1KE1 GPCPYIWS--LD-TQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYY-VGRKPKVEQL
: ::. . :. :... : .: :. : : :::: : . ..: ..: ...
NP_001 GECPFPLADHLNSTNHAIVQTLVNSVNSKIPKA-CCVPTELSAISMLYLDENEKVVLKNY
330 340 350 360 370 380
380 390
pF1KE1 SNMIVRSCKCS
..:.:..: :
NP_001 QDMVVEGCGCR
390
>>NP_002183 (OMIM: 147290) inhibin beta A chain prepropr (426 aa)
initn: 322 init1: 143 opt: 317 Z-score: 363.5 bits: 76.2 E(85289): 1.6e-13
Smith-Waterman score: 352; 26.6% identity (49.7% similar) in 447 aa overlap (1-390:1-426)
10 20 30 40
pF1KE1 MPPSGLRLLLLLLPLLWLLVL---TPGRP----AAGLSTCKTI----DMELVKRKRIEAI
:: :: .: : :..: ::: : .: :. . . .::.
NP_002 MPLLWLRGFL--LASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAV
10 20 30 40 50
50 60 70 80 90 100
pF1KE1 RGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVT
. .::. :.: . :. . :.:.: :: :. : .:. .: : ....
NP_002 KKHILNMLHLKKRPDVTQ----PVPKA--ALLNAIRKLHVGKVGENGYVEIEDDIGRRAE
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE1 RVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLL-------RLKL
..: .:: ...: . :. : .:. :. :::. :. : .
NP_002 MNELMEQTSEIITFAESGTARKTLHFEIS--KEGSDLSVV-ERAEVWLFLKVPKANRTRT
120 130 140 150 160
170 180 190 200
pF1KE1 KVEQHVELYQKYSNNSWR-----------------YLSNRLLAPSDSPEWLSFDVTGVVR
:: .. ::. ..: ::.... : : : :.. ..
NP_002 KVTIRLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKST-WHVFPVSSSIQ
170 180 190 200 210 220
210 220 230 240 250
pF1KE1 QWLSRGGEIEGFRLSAHCSCDSRDNTLQV-------------DINGFTTGRRGDLATIHG
. :..: :.. . .:. .: . .: : : .
NP_002 RLLDQGKSSLDVRIACE-QCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQ
230 240 250 260 270 280
260 270 280 290 300 310
pF1KE1 MNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWK-WI
.::::.:.: : : :.::.:. : .. . :: .:....: ::.::. ::
NP_002 SHRPFLMLQARQSEDHPH---RRRRRGLE---C-DGKVNICCKKQFFVSF-KDIGWNDWI
290 300 310 320 330
320 330 340 350 360
pF1KE1 HEPKGYHANFCLGPCP-YIWSLDTQ----YSKVLALYNQ--HNPGASAAPCCVPQALEPL
:.:::::.: : :: .: . . . .: :. : . :.: :. :::: :.:.
NP_002 IAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPM
340 350 360 370 380 390
370 380 390
pF1KE1 PIVYYV-GRKPKVEQLSNMIVRSCKCS
..:: :.. ....::::. : ::
NP_002 SMLYYDDGQNIIKKDIQNMIVEECGCS
400 410 420
>>XP_016867665 (OMIM: 147290) PREDICTED: inhibin beta A (426 aa)
initn: 322 init1: 143 opt: 317 Z-score: 363.5 bits: 76.2 E(85289): 1.6e-13
Smith-Waterman score: 352; 26.6% identity (49.7% similar) in 447 aa overlap (1-390:1-426)
10 20 30 40
pF1KE1 MPPSGLRLLLLLLPLLWLLVL---TPGRP----AAGLSTCKTI----DMELVKRKRIEAI
:: :: .: : :..: ::: : .: :. . . .::.
XP_016 MPLLWLRGFL--LASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAV
10 20 30 40 50
50 60 70 80 90 100
pF1KE1 RGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVT
. .::. :.: . :. . :.:.: :: :. : .:. .: : ....
XP_016 KKHILNMLHLKKRPDVTQ----PVPKA--ALLNAIRKLHVGKVGENGYVEIEDDIGRRAE
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE1 RVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLL-------RLKL
..: .:: ...: . :. : .:. :. :::. :. : .
XP_016 MNELMEQTSEIITFAESGTARKTLHFEIS--KEGSDLSVV-ERAEVWLFLKVPKANRTRT
120 130 140 150 160
170 180 190 200
pF1KE1 KVEQHVELYQKYSNNSWR-----------------YLSNRLLAPSDSPEWLSFDVTGVVR
:: .. ::. ..: ::.... : : : :.. ..
XP_016 KVTIRLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKST-WHVFPVSSSIQ
170 180 190 200 210 220
210 220 230 240 250
pF1KE1 QWLSRGGEIEGFRLSAHCSCDSRDNTLQV-------------DINGFTTGRRGDLATIHG
. :..: :.. . .:. .: . .: : : .
XP_016 RLLDQGKSSLDVRIACE-QCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQ
230 240 250 260 270 280
260 270 280 290 300 310
pF1KE1 MNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWK-WI
.::::.:.: : : :.::.:. : .. . :: .:....: ::.::. ::
XP_016 SHRPFLMLQARQSEDHPH---RRRRRGLE---C-DGKVNICCKKQFFVSF-KDIGWNDWI
290 300 310 320 330
320 330 340 350 360
pF1KE1 HEPKGYHANFCLGPCP-YIWSLDTQ----YSKVLALYNQ--HNPGASAAPCCVPQALEPL
:.:::::.: : :: .: . . . .: :. : . :.: :. :::: :.:.
XP_016 IAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPM
340 350 360 370 380 390
370 380 390
pF1KE1 PIVYYV-GRKPKVEQLSNMIVRSCKCS
..:: :.. ....::::. : ::
XP_016 SMLYYDDGQNIIKKDIQNMIVEECGCS
400 410 420
>>XP_016867664 (OMIM: 147290) PREDICTED: inhibin beta A (483 aa)
initn: 293 init1: 143 opt: 317 Z-score: 362.8 bits: 76.2 E(85289): 1.8e-13
Smith-Waterman score: 352; 26.6% identity (49.7% similar) in 447 aa overlap (1-390:58-483)
10 20
pF1KE1 MPPSGLRLLLLLLPLLWLLVL---TPGRP-
:: :: .: : :..: :::
XP_016 KSTHTKKPAREGGGKAGPFKKAITTTFAARMPLLWLRGFL--LASCWIIVRSSPTPGSEG
30 40 50 60 70 80
30 40 50 60 70
pF1KE1 ---AAGLSTCKTI----DMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLA
: .: :. . . .::.. .::. :.: . :. . :.:.: :
XP_016 HSAAPDCPSCALAALPKDVPNSQPEMVEAVKKHILNMLHLKKRPDVTQ----PVPKA--A
90 100 110 120 130
80 90 100 110 120 130
pF1KE1 LYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSE
: :. : .:. .: : .... ..: .:: ...: . :. :
XP_016 LLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESGTARKTLHFEIS-
140 150 160 170 180 190
140 150 160 170 180
pF1KE1 LREAVPEPVLLSRAELRLL-------RLKLKVEQHVELYQKYSNNSWR------------
.:. :. :::. :. : . :: .. ::. ..:
XP_016 -KEGSDLSVV-ERAEVWLFLKVPKANRTRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKG
200 210 220 230 240 250
190 200 210 220 230
pF1KE1 -----YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQV-
::.... : : : :.. ... :..: :.. . .:. .: .
XP_016 ERSELLLSEKVVDARKST-WHVFPVSSSIQRLLDQGKSSLDVRIACE-QCQESGASLVLL
260 270 280 290 300 310
240 250 260 270 280
pF1KE1 ------------DINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDT
.: : : . .::::.:.: : : :.::.:.
XP_016 GKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQSEDHPH---RRRRRGLE-
320 330 340 350 360 370
290 300 310 320 330
pF1KE1 NYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCP-YIWSLDTQ----Y
: .. . :: .:....: ::.::. :: :.:::::.: : :: .: . . . .
XP_016 --C-DGKVNICCKKQFFVSF-KDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFH
380 390 400 410 420
340 350 360 370 380 390
pF1KE1 SKVLALYNQ--HNPGASAAPCCVPQALEPLPIVYYV-GRKPKVEQLSNMIVRSCKCS
: :. : . :.: :. :::: :.:. ..:: :.. ....::::. : ::
XP_016 STVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS
430 440 450 460 470 480
390 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 12:11:48 2016 done: Sun Nov 6 12:11:49 2016
Total Scan time: 9.470 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]