Result of FASTA (omim) for
pFN21AE1813
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1813, 329 aa
1>>>pF1KE1813 329 - 329 aa - 329 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6184+/-0.000426; mu= 13.9177+/- 0.026
mean_var=66.2223+/-13.454, 0's: 0 Z-trim(110.7): 57 B-trim: 443 in 1/52
Lambda= 0.157606
statistics sampled from 19012 (19069) to 19012 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.595), E-opt: 0.2 (0.224), width: 16
Scan time: 5.530
The best scores are: opt bits E(85289)
NP_000387 (OMIM: 265800,601105) cathepsin K prepro ( 329) 2258 522.6 4.5e-148
NP_004070 (OMIM: 116845) cathepsin S isoform 1 pre ( 331) 1226 287.9 2e-77
NP_001244900 (OMIM: 116880) cathepsin L1 isoform 1 ( 333) 1131 266.3 6.3e-71
NP_001903 (OMIM: 116880) cathepsin L1 isoform 1 pr ( 333) 1131 266.3 6.3e-71
NP_666023 (OMIM: 116880) cathepsin L1 isoform 1 pr ( 333) 1131 266.3 6.3e-71
XP_005251773 (OMIM: 116880) PREDICTED: cathepsin L ( 333) 1131 266.3 6.3e-71
NP_001244901 (OMIM: 116880) cathepsin L1 isoform 1 ( 333) 1131 266.3 6.3e-71
NP_001324 (OMIM: 603308) cathepsin L2 preproprotei ( 334) 1130 266.1 7.4e-71
NP_001188504 (OMIM: 603308) cathepsin L2 prepropro ( 334) 1130 266.1 7.4e-71
XP_016869782 (OMIM: 116880) PREDICTED: cathepsin L ( 272) 849 202.2 1.1e-51
XP_011516565 (OMIM: 116880) PREDICTED: cathepsin L ( 272) 849 202.2 1.1e-51
NP_001186668 (OMIM: 116845) cathepsin S isoform 2 ( 281) 804 191.9 1.3e-48
NP_004381 (OMIM: 116820) pro-cathepsin H isoform a ( 335) 803 191.7 1.8e-48
XP_005254238 (OMIM: 116820) PREDICTED: pro-catheps ( 297) 778 186.0 8.3e-47
XP_016877441 (OMIM: 116820) PREDICTED: pro-catheps ( 297) 778 186.0 8.3e-47
XP_016877440 (OMIM: 116820) PREDICTED: pro-catheps ( 317) 778 186.0 8.8e-47
XP_011543630 (OMIM: 603539,615362) PREDICTED: cath ( 424) 587 142.7 1.3e-33
NP_003784 (OMIM: 603539,615362) cathepsin F precur ( 484) 587 142.7 1.5e-33
NP_001244902 (OMIM: 116880) cathepsin L1 isoform 2 ( 151) 569 138.4 9.2e-33
NP_001306066 (OMIM: 116820) pro-cathepsin H isofor ( 201) 481 118.4 1.3e-26
NP_001325 (OMIM: 600550) cathepsin O preproprotein ( 321) 466 115.1 2e-25
NP_001326 (OMIM: 602364) cathepsin W preproprotein ( 376) 380 95.6 1.8e-19
XP_011519578 (OMIM: 116820) PREDICTED: pro-catheps ( 169) 327 83.4 3.7e-16
NP_001805 (OMIM: 170650,245000,245010,602365) dipe ( 463) 286 74.2 5.8e-13
NP_001304166 (OMIM: 116810) cathepsin B isoform 2 ( 215) 226 60.5 3.8e-09
XP_016868590 (OMIM: 116810) PREDICTED: cathepsin B ( 245) 226 60.5 4.3e-09
NP_680093 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 226 60.5 5.7e-09
XP_016868588 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 226 60.5 5.7e-09
XP_006716308 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 226 60.5 5.7e-09
XP_011542114 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 226 60.5 5.7e-09
XP_016868589 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 226 60.5 5.7e-09
XP_006716307 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 226 60.5 5.7e-09
NP_680091 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 226 60.5 5.7e-09
NP_001899 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 226 60.5 5.7e-09
NP_680090 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 226 60.5 5.7e-09
XP_016868587 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 226 60.5 5.7e-09
XP_016868586 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 226 60.5 5.7e-09
NP_680092 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 226 60.5 5.7e-09
XP_005271164 (OMIM: 616064) PREDICTED: tubulointer ( 362) 203 55.3 2.3e-07
NP_001191344 (OMIM: 616064) tubulointerstitial nep ( 362) 203 55.3 2.3e-07
NP_001327 (OMIM: 603169) cathepsin Z preproprotein ( 303) 202 55.1 2.3e-07
XP_005271163 (OMIM: 616064) PREDICTED: tubulointer ( 440) 203 55.4 2.7e-07
NP_071447 (OMIM: 616064) tubulointerstitial nephri ( 467) 203 55.4 2.8e-07
XP_011540248 (OMIM: 616064) PREDICTED: tubulointer ( 408) 200 54.7 4e-07
NP_001191343 (OMIM: 616064) tubulointerstitial nep ( 436) 200 54.7 4.3e-07
XP_016866234 (OMIM: 606749) PREDICTED: tubulointer ( 438) 185 51.3 4.6e-06
>>NP_000387 (OMIM: 265800,601105) cathepsin K preproprot (329 aa)
initn: 2258 init1: 2258 opt: 2258 Z-score: 2779.3 bits: 522.6 E(85289): 4.5e-148
Smith-Waterman score: 2258; 100.0% identity (100.0% similar) in 329 aa overlap (1-329:1-329)
10 20 30 40 50 60
pF1KE1 MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
250 260 270 280 290 300
310 320
pF1KE1 NWGNKGYILMARNKNNACGIANLASFPKM
:::::::::::::::::::::::::::::
NP_000 NWGNKGYILMARNKNNACGIANLASFPKM
310 320
>>NP_004070 (OMIM: 116845) cathepsin S isoform 1 preprop (331 aa)
initn: 1079 init1: 449 opt: 1226 Z-score: 1511.1 bits: 287.9 E(85289): 2e-77
Smith-Waterman score: 1226; 55.5% identity (79.9% similar) in 328 aa overlap (6-329:7-331)
10 20 30 40 50
pF1KE1 MWGLKVLLLPVVSFA-LYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYIS
:::. . : :. . :: ::.:::::. :::..: .: ::::::::::..
NP_004 MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 IHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDS
.:::: :.:.:.:.:.::::::::::::.. :..:.:: . .: . : . . :::
NP_004 LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQR--NITYKSNPNRILPDS
70 80 90 100 110
120 130 140 150 160 170
pF1KE1 VDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE---ND
::.:.:: :: :: ::.::.:::::.:::::.::: :::::..:: :::::: .: :
NP_004 VDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNK
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 GCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKAL
::.::.::.::::. :.::::. .::: .....:.:. .:: : : :.: : : .:
NP_004 GCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE1 KRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIK
:.::: :::::..:: :: .: .::::. :: ..:.::.::.:::: .:...:..:
NP_004 KEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSC-TQNVNHGVLVVGYGDLNGKEYWLVK
240 250 260 270 280 290
300 310 320
pF1KE1 NSWGENWGNKGYILMARNKNNACGIANLASFPKM
::::.:.:..::: :::::.: ::::.. :.:..
NP_004 NSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
300 310 320 330
>>NP_001244900 (OMIM: 116880) cathepsin L1 isoform 1 pre (333 aa)
initn: 887 init1: 321 opt: 1131 Z-score: 1394.3 bits: 266.3 E(85289): 6.3e-71
Smith-Waterman score: 1131; 50.9% identity (76.7% similar) in 330 aa overlap (4-327:7-331)
10 20 30 40 50
pF1KE1 MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYI
: .. : ..: .: .. :...: :: : . :. . .: :: .::::.:.:
NP_001 MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMN-EEGWRRAVWEKNMKMI
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 SIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPD
.:: : : :.. .::: .::::::: : :.:.. . :.. .. : . .::
NP_001 ELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQN--RKPRKGKVFQEPLFY-EAPR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 SVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--ND
:::.:.::::::::::::::::::::..::::::. .:::.:..:: :::::: . :.
NP_001 SVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNE
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 GCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKAL
::.:: : :::::: : :.:::..::: . :::: ::: ..:. :. .::. .::::
NP_001 GCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKAL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE1 KRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQK----GNKH
.::: :::.::::::. :: ::..:.:.. .:.:....:.::.::::... .::.
NP_001 MKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKY
240 250 260 270 280 290
300 310 320
pF1KE1 WIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
:..::::::.:: ::. ::... : ::::. ::.:
NP_001 WLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
300 310 320 330
>>NP_001903 (OMIM: 116880) cathepsin L1 isoform 1 prepro (333 aa)
initn: 887 init1: 321 opt: 1131 Z-score: 1394.3 bits: 266.3 E(85289): 6.3e-71
Smith-Waterman score: 1131; 50.9% identity (76.7% similar) in 330 aa overlap (4-327:7-331)
10 20 30 40 50
pF1KE1 MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYI
: .. : ..: .: .. :...: :: : . :. . .: :: .::::.:.:
NP_001 MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMN-EEGWRRAVWEKNMKMI
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 SIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPD
.:: : : :.. .::: .::::::: : :.:.. . :.. .. : . .::
NP_001 ELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQN--RKPRKGKVFQEPLFY-EAPR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 SVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--ND
:::.:.::::::::::::::::::::..::::::. .:::.:..:: :::::: . :.
NP_001 SVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNE
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 GCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKAL
::.:: : :::::: : :.:::..::: . :::: ::: ..:. :. .::. .::::
NP_001 GCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKAL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE1 KRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQK----GNKH
.::: :::.::::::. :: ::..:.:.. .:.:....:.::.::::... .::.
NP_001 MKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKY
240 250 260 270 280 290
300 310 320
pF1KE1 WIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
:..::::::.:: ::. ::... : ::::. ::.:
NP_001 WLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
300 310 320 330
>>NP_666023 (OMIM: 116880) cathepsin L1 isoform 1 prepro (333 aa)
initn: 887 init1: 321 opt: 1131 Z-score: 1394.3 bits: 266.3 E(85289): 6.3e-71
Smith-Waterman score: 1131; 50.9% identity (76.7% similar) in 330 aa overlap (4-327:7-331)
10 20 30 40 50
pF1KE1 MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYI
: .. : ..: .: .. :...: :: : . :. . .: :: .::::.:.:
NP_666 MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMN-EEGWRRAVWEKNMKMI
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 SIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPD
.:: : : :.. .::: .::::::: : :.:.. . :.. .. : . .::
NP_666 ELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQN--RKPRKGKVFQEPLFY-EAPR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 SVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--ND
:::.:.::::::::::::::::::::..::::::. .:::.:..:: :::::: . :.
NP_666 SVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNE
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 GCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKAL
::.:: : :::::: : :.:::..::: . :::: ::: ..:. :. .::. .::::
NP_666 GCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKAL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE1 KRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQK----GNKH
.::: :::.::::::. :: ::..:.:.. .:.:....:.::.::::... .::.
NP_666 MKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKY
240 250 260 270 280 290
300 310 320
pF1KE1 WIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
:..::::::.:: ::. ::... : ::::. ::.:
NP_666 WLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
300 310 320 330
>>XP_005251773 (OMIM: 116880) PREDICTED: cathepsin L1 is (333 aa)
initn: 887 init1: 321 opt: 1131 Z-score: 1394.3 bits: 266.3 E(85289): 6.3e-71
Smith-Waterman score: 1131; 50.9% identity (76.7% similar) in 330 aa overlap (4-327:7-331)
10 20 30 40 50
pF1KE1 MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYI
: .. : ..: .: .. :...: :: : . :. . .: :: .::::.:.:
XP_005 MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMN-EEGWRRAVWEKNMKMI
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 SIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPD
.:: : : :.. .::: .::::::: : :.:.. . :.. .. : . .::
XP_005 ELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQN--RKPRKGKVFQEPLFY-EAPR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 SVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--ND
:::.:.::::::::::::::::::::..::::::. .:::.:..:: :::::: . :.
XP_005 SVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNE
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 GCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKAL
::.:: : :::::: : :.:::..::: . :::: ::: ..:. :. .::. .::::
XP_005 GCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKAL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE1 KRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQK----GNKH
.::: :::.::::::. :: ::..:.:.. .:.:....:.::.::::... .::.
XP_005 MKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKY
240 250 260 270 280 290
300 310 320
pF1KE1 WIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
:..::::::.:: ::. ::... : ::::. ::.:
XP_005 WLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
300 310 320 330
>>NP_001244901 (OMIM: 116880) cathepsin L1 isoform 1 pre (333 aa)
initn: 887 init1: 321 opt: 1131 Z-score: 1394.3 bits: 266.3 E(85289): 6.3e-71
Smith-Waterman score: 1131; 50.9% identity (76.7% similar) in 330 aa overlap (4-327:7-331)
10 20 30 40 50
pF1KE1 MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYI
: .. : ..: .: .. :...: :: : . :. . .: :: .::::.:.:
NP_001 MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMN-EEGWRRAVWEKNMKMI
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 SIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPD
.:: : : :.. .::: .::::::: : :.:.. . :.. .. : . .::
NP_001 ELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQN--RKPRKGKVFQEPLFY-EAPR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 SVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--ND
:::.:.::::::::::::::::::::..::::::. .:::.:..:: :::::: . :.
NP_001 SVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNE
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 GCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKAL
::.:: : :::::: : :.:::..::: . :::: ::: ..:. :. .::. .::::
NP_001 GCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKAL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE1 KRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQK----GNKH
.::: :::.::::::. :: ::..:.:.. .:.:....:.::.::::... .::.
NP_001 MKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKY
240 250 260 270 280 290
300 310 320
pF1KE1 WIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
:..::::::.:: ::. ::... : ::::. ::.:
NP_001 WLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
300 310 320 330
>>NP_001324 (OMIM: 603308) cathepsin L2 preproprotein [H (334 aa)
initn: 1121 init1: 447 opt: 1130 Z-score: 1393.1 bits: 266.1 E(85289): 7.4e-71
Smith-Waterman score: 1130; 50.6% identity (76.5% similar) in 332 aa overlap (4-329:7-334)
10 20 30 40 50
pF1KE1 MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYI
: .. : ..: . .. :::.: :: :::. :. . .: :: .::::.:.:
NP_001 MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGAN-EEGWRRAVWEKNMKMI
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 SIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPD
.:: : : : : . .::: .::::.:: : : .. .. :.. .. : . :
NP_001 ELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRN--QKFRKGKVFREPLFLD-LPK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 SVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--ND
:::.:::::::::::: :::::::::..::::::. .:::::..:: :::::: :.
NP_001 SVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQ
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 GCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKAL
::.::.:. :::::..: :.:::..::::. .: : : : ...:. :. . :.::::
NP_001 GCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKAL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE1 KRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGN----KH
.::: :::.:::.::. .:::::..:.:.. .:.: ::.:.::.::::.. .: :.
NP_001 MKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKY
240 250 260 270 280 290
300 310 320
pF1KE1 WIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
:..::::: .::..::. .:..::: ::::. ::.:..
NP_001 WLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
300 310 320 330
>>NP_001188504 (OMIM: 603308) cathepsin L2 preproprotein (334 aa)
initn: 1121 init1: 447 opt: 1130 Z-score: 1393.1 bits: 266.1 E(85289): 7.4e-71
Smith-Waterman score: 1130; 50.6% identity (76.5% similar) in 332 aa overlap (4-329:7-334)
10 20 30 40 50
pF1KE1 MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYI
: .. : ..: . .. :::.: :: :::. :. . .: :: .::::.:.:
NP_001 MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGAN-EEGWRRAVWEKNMKMI
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 SIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPD
.:: : : : : . .::: .::::.:: : : .. .. :.. .. : . :
NP_001 ELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRN--QKFRKGKVFREPLFLD-LPK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 SVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--ND
:::.:::::::::::: :::::::::..::::::. .:::::..:: :::::: :.
NP_001 SVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQ
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 GCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKAL
::.::.:. :::::..: :.:::..::::. .: : : : ...:. :. . :.::::
NP_001 GCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKAL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE1 KRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGN----KH
.::: :::.:::.::. .:::::..:.:.. .:.: ::.:.::.::::.. .: :.
NP_001 MKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKY
240 250 260 270 280 290
300 310 320
pF1KE1 WIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
:..::::: .::..::. .:..::: ::::. ::.:..
NP_001 WLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
300 310 320 330
>>XP_016869782 (OMIM: 116880) PREDICTED: cathepsin L1 is (272 aa)
initn: 811 init1: 321 opt: 849 Z-score: 1049.2 bits: 202.2 E(85289): 1.1e-51
Smith-Waterman score: 849; 51.7% identity (74.5% similar) in 263 aa overlap (4-263:7-264)
10 20 30 40 50
pF1KE1 MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYI
: .. : ..: .: .. :...: :: : . :. . .: :: .::::.:.:
XP_016 MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMN-EEGWRRAVWEKNMKMI
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 SIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPD
.:: : : :.. .::: .::::::: : :.:.. . :.. .. : . .::
XP_016 ELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQN--RKPRKGKVFQEPLFY-EAPR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 SVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--ND
:::.:.::::::::::::::::::::..::::::. .:::.:..:: :::::: . :.
XP_016 SVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNE
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 GCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKAL
::.:: : :::::: : :.:::..::: . :::: ::: ..:. :. .::. .::::
XP_016 GCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKAL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE1 KRAVARVGPVSVAIDASLTSFQFYSK-GVYYDESCNSDNLNHAVLAVGYGIQKGNKHWII
.::: :::.::::::. :: ::.. ::
XP_016 MKAVATVGPISVAIDAGHESFLFYKEAGVKNGAWVAT
240 250 260 270
329 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 18:55:16 2016 done: Sun Nov 6 18:55:17 2016
Total Scan time: 5.530 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]