Result of FASTA (omim) for
pFN21AE1775
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1775, 282 aa
1>>>pF1KE1775 282 - 282 aa - 282 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5064+/-0.000297; mu= 15.0932+/- 0.019
mean_var=78.0973+/-15.878, 0's: 0 Z-trim(118.3): 7 B-trim: 0 in 0/53
Lambda= 0.145130
statistics sampled from 31074 (31081) to 31074 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.726), E-opt: 0.2 (0.364), width: 16
Scan time: 7.790
The best scores are: opt bits E(85289)
NP_002677 (OMIM: 171190) phenylethanolamine N-meth ( 282) 1928 412.6 4.3e-115
XP_011523211 (OMIM: 171190) PREDICTED: phenylethan ( 184) 1250 270.5 1.6e-72
NP_006765 (OMIM: 604854) indolethylamine N-methylt ( 263) 602 134.9 1.5e-31
NP_001186148 (OMIM: 604854) indolethylamine N-meth ( 262) 593 133.0 5.6e-31
NP_006160 (OMIM: 600008) nicotinamide N-methyltran ( 264) 592 132.8 6.5e-31
>>NP_002677 (OMIM: 171190) phenylethanolamine N-methyltr (282 aa)
initn: 1928 init1: 1928 opt: 1928 Z-score: 2187.3 bits: 412.6 E(85289): 4.3e-115
Smith-Waterman score: 1928; 100.0% identity (100.0% similar) in 282 aa overlap (1-282:1-282)
10 20 30 40 50 60
pF1KE1 MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 FNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVR
190 200 210 220 230 240
250 260 270 280
pF1KE1 EALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
::::::::::::::::::::::::::::::::::::::::::
NP_002 EALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
250 260 270 280
>>XP_011523211 (OMIM: 171190) PREDICTED: phenylethanolam (184 aa)
initn: 1250 init1: 1250 opt: 1250 Z-score: 1422.8 bits: 270.5 E(85289): 1.6e-72
Smith-Waterman score: 1250; 100.0% identity (100.0% similar) in 184 aa overlap (99-282:1-184)
70 80 90 100 110 120
pF1KE1 EVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQ
::::::::::::::::::::::::::::::
XP_011 MTDFLEVNRQELGRWLQEEPGAFNWSMYSQ
10 20 30
130 140 150 160 170 180
pF1KE1 HACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVS
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE1 PDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGY
100 110 120 130 140 150
250 260 270 280
pF1KE1 KVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
::::::::::::::::::::::::::::::::::
XP_011 KVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
160 170 180
>>NP_006765 (OMIM: 604854) indolethylamine N-methyltrans (263 aa)
initn: 566 init1: 429 opt: 602 Z-score: 687.3 bits: 134.9 E(85289): 1.5e-31
Smith-Waterman score: 602; 39.2% identity (70.6% similar) in 255 aa overlap (27-279:11-259)
10 20 30 40 50
pF1KE1 MSGADRSPNAGAAPDSAPGQAAVASAYQR-FEPRAYLRNNYAPPRGDLCNPNGVGPWKLR
::. : :: :: . :. :. . ..:.
NP_006 MKGGFTGGDEYQKHFLPRDYLATYYSFD-GSPSPEAEMLKFNLE
10 20 30 40
60 70 80 90 100 110
pF1KE1 CLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPG
:: .::. : ..: ::::::::::.::.:.::. :.:::..:: . ::.:: .::..:::
NP_006 CLHKTFGPGGLQGDTLIDIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPG
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE1 AFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLP-ADAL
:..:. . :: .::.. :..::..::: ::::: ::: .:: .:: :: :: .
NP_006 AYDWTPAVKFACELEGNSGRWEEKEEKLRAAVKRVLKCDVHLGNPL---APAVLPLADCV
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE1 VSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEE
.. . .: . .: ... :: ....::.:::::. .:. :..:. ... : . .::
NP_006 LTLLAMECACCSLDAYRAALCNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKEE
170 180 190 200 210 220
240 250 260 270 280
pF1KE1 VREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
:..:.. .:. ...: . . ..... :: : :.:
NP_006 VEQAVLDAGFDIEQLLHSPQSYSVTNAANN--GVCFIVARKKPGP
230 240 250 260
>>NP_001186148 (OMIM: 604854) indolethylamine N-methyltr (262 aa)
initn: 525 init1: 388 opt: 593 Z-score: 677.1 bits: 133.0 E(85289): 5.6e-31
Smith-Waterman score: 593; 39.2% identity (70.6% similar) in 255 aa overlap (27-279:11-258)
10 20 30 40 50
pF1KE1 MSGADRSPNAGAAPDSAPGQAAVASAYQR-FEPRAYLRNNYAPPRGDLCNPNGVGPWKLR
::. : :: :: . :. :. . ..:.
NP_001 MKGGFTGGDEYQKHFLPRDYLATYYSFD-GSPSPEAEMLKFNLE
10 20 30 40
60 70 80 90 100 110
pF1KE1 CLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPG
:: .::. : ..: ::::::::::.::.:.::. :.:::..:: . ::.:: .::..:::
NP_001 CLHKTFGPG-LQGDTLIDIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPG
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE1 AFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLP-ADAL
:..:. . :: .::.. :..::..::: ::::: ::: .:: .:: :: :: .
NP_001 AYDWTPAVKFACELEGNSGRWEEKEEKLRAAVKRVLKCDVHLGNPL---APAVLPLADCV
110 120 130 140 150
180 190 200 210 220 230
pF1KE1 VSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEE
.. . .: . .: ... :: ....::.:::::. .:. :..:. ... : . .::
NP_001 LTLLAMECACCSLDAYRAALCNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKEE
160 170 180 190 200 210
240 250 260 270 280
pF1KE1 VREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
:..:.. .:. ...: . . ..... :: : :.:
NP_001 VEQAVLDAGFDIEQLLHSPQSYSVTNAANN--GVCFIVARKKPGP
220 230 240 250 260
>>NP_006160 (OMIM: 600008) nicotinamide N-methyltransfer (264 aa)
initn: 583 init1: 345 opt: 592 Z-score: 675.9 bits: 132.8 E(85289): 6.5e-31
Smith-Waterman score: 592; 39.7% identity (68.7% similar) in 252 aa overlap (30-280:15-260)
10 20 30 40 50
pF1KE1 MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNG-VGPWKLR
:.:: ::.. : :. . .. . :.
NP_006 MESGFTSKDTYLSHFNPRDYLEKYY--KFGSRHSAESQILKHLLK
10 20 30 40
60 70 80 90 100 110
pF1KE1 CLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPG
: . : :.: :::::::::.::::::: :..:..::. . : ::: .::..::
NP_006 NLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPE
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE1 AFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALV
::.:: ..: .::. .::..:: ::.:: :: : ::::: : : ::: ..
NP_006 AFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGA-VPLP-PADCVL
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE1 SAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEV
:..::.:. ::: .. ::: .. .::.::: :... ::. :.:. :: ... .:...: :
NP_006 STLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAV
170 180 190 200 210 220
240 250 260 270 280
pF1KE1 REALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
. :. ..:: .. .. .. .. . . .:.: :.:.
NP_006 EAAVKEAGYTIEWFE--VISQSYSSTMANNEGLFSLVARKLSRPL
230 240 250 260
282 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 13:51:02 2016 done: Sun Nov 6 13:51:04 2016
Total Scan time: 7.790 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]