FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE1759, 263 aa
  1>>>pF1KE1759 263 - 263 aa - 263 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.7318+/-0.000307; mu= 17.9607+/- 0.019
 mean_var=63.2616+/-12.279, 0's: 0 Z-trim(116.4): 5  B-trim: 90 in 1/53
 Lambda= 0.161252
 statistics sampled from 27603 (27608) to 27603 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.716), E-opt: 0.2 (0.324), width:  16
 Scan time:  6.950

The best scores are:                                      opt bits E(85289)
NP_006765 (OMIM: 604854) indolethylamine N-methylt ( 263) 1778 421.9  6e-118
NP_001186148 (OMIM: 604854) indolethylamine N-meth ( 262) 1758 417.2 1.5e-116
NP_006160 (OMIM: 600008) nicotinamide N-methyltran ( 264)  887 214.6 1.5e-55
NP_002677 (OMIM: 171190) phenylethanolamine N-meth ( 282)  590 145.5   1e-34
XP_011523211 (OMIM: 171190) PREDICTED: phenylethan ( 184)  388 98.4   1e-20


>>NP_006765 (OMIM: 604854) indolethylamine N-methyltrans  (263 aa)
 initn: 1778 init1: 1778 opt: 1778  Z-score: 2238.5  bits: 421.9 E(85289): 6e-118
Smith-Waterman score: 1778; 99.2% identity (99.2% similar) in 263 aa overlap (1-263:1-263)

               10        20        30        40        50        60
pF1KE1 MKGGFTGGDEYQKHFLPRDYLATYYSFDGSPSPEAEMLKFNLECLHKTFGPGGLQGDTLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MKGGFTGGDEYQKHFLPRDYLATYYSFDGSPSPEAEMLKFNLECLHKTFGPGGLQGDTLI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 DIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPGAYDWTPAVKFACELEGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPGAYDWTPAVKFACELEGN
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 SGRWEEKEEKLRAAVKRVLKCDVHLGNPLAPAVLPLADCVLTLLAMECACCSLDAYRAAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SGRWEEKEEKLRAAVKRVLKCDVHLGNPLAPAVLPLADCVLTLLAMECACCSLDAYRAAL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE1 CNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKGEVEQAVLDAGFDIEQLLHSPQ
       :::::::::::::::::::::::::::::::::::::: :::::::::::::::::::::
NP_006 CNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKEEVEQAVLDAGFDIEQLLHSPQ
              190       200       210       220       230       240

              250       260   
pF1KE1 SYSVTNAANNGVCCIVARKKPGP
       ::::::::::::: :::::::::
NP_006 SYSVTNAANNGVCFIVARKKPGP
              250       260   

>>NP_001186148 (OMIM: 604854) indolethylamine N-methyltr  (262 aa)
 initn: 1405 init1: 1405 opt: 1758  Z-score: 2213.4  bits: 417.2 E(85289): 1.5e-116
Smith-Waterman score: 1758; 98.9% identity (98.9% similar) in 263 aa overlap (1-263:1-262)

               10        20        30        40        50        60
pF1KE1 MKGGFTGGDEYQKHFLPRDYLATYYSFDGSPSPEAEMLKFNLECLHKTFGPGGLQGDTLI
       :::::::::::::::::::::::::::::::::::::::::::::::::::: :::::::
NP_001 MKGGFTGGDEYQKHFLPRDYLATYYSFDGSPSPEAEMLKFNLECLHKTFGPG-LQGDTLI
               10        20        30        40        50          

               70        80        90       100       110       120
pF1KE1 DIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPGAYDWTPAVKFACELEGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPGAYDWTPAVKFACELEGN
      60        70        80        90       100       110         

              130       140       150       160       170       180
pF1KE1 SGRWEEKEEKLRAAVKRVLKCDVHLGNPLAPAVLPLADCVLTLLAMECACCSLDAYRAAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGRWEEKEEKLRAAVKRVLKCDVHLGNPLAPAVLPLADCVLTLLAMECACCSLDAYRAAL
     120       130       140       150       160       170         

              190       200       210       220       230       240
pF1KE1 CNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKGEVEQAVLDAGFDIEQLLHSPQ
       :::::::::::::::::::::::::::::::::::::: :::::::::::::::::::::
NP_001 CNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKEEVEQAVLDAGFDIEQLLHSPQ
     180       190       200       210       220       230         

              250       260   
pF1KE1 SYSVTNAANNGVCCIVARKKPGP
       ::::::::::::: :::::::::
NP_001 SYSVTNAANNGVCFIVARKKPGP
     240       250       260  

>>NP_006160 (OMIM: 600008) nicotinamide N-methyltransfer  (264 aa)
 initn: 884 init1: 884 opt: 887  Z-score: 1118.2  bits: 214.6 E(85289): 1.5e-55
Smith-Waterman score: 887; 52.9% identity (74.1% similar) in 263 aa overlap (1-263:1-263)

               10        20        30        40        50        60
pF1KE1 MKGGFTGGDEYQKHFLPRDYLATYYSFDGSPSPEAEMLKFNLECLHKTFGPGGLQGDTLI
       :..:::. : : .:: :::::  ::.: .  : :...::  :. : : :   :..:: ::
NP_006 MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 DIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPGAYDWTPAVKFACELEGN
       ::::::::::.:.::.::..:...:..:.: .:::::::::: :.::.:.: ..:.::::
NP_006 DIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGN
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 SGRWEEKEEKLRAAVKRVLKCDVHLGNPLAPAVLPLADCVLTLLAMECACCSLDAYRAAL
         .  ::::::: :::.::::::  ..::. . :: :::::. : .. :: .: .:  ::
NP_006 RVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRAL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE1 CNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKGEVEQAVLDAGFDIEQLLHSPQ
        ::.::::::: ::   .:.   ::.:...:: . : .  :: :: .::. :: .    :
NP_006 RNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQ
              190       200       210       220       230       240

              250       260    
pF1KE1 SYSVTNAANNGVCCIVARKKPGP 
       ::: : : :.:.  .::::   : 
NP_006 SYSSTMANNEGLFSLVARKLSRPL
              250       260    

>>NP_002677 (OMIM: 171190) phenylethanolamine N-methyltr  (282 aa)
 initn: 576 init1: 429 opt: 590  Z-score: 744.4  bits: 145.5 E(85289): 1e-34
Smith-Waterman score: 590; 41.0% identity (72.5% similar) in 229 aa overlap (11-235:27-253)

                               10        20         30        40   
pF1KE1                 MKGGFTGGDEYQKHFLPRDYLATYYSFD-GSPSPEAEMLKFNLE
                                 ::. : :: :: . :.   :.      .  ..:.
NP_002 MSGADRSPNAGAAPDSAPGQAAVASAYQR-FEPRAYLRNNYAPPRGDLCNPNGVGPWKLR
               10        20         30        40        50         

            50        60        70        80        90       100   
pF1KE1 CLHKTFGPGGLQGDTLIDIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPG
       :: .::. : ..: ::::::::::.::.:.::. :.:::..:: . ::.:: .::..:::
NP_002 CLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPG
      60        70        80        90       100       110         

           110       120       130       140          150       160
pF1KE1 AYDWTPAVKFACELEGNSGRWEEKEEKLRAAVKRVLKCDVHLGNPL---APAVLPLADCV
       :..:.   . :: .::..  :..::..::: :::::  :::  .::   .:: :: :: .
NP_002 AFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLP-ADAL
     120       130       140       150       160       170         

              170       180       190       200       210       220
pF1KE1 LTLLAMECACCSLDAYRAALCNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKGE
       .. . .: .  .: ... :: ....::.:::::.   .:.   :..:. ... : . . :
NP_002 VSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEE
      180       190       200       210       220       230        

              230       240       250       260    
pF1KE1 VEQAVLDAGFDIEQLLHSPQSYSVTNAANNGVCCIVARKKPGP 
       :..:.. .:. ...:                             
NP_002 VREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
      240       250       260       270       280  

>>XP_011523211 (OMIM: 171190) PREDICTED: phenylethanolam  (184 aa)
 initn: 374 init1: 246 opt: 388  Z-score: 493.0  bits: 98.4 E(85289): 1e-20
Smith-Waterman score: 388; 37.8% identity (73.1% similar) in 156 aa overlap (83-235:1-155)

             60        70        80        90       100       110  
pF1KE1 GLQGDTLIDIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPGAYDWTPAVK
                                     ..:: . ::.:: .::..::::..:.   .
XP_011                               MTDFLEVNRQELGRWLQEEPGAFNWSMYSQ
                                             10        20        30

            120       130       140          150       160         
pF1KE1 FACELEGNSGRWEEKEEKLRAAVKRVLKCDVHLGNPL---APAVLPLADCVLTLLAMECA
        :: .::..  :..::..::: :::::  :::  .::   .:: :: :: ... . .: .
XP_011 HACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLP-ADALVSAFCLEAV
               40        50        60        70         80         

     170       180       190       200       210       220         
pF1KE1 CCSLDAYRAALCNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKGEVEQAVLDAG
         .: ... :: ....::.:::::.   .:.   :..:. ... : . . ::..:.. .:
XP_011 SPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSG
      90       100       110       120       130       140         

     230       240       250       260    
pF1KE1 FDIEQLLHSPQSYSVTNAANNGVCCIVARKKPGP 
       . ...:                             
XP_011 YKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
     150       160       170       180    




263 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sun Nov  6 16:25:15 2016 done: Sun Nov  6 16:25:17 2016
 Total Scan time:  6.950 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]