Result of FASTA (omim) for
pFN21AE1751
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1751, 254 aa
1>>>pF1KE1751 254 - 254 aa - 254 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9688+/-0.000271; mu= 17.9017+/- 0.017
mean_var=74.4412+/-14.787, 0's: 0 Z-trim(120.9): 5 B-trim: 0 in 0/55
Lambda= 0.148651
statistics sampled from 36855 (36860) to 36855 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.765), E-opt: 0.2 (0.432), width: 16
Scan time: 8.190
The best scores are: opt bits E(85289)
NP_003802 (OMIM: 606182) tumor necrosis factor lig ( 254) 1681 368.8 5.3e-102
NP_003798 (OMIM: 604520) tumor necrosis factor lig ( 240) 162 43.0 0.00059
XP_016882906 (OMIM: 604520) PREDICTED: tumor necro ( 240) 162 43.0 0.00059
NP_742011 (OMIM: 604520) tumor necrosis factor lig ( 204) 151 40.6 0.0027
>>NP_003802 (OMIM: 606182) tumor necrosis factor ligand (254 aa)
initn: 1681 init1: 1681 opt: 1681 Z-score: 1952.2 bits: 368.8 E(85289): 5.3e-102
Smith-Waterman score: 1681; 100.0% identity (100.0% similar) in 254 aa overlap (1-254:1-254)
10 20 30 40 50 60
pF1KE1 MEYASDASLDPEAPWPPAPRARACRVLPWALVAGLLLLLLLAAACAVFLACPWAVSGARA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MEYASDASLDPEAPWPPAPRARACRVLPWALVAGLLLLLLLAAACAVFLACPWAVSGARA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 SPGSAASPRLREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SPGSAASPRLREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 TGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRV
190 200 210 220 230 240
250
pF1KE1 TPEIPAGLPSPRSE
::::::::::::::
NP_003 TPEIPAGLPSPRSE
250
>>NP_003798 (OMIM: 604520) tumor necrosis factor ligand (240 aa)
initn: 190 init1: 64 opt: 162 Z-score: 192.0 bits: 43.0 E(85289): 0.00059
Smith-Waterman score: 169; 29.5% identity (52.6% similar) in 251 aa overlap (3-240:11-240)
10 20 30 40 50
pF1KE1 MEYASDASLD-PEAPWPPAPRARACRVLPWALVAGLLLLLLLAAACAVFLAC
.. :.. : : . . : ..: : : :. :::::..:. ::
NP_003 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSV---ARVGLGLLLLLMGAGLAV---Q
10 20 30 40 50
60 70 80 90 100
pF1KE1 PWAVSGARASPGSAASPRLREGPELSPDDPAGLLDLRQGMF----AQLVAQNVLLID--G
: . . : .. :: .:: : .. :.. :.. :.:.. : : :
NP_003 GWFLLQLHWRLGEMVT-RLPDGPAGSWEQ---LIQERRSHEVNPAAHLTGANSSLTGSGG
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE1 PLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLAL
:: : .. ::: . ::::.. . :::.::: ::.. ...: : : : .:
NP_003 PLLWETQLGLA---FLRGLSYHDGA--LVVTKAGYYYIYSKVQLGGV--GCPLGLASTIT
120 130 140 150 160
170 180 190 200 210 220
pF1KE1 HLQPLRSAAGAAALALTVDLPPASSEARNSAF-----GFQGRLLHLSAGQRLGVHLHTEA
: :. : : :. ..: .:. .: : ..:: ::... :.. :
NP_003 HGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDER
170 180 190 200 210 220
230 240 250
pF1KE1 RARHAWQLTQGA-TVLGLFRVTPEIPAGLPSPRSE
.: : .:. . .: : :
NP_003 LVR----LRDGTRSYFGAFMV
230 240
>>XP_016882906 (OMIM: 604520) PREDICTED: tumor necrosis (240 aa)
initn: 190 init1: 64 opt: 162 Z-score: 192.0 bits: 43.0 E(85289): 0.00059
Smith-Waterman score: 169; 29.5% identity (52.6% similar) in 251 aa overlap (3-240:11-240)
10 20 30 40 50
pF1KE1 MEYASDASLD-PEAPWPPAPRARACRVLPWALVAGLLLLLLLAAACAVFLAC
.. :.. : : . . : ..: : : :. :::::..:. ::
XP_016 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSV---ARVGLGLLLLLMGAGLAV---Q
10 20 30 40 50
60 70 80 90 100
pF1KE1 PWAVSGARASPGSAASPRLREGPELSPDDPAGLLDLRQGMF----AQLVAQNVLLID--G
: . . : .. :: .:: : .. :.. :.. :.:.. : : :
XP_016 GWFLLQLHWRLGEMVT-RLPDGPAGSWEQ---LIQERRSHEVNPAAHLTGANSSLTGSGG
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE1 PLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLAL
:: : .. ::: . ::::.. . :::.::: ::.. ...: : : : .:
XP_016 PLLWETQLGLA---FLRGLSYHDGA--LVVTKAGYYYIYSKVQLGGV--GCPLGLASTIT
120 130 140 150 160
170 180 190 200 210 220
pF1KE1 HLQPLRSAAGAAALALTVDLPPASSEARNSAF-----GFQGRLLHLSAGQRLGVHLHTEA
: :. : : :. ..: .:. .: : ..:: ::... :.. :
XP_016 HGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDER
170 180 190 200 210 220
230 240 250
pF1KE1 RARHAWQLTQGA-TVLGLFRVTPEIPAGLPSPRSE
.: : .:. . .: : :
XP_016 LVR----LRDGTRSYFGAFMV
230 240
>>NP_742011 (OMIM: 604520) tumor necrosis factor ligand (204 aa)
initn: 135 init1: 64 opt: 151 Z-score: 180.2 bits: 40.6 E(85289): 0.0027
Smith-Waterman score: 151; 30.1% identity (53.2% similar) in 186 aa overlap (71-240:30-204)
50 60 70 80 90
pF1KE1 LAAACAVFLACPWAVSGARASPGSAASPRLREGPELSPDDPAG----LLDLRQGMF----
:.. .. : ::: :.. :..
NP_742 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARDGPAGSWEQLIQERRSHEVNPA
10 20 30 40 50
100 110 120 130 140 150
pF1KE1 AQLVAQNVLLID--GPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELR
:.:.. : : ::: : .. ::: . ::::.. . :::.::: ::.. ...:
NP_742 AHLTGANSSLTGSGGPLLWETQLGLA---FLRGLSYHDGA--LVVTKAGYYYIYSKVQLG
60 70 80 90 100 110
160 170 180 190 200
pF1KE1 RVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAF-----GFQGRLLH
: : : .: : :. : : :. ..: .:. .: : ..:
NP_742 GV--GCPLGLASTITHGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVH
120 130 140 150 160 170
210 220 230 240 250
pF1KE1 LSAGQRLGVHLHTEARARHAWQLTQGA-TVLGLFRVTPEIPAGLPSPRSE
: ::... :.. : .: : .:. . .: : :
NP_742 LEAGEKVVVRVLDERLVR----LRDGTRSYFGAFMV
180 190 200
254 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 13:30:17 2016 done: Sun Nov 6 13:30:18 2016
Total Scan time: 8.190 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]