Result of FASTA (omim) for
pFN21AE1750
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1750, 253 aa
1>>>pF1KE1750 253 - 253 aa - 253 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8591+/-0.000311; mu= 17.7933+/- 0.019
mean_var=72.6246+/-14.671, 0's: 0 Z-trim(117.6): 308 B-trim: 112 in 1/51
Lambda= 0.150499
statistics sampled from 29483 (29800) to 29483 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.727), E-opt: 0.2 (0.349), width: 16
Scan time: 6.430
The best scores are: opt bits E(85289)
NP_001919 (OMIM: 134350,613912) complement factor ( 253) 1744 387.3 1.4e-107
NP_001304264 (OMIM: 134350,613912) complement fact ( 260) 1720 382.1 5.4e-106
NP_005308 (OMIM: 600311) granzyme M isoform 1 prep ( 257) 644 148.4 1.1e-35
NP_002095 (OMIM: 600784) granzyme K precursor [Hom ( 264) 628 145.0 1.3e-34
NP_006135 (OMIM: 140050) granzyme A precursor [Hom ( 262) 621 143.5 3.7e-34
NP_001012982 (OMIM: 602652) kallikrein-6 isoform A ( 244) 605 140.0 3.9e-33
NP_002765 (OMIM: 602652) kallikrein-6 isoform A pr ( 244) 605 140.0 3.9e-33
NP_009127 (OMIM: 605644) kallikrein-8 isoform 1 pr ( 260) 596 138.0 1.6e-32
NP_653088 (OMIM: 605644) kallikrein-8 isoform 2 pr ( 305) 589 136.6 5.1e-32
NP_001245280 (OMIM: 600311) granzyme M isoform 2 [ ( 218) 564 131.0 1.7e-30
NP_056411 (OMIM: 605505) kallikrein-13 precursor [ ( 277) 565 131.3 1.8e-30
NP_002760 (OMIM: 167800,276000,614044) trypsin-1 p ( 247) 564 131.1 1.9e-30
XP_011514713 (OMIM: 167800,276000,614044) PREDICTE ( 472) 566 131.7 2.2e-30
NP_002762 (OMIM: 613578) trypsin-3 isoform 2 prepr ( 247) 553 128.7 9.8e-30
NP_001827 (OMIM: 118938) chymase isoform 1 preprop ( 247) 547 127.4 2.4e-29
NP_031369 (OMIM: 613578) trypsin-3 isoform 1 prepr ( 304) 547 127.5 2.8e-29
NP_001184027 (OMIM: 613578) trypsin-3 isoform 4 pr ( 240) 544 126.7 3.7e-29
NP_001184026 (OMIM: 613578) trypsin-3 isoform 3 pr ( 261) 543 126.5 4.6e-29
NP_071329 (OMIM: 606135) kallikrein-14 preproprote ( 267) 538 125.4 9.9e-29
NP_001298111 (OMIM: 606135) kallikrein-14 prepropr ( 267) 538 125.4 9.9e-29
XP_011516267 (OMIM: 613578) PREDICTED: trypsin-3 i ( 333) 539 125.8 1e-28
NP_219491 (OMIM: 116831) granzyme H isoform 1 prep ( 246) 537 125.2 1.1e-28
NP_001332940 (OMIM: 123910) granzyme B isoform 2 [ ( 235) 533 124.3 1.9e-28
NP_002761 (OMIM: 167800,601564) trypsin-2 isoform ( 247) 530 123.7 3.1e-28
NP_004122 (OMIM: 123910) granzyme B isoform 1 prep ( 247) 528 123.2 4.2e-28
NP_665901 (OMIM: 605539) kallikrein-12 isoform 2 p ( 248) 528 123.2 4.2e-28
NP_001129504 (OMIM: 604434) kallikrein-11 isoform ( 250) 522 121.9 1.1e-27
NP_006844 (OMIM: 604434) kallikrein-11 isoform 1 p ( 250) 522 121.9 1.1e-27
XP_011534801 (OMIM: 116830) PREDICTED: cathepsin G ( 269) 522 122.0 1.1e-27
NP_659196 (OMIM: 604434) kallikrein-11 isoform 2 [ ( 282) 522 122.0 1.1e-27
NP_001902 (OMIM: 116830) cathepsin G preproprotein ( 255) 518 121.1 1.9e-27
NP_005542 (OMIM: 147960) kallikrein-2 isoform 1 pr ( 261) 516 120.7 2.7e-27
NP_001898 (OMIM: 118888) chymotrypsin-like proteas ( 264) 511 119.6 5.7e-27
NP_001182058 (OMIM: 613517,613858) serine protease ( 603) 508 119.3 1.6e-26
NP_004908 (OMIM: 204700,603767) kallikrein-4 isofo ( 254) 500 117.2 2.9e-26
NP_062544 (OMIM: 605539) kallikrein-12 isoform 1 p ( 254) 500 117.2 2.9e-26
NP_001639 (OMIM: 176820) prostate-specific antigen ( 261) 494 115.9 7.3e-26
NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 499 117.4 7.9e-26
NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 499 117.4 7.9e-26
NP_002248 (OMIM: 147910,615953) kallikrein-1 prepr ( 262) 493 115.7 8.6e-26
NP_036447 (OMIM: 605504) kallikrein-9 precursor [H ( 250) 488 114.6 1.8e-25
NP_001897 (OMIM: 118890) chymotrypsinogen B isofor ( 263) 480 112.8 6.1e-25
NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 480 113.1 9e-25
NP_036599 (OMIM: 609341) tryptase gamma preproprot ( 321) 476 112.1 1.3e-24
NP_254275 (OMIM: 609443) chymotrypsin-like elastas ( 269) 474 111.6 1.5e-24
NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 474 111.6 1.8e-24
NP_001962 (OMIM: 130120) chymotrypsin-like elastas ( 258) 472 111.1 2e-24
NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 474 111.8 2.2e-24
XP_011520748 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 472 111.2 2.5e-24
XP_011520749 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 472 111.2 2.5e-24
>>NP_001919 (OMIM: 134350,613912) complement factor D is (253 aa)
initn: 1744 init1: 1744 opt: 1744 Z-score: 2052.2 bits: 387.3 E(85289): 1.4e-107
Smith-Waterman score: 1744; 100.0% identity (100.0% similar) in 253 aa overlap (1-253:1-253)
10 20 30 40 50 60
pF1KE1 MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 RRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTR
190 200 210 220 230 240
250
pF1KE1 VASYAAWIDSVLA
:::::::::::::
NP_001 VASYAAWIDSVLA
250
>>NP_001304264 (OMIM: 134350,613912) complement factor D (260 aa)
initn: 1730 init1: 1623 opt: 1720 Z-score: 2023.9 bits: 382.1 E(85289): 5.4e-106
Smith-Waterman score: 1720; 97.3% identity (97.3% similar) in 260 aa overlap (1-253:1-260)
10 20 30 40 50
pF1KE1 MHSWERLAVLVLLGAAAC-------AAPPRGRILGGREAEAHARPYMASVQLNGAHLCGG
:::::::::::::::::: :::::::::::::::::::::::::::::::::::
NP_001 MHSWERLAVLVLLGAAACGEEAWAWAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGG
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 VLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDH
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 DLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPV
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE1 LDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRK
190 200 210 220 230 240
240 250
pF1KE1 KPGIYTRVASYAAWIDSVLA
::::::::::::::::::::
NP_001 KPGIYTRVASYAAWIDSVLA
250 260
>>NP_005308 (OMIM: 600311) granzyme M isoform 1 prepropr (257 aa)
initn: 513 init1: 237 opt: 644 Z-score: 761.4 bits: 148.4 E(85289): 1.1e-35
Smith-Waterman score: 644; 42.4% identity (68.8% similar) in 250 aa overlap (8-251:7-252)
10 20 30 40 50
pF1KE1 MHSWERLAVLVL-LGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQ
..::: ::: . .. .:.::::. :.::::::.: ::.:::::::: .
NP_005 MEACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPK
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 WVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQP-DTIDHDLLLL
:::.::::: . ......:: :.:..: . . . :. :: .: ....:: ::
NP_005 WVLTAAHCLAQRM-AQLRLVLGLHTLDSPGLT---FHIKAAIQHPRYKPVPALENDLALL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 QLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRAT
::. :. . ..::: . :: :: :..::::.....:: :... : :::
NP_005 QLDGKVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRM
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 CNRRTHHDGAITERLMCAESNRRDS--CKGDSGGPLVCGG--VLEGVVTSGSRVCGNRKK
:: .:... ..: .. .:. :::::::::::: :: ::.. .:::: . :
NP_005 CNNSRFWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFK
180 190 200 210 220 230
240 250
pF1KE1 PGIYTRVASYAAWIDSVLA
: . : :: :..:: .:
NP_005 PPVATAVAPYVSWIRKVTGRSA
240 250
>>NP_002095 (OMIM: 600784) granzyme K precursor [Homo sa (264 aa)
initn: 429 init1: 224 opt: 628 Z-score: 742.4 bits: 145.0 E(85289): 1.3e-34
Smith-Waterman score: 628; 42.7% identity (69.2% similar) in 234 aa overlap (26-252:27-258)
10 20 30 40 50
pF1KE1 MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQ
:.::.:. :.::.:::.: .: :.:::::. :
NP_002 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVLIDPQ
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 WVLSAAHCLEDAADGKVQ-VLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLL
:::.:::: . :. :.:::::::. : ::. .. . .: : ..:..:.
NP_002 WVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDPQSNDIMLV
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 QLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRP-DSLQHVLLPVLDRA
.:. : :. :. : : .. :: : :.::: .. . :: :.:..: . ::.:
NP_002 KLQTAAKLNKHVKMLHI-RSKTSLRSGTKCKVTGWGATDPDSLRPSDTLREVTVTVLSRK
130 140 150 160 170
180 190 200 210 220 230
pF1KE1 TCNRRTHHDGA--ITERLMCA--ESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRK
:: .....: ::. ..:: ....:::::::::::.: ::....: ::.. ::
NP_002 LCNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIV-SGGHECGVAT
180 190 200 210 220 230
240 250
pF1KE1 KPGIYTRVAS-YAAWIDSVLA
:::::: ... : .:: : :
NP_002 KPGIYTLLTKKYQTWIKSNLVPPHTN
240 250 260
>>NP_006135 (OMIM: 140050) granzyme A precursor [Homo sa (262 aa)
initn: 613 init1: 313 opt: 621 Z-score: 734.3 bits: 143.5 E(85289): 3.7e-34
Smith-Waterman score: 621; 41.3% identity (70.4% similar) in 230 aa overlap (25-248:28-254)
10 20 30 40 50
pF1KE1 MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVA
.:.:: :. :.::::. ..:. .:.:.:.:
NP_006 MRNSYRFLASSLSVVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 EQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLL
..:::.:::: . . ::.:::::... ::.:... : . :.: .: : . :: :
NP_006 KDWVLTAAHC---NLNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKL
70 80 90 100 110
120 130 140 150 160 170
pF1KE1 LQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRA
:::.::: .. : : . :: :::.:.::::: ..... :.:..: . ..::
NP_006 LQLTEKAKINKYVTILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITIIDRK
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 TCNRRTHHD--GAITERLMCAESNR--RDSCKGDSGGPLVCGGVLEGVVTSG-SRVCGNR
.:: :.:.. .: ..:: : : ::::.::::.::.: ::..::.. : ::.
NP_006 VCNDRNHYNFNPVIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDP
180 190 200 210 220 230
240 250
pF1KE1 KKPGIYTRVAS-YAAWIDSVLA
. ::.: ... . ::
NP_006 RGPGVYILLSKKHLNWIIMTIKGAV
240 250 260
>>NP_001012982 (OMIM: 602652) kallikrein-6 isoform A pre (244 aa)
initn: 593 init1: 242 opt: 605 Z-score: 715.9 bits: 140.0 E(85289): 3.9e-33
Smith-Waterman score: 605; 39.0% identity (68.1% similar) in 251 aa overlap (5-252:2-241)
10 20 30 40 50 60
pF1KE1 MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW
..: :.. : ::: : ..... : . ..::.:.. .: ::::::. :
NP_001 MKKLMVVLSLIAAA-WAEEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLW
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL
::.:::: . ..::.:: :.: : : :.. .:.::: ::: . . :.:..::.:
NP_001 VLTAAHCKKP----NLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRL
60 70 80 90 100 110
130 140 150 160 170
pF1KE1 SEKATLGPAVRPLPWQRVDRDVAPGTL-CDVAGWGIVNHAGRRPDSLQHVLLPVLDRATC
.. : :. ..::: ..:: . .: : . ::: . : ::..: . . ...: :
NP_001 ARPAKLSELIQPLP---LERDCSANTTSCHILGWGKTAD-GDFPDTIQCAYIHLVSREEC
120 130 140 150 160
180 190 200 210 220 230
pF1KE1 NRRTHHDGAITERLMCA--ESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGI
.. . : ::. ..:: :. .:::.:::::::::: :.:.:. :. ::...:::.
NP_001 EHA--YPGQITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGV
170 180 190 200 210 220
240 250
pF1KE1 YTRVASYAAWIDSVLA
:: : :. ::....
NP_001 YTNVCRYTNWIQKTIQAK
230 240
>>NP_002765 (OMIM: 602652) kallikrein-6 isoform A prepro (244 aa)
initn: 593 init1: 242 opt: 605 Z-score: 715.9 bits: 140.0 E(85289): 3.9e-33
Smith-Waterman score: 605; 39.0% identity (68.1% similar) in 251 aa overlap (5-252:2-241)
10 20 30 40 50 60
pF1KE1 MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW
..: :.. : ::: : ..... : . ..::.:.. .: ::::::. :
NP_002 MKKLMVVLSLIAAA-WAEEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLW
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL
::.:::: . ..::.:: :.: : : :.. .:.::: ::: . . :.:..::.:
NP_002 VLTAAHCKKP----NLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRL
60 70 80 90 100 110
130 140 150 160 170
pF1KE1 SEKATLGPAVRPLPWQRVDRDVAPGTL-CDVAGWGIVNHAGRRPDSLQHVLLPVLDRATC
.. : :. ..::: ..:: . .: : . ::: . : ::..: . . ...: :
NP_002 ARPAKLSELIQPLP---LERDCSANTTSCHILGWGKTAD-GDFPDTIQCAYIHLVSREEC
120 130 140 150 160
180 190 200 210 220 230
pF1KE1 NRRTHHDGAITERLMCA--ESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGI
.. . : ::. ..:: :. .:::.:::::::::: :.:.:. :. ::...:::.
NP_002 EHA--YPGQITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGV
170 180 190 200 210 220
240 250
pF1KE1 YTRVASYAAWIDSVLA
:: : :. ::....
NP_002 YTNVCRYTNWIQKTIQAK
230 240
>>NP_009127 (OMIM: 605644) kallikrein-8 isoform 1 prepro (260 aa)
initn: 545 init1: 246 opt: 596 Z-score: 705.0 bits: 138.0 E(85289): 1.6e-32
Smith-Waterman score: 596; 37.5% identity (66.0% similar) in 256 aa overlap (3-252:11-256)
10 20 30 40 50
pF1KE1 MHSWERLAVLVLLGA-AACAAPPRGRILGGREAEAHARPYMASVQLNGAHLC
.: . .:.: :: :. . . ..:::.: . :..:..:.. . ::
NP_009 MGRPRPRAAKTW--MFLLLLGGAWAGHSRAQEDKVLGGHECQPHSQPWQAALFQGQQLLC
10 20 30 40 50
60 70 80 90 100
pF1KE1 GGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHP---DSQP
:::::. .:::.:::: . : : :: :::.. . .. :....::: .:.
NP_009 GGVLVGGNWVLTAAHCKKP----KYTVRLGDHSLQNKDGPEQEIPVVQSIPHPCYNSSDV
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE1 DTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRR-PDSLQ
. .:::.:::: ..:.:: :.:. .:. . :: : :.::: :. . ::.:.
NP_009 EDHNHDLMLLQLRDQASLGSKVKPISL--ADHCTQPGQKCTVSGWGTVTSPRENFPDTLN
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE1 HVLLPVLDRATCNRRTHHDGAITERLMCAESNR-RDSCKGDSGGPLVCGGVLEGVVTSGS
. . .. . : . . : ::. ..:: :.. :.:.::::::::: :.:.:... ::
NP_009 CAEVKIFPQKKC--EDAYPGQITDGMVCAGSSKGADTCQGDSGGPLVCDGALQGITSWGS
180 190 200 210 220 230
230 240 250
pF1KE1 RVCGNRKKPGIYTRVASYAAWIDSVLA
:: :::.:: . : :: ...
NP_009 DPCGRSDKPGVYTNICRYLDWIKKIIGSKG
240 250 260
>>NP_653088 (OMIM: 605644) kallikrein-8 isoform 2 precur (305 aa)
initn: 531 init1: 246 opt: 589 Z-score: 695.9 bits: 136.6 E(85289): 5.1e-32
Smith-Waterman score: 589; 37.9% identity (66.7% similar) in 243 aa overlap (15-252:67-301)
10 20 30 40
pF1KE1 MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQ
::. . . ..:::.: . :..:..:..
NP_653 ENLPCVHLNPQWPSQPSHCPRGWRSNPLPPAAGHSRAQEDKVLGGHECQPHSQPWQAALF
40 50 60 70 80 90
50 60 70 80 90 100
pF1KE1 LNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHP
. :::::::. .:::.:::: . : : :: :::.. . .. :....:::
NP_653 QGQQLLCGGVLVGGNWVLTAAHCKKP----KYTVRLGDHSLQNKDGPEQEIPVVQSIPHP
100 110 120 130 140 150
110 120 130 140 150 160
pF1KE1 ---DSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGR
.:. . .:::.:::: ..:.:: :.:. . .:. . :: : :.::: :. .
NP_653 CYNSSDVEDHNHDLMLLQLRDQASLGSKVKPI--SLADHCTQPGQKCTVSGWGTVTSPRE
160 170 180 190 200 210
170 180 190 200 210
pF1KE1 R-PDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNR-RDSCKGDSGGPLVCGGVLE
::.:. . . .. . :. . : ::. ..:: :.. :.:.::::::::: :.:.
NP_653 NFPDTLNCAEVKIFPQKKCE--DAYPGQITDGMVCAGSSKGADTCQGDSGGPLVCDGALQ
220 230 240 250 260
220 230 240 250
pF1KE1 GVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
:... :: :: :::.:: . : :: ...
NP_653 GITSWGSDPCGRSDKPGVYTNICRYLDWIKKIIGSKG
270 280 290 300
>>NP_001245280 (OMIM: 600311) granzyme M isoform 2 [Homo (218 aa)
initn: 437 init1: 200 opt: 564 Z-score: 668.4 bits: 131.0 E(85289): 1.7e-30
Smith-Waterman score: 564; 41.9% identity (68.2% similar) in 217 aa overlap (40-251:1-213)
10 20 30 40 50 60
pF1KE1 LVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLE
:::.: ::.:::::::: .:::.:::::
NP_001 MASLQRNGSHLCGGVLVHPKWVLTAAHCLA
10 20 30
70 80 90 100 110 120
pF1KE1 DAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQP-DTIDHDLLLLQLSEKATLGP
. ......:: :.:..: . . . :. :: .: ....:: ::::. :. .
NP_001 QRM-AQLRLVLGLHTLDSPGLT---FHIKAAIQHPRYKPVPALENDLALLQLDGKVKPSR
40 50 60 70 80
130 140 150 160 170 180
pF1KE1 AVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGA
..::: . :: :: :..::::.....:: :... : ::: :: .:.
NP_001 TIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNGS
90 100 110 120 130 140
190 200 210 220 230 240
pF1KE1 ITERLMCAESNRRDS--CKGDSGGPLVCGG--VLEGVVTSGSRVCGNRKKPGIYTRVASY
.. ..: .. .:. :::::::::::: :: ::.. .:::: . :: . : :: :
NP_001 LSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVATAVAPY
150 160 170 180 190 200
250
pF1KE1 AAWIDSVLA
..:: .:
NP_001 VSWIRKVTGRSA
210
253 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 13:37:24 2016 done: Sun Nov 6 13:37:25 2016
Total Scan time: 6.430 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]