Result of FASTA (omim) for
pFN21AE1745
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1745, 247 aa
1>>>pF1KE1745 247 - 247 aa - 247 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1995+/-0.000315; mu= 14.9870+/- 0.019
mean_var=61.9699+/-12.652, 0's: 0 Z-trim(116.6): 281 B-trim: 1313 in 1/53
Lambda= 0.162924
statistics sampled from 27679 (27989) to 27679 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.714), E-opt: 0.2 (0.328), width: 16
Scan time: 6.200
The best scores are: opt bits E(85289)
NP_001827 (OMIM: 118938) chymase isoform 1 preprop ( 247) 1697 407.0 1.6e-113
NP_001295012 (OMIM: 118938) chymase isoform 2 [Hom ( 136) 945 230.1 1.6e-60
NP_001902 (OMIM: 116830) cathepsin G preproprotein ( 255) 855 209.1 6.3e-54
NP_004122 (OMIM: 123910) granzyme B isoform 1 prep ( 247) 832 203.6 2.6e-52
XP_011534801 (OMIM: 116830) PREDICTED: cathepsin G ( 269) 811 198.7 8.5e-51
NP_001332940 (OMIM: 123910) granzyme B isoform 2 [ ( 235) 787 193.1 3.8e-49
NP_219491 (OMIM: 116831) granzyme H isoform 1 prep ( 246) 775 190.2 2.8e-48
XP_011534985 (OMIM: 116831) PREDICTED: granzyme H ( 212) 661 163.4 2.9e-40
NP_002768 (OMIM: 177020) myeloblastin precursor [H ( 256) 565 140.9 2.1e-33
NP_001919 (OMIM: 134350,613912) complement factor ( 253) 547 136.7 3.9e-32
NP_005037 (OMIM: 604438) kallikrein-7 isoform 1 pr ( 253) 546 136.4 4.6e-32
NP_644806 (OMIM: 604438) kallikrein-7 isoform 1 pr ( 253) 546 136.4 4.6e-32
NP_001304264 (OMIM: 134350,613912) complement fact ( 260) 538 134.5 1.7e-31
NP_006135 (OMIM: 140050) granzyme A precursor [Hom ( 262) 528 132.2 8.8e-31
NP_009127 (OMIM: 605644) kallikrein-8 isoform 1 pr ( 260) 504 126.6 4.4e-29
NP_653088 (OMIM: 605644) kallikrein-8 isoform 2 pr ( 305) 504 126.6 5e-29
NP_001298111 (OMIM: 606135) kallikrein-14 prepropr ( 267) 498 125.2 1.2e-28
NP_071329 (OMIM: 606135) kallikrein-14 preproprote ( 267) 498 125.2 1.2e-28
NP_002760 (OMIM: 167800,276000,614044) trypsin-1 p ( 247) 493 124.0 2.5e-28
XP_011514713 (OMIM: 167800,276000,614044) PREDICTE ( 472) 493 124.1 4.4e-28
NP_056411 (OMIM: 605505) kallikrein-13 precursor [ ( 277) 486 122.3 8.7e-28
NP_004908 (OMIM: 204700,603767) kallikrein-4 isofo ( 254) 485 122.1 9.5e-28
NP_001184027 (OMIM: 613578) trypsin-3 isoform 4 pr ( 240) 484 121.8 1.1e-27
NP_002762 (OMIM: 613578) trypsin-3 isoform 2 prepr ( 247) 484 121.8 1.1e-27
NP_001184026 (OMIM: 613578) trypsin-3 isoform 3 pr ( 261) 484 121.9 1.1e-27
NP_031369 (OMIM: 613578) trypsin-3 isoform 1 prepr ( 304) 484 121.9 1.3e-27
NP_002095 (OMIM: 600784) granzyme K precursor [Hom ( 264) 483 121.6 1.4e-27
XP_011516267 (OMIM: 613578) PREDICTED: trypsin-3 i ( 333) 484 121.9 1.4e-27
XP_011526438 (OMIM: 177020) PREDICTED: myeloblasti ( 206) 475 119.7 4e-27
NP_002761 (OMIM: 167800,601564) trypsin-2 isoform ( 247) 454 114.8 1.4e-25
NP_002765 (OMIM: 602652) kallikrein-6 isoform A pr ( 244) 451 114.1 2.3e-25
NP_001012982 (OMIM: 602652) kallikrein-6 isoform A ( 244) 451 114.1 2.3e-25
NP_665901 (OMIM: 605539) kallikrein-12 isoform 2 p ( 248) 449 113.6 3.3e-25
NP_001230055 (OMIM: 604438) kallikrein-7 isoform 3 ( 246) 444 112.4 7.3e-25
NP_006844 (OMIM: 604434) kallikrein-11 isoform 1 p ( 250) 442 112.0 1e-24
NP_001129504 (OMIM: 604434) kallikrein-11 isoform ( 250) 442 112.0 1e-24
NP_659196 (OMIM: 604434) kallikrein-11 isoform 2 [ ( 282) 442 112.0 1.1e-24
NP_036447 (OMIM: 605504) kallikrein-9 precursor [H ( 250) 440 111.5 1.4e-24
NP_005308 (OMIM: 600311) granzyme M isoform 1 prep ( 257) 434 110.1 3.9e-24
NP_001257709 (OMIM: 116831) granzyme H isoform 2 p ( 182) 423 107.4 1.7e-23
NP_001897 (OMIM: 118890) chymotrypsinogen B isofor ( 263) 422 107.3 2.8e-23
NP_001193982 (OMIM: 604438) kallikrein-7 isoform 2 ( 181) 413 105.1 8.8e-23
NP_062544 (OMIM: 605539) kallikrein-12 isoform 1 p ( 254) 412 104.9 1.4e-22
NP_001898 (OMIM: 118888) chymotrypsin-like proteas ( 264) 412 104.9 1.4e-22
NP_000292 (OMIM: 173350,217090) plasminogen isofor ( 810) 417 106.4 1.6e-22
NP_005568 (OMIM: 152200) apolipoprotein(a) precurs (2040) 414 105.9 5.8e-22
NP_001257710 (OMIM: 116831) granzyme H isoform 3 p ( 160) 395 100.8 1.5e-21
NP_036559 (OMIM: 605643) kallikrein-5 preproprotei ( 293) 394 100.7 2.9e-21
XP_011525004 (OMIM: 605643) PREDICTED: kallikrein- ( 293) 394 100.7 2.9e-21
NP_001070959 (OMIM: 605643) kallikrein-5 prepropro ( 293) 394 100.7 2.9e-21
>>NP_001827 (OMIM: 118938) chymase isoform 1 preproprote (247 aa)
initn: 1697 init1: 1697 opt: 1697 Z-score: 2159.0 bits: 407.0 E(85289): 1.6e-113
Smith-Waterman score: 1697; 100.0% identity (100.0% similar) in 247 aa overlap (1-247:1-247)
10 20 30 40 50 60
pF1KE1 MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
190 200 210 220 230 240
pF1KE1 NQILQAN
:::::::
NP_001 NQILQAN
>>NP_001295012 (OMIM: 118938) chymase isoform 2 [Homo sa (136 aa)
initn: 945 init1: 945 opt: 945 Z-score: 1207.6 bits: 230.1 E(85289): 1.6e-60
Smith-Waterman score: 945; 100.0% identity (100.0% similar) in 136 aa overlap (112-247:1-136)
90 100 110 120 130 140
pF1KE1 TEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPG
::::::::::::::::::::::::::::::
NP_001 MLLKLKEKASLTLAVGTLPFPSQFNFVPPG
10 20 30
150 160 170 180 190 200
pF1KE1 RMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKG
40 50 60 70 80 90
210 220 230 240
pF1KE1 DSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
100 110 120 130
>>NP_001902 (OMIM: 116830) cathepsin G preproprotein [Ho (255 aa)
initn: 843 init1: 621 opt: 855 Z-score: 1089.2 bits: 209.1 E(85289): 6.3e-54
Smith-Waterman score: 855; 52.4% identity (77.6% similar) in 246 aa overlap (3-246:1-244)
10 20 30 40 50
pF1KE1 MLLLPLPLLL-FLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRN
. :: ::: ::: . ::::::::: : .::::::::::.: . : :. :::::.:..
NP_001 MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSR-CGGFLVRED
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 FVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEK
:::::::: : .:.:::::::: ..:.: :.. . . .:::.:: :...:::::.:...
NP_001 FVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 ASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSH-F
. . :. . .: . . :: .: ::::::.. .. :.:::.::.::.. . : . :
NP_001 VRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVS-MRRGTDTLREVQLRVQRDRQCLRIF
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 RDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRP
..: :.:::. :. :.:::::::::::: .::.::::::.:.. :: ::::.: . :
NP_001 GSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLP
180 190 200 210 220 230
240
pF1KE1 WINQILQAN
:: ...
NP_001 WIRTTMRSFKLLDQMETPL
240 250
>>NP_004122 (OMIM: 123910) granzyme B isoform 1 prepropr (247 aa)
initn: 839 init1: 426 opt: 832 Z-score: 1060.2 bits: 203.6 E(85289): 2.6e-52
Smith-Waterman score: 832; 53.7% identity (74.8% similar) in 246 aa overlap (3-245:1-245)
10 20 30 40 50
pF1KE1 MLLLPLPLLL-FLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRN
. :. ::: ::: ::.::::::: : ::::::::::: .. .. : ::::::: .
NP_004 MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYL-MIWDQKSLKRCGGFLIRDD
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 FVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEK
:::::::: : ::.:::::::: :.: : : . : . . :: :: ... .:::::.:..:
NP_004 FVLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 ASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQAC-SHF
:. : :: : .::. : ::. : :::::.:. : : ::::::. ... . : : .
NP_004 AKRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDL
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 RDF-DHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYR
: . : ...::::.:. :..:::::::::.: ::::::::::... :: . :..: .
NP_004 RHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFV
180 190 200 210 220 230
240
pF1KE1 PWINQILQAN
::.. ..
NP_004 HWIKKTMKRY
240
>>XP_011534801 (OMIM: 116830) PREDICTED: cathepsin G iso (269 aa)
initn: 820 init1: 620 opt: 811 Z-score: 1032.9 bits: 198.7 E(85289): 8.5e-51
Smith-Waterman score: 817; 49.6% identity (73.5% similar) in 260 aa overlap (3-246:1-258)
10 20 30 40
pF1KE1 MLLLPLPLLL-FLLCSRAEAG--------------EIIGGTECKPHSRPYMAYLEIVTSN
. :: ::: ::: . :::: ::::: : .::::::::::.: .
XP_011 MQPLLLLLAFLLPTGAEAGSASIELSAKCFLPGEIIGGRESRPHSRPYMAYLQIQSPA
10 20 30 40 50
50 60 70 80 90 100
pF1KE1 GPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTS
: :. :::::.:..:::::::: : .:.:::::::: ..:.: :.. . . .:::.::
XP_011 GQSR-CGGFLVREDFVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQR
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE1 TLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEV
:...:::::.:.... . :. . .: . . :: .: ::::::.. .. :.:::.::
XP_011 TIQNDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVS-MRRGTDTLREV
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE1 KLRLMDPQACSH-FRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDA
.::.. . : . : ..: :.:::. :. :.:::::::::::: .::.::::::.:..
XP_011 QLRVQRDRQCLRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSG
180 190 200 210 220 230
230 240
pF1KE1 KPPAVFTRISHYRPWINQILQAN
:: ::::.: . ::: ...
XP_011 VPPEVFTRVSSFLPWIRTTMRSFKLLDQMETPL
240 250 260
>>NP_001332940 (OMIM: 123910) granzyme B isoform 2 [Homo (235 aa)
initn: 797 init1: 426 opt: 787 Z-score: 1003.3 bits: 193.1 E(85289): 3.8e-49
Smith-Waterman score: 787; 53.3% identity (75.1% similar) in 229 aa overlap (19-245:6-233)
10 20 30 40 50 60
pF1KE1 MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
.:::::: : ::::::::::: .. .. : ::::::: .:
NP_001 MQTFPSGEIIGGHEAKPHSRPYMAYL-MIWDQKSLKRCGGFLIRDDF
10 20 30 40
70 80 90 100 110 120
pF1KE1 VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
::::::: : ::.:::::::: :.: : : . : . . :: :: ... .:::::.:..::
NP_001 VLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKA
50 60 70 80 90 100
130 140 150 160 170
pF1KE1 SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQAC-SHFR
. : :: : .::. : ::. : :::::.:. : : ::::::. ... . : : .:
NP_001 KRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLR
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE1 DF-DHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRP
. : ...::::.:. :..:::::::::.: ::::::::::... :: . :..: .
NP_001 HYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVH
170 180 190 200 210 220
240
pF1KE1 WINQILQAN
::.. ..
NP_001 WIKKTMKRY
230
>>NP_219491 (OMIM: 116831) granzyme H isoform 1 prepropr (246 aa)
initn: 637 init1: 374 opt: 775 Z-score: 987.8 bits: 190.2 E(85289): 2.8e-48
Smith-Waterman score: 775; 48.4% identity (74.4% similar) in 246 aa overlap (3-245:1-244)
10 20 30 40 50
pF1KE1 MLLLPLPLLL-FLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRN
. :. ::: ::: : . ::::: : :::::::::..... .. : :::.:.:..
NP_219 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKS-RKRCGGILVRKD
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 FVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEK
:::::::: : ::.:::::::: :.: : : . : . . :: :: ... .:::::.:..:
NP_219 FVLTAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 ASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFR
:. : :: : .::. : ::..: ::::: .. .. . ::::: : .. : ..
NP_219 AKWTTAVRPLRLPSSKAQVKPGQLCSVAGWGYVS-MSTLATTLQEVLLTVQKDCQCERLF
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 --DFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYR
.... ..:::.:.::...:::::::::.: :::::.::: . . ::.:. ..::.
NP_219 HGNYSRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFL
180 190 200 210 220 230
240
pF1KE1 PWINQILQAN
:::.. ..
NP_219 PWIKRTMKRL
240
>>XP_011534985 (OMIM: 116831) PREDICTED: granzyme H isof (212 aa)
initn: 645 init1: 374 opt: 661 Z-score: 843.9 bits: 163.4 E(85289): 2.9e-40
Smith-Waterman score: 661; 46.2% identity (75.0% similar) in 212 aa overlap (36-245:1-210)
10 20 30 40 50 60
pF1KE1 LPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAA
::..... .. : :::.:.:..::::::
XP_011 MAFVQFLQEKS-RKRCGGILVRKDFVLTAA
10 20
70 80 90 100 110 120
pF1KE1 HCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLA
:: : ::.:::::::: :.: : : . : . . :: :: ... .:::::.:..::. : :
XP_011 HCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKWTTA
30 40 50 60 70 80
130 140 150 160 170 180
pF1KE1 VGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFR--DFDH
: : .::. : ::..: ::::: .. .. . ::::: : .. : .. ....
XP_011 VRPLRLPSSKAQVKPGQLCSVAGWGYVS-MSTLATTLQEVLLTVQKDCQCERLFHGNYSR
90 100 110 120 130 140
190 200 210 220 230 240
pF1KE1 NLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQI
..:::.:.::...:::::::::.: :::::.::: . . ::.:. ..::. :::..
XP_011 ATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIKRT
150 160 170 180 190 200
pF1KE1 LQAN
..
XP_011 MKRL
210
>>NP_002768 (OMIM: 177020) myeloblastin precursor [Homo (256 aa)
initn: 404 init1: 131 opt: 565 Z-score: 720.7 bits: 140.9 E(85289): 2.1e-33
Smith-Waterman score: 565; 40.4% identity (66.1% similar) in 245 aa overlap (8-245:14-248)
10 20 30 40 50
pF1KE1 MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGF
:: .:: . :.:.::.:: : .:::::::: :.. .: :.::::
NP_002 MAHRPPSPALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQM-RGNPGSHFCGGT
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 LIRRNFVLTAAHC----AGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHD
::. .:::::::: : ..:.:::::. .: : :.. : . : . .:.. . .:
NP_002 LIHPSFVLTAAHCLRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLN-NYDAENKLND
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 IMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLM
..:..:. :.:. .:.:. .:.: . :: : .: . ::::.:. : ...:::... ..
NP_002 VLLIQLSSPANLSASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTVV
120 130 140 150 160 170
180 190 200 210 220
pF1KE1 DPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSY---GRSDAKPP
: ::. :. ::. . :::::::.: :. ::: :. : . :
NP_002 T------FFCRPHNI--CTFVPRRKAGICFGDSGGPLICDGIIQGIDSFVIWGCATRLFP
180 190 200 210 220 230
230 240
pF1KE1 AVFTRISHYRPWINQILQAN
:::.. : :: . :.
NP_002 DFFTRVALYVDWIRSTLRRVEAKGRP
240 250
>>NP_001919 (OMIM: 134350,613912) complement factor D is (253 aa)
initn: 493 init1: 290 opt: 547 Z-score: 698.0 bits: 136.7 E(85289): 3.9e-32
Smith-Waterman score: 547; 36.9% identity (64.3% similar) in 249 aa overlap (6-244:10-252)
10 20 30 40 50
pF1KE1 MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLI
: :: :. :.:.:: : . :.::::: ... :: ...::: :.
NP_001 MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQL---NG-AHLCGGVLV
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 RRNFVLTAAHC----AGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIM
...::.:::: : .. : ::::.... : . . .:.. :: . .:. ::..
NP_001 AEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 LLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDP
::.:.:::.: :: ::. : :: .: ::::: .. :.::.: : ..:
NP_001 LLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDR
120 130 140 150 160 170
180 190 200 210 220
pF1KE1 QACSHFRDFDHNLQ---LCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGR---SDAKP
.:.. : . .:. . : ... ::::::::.:.:: .:.:. : .. :
NP_001 ATCNRRTHHDGAITERLMCAESNR--RDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKK
180 190 200 210 220 230
230 240
pF1KE1 PAVFTRISHYRPWINQILQAN
:...::.. : ::...:
NP_001 PGIYTRVASYAAWIDSVLA
240 250
247 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 14:28:45 2016 done: Sun Nov 6 14:28:46 2016
Total Scan time: 6.200 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]