Result of FASTA (omim) for
pFN21AE1725
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1725, 235 aa
1>>>pF1KE1725 235 - 235 aa - 235 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.6605+/-0.000254; mu= 9.7805+/- 0.016
mean_var=118.5911+/-23.456, 0's: 0 Z-trim(124.0): 20 B-trim: 0 in 0/56
Lambda= 0.117774
statistics sampled from 44940 (44961) to 44940 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.832), E-opt: 0.2 (0.527), width: 16
Scan time: 8.310
The best scores are: opt bits E(85289)
NP_001191432 (OMIM: 600007) fms-related tyrosine k ( 235) 1613 283.7 1.8e-76
NP_001191431 (OMIM: 600007) fms-related tyrosine k ( 235) 1613 283.7 1.8e-76
NP_001450 (OMIM: 600007) fms-related tyrosine kina ( 235) 1613 283.7 1.8e-76
XP_011524978 (OMIM: 600007) PREDICTED: fms-related ( 245) 1133 202.2 6.7e-52
XP_011524977 (OMIM: 600007) PREDICTED: fms-related ( 245) 1133 202.2 6.7e-52
XP_011524979 (OMIM: 600007) PREDICTED: fms-related ( 186) 1115 199.0 4.5e-51
NP_001265566 (OMIM: 600007) fms-related tyrosine k ( 153) 1066 190.7 1.2e-48
NP_001265567 (OMIM: 600007) fms-related tyrosine k ( 153) 1066 190.7 1.2e-48
XP_011524984 (OMIM: 600007) PREDICTED: fms-related ( 153) 1066 190.7 1.2e-48
XP_016882023 (OMIM: 600007) PREDICTED: fms-related ( 208) 824 149.6 3.8e-36
XP_016882022 (OMIM: 600007) PREDICTED: fms-related ( 208) 824 149.6 3.8e-36
XP_006723179 (OMIM: 600007) PREDICTED: fms-related ( 196) 772 140.8 1.6e-33
XP_016882021 (OMIM: 600007) PREDICTED: fms-related ( 196) 772 140.8 1.6e-33
XP_005258740 (OMIM: 600007) PREDICTED: fms-related ( 200) 772 140.8 1.7e-33
XP_005258739 (OMIM: 600007) PREDICTED: fms-related ( 217) 772 140.8 1.8e-33
XP_005258738 (OMIM: 600007) PREDICTED: fms-related ( 217) 757 138.3 1e-32
XP_005258737 (OMIM: 600007) PREDICTED: fms-related ( 217) 757 138.3 1e-32
XP_011524980 (OMIM: 600007) PREDICTED: fms-related ( 227) 756 138.1 1.2e-32
XP_011524982 (OMIM: 600007) PREDICTED: fms-related ( 130) 752 137.3 1.3e-32
XP_016882024 (OMIM: 600007) PREDICTED: fms-related ( 135) 743 135.7 3.7e-32
>>NP_001191432 (OMIM: 600007) fms-related tyrosine kinas (235 aa)
initn: 1613 init1: 1613 opt: 1613 Z-score: 1493.8 bits: 283.7 E(85289): 1.8e-76
Smith-Waterman score: 1613; 100.0% identity (100.0% similar) in 235 aa overlap (1-235:1-235)
10 20 30 40 50 60
pF1KE1 MTVLAPAWSPTTYLLLLLLLSSGLSGTQDCSFQHSPISSDFAVKIRELSDYLLQDYPVTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTVLAPAWSPTTYLLLLLLLSSGLSGTQDCSFQHSPISSDFAVKIRELSDYLLQDYPVTV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 ASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCAFQPPPSCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCAFQPPPSCL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 RFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPDSSTLPPPWSPRPLEATAPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPDSSTLPPPWSPRPLEATAPT
130 140 150 160 170 180
190 200 210 220 230
pF1KE1 APQPPLLLLLLLPVGLLLLAAAWCLHWQRTRRRTPRPGEQVPPVPSPQDLLLVEH
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APQPPLLLLLLLPVGLLLLAAAWCLHWQRTRRRTPRPGEQVPPVPSPQDLLLVEH
190 200 210 220 230
>>NP_001191431 (OMIM: 600007) fms-related tyrosine kinas (235 aa)
initn: 1613 init1: 1613 opt: 1613 Z-score: 1493.8 bits: 283.7 E(85289): 1.8e-76
Smith-Waterman score: 1613; 100.0% identity (100.0% similar) in 235 aa overlap (1-235:1-235)
10 20 30 40 50 60
pF1KE1 MTVLAPAWSPTTYLLLLLLLSSGLSGTQDCSFQHSPISSDFAVKIRELSDYLLQDYPVTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTVLAPAWSPTTYLLLLLLLSSGLSGTQDCSFQHSPISSDFAVKIRELSDYLLQDYPVTV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 ASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCAFQPPPSCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCAFQPPPSCL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 RFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPDSSTLPPPWSPRPLEATAPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPDSSTLPPPWSPRPLEATAPT
130 140 150 160 170 180
190 200 210 220 230
pF1KE1 APQPPLLLLLLLPVGLLLLAAAWCLHWQRTRRRTPRPGEQVPPVPSPQDLLLVEH
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APQPPLLLLLLLPVGLLLLAAAWCLHWQRTRRRTPRPGEQVPPVPSPQDLLLVEH
190 200 210 220 230
>>NP_001450 (OMIM: 600007) fms-related tyrosine kinase 3 (235 aa)
initn: 1613 init1: 1613 opt: 1613 Z-score: 1493.8 bits: 283.7 E(85289): 1.8e-76
Smith-Waterman score: 1613; 100.0% identity (100.0% similar) in 235 aa overlap (1-235:1-235)
10 20 30 40 50 60
pF1KE1 MTVLAPAWSPTTYLLLLLLLSSGLSGTQDCSFQHSPISSDFAVKIRELSDYLLQDYPVTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTVLAPAWSPTTYLLLLLLLSSGLSGTQDCSFQHSPISSDFAVKIRELSDYLLQDYPVTV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 ASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCAFQPPPSCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCAFQPPPSCL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 RFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPDSSTLPPPWSPRPLEATAPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPDSSTLPPPWSPRPLEATAPT
130 140 150 160 170 180
190 200 210 220 230
pF1KE1 APQPPLLLLLLLPVGLLLLAAAWCLHWQRTRRRTPRPGEQVPPVPSPQDLLLVEH
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APQPPLLLLLLLPVGLLLLAAAWCLHWQRTRRRTPRPGEQVPPVPSPQDLLLVEH
190 200 210 220 230
>>XP_011524978 (OMIM: 600007) PREDICTED: fms-related tyr (245 aa)
initn: 1075 init1: 1075 opt: 1133 Z-score: 1052.8 bits: 202.2 E(85289): 6.7e-52
Smith-Waterman score: 1133; 78.1% identity (81.6% similar) in 228 aa overlap (1-228:1-223)
10 20 30 40 50 60
pF1KE1 MTVLAPAWSPTTYLLLLLLLSSGLSGTQDCSFQHSPISSDFAVKIRELSDYLLQDYPVTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MTVLAPAWSPTTYLLLLLLLSSGLSGTQDCSFQHSPISSDFAVKIRELSDYLLQDYPVTV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 ASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCAFQPPPSCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCAFQPPPSCL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 RFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPDSSTLPPPWSPRPLEATAPT
:::::::::::::::::::::::::::::::::::::::: . : : :: : : :
XP_011 RFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPGA---PRPQSPGPAACGALT
130 140 150 160 170
190 200 210 220 230
pF1KE1 APQPPLLLLLLLPVGLLLLAAAWCLHWQRTRRRTPRPGEQVPPVPSPQDLLLVEH
:.: : : :. : . . : .: .:::.
XP_011 WPRPHPGEDTEAHRGES--PARGCIAWTQRKLARGRSLPWAPLIPSPEWRQRQNPAPAPF
180 190 200 210 220 230
XP_011 TQLCTKPLSP
240
>>XP_011524977 (OMIM: 600007) PREDICTED: fms-related tyr (245 aa)
initn: 1075 init1: 1075 opt: 1133 Z-score: 1052.8 bits: 202.2 E(85289): 6.7e-52
Smith-Waterman score: 1133; 78.1% identity (81.6% similar) in 228 aa overlap (1-228:1-223)
10 20 30 40 50 60
pF1KE1 MTVLAPAWSPTTYLLLLLLLSSGLSGTQDCSFQHSPISSDFAVKIRELSDYLLQDYPVTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MTVLAPAWSPTTYLLLLLLLSSGLSGTQDCSFQHSPISSDFAVKIRELSDYLLQDYPVTV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 ASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCAFQPPPSCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCAFQPPPSCL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 RFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPDSSTLPPPWSPRPLEATAPT
:::::::::::::::::::::::::::::::::::::::: . : : :: : : :
XP_011 RFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPGA---PRPQSPGPAACGALT
130 140 150 160 170
190 200 210 220 230
pF1KE1 APQPPLLLLLLLPVGLLLLAAAWCLHWQRTRRRTPRPGEQVPPVPSPQDLLLVEH
:.: : : :. : . . : .: .:::.
XP_011 WPRPHPGEDTEAHRGES--PARGCIAWTQRKLARGRSLPWAPLIPSPEWRQRQNPAPAPF
180 190 200 210 220 230
XP_011 TQLCTKPLSP
240
>>XP_011524979 (OMIM: 600007) PREDICTED: fms-related tyr (186 aa)
initn: 1075 init1: 1075 opt: 1115 Z-score: 1037.9 bits: 199.0 E(85289): 4.5e-51
Smith-Waterman score: 1115; 91.8% identity (92.9% similar) in 184 aa overlap (1-184:1-181)
10 20 30 40 50 60
pF1KE1 MTVLAPAWSPTTYLLLLLLLSSGLSGTQDCSFQHSPISSDFAVKIRELSDYLLQDYPVTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MTVLAPAWSPTTYLLLLLLLSSGLSGTQDCSFQHSPISSDFAVKIRELSDYLLQDYPVTV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 ASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCAFQPPPSCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCAFQPPPSCL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 RFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPDSSTLPPPWSPRPLEATAPT
:::::::::::::::::::::::::::::::::::::::: . : : :: : : :
XP_011 RFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPGA---PRPQSPGPAACGALT
130 140 150 160 170
190 200 210 220 230
pF1KE1 APQPPLLLLLLLPVGLLLLAAAWCLHWQRTRRRTPRPGEQVPPVPSPQDLLLVEH
:.:
XP_011 WPRPHPAEP
180
>>NP_001265566 (OMIM: 600007) fms-related tyrosine kinas (153 aa)
initn: 1066 init1: 1066 opt: 1066 Z-score: 994.1 bits: 190.7 E(85289): 1.2e-48
Smith-Waterman score: 1066; 100.0% identity (100.0% similar) in 153 aa overlap (83-235:1-153)
60 70 80 90 100 110
pF1KE1 LQDYPVTVASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCA
::::::::::::::::::::::::::::::
NP_001 MERLKTVAGSKMQGLLERVNTEIHFVTKCA
10 20 30
120 130 140 150 160 170
pF1KE1 FQPPPSCLRFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPDSSTLPPPWSPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FQPPPSCLRFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPDSSTLPPPWSPR
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE1 PLEATAPTAPQPPLLLLLLLPVGLLLLAAAWCLHWQRTRRRTPRPGEQVPPVPSPQDLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLEATAPTAPQPPLLLLLLLPVGLLLLAAAWCLHWQRTRRRTPRPGEQVPPVPSPQDLLL
100 110 120 130 140 150
pF1KE1 VEH
:::
NP_001 VEH
>>NP_001265567 (OMIM: 600007) fms-related tyrosine kinas (153 aa)
initn: 1066 init1: 1066 opt: 1066 Z-score: 994.1 bits: 190.7 E(85289): 1.2e-48
Smith-Waterman score: 1066; 100.0% identity (100.0% similar) in 153 aa overlap (83-235:1-153)
60 70 80 90 100 110
pF1KE1 LQDYPVTVASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCA
::::::::::::::::::::::::::::::
NP_001 MERLKTVAGSKMQGLLERVNTEIHFVTKCA
10 20 30
120 130 140 150 160 170
pF1KE1 FQPPPSCLRFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPDSSTLPPPWSPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FQPPPSCLRFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPDSSTLPPPWSPR
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE1 PLEATAPTAPQPPLLLLLLLPVGLLLLAAAWCLHWQRTRRRTPRPGEQVPPVPSPQDLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLEATAPTAPQPPLLLLLLLPVGLLLLAAAWCLHWQRTRRRTPRPGEQVPPVPSPQDLLL
100 110 120 130 140 150
pF1KE1 VEH
:::
NP_001 VEH
>>XP_011524984 (OMIM: 600007) PREDICTED: fms-related tyr (153 aa)
initn: 1066 init1: 1066 opt: 1066 Z-score: 994.1 bits: 190.7 E(85289): 1.2e-48
Smith-Waterman score: 1066; 100.0% identity (100.0% similar) in 153 aa overlap (83-235:1-153)
60 70 80 90 100 110
pF1KE1 LQDYPVTVASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCA
::::::::::::::::::::::::::::::
XP_011 MERLKTVAGSKMQGLLERVNTEIHFVTKCA
10 20 30
120 130 140 150 160 170
pF1KE1 FQPPPSCLRFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPDSSTLPPPWSPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQPPPSCLRFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPDSSTLPPPWSPR
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE1 PLEATAPTAPQPPLLLLLLLPVGLLLLAAAWCLHWQRTRRRTPRPGEQVPPVPSPQDLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLEATAPTAPQPPLLLLLLLPVGLLLLAAAWCLHWQRTRRRTPRPGEQVPPVPSPQDLLL
100 110 120 130 140 150
pF1KE1 VEH
:::
XP_011 VEH
>>XP_016882023 (OMIM: 600007) PREDICTED: fms-related tyr (208 aa)
initn: 766 init1: 766 opt: 824 Z-score: 770.0 bits: 149.6 E(85289): 3.8e-36
Smith-Waterman score: 824; 72.2% identity (76.7% similar) in 180 aa overlap (49-228:12-186)
20 30 40 50 60 70
pF1KE1 LLSSGLSGTQDCSFQHSPISSDFAVKIRELSDYLLQDYPVTVASNLQDEELCGGLWRLVL
::::::::::::::::::::::::::::::
XP_016 MTVLAPAWSPTSDYLLQDYPVTVASNLQDEELCGGLWRLVL
10 20 30 40
80 90 100 110 120 130
pF1KE1 AQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCAFQPPPSCLRFVQTNISRLLQETSEQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCAFQPPPSCLRFVQTNISRLLQETSEQL
50 60 70 80 90 100
140 150 160 170 180 190
pF1KE1 VALKPWITRQNFSRCLELQCQPDSSTLPPPWSPRPLEATAPTAPQPPLLLLLLLPVGLLL
:::::::::::::::::::::: . : : :: : : : :.: :
XP_016 VALKPWITRQNFSRCLELQCQPGA---PRPQSPGPAACGALTWPRPHPGEDTEAHRGES-
110 120 130 140 150
200 210 220 230
pF1KE1 LAAAWCLHWQRTRRRTPRPGEQVPPVPSPQDLLLVEH
: :. : . . : .: .:::.
XP_016 -PARGCIAWTQRKLARGRSLPWAPLIPSPEWRQRQNPAPAPFTQLCTKPLSP
160 170 180 190 200
235 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 22:57:59 2016 done: Mon Nov 7 22:58:00 2016
Total Scan time: 8.310 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]