Result of FASTA (omim) for
pFN21AE1718
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1718, 224 aa
1>>>pF1KE1718 224 - 224 aa - 224 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0967+/-0.000413; mu= 14.2730+/- 0.025
mean_var=57.5582+/-11.886, 0's: 0 Z-trim(109.8): 39 B-trim: 70 in 2/47
Lambda= 0.169052
statistics sampled from 18013 (18050) to 18013 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.591), E-opt: 0.2 (0.212), width: 16
Scan time: 4.970
The best scores are: opt bits E(85289)
NP_001315986 (OMIM: 123260) C-reactive protein iso ( 224) 1502 374.8 6.4e-104
NP_000558 (OMIM: 123260) C-reactive protein isofor ( 224) 1502 374.8 6.4e-104
NP_001630 (OMIM: 104770) serum amyloid P-component ( 223) 777 198.0 1.1e-50
NP_001315987 (OMIM: 123260) C-reactive protein iso ( 91) 435 114.4 6.4e-26
NP_002513 (OMIM: 602367) neuronal pentraxin-1 prec ( 432) 304 82.8 1e-15
NP_001013680 (OMIM: 613442) pentraxin-4 isoform 2 ( 473) 289 79.1 1.4e-14
NP_001315537 (OMIM: 613442) pentraxin-4 isoform 1 ( 478) 289 79.1 1.4e-14
NP_055108 (OMIM: 609474) neuronal pentraxin recept ( 500) 281 77.2 5.6e-14
NP_002514 (OMIM: 600750) neuronal pentraxin-2 prec ( 431) 277 76.2 9.7e-14
NP_699197 (OMIM: 611691) sushi, von Willebrand fac (3571) 266 73.9 3.9e-12
NP_002843 (OMIM: 602492) pentraxin-related protein ( 381) 250 69.6 8.4e-12
XP_016866574 (OMIM: 612243,616503) PREDICTED: G-pr (1116) 159 47.6 0.0001
NP_001027566 (OMIM: 612243,616503) G-protein coupl (1193) 159 47.6 0.00011
NP_065188 (OMIM: 612243,616503) G-protein coupled (1221) 159 47.6 0.00011
XP_005267118 (OMIM: 612243,616503) PREDICTED: G-pr (1222) 159 47.6 0.00011
NP_001027567 (OMIM: 612243,616503) G-protein coupl (1222) 159 47.6 0.00011
XP_006715581 (OMIM: 612243,616503) PREDICTED: G-pr (1223) 159 47.6 0.00011
XP_006715580 (OMIM: 612243,616503) PREDICTED: G-pr (1249) 159 47.6 0.00011
XP_011534266 (OMIM: 612243,616503) PREDICTED: G-pr (1250) 159 47.6 0.00011
NP_940971 (OMIM: 612243,616503) G-protein coupled (1250) 159 47.6 0.00011
XP_006715579 (OMIM: 612243,616503) PREDICTED: G-pr (1251) 159 47.6 0.00011
>>NP_001315986 (OMIM: 123260) C-reactive protein isoform (224 aa)
initn: 1502 init1: 1502 opt: 1502 Z-score: 1986.7 bits: 374.8 E(85289): 6.4e-104
Smith-Waterman score: 1502; 100.0% identity (100.0% similar) in 224 aa overlap (1-224:1-224)
10 20 30 40 50 60
pF1KE1 MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 ASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMW
130 140 150 160 170 180
190 200 210 220
pF1KE1 DFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP
::::::::::::::::::::::::::::::::::::::::::::
NP_001 DFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP
190 200 210 220
>>NP_000558 (OMIM: 123260) C-reactive protein isoform 1 (224 aa)
initn: 1502 init1: 1502 opt: 1502 Z-score: 1986.7 bits: 374.8 E(85289): 6.4e-104
Smith-Waterman score: 1502; 100.0% identity (100.0% similar) in 224 aa overlap (1-224:1-224)
10 20 30 40 50 60
pF1KE1 MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 ASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMW
130 140 150 160 170 180
190 200 210 220
pF1KE1 DFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP
::::::::::::::::::::::::::::::::::::::::::::
NP_000 DFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP
190 200 210 220
>>NP_001630 (OMIM: 104770) serum amyloid P-component pre (223 aa)
initn: 769 init1: 582 opt: 777 Z-score: 1031.1 bits: 198.0 E(85289): 1.1e-50
Smith-Waterman score: 777; 51.3% identity (79.5% similar) in 224 aa overlap (1-223:1-222)
10 20 30 40 50
pF1KE1 MEKLLCFL-VLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYT
:.: : .. ::::: .::..::.: :.::::.:: :..:.: .:: :::. ::.:.. :.
NP_001 MNKPLLWISVLTSLLEAFAHTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 ELSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWE
.:: :.::.::: :. .:::.:.. . ::. .: .. .: : ::::::.:::
NP_001 DLS--RAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWE
70 80 90 100 110
120 130 140 150 160 170
pF1KE1 SASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNM
:.:::.:::..: : :.:.:..:: : :. .:.:::::::.::.:. :::.::.::.. :
NP_001 SSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYM
120 130 140 150 160 170
180 190 200 210 220
pF1KE1 WDFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP
:: :: :..: . : : :. :.:.:.::.::..: :. :: .:
NP_001 WDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV
180 190 200 210 220
>>NP_001315987 (OMIM: 123260) C-reactive protein isoform (91 aa)
initn: 432 init1: 432 opt: 435 Z-score: 586.4 bits: 114.4 E(85289): 6.4e-26
Smith-Waterman score: 435; 79.8% identity (91.7% similar) in 84 aa overlap (1-84:1-84)
10 20 30 40 50 60
pF1KE1 MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWES
:::::: ..... . . . . .:
NP_001 LSSTRGPNVLNWRALKYEVQGEVFTKPQLWP
70 80 90
>>NP_002513 (OMIM: 602367) neuronal pentraxin-1 precurso (432 aa)
initn: 223 init1: 138 opt: 304 Z-score: 403.2 bits: 82.8 E(85289): 1e-15
Smith-Waterman score: 304; 29.5% identity (61.4% similar) in 207 aa overlap (18-214:218-418)
10 20 30 40
pF1KE1 MEKLLCFLVLTSLSHAFGQTDM---SRKAFVFPKESDTSYVSLKAPL
:: : .. ..:: ... :...: :
NP_002 KGGPRNDTEERVKIETALTSLHQRISELEKGQKDNRPGDKFQLTFPLRTNYMYAKVKKSL
190 200 210 220 230 240
50 60 70 80 90 100
pF1KE1 TKPLKAFTVCLHFYTELSSTRGYSI-FSYATKRQDNE-ILIFWSKDIGYSFTVGGSEILF
. . :::::. . . :.: : . ::::. : :: .:: :... . . .. .
NP_002 PE-MYAFTVCM--WLKSSATPGVGTPFSYAVPGQANELVLIEWGNN---PMEILINDKVA
250 260 270 280 290 300
110 120 130 140 150
pF1KE1 EVPEVTVAPV--HICTSWESASGIVEFWVDG-KPRVRKSLKKGYTVGAEASIILGQEQDS
..: : :::..: . .:. : . :: . ..: . . .. ..::::::.
NP_002 KLPFVINDGKWHHICVTWTTRDGVWEAYQDGTQGGSGENLAPYHPIKPQGVLVLGQEQDT
310 320 330 340 350 360
160 170 180 190 200 210
pF1KE1 FGGNFEGSQSLVGDIGNVNMWDFVLSPDEINTIYLGGP--FSPNVLNWRALKYEVQGEVF
.::.:...:..::.... :.:: :.: :. .. . .: ::. : . :. :
NP_002 LGGGFDATQAFVGELAHFNIWDRKLTPGEVYNLATCSTKALSGNVIAWAESHIEIYGGAT
370 380 390 400 410 420
220
pF1KE1 TKPQLWP
NP_002 KWTFEACRQIN
430
>>NP_001013680 (OMIM: 613442) pentraxin-4 isoform 2 [Hom (473 aa)
initn: 247 init1: 177 opt: 289 Z-score: 382.8 bits: 79.1 E(85289): 1.4e-14
Smith-Waterman score: 289; 30.4% identity (63.0% similar) in 181 aa overlap (27-198:268-443)
10 20 30 40 50
pF1KE1 MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLH
.:::. : . : :. .. :.:.. :
NP_001 RVLSGTAPKDPRQQAWSPQVPGEICGVGPTLVFPNASTRNVVFLSPGFVTALRALSFCS-
240 250 260 270 280 290
60 70 80 90 100 110
pF1KE1 FYTELSSTRGYSIFSYATKRQDNEILIFWSKDI---GYSFTVGGSEILFEVPEVTVAPV-
... .: : ...::::. .::. :.. ..: : : :. . :.: .
NP_001 -WVRTASGRLGTLLSYATEDNDNK-LVLHGRDSLLPGSIHFVIGDPAFRELPLQLLLDGQ
300 310 320 330 340 350
120 130 140 150 160
pF1KE1 --HICTSWESASGIVEFWVDGKPRVRKS---LKKGYTVGAEASIILGQEQDSFGGNFEGS
:::. : :..: ..:. :. . ...:: . .:..::::::: ::.:..:
NP_001 WHHICVIWTSTQG--RYWLHVDRRLVATGSRFREGYEIPPGGSLVLGQEQDSVGGGFDSS
360 370 380 390 400 410
170 180 190 200 210 220
pF1KE1 QSLVGDIGNVNMWDFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP
...::..... .:: .: : :. .. .: :
NP_001 EAFVGSMSGLAIWDRALVPGEVANLAIGKEFPTGAILTLANAALAGGFVQGANCTCLERC
420 430 440 450 460 470
NP_001 P
>>NP_001315537 (OMIM: 613442) pentraxin-4 isoform 1 prec (478 aa)
initn: 247 init1: 177 opt: 289 Z-score: 382.8 bits: 79.1 E(85289): 1.4e-14
Smith-Waterman score: 289; 30.4% identity (63.0% similar) in 181 aa overlap (27-198:273-448)
10 20 30 40 50
pF1KE1 MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLH
.:::. : . : :. .. :.:.. :
NP_001 RVLSGTAPKDPRQQAWSPQVPGEICGVGPTLVFPNASTRNVVFLSPGFVTALRALSFCS-
250 260 270 280 290 300
60 70 80 90 100 110
pF1KE1 FYTELSSTRGYSIFSYATKRQDNEILIFWSKDI---GYSFTVGGSEILFEVPEVTVAPV-
... .: : ...::::. .::. :.. ..: : : :. . :.: .
NP_001 -WVRTASGRLGTLLSYATEDNDNK-LVLHGRDSLLPGSIHFVIGDPAFRELPLQLLLDGQ
310 320 330 340 350
120 130 140 150 160
pF1KE1 --HICTSWESASGIVEFWVDGKPRVRKS---LKKGYTVGAEASIILGQEQDSFGGNFEGS
:::. : :..: ..:. :. . ...:: . .:..::::::: ::.:..:
NP_001 WHHICVIWTSTQG--RYWLHVDRRLVATGSRFREGYEIPPGGSLVLGQEQDSVGGGFDSS
360 370 380 390 400 410
170 180 190 200 210 220
pF1KE1 QSLVGDIGNVNMWDFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP
...::..... .:: .: : :. .. .: :
NP_001 EAFVGSMSGLAIWDRALVPGEVANLAIGKEFPTGAILTLANAALAGGFVQGANCTCLERC
420 430 440 450 460 470
NP_001 P
>>NP_055108 (OMIM: 609474) neuronal pentraxin receptor [ (500 aa)
initn: 255 init1: 165 opt: 281 Z-score: 371.9 bits: 77.2 E(85289): 5.6e-14
Smith-Waterman score: 281; 27.6% identity (59.6% similar) in 203 aa overlap (14-214:285-484)
10 20 30 40
pF1KE1 MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAP
: :.. : . . .: ... :. ..
NP_055 ALSHSSRRQRQEVEKELDVLQGRVAELEHGSSAYSPPDAFKIS--IPIRNNYMYARVRKA
260 270 280 290 300 310
50 60 70 80 90 100
pF1KE1 LTKPLKAFTVCLHFYTELSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFE
: . : :::.:. . .. :.: . :::.. : :::... . . . .. . .
NP_055 LPE-LYAFTACMWLRSRSSGTGQGTPFSYSVPGQANEIVLLEAGHEPMELLINDKVAQLP
320 330 340 350 360 370
110 120 130 140 150 160
pF1KE1 VPEVTVAPVHICTSWESASGIVEFWVDGKPRVR-KSLKKGYTVGAEASIILGQEQDSFGG
. . ::: .: . .:. . ::. . ..: . . .. .:::::::..::
NP_055 LSLKDNGWHHICIAWTTRDGLWSAYQDGELQGSGENLAAWHPIKPHGILILGQEQDTLGG
380 390 400 410 420 430
170 180 190 200 210 220
pF1KE1 NFEGSQSLVGDIGNVNMWDFVLSPDEINTIY-LGGPFSPNVLNWRALKYEVQGEVFTKPQ
:...:..::::.. :.:: .:.: .. : .:. ::: :. :. :
NP_055 RFDATQAFVGDIAQFNLWDHALTPAQVLGIANCTAPLLGNVLPWEDKLVEAFGGATKAAF
440 450 460 470 480 490
pF1KE1 LWP
NP_055 DVCKGRAKA
500
>>NP_002514 (OMIM: 600750) neuronal pentraxin-2 precurso (431 aa)
initn: 244 init1: 149 opt: 277 Z-score: 367.7 bits: 76.2 E(85289): 9.7e-14
Smith-Waterman score: 277; 30.4% identity (57.9% similar) in 214 aa overlap (16-224:218-420)
10 20 30 40
pF1KE1 MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLT
:: . : . . .: ... : ..: :
NP_002 HNETSAHRQKTESTLNALLQRVTELERGNSAFKSPDAFKVS--LPLRTNYLYGKIKKTLP
190 200 210 220 230 240
50 60 70 80 90 100
pF1KE1 KPLKAFTVCLHFYTELSSTRGYSIFSYATKRQDNEI-LIFWSKDIGYSFTVGGSEILFEV
. : :::.:: . . : : . ::::. : ::: :: :... . . .. . ..
NP_002 E-LYAFTICLWLRSSASPGIG-TPFSYAVPGQANEIVLIEWGNN---PIELLINDKVAQL
250 260 270 280 290 300
110 120 130 140 150 160
pF1KE1 PEVTVAPV--HICTSWESASGIVEFWVDG-KPRVRKSLKKGYTVGAEASIILGQEQDSFG
: . :::..: . .:. : . :: : . ..: . . . .:::::::. :
NP_002 PLFVSDGKWHHICVTWTTRDGMWEAFQDGEKLGTGENLAPWHPIKPGGVLILGQEQDTVG
310 320 330 340 350 360
170 180 190 200 210 220
pF1KE1 GNFEGSQSLVGDIGNVNMWDFVLSPDEINTIYLGGPFSP-NVLNWRALKYEVQGEVFTKP
: :...:..::.... :.:: :: .:: .: . : :.. : . . .::
NP_002 GRFDATQAFVGELSQFNIWDRVLRAQEIVNIANCSTNMPGNIIPW----VDNNVDVFGGA
370 380 390 400 410
pF1KE1 QLWP
. ::
NP_002 SKWPVETCEERLLDL
420 430
>>NP_699197 (OMIM: 611691) sushi, von Willebrand factor (3571 aa)
initn: 211 init1: 147 opt: 266 Z-score: 339.0 bits: 73.9 E(85289): 3.9e-12
Smith-Waterman score: 266; 31.7% identity (64.0% similar) in 186 aa overlap (37-216:1438-1619)
10 20 30 40 50 60
pF1KE1 FLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSSTRG
:: : . : . :.:.: : :. . :. .
NP_699 KCQPGFSGKRCETEQSTGFNLDFEVSGIYGYVMLDGMLPS-LHALT-CT-FWMKSSDDMN
1410 1420 1430 1440 1450 1460
70 80 90 100 110 120
pF1KE1 YSI-FSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVH-ICTSWESASGI
:. .:::. ... :.. . . :. . :.: : . . : :. . : : .: ::.::
NP_699 YGTPISYAVDNGSDNTLLLTDYN-GWVLYVNGREKITNCPSVNDGRWHHIAITWTSANGI
1470 1480 1490 1500 1510 1520
130 140 150 160 170 180
pF1KE1 VEFWVDGK-PRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMWDFV
. ..::: .:. : . . ....::::::. : .: ..:.::.:...:.::.:
NP_699 WKVYIDGKLSDGGAGLSVGLPIPGGGALVLGQEQDKKGEGFSPAESFVGSISQLNLWDYV
1530 1540 1550 1560 1570 1580
190 200 210 220
pF1KE1 LSPDEINTIYLGGPF---SPNVLNWRALKYEVQGEVFTKPQLWP
:::...... . : . ::: : . . :.:
NP_699 LSPQQVKSLATSCPEELSKGNVLAWPDFLSGIVGKVKIDSKSIFCSDCPRLGGSVPHLRT
1590 1600 1610 1620 1630 1640
NP_699 ASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSA
1650 1660 1670 1680 1690 1700
224 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 23:25:22 2016 done: Mon Nov 7 23:25:23 2016
Total Scan time: 4.970 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]