Result of FASTA (omim) for
pFN21AE1685
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1685, 197 aa
1>>>pF1KE1685 197 - 197 aa - 197 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4676+/-0.000266; mu= 13.3622+/- 0.017
mean_var=74.6536+/-14.994, 0's: 0 Z-trim(120.4): 16 B-trim: 40 in 1/57
Lambda= 0.148439
statistics sampled from 35684 (35702) to 35684 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.783), E-opt: 0.2 (0.419), width: 16
Scan time: 6.640
The best scores are: opt bits E(85289)
NP_037410 (OMIM: 604628) interleukin-17C precursor ( 197) 1393 306.6 1.7e-83
NP_612141 (OMIM: 607587) interleukin-17D precursor ( 202) 272 66.5 3.2e-11
XP_005266478 (OMIM: 607587) PREDICTED: interleukin ( 209) 272 66.6 3.2e-11
NP_758525 (OMIM: 605658) interleukin-25 isoform 2 ( 161) 223 56.0 3.8e-08
NP_073626 (OMIM: 605658) interleukin-25 isoform 1 ( 177) 223 56.0 4.1e-08
NP_055258 (OMIM: 604627) interleukin-17B isoform 1 ( 180) 201 51.3 1.1e-06
XP_016864835 (OMIM: 604627) PREDICTED: interleukin ( 245) 200 51.2 1.6e-06
XP_016864836 (OMIM: 604627) PREDICTED: interleukin ( 128) 196 50.1 1.7e-06
XP_016864837 (OMIM: 604627) PREDICTED: interleukin ( 128) 196 50.1 1.7e-06
NP_001304916 (OMIM: 604627) interleukin-17B isofor ( 128) 196 50.1 1.7e-06
XP_011535924 (OMIM: 604627) PREDICTED: interleukin ( 128) 196 50.1 1.7e-06
XP_005266479 (OMIM: 607587) PREDICTED: interleukin ( 114) 191 49.0 3.3e-06
XP_011512578 (OMIM: 606496,613956) PREDICTED: inte ( 163) 183 47.4 1.5e-05
NP_443104 (OMIM: 606496,613956) interleukin-17F pr ( 163) 183 47.4 1.5e-05
NP_002181 (OMIM: 603149) interleukin-17A precursor ( 155) 167 44.0 0.00015
>>NP_037410 (OMIM: 604628) interleukin-17C precursor [Ho (197 aa)
initn: 1393 init1: 1393 opt: 1393 Z-score: 1620.1 bits: 306.6 E(85289): 1.7e-83
Smith-Waterman score: 1393; 100.0% identity (100.0% similar) in 197 aa overlap (1-197:1-197)
10 20 30 40 50 60
pF1KE1 MTLLPGLLFLTWLHTCLAHHDPSLRGHPHSHGTPHCYSAEELPLGQAPPHLLARGAKWGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 MTLLPGLLFLTWLHTCLAHHDPSLRGHPHSHGTPHCYSAEELPLGQAPPHLLARGAKWGQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 ALPVALVSSLEAASHRGRHERPSATTQCPVLRPEEVLEADTHQRSISPWRYRVDTDEDRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 ALPVALVSSLEAASHRGRHERPSATTQCPVLRPEEVLEADTHQRSISPWRYRVDTDEDRY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 PQKLAFAECLCRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFAFHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 PQKLAFAECLCRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFAFHT
130 140 150 160 170 180
190
pF1KE1 EFIHVPVGCTCVLPRSV
:::::::::::::::::
NP_037 EFIHVPVGCTCVLPRSV
190
>>NP_612141 (OMIM: 607587) interleukin-17D precursor [Ho (202 aa)
initn: 285 init1: 203 opt: 272 Z-score: 322.5 bits: 66.5 E(85289): 3.2e-11
Smith-Waterman score: 272; 32.7% identity (59.4% similar) in 165 aa overlap (32-192:17-170)
10 20 30 40 50
pF1KE1 TLLPGLLFLTWLHTCLAHHDPSLRGHPHSHGTPHCYSAEELPLGQA--PPHLLARGAKWG
:.:. : : : : .:: . .:
NP_612 MLVAGFLLALPPSWAAGAPRAGRRPARPRGCADRPEELLEQ--LYG
10 20 30 40
60 70 80 90 100 110
pF1KE1 QALPVALVSSLEAASHRGRHERPSATTQCPVL-RP-EEVLEADTHQRSISPWRYRVDTDE
. : ....:... . . : .:. .. ::. :: .. .. :. ::.::: ::.. :
NP_612 R-LAAGVLSAFHHTLQLGPREQARNAS-CPAGGRPADRRFRPPTNLRSVSPWAYRISYDP
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE1 DRYPQKLAFAECLCRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFA
:::. : : ::::::. . :.: . . :. . . .:::: : : .. : .
NP_612 ARYPRYLPEAYCLCRGCLTGLFGEEDVRFRSAPVYMPTVVLRRTPACAGGRSVYTEA---
110 120 130 140 150
180 190
pF1KE1 FHTEFIHVPVGCTCVLPRSV
.. .:::::::
NP_612 ----YVTIPVGCTCVPEPEKDADSINSSIDKQGAKLLLGPNDAPAGP
160 170 180 190 200
>>XP_005266478 (OMIM: 607587) PREDICTED: interleukin-17D (209 aa)
initn: 285 init1: 203 opt: 272 Z-score: 322.3 bits: 66.6 E(85289): 3.2e-11
Smith-Waterman score: 272; 32.7% identity (59.4% similar) in 165 aa overlap (32-192:24-177)
10 20 30 40 50
pF1KE1 TLLPGLLFLTWLHTCLAHHDPSLRGHPHSHGTPHCYSAEELPLGQA--PPHLLARGAKWG
:.:. : : : : .:: . .:
XP_005 MLGALVWMLVAGFLLALPPSWAAGAPRAGRRPARPRGCADRPEELLEQ--LYG
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 QALPVALVSSLEAASHRGRHERPSATTQCPVL-RP-EEVLEADTHQRSISPWRYRVDTDE
. : ....:... . . : .:. .. ::. :: .. .. :. ::.::: ::.. :
XP_005 R-LAAGVLSAFHHTLQLGPREQARNAS-CPAGGRPADRRFRPPTNLRSVSPWAYRISYDP
60 70 80 90 100
120 130 140 150 160 170
pF1KE1 DRYPQKLAFAECLCRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFA
:::. : : ::::::. . :.: . . :. . . .:::: : : .. : .
XP_005 ARYPRYLPEAYCLCRGCLTGLFGEEDVRFRSAPVYMPTVVLRRTPACAGGRSVYTEA---
110 120 130 140 150 160
180 190
pF1KE1 FHTEFIHVPVGCTCVLPRSV
.. .:::::::
XP_005 ----YVTIPVGCTCVPEPEKDADSINSSIDKQGAKLLLGPNDAPAGP
170 180 190 200
>>NP_758525 (OMIM: 605658) interleukin-25 isoform 2 prec (161 aa)
initn: 199 init1: 159 opt: 223 Z-score: 267.3 bits: 56.0 E(85289): 3.8e-08
Smith-Waterman score: 230; 33.5% identity (55.3% similar) in 170 aa overlap (27-195:15-158)
10 20 30 40 50 60
pF1KE1 MTLLPGLLFLTWLHTCLAHHDPSLRGHPHSHGTPHCYSAEELPLGQAPPHLLARGAKWGQ
: .:: : : .. :: . : : :.
NP_758 MYQVVAFLAMVMGTHTYSHW-PSCCPSK----GQDTSEELLR---WS-
10 20 30
70 80 90 100 110 120
pF1KE1 ALPVALVSSLEAASHRGRHERPSATTQCPVLRPEEVLEADTHQRSISPWRYRVDTDEDRY
..:: :: : .:: : . : : : .. ..:.::::::..: : .:
NP_758 TVPVP---PLEPARP-NRH--PES---C---RASE--DGPLNSRAISPWRYELDRDLNRL
40 50 60 70 80
130 140 150 160 170
pF1KE1 PQKLAFAECLCRGCIDARTGRETAAL-NSVRLLQSLLVLRRRPCSRDGSGLPTPGAFAFH
:: : :.::: :.. .:: . :: : .. :. :::: . .: : .. ..
NP_758 PQDLYHARCLCPHCVSLQTGSHMDPRGNSELLYHNQTVFYRRPCHGE-KG--THKGYCLE
90 100 110 120 130 140
180 190
pF1KE1 TEFIHVPVGCTCVLPRSV
.. .: ..:.:: ::
NP_758 RRLYRVSLACVCVRPRVMG
150 160
>>NP_073626 (OMIM: 605658) interleukin-25 isoform 1 prec (177 aa)
initn: 199 init1: 159 opt: 223 Z-score: 266.7 bits: 56.0 E(85289): 4.1e-08
Smith-Waterman score: 230; 33.5% identity (55.3% similar) in 170 aa overlap (27-195:31-174)
10 20 30 40 50
pF1KE1 MTLLPGLLFLTWLHTCLAHHDPSLRGHPHSHGTPHCYSAEELPLGQAPPHLLARGA
: .:: : : .. :: . : :
NP_073 MRERPRLGEDSSLISLFLQVVAFLAMVMGTHTYSHW-PSCCPSK----GQDTSEELLR--
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 KWGQALPVALVSSLEAASHRGRHERPSATTQCPVLRPEEVLEADTHQRSISPWRYRVDTD
:. ..:: :: : .:: : . : : : .. ..:.::::::..: :
NP_073 -WS-TVPVP---PLEPARP-NRH--PES---C---RASE--DGPLNSRAISPWRYELDRD
60 70 80 90
120 130 140 150 160 170
pF1KE1 EDRYPQKLAFAECLCRGCIDARTGRETAAL-NSVRLLQSLLVLRRRPCSRDGSGLPTPGA
.: :: : :.::: :.. .:: . :: : .. :. :::: . .: : .
NP_073 LNRLPQDLYHARCLCPHCVSLQTGSHMDPRGNSELLYHNQTVFYRRPCHGE-KG--THKG
100 110 120 130 140 150
180 190
pF1KE1 FAFHTEFIHVPVGCTCVLPRSV
. .. .. .: ..:.:: ::
NP_073 YCLERRLYRVSLACVCVRPRVMG
160 170
>>NP_055258 (OMIM: 604627) interleukin-17B isoform 1 pre (180 aa)
initn: 197 init1: 162 opt: 201 Z-score: 241.1 bits: 51.3 E(85289): 1.1e-06
Smith-Waterman score: 205; 30.2% identity (53.5% similar) in 159 aa overlap (45-193:31-180)
20 30 40 50 60 70
pF1KE1 TCLAHHDPSLRGHPHSHGTPHCYSAEELPLGQAPPHLLARGAKWGQALPVALVSSLEAAS
::. : :: : . .:. ::: .. .
NP_055 MDWPHNLLFLLTISIFLGLGQPRSPKSKRKGQGRPGPLAPGP---HQVPLDLVSRMKPYA
10 20 30 40 50
80 90 100 110 120
pF1KE1 HRGRHERPSATTQCPVLRPEEVL-----EAD-----THQRSISPWRYRVDTDEDRYPQKL
. ..:: . . :: : :.. ...::.::: : .. : .: : :
NP_055 RMEEYER-NIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE1 AFAECLCRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFAFHTEFIH
:.::: ::.. : .: .. :: .. : . .::: : : : .. .
NP_055 PEARCLCLGCVNPFTMQEDRSMVSVPVF-SQVPVRRRLCPPP----PRTGPCRQRAVMET
120 130 140 150 160 170
190
pF1KE1 VPVGCTCVLPRSV
. :::::..
NP_055 IAVGCTCIF
180
>>XP_016864835 (OMIM: 604627) PREDICTED: interleukin-17B (245 aa)
initn: 197 init1: 162 opt: 200 Z-score: 238.0 bits: 51.2 E(85289): 1.6e-06
Smith-Waterman score: 205; 30.2% identity (53.5% similar) in 159 aa overlap (45-193:96-245)
20 30 40 50 60 70
pF1KE1 TCLAHHDPSLRGHPHSHGTPHCYSAEELPLGQAPPHLLARGAKWGQALPVALVSSLEAAS
::. : :: : . .:. ::: .. .
XP_016 GRPGQSALFLLTISIFLGLGQPRSPKSKRKGQGRPGPLAPGP---HQVPLDLVSRMKPYA
70 80 90 100 110 120
80 90 100 110 120
pF1KE1 HRGRHERPSATTQCPVLRPEEVL-----EAD-----THQRSISPWRYRVDTDEDRYPQKL
. ..:: . . :: : :.. ...::.::: : .. : .: : :
XP_016 RMEEYER-NIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDL
130 140 150 160 170 180
130 140 150 160 170 180
pF1KE1 AFAECLCRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFAFHTEFIH
:.::: ::.. : .: .. :: .. : . .::: : : : .. .
XP_016 PEARCLCLGCVNPFTMQEDRSMVSVPVF-SQVPVRRRLCPPP----PRTGPCRQRAVMET
190 200 210 220 230
190
pF1KE1 VPVGCTCVLPRSV
. :::::..
XP_016 IAVGCTCIF
240
>>XP_016864836 (OMIM: 604627) PREDICTED: interleukin-17B (128 aa)
initn: 213 init1: 162 opt: 196 Z-score: 237.5 bits: 50.1 E(85289): 1.7e-06
Smith-Waterman score: 196; 34.4% identity (60.2% similar) in 93 aa overlap (101-193:41-128)
80 90 100 110 120 130
pF1KE1 EAASHRGRHERPSATTQCPVLRPEEVLEADTHQRSISPWRYRVDTDEDRYPQKLAFAECL
...::.::: : .. : .: : : :.::
XP_016 ERNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCL
20 30 40 50 60 70
140 150 160 170 180 190
pF1KE1 CRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFAFHTEFIHVPVGCT
: ::.. : .: .. :: ..... : ::: : : : .. . . ::::
XP_016 CLGCVNPFTMQEDRSMVSVPVFSQVPV-RRRLCPPP----PRTGPCRQRAVMETIAVGCT
80 90 100 110 120
pF1KE1 CVLPRSV
:..
XP_016 CIF
>>XP_016864837 (OMIM: 604627) PREDICTED: interleukin-17B (128 aa)
initn: 213 init1: 162 opt: 196 Z-score: 237.5 bits: 50.1 E(85289): 1.7e-06
Smith-Waterman score: 196; 34.4% identity (60.2% similar) in 93 aa overlap (101-193:41-128)
80 90 100 110 120 130
pF1KE1 EAASHRGRHERPSATTQCPVLRPEEVLEADTHQRSISPWRYRVDTDEDRYPQKLAFAECL
...::.::: : .. : .: : : :.::
XP_016 ERNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCL
20 30 40 50 60 70
140 150 160 170 180 190
pF1KE1 CRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFAFHTEFIHVPVGCT
: ::.. : .: .. :: ..... : ::: : : : .. . . ::::
XP_016 CLGCVNPFTMQEDRSMVSVPVFSQVPV-RRRLCPPP----PRTGPCRQRAVMETIAVGCT
80 90 100 110 120
pF1KE1 CVLPRSV
:..
XP_016 CIF
>>NP_001304916 (OMIM: 604627) interleukin-17B isoform 2 (128 aa)
initn: 213 init1: 162 opt: 196 Z-score: 237.5 bits: 50.1 E(85289): 1.7e-06
Smith-Waterman score: 196; 34.4% identity (60.2% similar) in 93 aa overlap (101-193:41-128)
80 90 100 110 120 130
pF1KE1 EAASHRGRHERPSATTQCPVLRPEEVLEADTHQRSISPWRYRVDTDEDRYPQKLAFAECL
...::.::: : .. : .: : : :.::
NP_001 ERNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCL
20 30 40 50 60 70
140 150 160 170 180 190
pF1KE1 CRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFAFHTEFIHVPVGCT
: ::.. : .: .. :: ..... : ::: : : : .. . . ::::
NP_001 CLGCVNPFTMQEDRSMVSVPVFSQVPV-RRRLCPPP----PRTGPCRQRAVMETIAVGCT
80 90 100 110 120
pF1KE1 CVLPRSV
:..
NP_001 CIF
197 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 15:26:44 2016 done: Mon Nov 7 15:26:45 2016
Total Scan time: 6.640 Total Display time: -0.030
Function used was FASTA [36.3.4 Apr, 2011]