Result of FASTA (omim) for
pFN21AE1659
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1659, 176 aa
1>>>pF1KE1659 176 - 176 aa - 176 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4679+/-0.000343; mu= 11.2034+/- 0.021
mean_var=56.4682+/-11.086, 0's: 0 Z-trim(113.8): 15 B-trim: 0 in 0/54
Lambda= 0.170676
statistics sampled from 23351 (23366) to 23351 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.666), E-opt: 0.2 (0.274), width: 16
Scan time: 5.690
The best scores are: opt bits E(85289)
NP_061194 (OMIM: 605619) interleukin-20 precursor ( 176) 1154 292.1 3.2e-79
XP_005273209 (OMIM: 605619) PREDICTED: interleukin ( 261) 1154 292.1 4.6e-79
NP_037503 (OMIM: 605687) interleukin-19 isoform 2 ( 177) 457 120.4 1.5e-27
NP_715639 (OMIM: 605687) interleukin-19 isoform 1 ( 215) 457 120.4 1.8e-27
XP_011507752 (OMIM: 605687) PREDICTED: interleukin ( 207) 328 88.7 6.3e-18
XP_016855610 (OMIM: 604136) PREDICTED: interleukin ( 179) 292 79.8 2.6e-15
XP_011507403 (OMIM: 604136) PREDICTED: interleukin ( 179) 292 79.8 2.6e-15
NP_006841 (OMIM: 604136) interleukin-24 isoform 1 ( 206) 292 79.8 2.9e-15
NP_001172085 (OMIM: 604136) interleukin-24 isoform ( 207) 292 79.8 2.9e-15
NP_000563 (OMIM: 124092,180300,609423,614395) inte ( 178) 213 60.3 1.8e-09
NP_060872 (OMIM: 605679) interleukin-26 precursor ( 171) 125 38.7 0.0058
>>NP_061194 (OMIM: 605619) interleukin-20 precursor [Hom (176 aa)
initn: 1154 init1: 1154 opt: 1154 Z-score: 1543.3 bits: 292.1 E(85289): 3.2e-79
Smith-Waterman score: 1154; 100.0% identity (100.0% similar) in 176 aa overlap (1-176:1-176)
10 20 30 40 50 60
pF1KE1 MKASSLAFSLLSAAFYLLWTPSTGLKTLNLGSCVIATNLQEIRNGFSEIRGSVQAKDGNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 MKASSLAFSLLSAAFYLLWTPSTGLKTLNLGSCVIATNLQEIRNGFSEIRGSVQAKDGNI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 DIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNYQTPDHYTLRKISSLANSFLTIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 DIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNYQTPDHYTLRKISSLANSFLTIK
70 80 90 100 110 120
130 140 150 160 170
pF1KE1 KDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKALGELDILLQWMEETE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 KDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKALGELDILLQWMEETE
130 140 150 160 170
>>XP_005273209 (OMIM: 605619) PREDICTED: interleukin-20 (261 aa)
initn: 1154 init1: 1154 opt: 1154 Z-score: 1540.4 bits: 292.1 E(85289): 4.6e-79
Smith-Waterman score: 1154; 100.0% identity (100.0% similar) in 176 aa overlap (1-176:86-261)
10 20 30
pF1KE1 MKASSLAFSLLSAAFYLLWTPSTGLKTLNL
::::::::::::::::::::::::::::::
XP_005 SDSELRPEIFSSREAWQFFLLLWSPDFRPKMKASSLAFSLLSAAFYLLWTPSTGLKTLNL
60 70 80 90 100 110
40 50 60 70 80 90
pF1KE1 GSCVIATNLQEIRNGFSEIRGSVQAKDGNIDIRILRRTESLQDTKPANRCCLLRHLLRLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSCVIATNLQEIRNGFSEIRGSVQAKDGNIDIRILRRTESLQDTKPANRCCLLRHLLRLY
120 130 140 150 160 170
100 110 120 130 140 150
pF1KE1 LDRVFKNYQTPDHYTLRKISSLANSFLTIKKDLRLCHAHMTCHCGEEAMKKYSQILSHFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDRVFKNYQTPDHYTLRKISSLANSFLTIKKDLRLCHAHMTCHCGEEAMKKYSQILSHFE
180 190 200 210 220 230
160 170
pF1KE1 KLEPQAAVVKALGELDILLQWMEETE
::::::::::::::::::::::::::
XP_005 KLEPQAAVVKALGELDILLQWMEETE
240 250 260
>>NP_037503 (OMIM: 605687) interleukin-19 isoform 2 prec (177 aa)
initn: 436 init1: 403 opt: 457 Z-score: 615.7 bits: 120.4 E(85289): 1.5e-27
Smith-Waterman score: 457; 40.2% identity (72.4% similar) in 174 aa overlap (1-174:1-169)
10 20 30 40 50 60
pF1KE1 MKASSLAFSLLSAAFYLLWTPSTGLKTLNLGSCVIATNLQEIRNGFSEIRGSVQAKDGNI
:: . ... ::.. . : . . ::. :.:.:....:...:.::. ..::::
NP_037 MKLQCVSLWLLGTILILCSVDNHGLRR-----CLISTDMHHIEESFQEIKRAIQAKDTFP
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 DIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNYQTPDHYTLRKISSLANSFLTIK
.. :: :.:: :: . ::. ..:: .:.:::::..: :. ::::::.::::: ..
NP_037 NVTILSTLETLQIIKPLDVCCVTKNLLAFYVDRVFKDHQEPNPKILRKISSIANSFLYMQ
60 70 80 90 100 110
130 140 150 160 170
pF1KE1 KDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKALGELDILLQWMEETE
: :: :. . ::: .:: . : .....:: .::..:.:::::..: :...
NP_037 KTLRQCQEQRQCHCRQEATNATRVIHDNYDQLEVHAAAIKSLGELDVFLAWINKNHEVMF
120 130 140 150 160 170
NP_037 SA
>>NP_715639 (OMIM: 605687) interleukin-19 isoform 1 [Hom (215 aa)
initn: 436 init1: 403 opt: 457 Z-score: 614.3 bits: 120.4 E(85289): 1.8e-27
Smith-Waterman score: 457; 40.2% identity (72.4% similar) in 174 aa overlap (1-174:39-207)
10 20 30
pF1KE1 MKASSLAFSLLSAAFYLLWTPSTGLKTLNL
:: . ... ::.. . : . . ::.
NP_715 HRSACSLPLTHVHTHIHVCVPVLWGSVPRGMKLQCVSLWLLGTILILCSVDNHGLRR---
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE1 GSCVIATNLQEIRNGFSEIRGSVQAKDGNIDIRILRRTESLQDTKPANRCCLLRHLLRLY
:.:.:....:...:.::. ..:::: .. :: :.:: :: . ::. ..:: .:
NP_715 --CLISTDMHHIEESFQEIKRAIQAKDTFPNVTILSTLETLQIIKPLDVCCVTKNLLAFY
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE1 LDRVFKNYQTPDHYTLRKISSLANSFLTIKKDLRLCHAHMTCHCGEEAMKKYSQILSHFE
.:::::..: :. ::::::.::::: ..: :: :. . ::: .:: . : ....
NP_715 VDRVFKDHQEPNPKILRKISSIANSFLYMQKTLRQCQEQRQCHCRQEATNATRVIHDNYD
130 140 150 160 170 180
160 170
pF1KE1 KLEPQAAVVKALGELDILLQWMEETE
.:: .::..:.:::::..: :...
NP_715 QLEVHAAAIKSLGELDVFLAWINKNHEVMFSA
190 200 210
>>XP_011507752 (OMIM: 605687) PREDICTED: interleukin-19 (207 aa)
initn: 291 init1: 274 opt: 328 Z-score: 442.9 bits: 88.7 E(85289): 6.3e-18
Smith-Waterman score: 328; 41.1% identity (71.3% similar) in 129 aa overlap (1-129:1-124)
10 20 30 40 50 60
pF1KE1 MKASSLAFSLLSAAFYLLWTPSTGLKTLNLGSCVIATNLQEIRNGFSEIRGSVQAKDGNI
:: . ... ::.. . : . . ::. :.:.:....:...:.::. ..::::
XP_011 MKLQCVSLWLLGTILILCSVDNHGLRR-----CLISTDMHHIEESFQEIKRAIQAKDTFP
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 DIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNYQTPDHYTLRKISSLANSFLTIK
.. :: :.:: :: . ::. ..:: .:.:::::..: :. ::::::.::::: ..
XP_011 NVTILSTLETLQIIKPLDVCCVTKNLLAFYVDRVFKDHQEPNPKILRKISSIANSFLYMQ
60 70 80 90 100 110
130 140 150 160 170
pF1KE1 KDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKALGELDILLQWMEETE
: :: : .:
XP_011 KTLRQCVSHWVRIPASAPCLPKERPGSAGPHRPPDMVLGVKGNSLRTSTGRTVENLSQWP
120 130 140 150 160 170
>>XP_016855610 (OMIM: 604136) PREDICTED: interleukin-24 (179 aa)
initn: 251 init1: 149 opt: 292 Z-score: 396.0 bits: 79.8 E(85289): 2.6e-15
Smith-Waterman score: 292; 33.1% identity (68.1% similar) in 163 aa overlap (17-174:14-175)
10 20 30 40 50
pF1KE1 MKASSLAFSLLSAAFYLLWTPSTGLK--TLNLGSCVIATNL-QEIRNGFSEIRGSVQAKD
:::. .: . ...: : . . :.. ..: .. ..::.:
XP_016 MQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQD
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 GNIDIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNYQ--TPDHYTLRKISSLANS
. . :.:.. : ::... :. : :.. ::..:: :::::. : . ::...:.:::.
XP_016 NITSARLLQQ-EVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANN
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 FLTIKKDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKALGELDILLQWMEET
:. : ..:. . . . : ... . :..:. .::..:::::.:::: ::..
XP_016 FVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKF
120 130 140 150 160 170
pF1KE1 E
XP_016 YKL
>>XP_011507403 (OMIM: 604136) PREDICTED: interleukin-24 (179 aa)
initn: 251 init1: 149 opt: 292 Z-score: 396.0 bits: 79.8 E(85289): 2.6e-15
Smith-Waterman score: 292; 33.1% identity (68.1% similar) in 163 aa overlap (17-174:14-175)
10 20 30 40 50
pF1KE1 MKASSLAFSLLSAAFYLLWTPSTGLK--TLNLGSCVIATNL-QEIRNGFSEIRGSVQAKD
:::. .: . ...: : . . :.. ..: .. ..::.:
XP_011 MQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQD
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 GNIDIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNYQ--TPDHYTLRKISSLANS
. . :.:.. : ::... :. : :.. ::..:: :::::. : . ::...:.:::.
XP_011 NITSARLLQQ-EVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANN
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 FLTIKKDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKALGELDILLQWMEET
:. : ..:. . . . : ... . :..:. .::..:::::.:::: ::..
XP_011 FVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKF
120 130 140 150 160 170
pF1KE1 E
XP_011 YKL
>>NP_006841 (OMIM: 604136) interleukin-24 isoform 1 prec (206 aa)
initn: 251 init1: 149 opt: 292 Z-score: 395.0 bits: 79.8 E(85289): 2.9e-15
Smith-Waterman score: 292; 33.1% identity (68.1% similar) in 163 aa overlap (17-174:41-202)
10 20 30 40
pF1KE1 MKASSLAFSLLSAAFYLLWTPSTGLK--TLNLGSCVIATNL-QEIR
:::. .: . ...: : . . :..
NP_006 WTLARPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLW
20 30 40 50 60 70
50 60 70 80 90 100
pF1KE1 NGFSEIRGSVQAKDGNIDIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNYQ--TP
..: .. ..::.:. . :.:.. : ::... :. : :.. ::..:: :::::. :
NP_006 EAFWAVKDTMQAQDNITSARLLQQ-EVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTV
80 90 100 110 120
110 120 130 140 150 160
pF1KE1 DHYTLRKISSLANSFLTIKKDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKA
. ::...:.:::.:. : ..:. . . . : ... . :..:. .::..::
NP_006 EVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKA
130 140 150 160 170 180
170
pF1KE1 LGELDILLQWMEETE
:::.:::: ::..
NP_006 LGEVDILLTWMQKFYKL
190 200
>>NP_001172085 (OMIM: 604136) interleukin-24 isoform 3 p (207 aa)
initn: 251 init1: 149 opt: 292 Z-score: 395.0 bits: 79.8 E(85289): 2.9e-15
Smith-Waterman score: 292; 33.1% identity (68.1% similar) in 163 aa overlap (17-174:42-203)
10 20 30 40
pF1KE1 MKASSLAFSLLSAAFYLLWTPSTGLK--TLNLGSCVIATNL-QEIR
:::. .: . ...: : . . :..
NP_001 TLASRPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLW
20 30 40 50 60 70
50 60 70 80 90 100
pF1KE1 NGFSEIRGSVQAKDGNIDIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNYQ--TP
..: .. ..::.:. . :.:.. : ::... :. : :.. ::..:: :::::. :
NP_001 EAFWAVKDTMQAQDNITSARLLQQ-EVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTV
80 90 100 110 120 130
110 120 130 140 150 160
pF1KE1 DHYTLRKISSLANSFLTIKKDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKA
. ::...:.:::.:. : ..:. . . . : ... . :..:. .::..::
NP_001 EVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKA
140 150 160 170 180 190
170
pF1KE1 LGELDILLQWMEETE
:::.:::: ::..
NP_001 LGEVDILLTWMQKFYKL
200
>>NP_000563 (OMIM: 124092,180300,609423,614395) interleu (178 aa)
initn: 168 init1: 78 opt: 213 Z-score: 290.9 bits: 60.3 E(85289): 1.8e-09
Smith-Waterman score: 213; 27.0% identity (64.2% similar) in 159 aa overlap (20-173:19-169)
10 20 30 40 50
pF1KE1 MKASSLAFSLLSAAFYLLWTPSTGLKTLNLGSCV-----IATNLQEIRNGFSEIRGSVQA
.:. : .. : ::. . . :...:..::... :
NP_000 MHSSALLCCLVLLTGVRASPGQGTQSEN--SCTHFPGNLPNMLRDLRDAFSRVKTFFQM
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 KDGNIDIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNYQTPDHYTLRKISSLANS
:: ..: .:... :.: : : : .....::..:. . .. : ...::...
NP_000 KD-QLDNLLLKESL-LEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGEN
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 FLTIKKDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKALGELDILLQWMEET
. :.. :: :: . : :. : :. . :.::. . .. ::..:.::.....:
NP_000 LKTLRLRLRRCHRFLPC---ENKSKAVEQVKNAFNKLQ-EKGIYKAMSEFDIFINYIEAY
120 130 140 150 160 170
pF1KE1 E
NP_000 MTMKIRN
176 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 18:41:36 2016 done: Sun Nov 6 18:41:37 2016
Total Scan time: 5.690 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]