Result of FASTA (omim) for
pFN21AE1652
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1652, 169 aa
1>>>pF1KE1652 169 - 169 aa - 169 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9491+/-0.000318; mu= 14.6928+/- 0.020
mean_var=65.4244+/-13.511, 0's: 0 Z-trim(116.8): 29 B-trim: 689 in 1/54
Lambda= 0.158564
statistics sampled from 28143 (28172) to 28143 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.723), E-opt: 0.2 (0.33), width: 16
Scan time: 4.880
The best scores are: opt bits E(85289)
NP_062564 (OMIM: 605542) interleukin-36 gamma isof ( 169) 1146 270.2 1.1e-72
NP_001265497 (OMIM: 605542) interleukin-36 gamma i ( 134) 779 186.2 1.7e-47
XP_011509267 (OMIM: 605509) PREDICTED: interleukin ( 158) 616 149.0 3.3e-36
NP_055255 (OMIM: 605509) interleukin-36 alpha [Hom ( 158) 616 149.0 3.3e-36
XP_005263696 (OMIM: 605509) PREDICTED: interleukin ( 158) 616 149.0 3.3e-36
XP_016859295 (OMIM: 605509) PREDICTED: interleukin ( 158) 616 149.0 3.3e-36
XP_011509264 (OMIM: 605508) PREDICTED: interleukin ( 157) 461 113.5 1.5e-25
NP_775270 (OMIM: 605508) interleukin-36 beta isofo ( 157) 461 113.5 1.5e-25
NP_775297 (OMIM: 605510) interleukin-37 isoform 5 ( 192) 313 79.7 2.8e-15
NP_775294 (OMIM: 605510) interleukin-37 isoform 2 ( 197) 313 79.7 2.9e-15
NP_055254 (OMIM: 605510) interleukin-37 isoform 1 ( 218) 313 79.7 3.1e-15
XP_011509265 (OMIM: 605510) PREDICTED: interleukin ( 218) 313 79.7 3.1e-15
NP_055253 (OMIM: 605508) interleukin-36 beta isofo ( 164) 259 67.3 1.3e-11
NP_775295 (OMIM: 605510) interleukin-37 isoform 3 ( 157) 258 67.1 1.5e-11
XP_011509266 (OMIM: 605510) PREDICTED: interleukin ( 178) 258 67.1 1.6e-11
NP_775296 (OMIM: 605510) interleukin-37 isoform 4 ( 178) 258 67.1 1.6e-11
NP_115945 (OMIM: 615296) interleukin-1 family memb ( 152) 232 61.1 8.8e-10
NP_775184 (OMIM: 615296) interleukin-1 family memb ( 152) 232 61.1 8.8e-10
NP_775262 (OMIM: 605507,614204) interleukin-36 rec ( 155) 230 60.7 1.2e-09
NP_036407 (OMIM: 605507,614204) interleukin-36 rec ( 155) 230 60.7 1.2e-09
NP_776213 (OMIM: 137215,147679,612628,612852) inte ( 180) 216 57.5 1.3e-08
NP_000568 (OMIM: 137215,147679,612628,612852) inte ( 159) 211 56.3 2.6e-08
XP_011509423 (OMIM: 137215,147679,612628,612852) P ( 143) 210 56.1 2.8e-08
XP_005263718 (OMIM: 137215,147679,612628,612852) P ( 143) 210 56.1 2.8e-08
NP_776215 (OMIM: 137215,147679,612628,612852) inte ( 143) 210 56.1 2.8e-08
NP_001305843 (OMIM: 137215,147679,612628,612852) i ( 143) 210 56.1 2.8e-08
NP_776214 (OMIM: 137215,147679,612628,612852) inte ( 177) 211 56.3 2.8e-08
XP_016859477 (OMIM: 137215,147720) PREDICTED: inte ( 238) 156 43.9 0.00022
NP_000567 (OMIM: 137215,147720) interleukin-1 beta ( 269) 156 43.9 0.00024
>>NP_062564 (OMIM: 605542) interleukin-36 gamma isoform (169 aa)
initn: 1146 init1: 1146 opt: 1146 Z-score: 1425.9 bits: 270.2 E(85289): 1.1e-72
Smith-Waterman score: 1146; 100.0% identity (100.0% similar) in 169 aa overlap (1-169:1-169)
10 20 30 40 50 60
pF1KE1 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPVTVAVIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPVTVAVIT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 CKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 CKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFY
70 80 90 100 110 120
130 140 150 160
pF1KE1 RAKTGRTSTLESVAFPDWFIASSKRDQPIILTSELGKSYNTAFELNIND
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 RAKTGRTSTLESVAFPDWFIASSKRDQPIILTSELGKSYNTAFELNIND
130 140 150 160
>>NP_001265497 (OMIM: 605542) interleukin-36 gamma isofo (134 aa)
initn: 894 init1: 779 opt: 779 Z-score: 973.6 bits: 186.2 E(85289): 1.7e-47
Smith-Waterman score: 826; 78.7% identity (79.3% similar) in 169 aa overlap (1-169:1-134)
10 20 30 40 50 60
pF1KE1 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPVTVAVIT
:::::::::::::::::: .::::::
NP_001 MRGTPGDADGGGRAVYQS-----------------------------------ITVAVIT
10 20
70 80 90 100 110 120
pF1KE1 CKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFY
30 40 50 60 70 80
130 140 150 160
pF1KE1 RAKTGRTSTLESVAFPDWFIASSKRDQPIILTSELGKSYNTAFELNIND
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RAKTGRTSTLESVAFPDWFIASSKRDQPIILTSELGKSYNTAFELNIND
90 100 110 120 130
>>XP_011509267 (OMIM: 605509) PREDICTED: interleukin-36 (158 aa)
initn: 617 init1: 561 opt: 616 Z-score: 771.1 bits: 149.0 E(85289): 3.3e-36
Smith-Waterman score: 616; 59.9% identity (87.8% similar) in 147 aa overlap (22-167:10-156)
10 20 30 40 50 60
pF1KE1 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPVTVAVIT
: :.:.:.:..::.:: :.:.::::.: ..:::.:.:.
XP_011 MEKALKIDTPQQGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALIS
10 20 30 40
70 80 90 100 110 120
pF1KE1 CKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFY
:.. :.::. ::.:::::... ..::.: :::.::::::::. :::::.:::::: ::::
XP_011 CRHVETLEKDRGNPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFY
50 60 70 80 90 100
130 140 150 160
pF1KE1 RAKTGRTSTLESVAFPDWFIA-SSKRDQPIILTSELGKSYNTAFELNIND
....::.::.:::::: :::: ::. :.:::.::::. .: : :..
XP_011 HSQSGRNSTFESVAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF
110 120 130 140 150
>>NP_055255 (OMIM: 605509) interleukin-36 alpha [Homo sa (158 aa)
initn: 617 init1: 561 opt: 616 Z-score: 771.1 bits: 149.0 E(85289): 3.3e-36
Smith-Waterman score: 616; 59.9% identity (87.8% similar) in 147 aa overlap (22-167:10-156)
10 20 30 40 50 60
pF1KE1 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPVTVAVIT
: :.:.:.:..::.:: :.:.::::.: ..:::.:.:.
NP_055 MEKALKIDTPQQGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALIS
10 20 30 40
70 80 90 100 110 120
pF1KE1 CKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFY
:.. :.::. ::.:::::... ..::.: :::.::::::::. :::::.:::::: ::::
NP_055 CRHVETLEKDRGNPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFY
50 60 70 80 90 100
130 140 150 160
pF1KE1 RAKTGRTSTLESVAFPDWFIA-SSKRDQPIILTSELGKSYNTAFELNIND
....::.::.:::::: :::: ::. :.:::.::::. .: : :..
NP_055 HSQSGRNSTFESVAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF
110 120 130 140 150
>>XP_005263696 (OMIM: 605509) PREDICTED: interleukin-36 (158 aa)
initn: 617 init1: 561 opt: 616 Z-score: 771.1 bits: 149.0 E(85289): 3.3e-36
Smith-Waterman score: 616; 59.9% identity (87.8% similar) in 147 aa overlap (22-167:10-156)
10 20 30 40 50 60
pF1KE1 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPVTVAVIT
: :.:.:.:..::.:: :.:.::::.: ..:::.:.:.
XP_005 MEKALKIDTPQQGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALIS
10 20 30 40
70 80 90 100 110 120
pF1KE1 CKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFY
:.. :.::. ::.:::::... ..::.: :::.::::::::. :::::.:::::: ::::
XP_005 CRHVETLEKDRGNPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFY
50 60 70 80 90 100
130 140 150 160
pF1KE1 RAKTGRTSTLESVAFPDWFIA-SSKRDQPIILTSELGKSYNTAFELNIND
....::.::.:::::: :::: ::. :.:::.::::. .: : :..
XP_005 HSQSGRNSTFESVAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF
110 120 130 140 150
>>XP_016859295 (OMIM: 605509) PREDICTED: interleukin-36 (158 aa)
initn: 617 init1: 561 opt: 616 Z-score: 771.1 bits: 149.0 E(85289): 3.3e-36
Smith-Waterman score: 616; 59.9% identity (87.8% similar) in 147 aa overlap (22-167:10-156)
10 20 30 40 50 60
pF1KE1 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPVTVAVIT
: :.:.:.:..::.:: :.:.::::.: ..:::.:.:.
XP_016 MEKALKIDTPQQGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALIS
10 20 30 40
70 80 90 100 110 120
pF1KE1 CKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFY
:.. :.::. ::.:::::... ..::.: :::.::::::::. :::::.:::::: ::::
XP_016 CRHVETLEKDRGNPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFY
50 60 70 80 90 100
130 140 150 160
pF1KE1 RAKTGRTSTLESVAFPDWFIA-SSKRDQPIILTSELGKSYNTAFELNIND
....::.::.:::::: :::: ::. :.:::.::::. .: : :..
XP_016 HSQSGRNSTFESVAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF
110 120 130 140 150
>>XP_011509264 (OMIM: 605508) PREDICTED: interleukin-36 (157 aa)
initn: 462 init1: 388 opt: 461 Z-score: 579.5 bits: 113.5 E(85289): 1.5e-25
Smith-Waterman score: 461; 45.0% identity (74.2% similar) in 151 aa overlap (17-166:4-154)
10 20 30 40 50 60
pF1KE1 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPVTVAVIT
: : . .: : :.::.:.:..:.:.: : :. :::. .:.
XP_011 MNPQREAAPKSYAIRDSRQMVWVLSGNSLIAAPLSRSIKPVTLHLIA
10 20 30 40
70 80 90 100 110 120
pF1KE1 CKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFY
:. : .. .:. .::::.. ..::.: .. .:::::::..::::: . . :::::.
XP_011 CRDTEFSDKEKGNMVYLGIKGKDLCLFCAEIQGKPTLQLKEKNIMDLYVEKKAQKPFLFF
50 60 70 80 90 100
130 140 150 160
pF1KE1 RAKTGRTSTLESVAFPDWFIASSKRD-QPIILTSELGKSYNTAFELNIND
. : : ::...::..: ::::.: . :::.::.: : . :: : :.
XP_011 HNKEGSTSVFQSVSYPGWFIATSTTSGQPIFLTKERGITNNTNFYLDSVE
110 120 130 140 150
>>NP_775270 (OMIM: 605508) interleukin-36 beta isoform 2 (157 aa)
initn: 462 init1: 388 opt: 461 Z-score: 579.5 bits: 113.5 E(85289): 1.5e-25
Smith-Waterman score: 461; 45.0% identity (74.2% similar) in 151 aa overlap (17-166:4-154)
10 20 30 40 50 60
pF1KE1 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPVTVAVIT
: : . .: : :.::.:.:..:.:.: : :. :::. .:.
NP_775 MNPQREAAPKSYAIRDSRQMVWVLSGNSLIAAPLSRSIKPVTLHLIA
10 20 30 40
70 80 90 100 110 120
pF1KE1 CKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFY
:. : .. .:. .::::.. ..::.: .. .:::::::..::::: . . :::::.
NP_775 CRDTEFSDKEKGNMVYLGIKGKDLCLFCAEIQGKPTLQLKEKNIMDLYVEKKAQKPFLFF
50 60 70 80 90 100
130 140 150 160
pF1KE1 RAKTGRTSTLESVAFPDWFIASSKRD-QPIILTSELGKSYNTAFELNIND
. : : ::...::..: ::::.: . :::.::.: : . :: : :.
NP_775 HNKEGSTSVFQSVSYPGWFIATSTTSGQPIFLTKERGITNNTNFYLDSVE
110 120 130 140 150
>>NP_775297 (OMIM: 605510) interleukin-37 isoform 5 [Hom (192 aa)
initn: 264 init1: 120 opt: 313 Z-score: 395.3 bits: 79.7 E(85289): 2.8e-15
Smith-Waterman score: 313; 36.3% identity (67.8% similar) in 146 aa overlap (22-163:31-175)
10 20 30 40 50
pF1KE1 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSV
: .:.: ...: .:.. ::.::: .. .
NP_775 MSGCDRRETETKGKNSFKKRLRGPKVKNLNPKKFSIHDQDHKVLVLDSGNLIAVPDKNYI
10 20 30 40 50 60
60 70 80 90 100
pF1KE1 TPVTVAVITCKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQ--PTLQLKEQKIMDLYG
: ... . : . .:.:: ::... :.::::.: : :.::::..:.: : .
NP_775 RPEIFFALASSLSSASAE-KGSPILLGVSKGEFCLYCDKDKGQSHPSLQLKKEKLMKLAA
70 80 90 100 110
110 120 130 140 150 160
pF1KE1 QPEPVK-PFLFYRAKTGRTSTLESVAFPDWFIASSKR-DQPIILTSELGKSYNTAFELNI
: : .. ::.::::..: . :::.: : ::: .: ..:. .:... . . :
NP_775 QKESARRPFIFYRAQVGSWNMLESAAHPGWFICTSCNCNEPVGVTDKFENRKHIEFSFQP
120 130 140 150 160 170
pF1KE1 ND
NP_775 VCKAEMSPSEVSD
180 190
>>NP_775294 (OMIM: 605510) interleukin-37 isoform 2 [Hom (197 aa)
initn: 264 init1: 120 opt: 313 Z-score: 395.1 bits: 79.7 E(85289): 2.9e-15
Smith-Waterman score: 313; 36.3% identity (67.8% similar) in 146 aa overlap (22-163:36-180)
10 20 30 40 50
pF1KE1 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSV
: .:.: ...: .:.. ::.::: .. .
NP_775 ENSGVKMGSEDWEKDEPQCCLEGPKVKNLNPKKFSIHDQDHKVLVLDSGNLIAVPDKNYI
10 20 30 40 50 60
60 70 80 90 100
pF1KE1 TPVTVAVITCKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQ--PTLQLKEQKIMDLYG
: ... . : . .:.:: ::... :.::::.: : :.::::..:.: : .
NP_775 RPEIFFALASSLSSASAE-KGSPILLGVSKGEFCLYCDKDKGQSHPSLQLKKEKLMKLAA
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE1 QPEPVK-PFLFYRAKTGRTSTLESVAFPDWFIASSKR-DQPIILTSELGKSYNTAFELNI
: : .. ::.::::..: . :::.: : ::: .: ..:. .:... . . :
NP_775 QKESARRPFIFYRAQVGSWNMLESAAHPGWFICTSCNCNEPVGVTDKFENRKHIEFSFQP
130 140 150 160 170 180
pF1KE1 ND
NP_775 VCKAEMSPSEVSD
190
169 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 18:18:49 2016 done: Sun Nov 6 18:18:50 2016
Total Scan time: 4.880 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]