Result of FASTA (omim) for
pFN21AE1643
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1643, 158 aa
1>>>pF1KE1643 158 - 158 aa - 158 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7545+/-0.000316; mu= 14.8458+/- 0.020
mean_var=57.1779+/-11.348, 0's: 0 Z-trim(115.6): 29 B-trim: 19 in 1/55
Lambda= 0.169613
statistics sampled from 26086 (26116) to 26086 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.702), E-opt: 0.2 (0.306), width: 16
Scan time: 5.330
The best scores are: opt bits E(85289)
NP_055255 (OMIM: 605509) interleukin-36 alpha [Hom ( 158) 1059 266.8 1.1e-71
XP_011509267 (OMIM: 605509) PREDICTED: interleukin ( 158) 1059 266.8 1.1e-71
XP_005263696 (OMIM: 605509) PREDICTED: interleukin ( 158) 1059 266.8 1.1e-71
XP_016859295 (OMIM: 605509) PREDICTED: interleukin ( 158) 1059 266.8 1.1e-71
NP_062564 (OMIM: 605542) interleukin-36 gamma isof ( 169) 616 158.4 4.8e-39
XP_011509264 (OMIM: 605508) PREDICTED: interleukin ( 157) 502 130.5 1.1e-30
NP_775270 (OMIM: 605508) interleukin-36 beta isofo ( 157) 502 130.5 1.1e-30
NP_001265497 (OMIM: 605542) interleukin-36 gamma i ( 134) 481 125.3 3.5e-29
NP_775297 (OMIM: 605510) interleukin-37 isoform 5 ( 192) 306 82.6 3.6e-16
NP_775294 (OMIM: 605510) interleukin-37 isoform 2 ( 197) 306 82.6 3.7e-16
XP_011509265 (OMIM: 605510) PREDICTED: interleukin ( 218) 306 82.6 4e-16
NP_055254 (OMIM: 605510) interleukin-37 isoform 1 ( 218) 306 82.6 4e-16
NP_055253 (OMIM: 605508) interleukin-36 beta isofo ( 164) 266 72.7 2.8e-13
NP_775262 (OMIM: 605507,614204) interleukin-36 rec ( 155) 245 67.6 9.5e-12
NP_036407 (OMIM: 605507,614204) interleukin-36 rec ( 155) 245 67.6 9.5e-12
XP_011509423 (OMIM: 137215,147679,612628,612852) P ( 143) 235 65.1 4.9e-11
XP_005263718 (OMIM: 137215,147679,612628,612852) P ( 143) 235 65.1 4.9e-11
NP_776215 (OMIM: 137215,147679,612628,612852) inte ( 143) 235 65.1 4.9e-11
NP_001305843 (OMIM: 137215,147679,612628,612852) i ( 143) 235 65.1 4.9e-11
NP_000568 (OMIM: 137215,147679,612628,612852) inte ( 159) 235 65.1 5.3e-11
NP_776214 (OMIM: 137215,147679,612628,612852) inte ( 177) 235 65.2 5.8e-11
NP_776213 (OMIM: 137215,147679,612628,612852) inte ( 180) 235 65.2 5.9e-11
NP_775184 (OMIM: 615296) interleukin-1 family memb ( 152) 231 64.1 1e-10
NP_115945 (OMIM: 615296) interleukin-1 family memb ( 152) 231 64.1 1e-10
NP_775295 (OMIM: 605510) interleukin-37 isoform 3 ( 157) 220 61.5 6.7e-10
NP_775296 (OMIM: 605510) interleukin-37 isoform 4 ( 178) 220 61.5 7.4e-10
XP_011509266 (OMIM: 605510) PREDICTED: interleukin ( 178) 220 61.5 7.4e-10
XP_016859477 (OMIM: 137215,147720) PREDICTED: inte ( 238) 191 54.5 1.3e-07
NP_000567 (OMIM: 137215,147720) interleukin-1 beta ( 269) 191 54.5 1.4e-07
>>NP_055255 (OMIM: 605509) interleukin-36 alpha [Homo sa (158 aa)
initn: 1059 init1: 1059 opt: 1059 Z-score: 1408.3 bits: 266.8 E(85289): 1.1e-71
Smith-Waterman score: 1059; 99.4% identity (100.0% similar) in 158 aa overlap (1-158:1-158)
10 20 30 40 50 60
pF1KE1 MEKALKIDTPQRGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRG
:::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MEKALKIDTPQQGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 NPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFES
70 80 90 100 110 120
130 140 150
pF1KE1 VAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF
::::::::::::::::::::::::::::::::::::::
NP_055 VAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF
130 140 150
>>XP_011509267 (OMIM: 605509) PREDICTED: interleukin-36 (158 aa)
initn: 1059 init1: 1059 opt: 1059 Z-score: 1408.3 bits: 266.8 E(85289): 1.1e-71
Smith-Waterman score: 1059; 99.4% identity (100.0% similar) in 158 aa overlap (1-158:1-158)
10 20 30 40 50 60
pF1KE1 MEKALKIDTPQRGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRG
:::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEKALKIDTPQQGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 NPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFES
70 80 90 100 110 120
130 140 150
pF1KE1 VAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF
::::::::::::::::::::::::::::::::::::::
XP_011 VAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF
130 140 150
>>XP_005263696 (OMIM: 605509) PREDICTED: interleukin-36 (158 aa)
initn: 1059 init1: 1059 opt: 1059 Z-score: 1408.3 bits: 266.8 E(85289): 1.1e-71
Smith-Waterman score: 1059; 99.4% identity (100.0% similar) in 158 aa overlap (1-158:1-158)
10 20 30 40 50 60
pF1KE1 MEKALKIDTPQRGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRG
:::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEKALKIDTPQQGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 NPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFES
70 80 90 100 110 120
130 140 150
pF1KE1 VAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF
::::::::::::::::::::::::::::::::::::::
XP_005 VAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF
130 140 150
>>XP_016859295 (OMIM: 605509) PREDICTED: interleukin-36 (158 aa)
initn: 1059 init1: 1059 opt: 1059 Z-score: 1408.3 bits: 266.8 E(85289): 1.1e-71
Smith-Waterman score: 1059; 99.4% identity (100.0% similar) in 158 aa overlap (1-158:1-158)
10 20 30 40 50 60
pF1KE1 MEKALKIDTPQRGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRG
:::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEKALKIDTPQQGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 NPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFES
70 80 90 100 110 120
130 140 150
pF1KE1 VAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF
::::::::::::::::::::::::::::::::::::::
XP_016 VAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF
130 140 150
>>NP_062564 (OMIM: 605542) interleukin-36 gamma isoform (169 aa)
initn: 617 init1: 561 opt: 616 Z-score: 822.0 bits: 158.4 E(85289): 4.8e-39
Smith-Waterman score: 616; 59.9% identity (87.8% similar) in 147 aa overlap (10-156:22-167)
10 20 30 40
pF1KE1 MEKALKIDTPQRGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALIS
: :.:.:.:..::.:: :.:.::::.: ..:::.:.:.
NP_062 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPVTVAVIT
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 CRHVETLEKDRGNPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFY
:.. :.::. ::.:::::... ..::.: :::.::::::::. :::::.:::::: ::::
NP_062 CKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFY
70 80 90 100 110 120
110 120 130 140 150
pF1KE1 HSQSGRNSTFESVAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF
....::.::.:::::: :::: ::. :.:::.::::. .: : :..
NP_062 RAKTGRTSTLESVAFPDWFIA-SSKRDQPIILTSELGKSYNTAFELNIND
130 140 150 160
>>XP_011509264 (OMIM: 605508) PREDICTED: interleukin-36 (157 aa)
initn: 504 init1: 484 opt: 502 Z-score: 671.7 bits: 130.5 E(85289): 1.1e-30
Smith-Waterman score: 502; 49.0% identity (80.0% similar) in 145 aa overlap (10-154:9-153)
10 20 30 40 50 60
pF1KE1 MEKALKIDTPQRGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRG
:. .:.: . ::::. ..:::.: . ..:::. ::.:: .: .:..:
XP_011 MNPQREAAPKSYAIRDSRQMVWVLSGNSLIAAPLSRSIKPVTLHLIACRDTEFSDKEKG
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 NPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFES
: .:::..: .:::.::.. .::::::::.::::: . . : :::.:.. : .:.:.:
XP_011 NMVYLGIKGKDLCLFCAEIQGKPTLQLKEKNIMDLYVEKKAQKPFLFFHNKEGSTSVFQS
60 70 80 90 100 110
130 140 150
pF1KE1 VAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF
:..::::::.:. .: :..::.: : .:.:.: :
XP_011 VSYPGWFIATSTTSGQPIFLTKERGITNNTNFYLDSVE
120 130 140 150
>>NP_775270 (OMIM: 605508) interleukin-36 beta isoform 2 (157 aa)
initn: 504 init1: 484 opt: 502 Z-score: 671.7 bits: 130.5 E(85289): 1.1e-30
Smith-Waterman score: 502; 49.0% identity (80.0% similar) in 145 aa overlap (10-154:9-153)
10 20 30 40 50 60
pF1KE1 MEKALKIDTPQRGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRG
:. .:.: . ::::. ..:::.: . ..:::. ::.:: .: .:..:
NP_775 MNPQREAAPKSYAIRDSRQMVWVLSGNSLIAAPLSRSIKPVTLHLIACRDTEFSDKEKG
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 NPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFES
: .:::..: .:::.::.. .::::::::.::::: . . : :::.:.. : .:.:.:
NP_775 NMVYLGIKGKDLCLFCAEIQGKPTLQLKEKNIMDLYVEKKAQKPFLFFHNKEGSTSVFQS
60 70 80 90 100 110
130 140 150
pF1KE1 VAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF
:..::::::.:. .: :..::.: : .:.:.: :
NP_775 VSYPGWFIATSTTSGQPIFLTKERGITNNTNFYLDSVE
120 130 140 150
>>NP_001265497 (OMIM: 605542) interleukin-36 gamma isofo (134 aa)
initn: 482 init1: 426 opt: 481 Z-score: 644.9 bits: 125.3 E(85289): 3.5e-29
Smith-Waterman score: 481; 60.9% identity (87.8% similar) in 115 aa overlap (42-156:19-132)
20 30 40 50 60 70
pF1KE1 RGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRGNPIYLGLNGLN
.:.:.:.:.. :.::. ::.:::::... .
NP_001 MRGTPGDADGGGRAVYQSITVAVITCKYPEALEQGRGDPIYLGIQNPE
10 20 30 40
80 90 100 110 120 130
pF1KE1 LCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFESVAFPGWFIAVS
.::.: :::.::::::::. :::::.:::::: ::::....::.::.:::::: :::: :
NP_001 MCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFYRAKTGRTSTLESVAFPDWFIA-S
50 60 70 80 90 100
140 150
pF1KE1 SEGGCPLILTQELGKANTTDFGLTMLF
:. :.:::.::::. .: : :..
NP_001 SKRDQPIILTSELGKSYNTAFELNIND
110 120 130
>>NP_775297 (OMIM: 605510) interleukin-37 isoform 5 [Hom (192 aa)
initn: 271 init1: 105 opt: 306 Z-score: 411.2 bits: 82.6 E(85289): 3.6e-16
Smith-Waterman score: 306; 37.6% identity (67.1% similar) in 149 aa overlap (10-154:31-177)
10 20 30
pF1KE1 MEKALKIDTPQRGSIQDINHRVWVLQDQTLIAVPRKDRM
:.. ::.: .:.: ::.. .::::: :. .
NP_775 MSGCDRRETETKGKNSFKKRLRGPKVKNLNPKKFSIHDQDHKVLVLDSGNLIAVPDKNYI
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE1 SP-VTIALISCRHVETLEKDRGNPIYLGLNGLNLCLMCAKVGDQ--PTLQLKEKDIMDLY
: . .:: : . :: :.:: ::.. ..::.: : : :.::::.. .: :
NP_775 RPEIFFALASSLSSASAEK--GSPILLGVSKGEFCLYCDKDKGQSHPSLQLKKEKLMKLA
70 80 90 100 110
100 110 120 130 140 150
pF1KE1 NQPEPVKS-FLFYHSQSGRNSTFESVAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLT
: : .. :.::..: : . .::.: ::::: .: . . :. .:... . . .:..
NP_775 AQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTSCNCNEPVGVTDKFENRKHIEFSFQ
120 130 140 150 160 170
pF1KE1 MLF
NP_775 PVCKAEMSPSEVSD
180 190
>>NP_775294 (OMIM: 605510) interleukin-37 isoform 2 [Hom (197 aa)
initn: 271 init1: 105 opt: 306 Z-score: 411.1 bits: 82.6 E(85289): 3.7e-16
Smith-Waterman score: 306; 37.6% identity (67.1% similar) in 149 aa overlap (10-154:36-182)
10 20 30
pF1KE1 MEKALKIDTPQRGSIQDINHRVWVLQDQTLIAVPRKDRM
:.. ::.: .:.: ::.. .::::: :. .
NP_775 ENSGVKMGSEDWEKDEPQCCLEGPKVKNLNPKKFSIHDQDHKVLVLDSGNLIAVPDKNYI
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE1 SP-VTIALISCRHVETLEKDRGNPIYLGLNGLNLCLMCAKVGDQ--PTLQLKEKDIMDLY
: . .:: : . :: :.:: ::.. ..::.: : : :.::::.. .: :
NP_775 RPEIFFALASSLSSASAEK--GSPILLGVSKGEFCLYCDKDKGQSHPSLQLKKEKLMKLA
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE1 NQPEPVKS-FLFYHSQSGRNSTFESVAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLT
: : .. :.::..: : . .::.: ::::: .: . . :. .:... . . .:..
NP_775 AQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTSCNCNEPVGVTDKFENRKHIEFSFQ
130 140 150 160 170 180
pF1KE1 MLF
NP_775 PVCKAEMSPSEVSD
190
158 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 11:01:18 2016 done: Sun Nov 6 11:01:19 2016
Total Scan time: 5.330 Total Display time: -0.030
Function used was FASTA [36.3.4 Apr, 2011]