Result of FASTA (omim) for
pFN21AE1640
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1640, 155 aa
1>>>pF1KE1640 155 - 155 aa - 155 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2270+/-0.000292; mu= 12.3312+/- 0.018
mean_var=65.0759+/-13.075, 0's: 0 Z-trim(118.5): 15 B-trim: 0 in 0/54
Lambda= 0.158988
statistics sampled from 31499 (31514) to 31499 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.75), E-opt: 0.2 (0.369), width: 16
Scan time: 4.750
The best scores are: opt bits E(85289)
NP_002181 (OMIM: 603149) interleukin-17A precursor ( 155) 1077 255.0 3.6e-68
NP_443104 (OMIM: 606496,613956) interleukin-17F pr ( 163) 431 106.8 1.5e-23
XP_011512578 (OMIM: 606496,613956) PREDICTED: inte ( 163) 431 106.8 1.5e-23
XP_016864836 (OMIM: 604627) PREDICTED: interleukin ( 128) 198 53.3 1.5e-07
NP_001304916 (OMIM: 604627) interleukin-17B isofor ( 128) 198 53.3 1.5e-07
XP_011535924 (OMIM: 604627) PREDICTED: interleukin ( 128) 198 53.3 1.5e-07
XP_016864837 (OMIM: 604627) PREDICTED: interleukin ( 128) 198 53.3 1.5e-07
NP_055258 (OMIM: 604627) interleukin-17B isoform 1 ( 180) 198 53.4 2e-07
XP_016864835 (OMIM: 604627) PREDICTED: interleukin ( 245) 198 53.5 2.6e-07
NP_612141 (OMIM: 607587) interleukin-17D precursor ( 202) 189 51.4 9.2e-07
XP_005266478 (OMIM: 607587) PREDICTED: interleukin ( 209) 189 51.4 9.5e-07
NP_037410 (OMIM: 604628) interleukin-17C precursor ( 197) 167 46.3 3e-05
XP_005266479 (OMIM: 607587) PREDICTED: interleukin ( 114) 154 43.2 0.00015
NP_758525 (OMIM: 605658) interleukin-25 isoform 2 ( 161) 134 38.7 0.0048
NP_073626 (OMIM: 605658) interleukin-25 isoform 1 ( 177) 134 38.7 0.0052
>>NP_002181 (OMIM: 603149) interleukin-17A precursor [Ho (155 aa)
initn: 1077 init1: 1077 opt: 1077 Z-score: 1344.9 bits: 255.0 E(85289): 3.6e-68
Smith-Waterman score: 1077; 100.0% identity (100.0% similar) in 155 aa overlap (1-155:1-155)
10 20 30 40 50 60
pF1KE1 MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 KRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEIL
70 80 90 100 110 120
130 140 150
pF1KE1 VLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA
:::::::::::::::::::::::::::::::::::
NP_002 VLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA
130 140 150
>>NP_443104 (OMIM: 606496,613956) interleukin-17F precur (163 aa)
initn: 411 init1: 411 opt: 431 Z-score: 543.7 bits: 106.8 E(85289): 1.5e-23
Smith-Waterman score: 431; 49.0% identity (68.2% similar) in 151 aa overlap (7-154:18-162)
10 20 30 40
pF1KE1 MTPGKTSLVSLLLLLSLEA--IVKAGITIPRNP-GCPNSEDKNFPRTVM
:...: .: : : :.: :. ..: .:: : :
NP_443 MTVKTLHGPAMVKYLLLSILGLAFLSEAAARKIPKVGHTFFQKPESCPP-----VPGGSM
10 20 30 40 50
50 60 70 80 90 100
pF1KE1 VNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNV
.:.: : : . : . .::::::: . ::.:::: . .:.::.::::::.:.
NP_443 -KLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKE
60 70 80 90 100 110
110 120 130 140 150
pF1KE1 DYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA
: ::::::::: ::.::. : ::.:::.::.::::::::..:::
NP_443 DISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ
120 130 140 150 160
>>XP_011512578 (OMIM: 606496,613956) PREDICTED: interleu (163 aa)
initn: 411 init1: 411 opt: 431 Z-score: 543.7 bits: 106.8 E(85289): 1.5e-23
Smith-Waterman score: 431; 49.0% identity (68.2% similar) in 151 aa overlap (7-154:18-162)
10 20 30 40
pF1KE1 MTPGKTSLVSLLLLLSLEA--IVKAGITIPRNP-GCPNSEDKNFPRTVM
:...: .: : : :.: :. ..: .:: : :
XP_011 MTVKTLHGPAMVKYLLLSILGLAFLSEAAARKIPKVGHTFFQKPESCPP-----VPGGSM
10 20 30 40 50
50 60 70 80 90 100
pF1KE1 VNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNV
.:.: : : . : . .::::::: . ::.:::: . .:.::.::::::.:.
XP_011 -KLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKE
60 70 80 90 100 110
110 120 130 140 150
pF1KE1 DYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA
: ::::::::: ::.::. : ::.:::.::.::::::::..:::
XP_011 DISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ
120 130 140 150 160
>>XP_016864836 (OMIM: 604627) PREDICTED: interleukin-17B (128 aa)
initn: 193 init1: 125 opt: 198 Z-score: 256.5 bits: 53.3 E(85289): 1.5e-07
Smith-Waterman score: 198; 39.3% identity (59.5% similar) in 84 aa overlap (69-147:44-127)
40 50 60 70 80 90
pF1KE1 KNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLG
:: :::. :.:: : : . ::.: ::
XP_016 IEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLG
20 30 40 50 60 70
100 110 120 130 140 150
pF1KE1 CINA-DGNVDYHMNSVPIQQEILVLRR--EPPHCPNSFRLEKIL--VSVGCTCVTPIVHH
:.: . : : :::. ... : :: :: . : . .. ..:::::.
XP_016 CVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF
80 90 100 110 120
pF1KE1 VA
>>NP_001304916 (OMIM: 604627) interleukin-17B isoform 2 (128 aa)
initn: 193 init1: 125 opt: 198 Z-score: 256.5 bits: 53.3 E(85289): 1.5e-07
Smith-Waterman score: 198; 39.3% identity (59.5% similar) in 84 aa overlap (69-147:44-127)
40 50 60 70 80 90
pF1KE1 KNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLG
:: :::. :.:: : : . ::.: ::
NP_001 IEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLG
20 30 40 50 60 70
100 110 120 130 140 150
pF1KE1 CINA-DGNVDYHMNSVPIQQEILVLRR--EPPHCPNSFRLEKIL--VSVGCTCVTPIVHH
:.: . : : :::. ... : :: :: . : . .. ..:::::.
NP_001 CVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF
80 90 100 110 120
pF1KE1 VA
>>XP_011535924 (OMIM: 604627) PREDICTED: interleukin-17B (128 aa)
initn: 193 init1: 125 opt: 198 Z-score: 256.5 bits: 53.3 E(85289): 1.5e-07
Smith-Waterman score: 198; 39.3% identity (59.5% similar) in 84 aa overlap (69-147:44-127)
40 50 60 70 80 90
pF1KE1 KNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLG
:: :::. :.:: : : . ::.: ::
XP_011 IEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLG
20 30 40 50 60 70
100 110 120 130 140 150
pF1KE1 CINA-DGNVDYHMNSVPIQQEILVLRR--EPPHCPNSFRLEKIL--VSVGCTCVTPIVHH
:.: . : : :::. ... : :: :: . : . .. ..:::::.
XP_011 CVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF
80 90 100 110 120
pF1KE1 VA
>>XP_016864837 (OMIM: 604627) PREDICTED: interleukin-17B (128 aa)
initn: 193 init1: 125 opt: 198 Z-score: 256.5 bits: 53.3 E(85289): 1.5e-07
Smith-Waterman score: 198; 39.3% identity (59.5% similar) in 84 aa overlap (69-147:44-127)
40 50 60 70 80 90
pF1KE1 KNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLG
:: :::. :.:: : : . ::.: ::
XP_016 IEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLG
20 30 40 50 60 70
100 110 120 130 140 150
pF1KE1 CINA-DGNVDYHMNSVPIQQEILVLRR--EPPHCPNSFRLEKIL--VSVGCTCVTPIVHH
:.: . : : :::. ... : :: :: . : . .. ..:::::.
XP_016 CVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF
80 90 100 110 120
pF1KE1 VA
>>NP_055258 (OMIM: 604627) interleukin-17B isoform 1 pre (180 aa)
initn: 193 init1: 125 opt: 198 Z-score: 254.3 bits: 53.4 E(85289): 2e-07
Smith-Waterman score: 198; 39.3% identity (59.5% similar) in 84 aa overlap (69-147:96-179)
40 50 60 70 80 90
pF1KE1 KNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLG
:: :::. :.:: : : . ::.: ::
NP_055 IEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLG
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE1 CINA-DGNVDYHMNSVPIQQEILVLRR--EPPHCPNSFRLEKIL--VSVGCTCVTPIVHH
:.: . : : :::. ... : :: :: . : . .. ..:::::.
NP_055 CVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF
130 140 150 160 170 180
pF1KE1 VA
>>XP_016864835 (OMIM: 604627) PREDICTED: interleukin-17B (245 aa)
initn: 193 init1: 125 opt: 198 Z-score: 252.3 bits: 53.5 E(85289): 2.6e-07
Smith-Waterman score: 198; 39.3% identity (59.5% similar) in 84 aa overlap (69-147:161-244)
40 50 60 70 80 90
pF1KE1 KNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLG
:: :::. :.:: : : . ::.: ::
XP_016 IEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLG
140 150 160 170 180 190
100 110 120 130 140 150
pF1KE1 CINA-DGNVDYHMNSVPIQQEILVLRR--EPPHCPNSFRLEKIL--VSVGCTCVTPIVHH
:.: . : : :::. ... : :: :: . : . .. ..:::::.
XP_016 CVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF
200 210 220 230 240
pF1KE1 VA
>>NP_612141 (OMIM: 607587) interleukin-17D precursor [Ho (202 aa)
initn: 191 init1: 109 opt: 189 Z-score: 242.4 bits: 51.4 E(85289): 9.2e-07
Smith-Waterman score: 189; 39.8% identity (60.2% similar) in 83 aa overlap (69-147:89-170)
40 50 60 70 80 90
pF1KE1 KNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLG
::.::: . . :: ::: . :: : :
NP_612 QLGPREQARNASCPAGGRPADRRFRPPTNLRSVSPWAYRISYDPARYPRYLPEAYCLCRG
60 70 80 90 100 110
100 110 120 130 140 150
pF1KE1 CINAD-GNVDYHMNSVPIQQEILVLRREPPHCPN--SFRLEK-ILVSVGCTCVTPIVHHV
:... :. : .. :.:. . .:::: : : . : : . . ::::::
NP_612 CLTGLFGEEDVRFRSAPVYMPTVVLRRTPA-CAGGRSVYTEAYVTIPVGCTCVPEPEKDA
120 130 140 150 160 170
pF1KE1 A
NP_612 DSINSSIDKQGAKLLLGPNDAPAGP
180 190 200
155 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 16:48:26 2016 done: Sun Nov 6 16:48:27 2016
Total Scan time: 4.750 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]