Result of FASTA (omim) for
pFN21AE1636
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1636, 152 aa
1>>>pF1KE1636 152 - 152 aa - 152 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7211+/-0.000273; mu= 15.1751+/- 0.017
mean_var=57.9448+/-11.290, 0's: 0 Z-trim(118.5): 34 B-trim: 3 in 1/57
Lambda= 0.168487
statistics sampled from 31498 (31536) to 31498 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.761), E-opt: 0.2 (0.37), width: 16
Scan time: 4.970
The best scores are: opt bits E(85289)
NP_775184 (OMIM: 615296) interleukin-1 family memb ( 152) 1041 260.4 8.3e-70
NP_115945 (OMIM: 615296) interleukin-1 family memb ( 152) 1041 260.4 8.3e-70
NP_775262 (OMIM: 605507,614204) interleukin-36 rec ( 155) 371 97.5 9e-21
NP_036407 (OMIM: 605507,614204) interleukin-36 rec ( 155) 371 97.5 9e-21
XP_011509423 (OMIM: 137215,147679,612628,612852) P ( 143) 312 83.1 1.7e-16
NP_001305843 (OMIM: 137215,147679,612628,612852) i ( 143) 312 83.1 1.7e-16
NP_776215 (OMIM: 137215,147679,612628,612852) inte ( 143) 312 83.1 1.7e-16
XP_005263718 (OMIM: 137215,147679,612628,612852) P ( 143) 312 83.1 1.7e-16
NP_000568 (OMIM: 137215,147679,612628,612852) inte ( 159) 312 83.2 1.9e-16
NP_776214 (OMIM: 137215,147679,612628,612852) inte ( 177) 312 83.2 2.1e-16
NP_776213 (OMIM: 137215,147679,612628,612852) inte ( 180) 312 83.2 2.1e-16
NP_062564 (OMIM: 605542) interleukin-36 gamma isof ( 169) 235 64.5 8.6e-11
XP_011509264 (OMIM: 605508) PREDICTED: interleukin ( 157) 234 64.2 9.6e-11
NP_775270 (OMIM: 605508) interleukin-36 beta isofo ( 157) 234 64.2 9.6e-11
XP_005263696 (OMIM: 605509) PREDICTED: interleukin ( 158) 232 63.7 1.4e-10
XP_011509267 (OMIM: 605509) PREDICTED: interleukin ( 158) 232 63.7 1.4e-10
NP_055255 (OMIM: 605509) interleukin-36 alpha [Hom ( 158) 232 63.7 1.4e-10
XP_016859295 (OMIM: 605509) PREDICTED: interleukin ( 158) 232 63.7 1.4e-10
NP_001265497 (OMIM: 605542) interleukin-36 gamma i ( 134) 216 59.8 1.8e-09
NP_775295 (OMIM: 605510) interleukin-37 isoform 3 ( 157) 216 59.8 2e-09
XP_011509266 (OMIM: 605510) PREDICTED: interleukin ( 178) 206 57.4 1.2e-08
NP_775296 (OMIM: 605510) interleukin-37 isoform 4 ( 178) 206 57.4 1.2e-08
NP_775297 (OMIM: 605510) interleukin-37 isoform 5 ( 192) 206 57.5 1.3e-08
NP_775294 (OMIM: 605510) interleukin-37 isoform 2 ( 197) 206 57.5 1.3e-08
NP_055254 (OMIM: 605510) interleukin-37 isoform 1 ( 218) 206 57.5 1.4e-08
XP_011509265 (OMIM: 605510) PREDICTED: interleukin ( 218) 206 57.5 1.4e-08
XP_016859477 (OMIM: 137215,147720) PREDICTED: inte ( 238) 147 43.2 0.00031
NP_000567 (OMIM: 137215,147720) interleukin-1 beta ( 269) 147 43.2 0.00034
XP_011518013 (OMIM: 261100,602997) PREDICTED: cubi (2237) 137 41.4 0.01
>>NP_775184 (OMIM: 615296) interleukin-1 family member 1 (152 aa)
initn: 1041 init1: 1041 opt: 1041 Z-score: 1374.2 bits: 260.4 E(85289): 8.3e-70
Smith-Waterman score: 1041; 98.7% identity (98.7% similar) in 152 aa overlap (1-152:1-152)
10 20 30 40 50 60
pF1KE1 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCCAEKICTLPNRGLDRTKVPIFLG
::::::::::::::::::::::::::::::::::::::::::: :::::: :::::::::
NP_775 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCCAEKICILPNRGLARTKVPIFLG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 IQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 IQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPGW
70 80 90 100 110 120
130 140 150
pF1KE1 FLCGPAEPQQPVQLTKESEPSARTKFYFEQSW
::::::::::::::::::::::::::::::::
NP_775 FLCGPAEPQQPVQLTKESEPSARTKFYFEQSW
130 140 150
>>NP_115945 (OMIM: 615296) interleukin-1 family member 1 (152 aa)
initn: 1041 init1: 1041 opt: 1041 Z-score: 1374.2 bits: 260.4 E(85289): 8.3e-70
Smith-Waterman score: 1041; 98.7% identity (98.7% similar) in 152 aa overlap (1-152:1-152)
10 20 30 40 50 60
pF1KE1 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCCAEKICTLPNRGLDRTKVPIFLG
::::::::::::::::::::::::::::::::::::::::::: :::::: :::::::::
NP_115 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCCAEKICILPNRGLARTKVPIFLG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 IQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 IQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPGW
70 80 90 100 110 120
130 140 150
pF1KE1 FLCGPAEPQQPVQLTKESEPSARTKFYFEQSW
::::::::::::::::::::::::::::::::
NP_115 FLCGPAEPQQPVQLTKESEPSARTKFYFEQSW
130 140 150
>>NP_775262 (OMIM: 605507,614204) interleukin-36 recepto (155 aa)
initn: 348 init1: 210 opt: 371 Z-score: 493.9 bits: 97.5 E(85289): 9e-21
Smith-Waterman score: 371; 44.4% identity (69.4% similar) in 144 aa overlap (12-150:11-153)
10 20 30 40 50
pF1KE1 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCC-AEKICTLPNRGLDRTKVPIFL
.: . :.:: ...:::.: : . .:.: ..::: :: . :..:
NP_775 MVLSGALCFRMKDSALKVLYLHNNQLLAGGLHAGKVIKGEEISVVPNRWLDASLSPVIL
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 GIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPG
:.::::.::.: .: :.: :: ::: ::: :..:. :::.. . : . .:.::.::
NP_775 GVQGGSQCLSCGVGQE-PTLTLEPVNIMELYLGAKESKSFTFYRRDMGLTSSFESAAYPG
60 70 80 90 100 110
120 130 140 150
pF1KE1 WFLCGPAEPQQPVQLTKESEPSAR----TKFYFEQSW
:::: : .:::.::. : .. : :::.:
NP_775 WFLCTVPEADQPVRLTQLPENGGWNAPITDFYFQQCD
120 130 140 150
>>NP_036407 (OMIM: 605507,614204) interleukin-36 recepto (155 aa)
initn: 348 init1: 210 opt: 371 Z-score: 493.9 bits: 97.5 E(85289): 9e-21
Smith-Waterman score: 371; 44.4% identity (69.4% similar) in 144 aa overlap (12-150:11-153)
10 20 30 40 50
pF1KE1 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCC-AEKICTLPNRGLDRTKVPIFL
.: . :.:: ...:::.: : . .:.: ..::: :: . :..:
NP_036 MVLSGALCFRMKDSALKVLYLHNNQLLAGGLHAGKVIKGEEISVVPNRWLDASLSPVIL
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 GIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPG
:.::::.::.: .: :.: :: ::: ::: :..:. :::.. . : . .:.::.::
NP_036 GVQGGSQCLSCGVGQE-PTLTLEPVNIMELYLGAKESKSFTFYRRDMGLTSSFESAAYPG
60 70 80 90 100 110
120 130 140 150
pF1KE1 WFLCGPAEPQQPVQLTKESEPSAR----TKFYFEQSW
:::: : .:::.::. : .. : :::.:
NP_036 WFLCTVPEADQPVRLTQLPENGGWNAPITDFYFQQCD
120 130 140 150
>>XP_011509423 (OMIM: 137215,147679,612628,612852) PREDI (143 aa)
initn: 322 init1: 260 opt: 312 Z-score: 416.9 bits: 83.1 E(85289): 1.7e-16
Smith-Waterman score: 312; 41.6% identity (67.9% similar) in 137 aa overlap (16-150:10-141)
10 20 30 40 50
pF1KE1 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCC-AEKICTLPNRGLDRTKVPIFL
.::..: :..::..: . : ::: ..: . .::
XP_011 MQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPH-----ALFL
10 20 30 40
60 70 80 90 100 110
pF1KE1 GIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPG
::.::. ::.::.. . :::: ::: .: .. .. ::.:..:.:: . .:.:: ::
XP_011 GIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPG
50 60 70 80 90 100
120 130 140 150
pF1KE1 WFLCGPAEPQQPVQLTK-ESEPSARTKFYFEQSW
:::: : .:::.::. .: :::::..
XP_011 WFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE
110 120 130 140
>>NP_001305843 (OMIM: 137215,147679,612628,612852) inter (143 aa)
initn: 322 init1: 260 opt: 312 Z-score: 416.9 bits: 83.1 E(85289): 1.7e-16
Smith-Waterman score: 312; 41.6% identity (67.9% similar) in 137 aa overlap (16-150:10-141)
10 20 30 40 50
pF1KE1 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCC-AEKICTLPNRGLDRTKVPIFL
.::..: :..::..: . : ::: ..: . .::
NP_001 MQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPH-----ALFL
10 20 30 40
60 70 80 90 100 110
pF1KE1 GIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPG
::.::. ::.::.. . :::: ::: .: .. .. ::.:..:.:: . .:.:: ::
NP_001 GIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPG
50 60 70 80 90 100
120 130 140 150
pF1KE1 WFLCGPAEPQQPVQLTK-ESEPSARTKFYFEQSW
:::: : .:::.::. .: :::::..
NP_001 WFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE
110 120 130 140
>>NP_776215 (OMIM: 137215,147679,612628,612852) interleu (143 aa)
initn: 322 init1: 260 opt: 312 Z-score: 416.9 bits: 83.1 E(85289): 1.7e-16
Smith-Waterman score: 312; 41.6% identity (67.9% similar) in 137 aa overlap (16-150:10-141)
10 20 30 40 50
pF1KE1 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCC-AEKICTLPNRGLDRTKVPIFL
.::..: :..::..: . : ::: ..: . .::
NP_776 MQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPH-----ALFL
10 20 30 40
60 70 80 90 100 110
pF1KE1 GIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPG
::.::. ::.::.. . :::: ::: .: .. .. ::.:..:.:: . .:.:: ::
NP_776 GIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPG
50 60 70 80 90 100
120 130 140 150
pF1KE1 WFLCGPAEPQQPVQLTK-ESEPSARTKFYFEQSW
:::: : .:::.::. .: :::::..
NP_776 WFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE
110 120 130 140
>>XP_005263718 (OMIM: 137215,147679,612628,612852) PREDI (143 aa)
initn: 322 init1: 260 opt: 312 Z-score: 416.9 bits: 83.1 E(85289): 1.7e-16
Smith-Waterman score: 312; 41.6% identity (67.9% similar) in 137 aa overlap (16-150:10-141)
10 20 30 40 50
pF1KE1 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCC-AEKICTLPNRGLDRTKVPIFL
.::..: :..::..: . : ::: ..: . .::
XP_005 MQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPH-----ALFL
10 20 30 40
60 70 80 90 100 110
pF1KE1 GIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPG
::.::. ::.::.. . :::: ::: .: .. .. ::.:..:.:: . .:.:: ::
XP_005 GIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPG
50 60 70 80 90 100
120 130 140 150
pF1KE1 WFLCGPAEPQQPVQLTK-ESEPSARTKFYFEQSW
:::: : .:::.::. .: :::::..
XP_005 WFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE
110 120 130 140
>>NP_000568 (OMIM: 137215,147679,612628,612852) interleu (159 aa)
initn: 322 init1: 260 opt: 312 Z-score: 416.3 bits: 83.2 E(85289): 1.9e-16
Smith-Waterman score: 312; 41.6% identity (67.9% similar) in 137 aa overlap (16-150:26-157)
10 20 30 40
pF1KE1 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCC-AEKICTLPNRG
.::..: :..::..: . : ::: ..: .
NP_000 MALETICRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEP
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 LDRTKVPIFLGIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSA
.::::.::. ::.::.. . :::: ::: .: .. .. ::.:..:.:: .
NP_000 H-----ALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPT
70 80 90 100 110
110 120 130 140 150
pF1KE1 FRLEAAAWPGWFLCGPAEPQQPVQLTK-ESEPSARTKFYFEQSW
.:.:: :::::: : .:::.::. .: :::::..
NP_000 TSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE
120 130 140 150
>>NP_776214 (OMIM: 137215,147679,612628,612852) interleu (177 aa)
initn: 322 init1: 260 opt: 312 Z-score: 415.6 bits: 83.2 E(85289): 2.1e-16
Smith-Waterman score: 312; 41.6% identity (67.9% similar) in 137 aa overlap (16-150:44-175)
10 20 30 40
pF1KE1 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCC-AEKICT
.::..: :..::..: . : ::: .
NP_776 LLLFLFHSETICRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDV
20 30 40 50 60 70
50 60 70 80 90 100
pF1KE1 LPNRGLDRTKVPIFLGIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQS
.: . .::::.::. ::.::.. . :::: ::: .: .. .. ::.:..:
NP_776 VPIEPH-----ALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRS
80 90 100 110 120
110 120 130 140 150
pF1KE1 SSGSAFRLEAAAWPGWFLCGPAEPQQPVQLTK-ESEPSARTKFYFEQSW
.:: . .:.:: :::::: : .:::.::. .: :::::..
NP_776 DSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE
130 140 150 160 170
152 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 18:18:19 2016 done: Sun Nov 6 18:18:20 2016
Total Scan time: 4.970 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]