Result of FASTA (omim) for
pFN21AE1614
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1614, 126 aa
1>>>pF1KE1614 126 - 126 aa - 126 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.6028+/-0.000281; mu= 13.5396+/- 0.018
mean_var=50.4079+/- 9.973, 0's: 0 Z-trim(116.6): 40 B-trim: 55 in 1/54
Lambda= 0.180645
statistics sampled from 27904 (27944) to 27904 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.736), E-opt: 0.2 (0.328), width: 16
Scan time: 4.180
The best scores are: opt bits E(85289)
NP_005331 (OMIM: 137200,601314) histidine triad nu ( 126) 865 232.5 1.4e-61
NP_115982 (OMIM: 609997) histidine triad nucleotid ( 163) 543 148.6 3.1e-36
XP_016864899 (OMIM: 137200,601314) PREDICTED: hist ( 103) 481 132.4 1.6e-31
XP_016870327 (OMIM: 208920,606350) PREDICTED: apra ( 204) 157 48.1 7.3e-06
XP_011516240 (OMIM: 208920,606350) PREDICTED: apra ( 254) 157 48.2 8.7e-06
XP_006716855 (OMIM: 208920,606350) PREDICTED: apra ( 254) 157 48.2 8.7e-06
XP_011516241 (OMIM: 208920,606350) PREDICTED: apra ( 254) 157 48.2 8.7e-06
NP_001182181 (OMIM: 208920,606350) aprataxin isofo ( 284) 157 48.2 9.6e-06
NP_001182183 (OMIM: 208920,606350) aprataxin isofo ( 288) 157 48.2 9.7e-06
XP_016870326 (OMIM: 208920,606350) PREDICTED: apra ( 288) 157 48.2 9.7e-06
NP_001182180 (OMIM: 208920,606350) aprataxin isofo ( 292) 157 48.2 9.8e-06
NP_001182179 (OMIM: 208920,606350) aprataxin isofo ( 302) 157 48.2 1e-05
NP_778239 (OMIM: 208920,606350) aprataxin isoform ( 306) 157 48.2 1e-05
XP_006716854 (OMIM: 208920,606350) PREDICTED: apra ( 342) 157 48.2 1.1e-05
NP_001182178 (OMIM: 208920,606350) aprataxin isofo ( 342) 157 48.2 1.1e-05
NP_778243 (OMIM: 208920,606350) aprataxin isoform ( 342) 157 48.2 1.1e-05
NP_001182177 (OMIM: 208920,606350) aprataxin isofo ( 356) 157 48.2 1.2e-05
NP_612638 (OMIM: 609998) histidine triad nucleotid ( 182) 152 46.8 1.6e-05
XP_016870325 (OMIM: 208920,606350) PREDICTED: apra ( 308) 122 39.1 0.0057
XP_016870324 (OMIM: 208920,606350) PREDICTED: apra ( 315) 122 39.1 0.0058
XP_016870323 (OMIM: 208920,606350) PREDICTED: apra ( 325) 122 39.1 0.006
XP_016870322 (OMIM: 208920,606350) PREDICTED: apra ( 338) 122 39.1 0.0062
NP_002003 (OMIM: 601153) bis(5'-adenosyl)-triphosp ( 147) 118 37.9 0.0063
NP_001307828 (OMIM: 601153) bis(5'-adenosyl)-triph ( 147) 118 37.9 0.0063
NP_001159715 (OMIM: 601153) bis(5'-adenosyl)-triph ( 147) 118 37.9 0.0063
NP_001307829 (OMIM: 601153) bis(5'-adenosyl)-triph ( 147) 118 37.9 0.0063
XP_016870321 (OMIM: 208920,606350) PREDICTED: apra ( 369) 122 39.1 0.0066
XP_016870320 (OMIM: 208920,606350) PREDICTED: apra ( 423) 122 39.2 0.0074
>>NP_005331 (OMIM: 137200,601314) histidine triad nucleo (126 aa)
initn: 865 init1: 865 opt: 865 Z-score: 1226.6 bits: 232.5 E(85289): 1.4e-61
Smith-Waterman score: 865; 100.0% identity (100.0% similar) in 126 aa overlap (1-126:1-126)
10 20 30 40 50 60
pF1KE1 MADEIAKAQVARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MADEIAKAQVARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 SQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQ
70 80 90 100 110 120
pF1KE1 MHWPPG
::::::
NP_005 MHWPPG
>>NP_115982 (OMIM: 609997) histidine triad nucleotide-bi (163 aa)
initn: 544 init1: 496 opt: 543 Z-score: 771.4 bits: 148.6 E(85289): 3.1e-36
Smith-Waterman score: 543; 59.5% identity (86.5% similar) in 126 aa overlap (3-126:38-163)
10 20 30
pF1KE1 MADEIAKAQVARPGG--DTIFGKIIRKEIPAK
.:.:::: : ::: :::..:. : .::
NP_115 AAGLRAARRAVAATGVRGGQVRGAAGVTDGNEVAKAQQATPGGAAPTIFSRILDKSLPAD
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE1 IIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGL
:..::..::.:.:..::::.:::::::: : .:: ::..:..:::::..:.:. : ::
NP_115 ILYEDQQCLVFRDVAPQAPVHFLVIPKKPIPRISQAEEEDQQLLGHLLLVAKQTAKAEGL
70 80 90 100 110 120
100 110 120
pF1KE1 NKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
. :::.:.:.:. :.:::::.:.:::::::..::::
NP_115 GDGYRLVINDGKLGAQSVYHLHIHVLGGRQLQWPPG
130 140 150 160
>>XP_016864899 (OMIM: 137200,601314) PREDICTED: histidin (103 aa)
initn: 481 init1: 481 opt: 481 Z-score: 687.1 bits: 132.4 E(85289): 1.6e-31
Smith-Waterman score: 481; 97.3% identity (100.0% similar) in 74 aa overlap (1-74:1-74)
10 20 30 40 50 60
pF1KE1 MADEIAKAQVARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MADEIAKAQVARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 SQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQ
::::::::::::..
XP_016 SQISVAEDDDESVITKEKPEKPLGLQLPSCFPKLLHHFVSHQQ
70 80 90 100
>>XP_016870327 (OMIM: 208920,606350) PREDICTED: aprataxi (204 aa)
initn: 102 init1: 69 opt: 157 Z-score: 226.3 bits: 48.1 E(85289): 7.3e-06
Smith-Waterman score: 157; 29.9% identity (61.9% similar) in 97 aa overlap (20-116:82-176)
10 20 30 40
pF1KE1 MADEIAKAQVARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAP
: : . : ...:.. ....: :.:
XP_016 PGSNSGQCSVPLKKGKDAPIKKESLGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKAR
60 70 80 90 100 110
50 60 70 80 90 100
pF1KE1 THFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVY
:.::.: ::..... . :: :. ::.: .:.. .. :. . : . :.
XP_016 YHWLVLPWTSISSLKAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRL--GYHAIPSMS
120 130 140 150 160
110 120
pF1KE1 HVHLHVLGGRQMHWPPG
::::::.
XP_016 HVHLHVISQDFDSPCLKNKKHWNSFNTEYFLESQE
170 180 190 200
>>XP_011516240 (OMIM: 208920,606350) PREDICTED: aprataxi (254 aa)
initn: 102 init1: 69 opt: 157 Z-score: 224.9 bits: 48.2 E(85289): 8.7e-06
Smith-Waterman score: 157; 29.9% identity (61.9% similar) in 97 aa overlap (20-116:82-176)
10 20 30 40
pF1KE1 MADEIAKAQVARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAP
: : . : ...:.. ....: :.:
XP_011 PGSNSGQCSVPLKKGKDAPIKKESLGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKAR
60 70 80 90 100 110
50 60 70 80 90 100
pF1KE1 THFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVY
:.::.: ::..... . :: :. ::.: .:.. .. :. . : . :.
XP_011 YHWLVLPWTSISSLKAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRL--GYHAIPSMS
120 130 140 150 160
110 120
pF1KE1 HVHLHVLGGRQMHWPPG
::::::.
XP_011 HVHLHVISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMPELLKLPL
170 180 190 200 210 220
>>XP_006716855 (OMIM: 208920,606350) PREDICTED: aprataxi (254 aa)
initn: 102 init1: 69 opt: 157 Z-score: 224.9 bits: 48.2 E(85289): 8.7e-06
Smith-Waterman score: 157; 29.9% identity (61.9% similar) in 97 aa overlap (20-116:82-176)
10 20 30 40
pF1KE1 MADEIAKAQVARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAP
: : . : ...:.. ....: :.:
XP_006 PGSNSGQCSVPLKKGKDAPIKKESLGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKAR
60 70 80 90 100 110
50 60 70 80 90 100
pF1KE1 THFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVY
:.::.: ::..... . :: :. ::.: .:.. .. :. . : . :.
XP_006 YHWLVLPWTSISSLKAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRL--GYHAIPSMS
120 130 140 150 160
110 120
pF1KE1 HVHLHVLGGRQMHWPPG
::::::.
XP_006 HVHLHVISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMPELLKLPL
170 180 190 200 210 220
>>XP_011516241 (OMIM: 208920,606350) PREDICTED: aprataxi (254 aa)
initn: 102 init1: 69 opt: 157 Z-score: 224.9 bits: 48.2 E(85289): 8.7e-06
Smith-Waterman score: 157; 29.9% identity (61.9% similar) in 97 aa overlap (20-116:82-176)
10 20 30 40
pF1KE1 MADEIAKAQVARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAP
: : . : ...:.. ....: :.:
XP_011 PGSNSGQCSVPLKKGKDAPIKKESLGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKAR
60 70 80 90 100 110
50 60 70 80 90 100
pF1KE1 THFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVY
:.::.: ::..... . :: :. ::.: .:.. .. :. . : . :.
XP_011 YHWLVLPWTSISSLKAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRL--GYHAIPSMS
120 130 140 150 160
110 120
pF1KE1 HVHLHVLGGRQMHWPPG
::::::.
XP_011 HVHLHVISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMPELLKLPL
170 180 190 200 210 220
>>NP_001182181 (OMIM: 208920,606350) aprataxin isoform i (284 aa)
initn: 102 init1: 69 opt: 157 Z-score: 224.1 bits: 48.2 E(85289): 9.6e-06
Smith-Waterman score: 157; 29.9% identity (61.9% similar) in 97 aa overlap (20-116:112-206)
10 20 30 40
pF1KE1 MADEIAKAQVARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAP
: : . : ...:.. ....: :.:
NP_001 IDSVVIGKDQEVKLQPGQVLHMESLGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKAR
90 100 110 120 130 140
50 60 70 80 90 100
pF1KE1 THFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVY
:.::.: ::..... . :: :. ::.: .:.. .. :. . : . :.
NP_001 YHWLVLPWTSISSLKAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRL--GYHAIPSMS
150 160 170 180 190
110 120
pF1KE1 HVHLHVLGGRQMHWPPG
::::::.
NP_001 HVHLHVISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMPELLKLPL
200 210 220 230 240 250
>>NP_001182183 (OMIM: 208920,606350) aprataxin isoform h (288 aa)
initn: 102 init1: 69 opt: 157 Z-score: 224.0 bits: 48.2 E(85289): 9.7e-06
Smith-Waterman score: 157; 29.9% identity (61.9% similar) in 97 aa overlap (20-116:116-210)
10 20 30 40
pF1KE1 MADEIAKAQVARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAP
: : . : ...:.. ....: :.:
NP_001 PGSNSGQCSVPLKKGKDAPIKKESLGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKAR
90 100 110 120 130 140
50 60 70 80 90 100
pF1KE1 THFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVY
:.::.: ::..... . :: :. ::.: .:.. .. :. . : . :.
NP_001 YHWLVLPWTSISSLKAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRL--GYHAIPSMS
150 160 170 180 190 200
110 120
pF1KE1 HVHLHVLGGRQMHWPPG
::::::.
NP_001 HVHLHVISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMPELLKLPL
210 220 230 240 250 260
>>XP_016870326 (OMIM: 208920,606350) PREDICTED: aprataxi (288 aa)
initn: 102 init1: 69 opt: 157 Z-score: 224.0 bits: 48.2 E(85289): 9.7e-06
Smith-Waterman score: 157; 29.9% identity (61.9% similar) in 97 aa overlap (20-116:116-210)
10 20 30 40
pF1KE1 MADEIAKAQVARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAP
: : . : ...:.. ....: :.:
XP_016 PGSNSGQCSVPLKKGKDAPIKKESLGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKAR
90 100 110 120 130 140
50 60 70 80 90 100
pF1KE1 THFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVY
:.::.: ::..... . :: :. ::.: .:.. .. :. . : . :.
XP_016 YHWLVLPWTSISSLKAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRL--GYHAIPSMS
150 160 170 180 190 200
110 120
pF1KE1 HVHLHVLGGRQMHWPPG
::::::.
XP_016 HVHLHVISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMPELLKLPL
210 220 230 240 250 260
126 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 15:33:47 2016 done: Mon Nov 7 15:33:48 2016
Total Scan time: 4.180 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]