Result of FASTA (omim) for
pFN21AE1560
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1560, 246 aa
1>>>pF1KE1560 246 - 246 aa - 246 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0020+/-0.000324; mu= 15.8371+/- 0.020
mean_var=58.4872+/-12.035, 0's: 0 Z-trim(116.4): 299 B-trim: 2220 in 2/52
Lambda= 0.167704
statistics sampled from 27231 (27549) to 27231 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.705), E-opt: 0.2 (0.323), width: 16
Scan time: 6.950
The best scores are: opt bits E(85289)
NP_219491 (OMIM: 116831) granzyme H isoform 1 prep ( 246) 1676 413.4 1.9e-115
XP_011534985 (OMIM: 116831) PREDICTED: granzyme H ( 212) 1445 357.4 1.1e-98
NP_004122 (OMIM: 123910) granzyme B isoform 1 prep ( 247) 1178 292.9 3.6e-79
NP_001332940 (OMIM: 123910) granzyme B isoform 2 [ ( 235) 1104 275.0 8.4e-74
NP_001902 (OMIM: 116830) cathepsin G preproprotein ( 255) 982 245.5 6.9e-65
NP_001257709 (OMIM: 116831) granzyme H isoform 2 p ( 182) 916 229.4 3.3e-60
XP_011534801 (OMIM: 116830) PREDICTED: cathepsin G ( 269) 910 228.0 1.3e-59
NP_001827 (OMIM: 118938) chymase isoform 1 preprop ( 247) 775 195.4 8e-50
NP_001257710 (OMIM: 116831) granzyme H isoform 3 p ( 160) 765 192.8 3e-49
NP_006135 (OMIM: 140050) granzyme A precursor [Hom ( 262) 567 145.1 1.2e-34
NP_002095 (OMIM: 600784) granzyme K precursor [Hom ( 264) 555 142.2 9e-34
NP_009127 (OMIM: 605644) kallikrein-8 isoform 1 pr ( 260) 552 141.4 1.5e-33
NP_071329 (OMIM: 606135) kallikrein-14 preproprote ( 267) 548 140.5 2.9e-33
NP_001298111 (OMIM: 606135) kallikrein-14 prepropr ( 267) 548 140.5 2.9e-33
NP_653088 (OMIM: 605644) kallikrein-8 isoform 2 pr ( 305) 548 140.5 3.3e-33
NP_001919 (OMIM: 134350,613912) complement factor ( 253) 537 137.8 1.8e-32
NP_001304264 (OMIM: 134350,613912) complement fact ( 260) 535 137.3 2.5e-32
NP_002768 (OMIM: 177020) myeloblastin precursor [H ( 256) 531 136.3 4.9e-32
NP_006844 (OMIM: 604434) kallikrein-11 isoform 1 p ( 250) 518 133.2 4.2e-31
NP_001129504 (OMIM: 604434) kallikrein-11 isoform ( 250) 518 133.2 4.2e-31
NP_659196 (OMIM: 604434) kallikrein-11 isoform 2 [ ( 282) 518 133.2 4.7e-31
NP_005308 (OMIM: 600311) granzyme M isoform 1 prep ( 257) 505 130.0 3.8e-30
NP_002760 (OMIM: 167800,276000,614044) trypsin-1 p ( 247) 488 125.9 6.4e-29
XP_011514713 (OMIM: 167800,276000,614044) PREDICTE ( 472) 488 126.1 1.1e-28
NP_056411 (OMIM: 605505) kallikrein-13 precursor [ ( 277) 482 124.5 1.9e-28
NP_002765 (OMIM: 602652) kallikrein-6 isoform A pr ( 244) 481 124.2 2.1e-28
NP_001012982 (OMIM: 602652) kallikrein-6 isoform A ( 244) 481 124.2 2.1e-28
NP_036447 (OMIM: 605504) kallikrein-9 precursor [H ( 250) 480 124.0 2.5e-28
NP_005037 (OMIM: 604438) kallikrein-7 isoform 1 pr ( 253) 472 122.1 9.6e-28
NP_644806 (OMIM: 604438) kallikrein-7 isoform 1 pr ( 253) 472 122.1 9.6e-28
NP_004908 (OMIM: 204700,603767) kallikrein-4 isofo ( 254) 465 120.4 3.1e-27
NP_002762 (OMIM: 613578) trypsin-3 isoform 2 prepr ( 247) 453 117.5 2.3e-26
XP_011526438 (OMIM: 177020) PREDICTED: myeloblasti ( 206) 441 114.5 1.5e-25
NP_665901 (OMIM: 605539) kallikrein-12 isoform 2 p ( 248) 440 114.3 2e-25
NP_002761 (OMIM: 167800,601564) trypsin-2 isoform ( 247) 439 114.1 2.4e-25
NP_001184026 (OMIM: 613578) trypsin-3 isoform 3 pr ( 261) 439 114.1 2.5e-25
NP_031369 (OMIM: 613578) trypsin-3 isoform 1 prepr ( 304) 435 113.1 5.5e-25
NP_001691 (OMIM: 162815) azurocidin preproprotein ( 251) 434 112.9 5.6e-25
NP_001184027 (OMIM: 613578) trypsin-3 isoform 4 pr ( 240) 433 112.6 6.4e-25
XP_011516267 (OMIM: 613578) PREDICTED: trypsin-3 i ( 333) 433 112.7 8.4e-25
NP_001070960 (OMIM: 605643) kallikrein-5 prepropro ( 293) 432 112.4 8.9e-25
XP_011525004 (OMIM: 605643) PREDICTED: kallikrein- ( 293) 432 112.4 8.9e-25
XP_011525005 (OMIM: 605643) PREDICTED: kallikrein- ( 293) 432 112.4 8.9e-25
NP_036559 (OMIM: 605643) kallikrein-5 preproprotei ( 293) 432 112.4 8.9e-25
NP_001070959 (OMIM: 605643) kallikrein-5 prepropro ( 293) 432 112.4 8.9e-25
NP_001245280 (OMIM: 600311) granzyme M isoform 2 [ ( 218) 423 110.2 3.1e-24
NP_002763 (OMIM: 226200,606635) enteropeptidase pr (1019) 426 111.3 6.9e-24
XP_011527961 (OMIM: 226200,606635) PREDICTED: ente (1034) 426 111.3 7e-24
XP_011527960 (OMIM: 226200,606635) PREDICTED: ente (1037) 426 111.3 7e-24
XP_011527959 (OMIM: 226200,606635) PREDICTED: ente (1049) 426 111.3 7.1e-24
>>NP_219491 (OMIM: 116831) granzyme H isoform 1 prepropr (246 aa)
initn: 1676 init1: 1676 opt: 1676 Z-score: 2193.6 bits: 413.4 E(85289): 1.9e-115
Smith-Waterman score: 1676; 100.0% identity (100.0% similar) in 246 aa overlap (1-246:1-246)
10 20 30 40 50 60
pF1KE1 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_219 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_219 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 TTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_219 TTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 SRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_219 SRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIK
190 200 210 220 230 240
pF1KE1 RTMKRL
::::::
NP_219 RTMKRL
>>XP_011534985 (OMIM: 116831) PREDICTED: granzyme H isof (212 aa)
initn: 1445 init1: 1445 opt: 1445 Z-score: 1892.5 bits: 357.4 E(85289): 1.1e-98
Smith-Waterman score: 1445; 100.0% identity (100.0% similar) in 212 aa overlap (35-246:1-212)
10 20 30 40 50 60
pF1KE1 LLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVLTAAH
::::::::::::::::::::::::::::::
XP_011 MAFVQFLQEKSRKRCGGILVRKDFVLTAAH
10 20 30
70 80 90 100 110 120
pF1KE1 CQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKWTTAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKWTTAV
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE1 RPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNYSRAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNYSRAT
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE1 EICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIKRTMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIKRTMK
160 170 180 190 200 210
pF1KE1 RL
::
XP_011 RL
>>NP_004122 (OMIM: 123910) granzyme B isoform 1 prepropr (247 aa)
initn: 1178 init1: 837 opt: 1178 Z-score: 1542.4 bits: 292.9 E(85289): 3.6e-79
Smith-Waterman score: 1178; 71.5% identity (85.8% similar) in 246 aa overlap (1-245:1-246)
10 20 30 40 50 60
pF1KE1 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL
:::.:::::::: : : . :::::::::::::::::.... ..:: :::::.:.: ::::
NP_004 MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW
::::: ::::::::::::::::: :::::::::::::::::::::::::::::::::::
NP_004 TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR
70 80 90 100 110 120
130 140 150 160 170
pF1KE1 TTAVRPLRLPSSKAQVKPGQLCSVAGWGYVS-MSTLATTLQEVLLTVQKDCQCERLFHGN
: ::.::::::.:::::::: ::::::: .. .. . ::::: .:::.: .:: ..
NP_004 TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE1 YSRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWI
:. . :.:::::. .:.:::::::::::. :::::.::: ..: :: . ::: :. ::
NP_004 YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI
190 200 210 220 230 240
240
pF1KE1 KRTMKRL
:.::::
NP_004 KKTMKRY
>>NP_001332940 (OMIM: 123910) granzyme B isoform 2 [Homo (235 aa)
initn: 1104 init1: 763 opt: 1104 Z-score: 1446.0 bits: 275.0 E(85289): 8.4e-74
Smith-Waterman score: 1104; 71.8% identity (86.3% similar) in 227 aa overlap (20-245:8-234)
10 20 30 40 50 60
pF1KE1 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL
:::::::::::::::::.... ..:: :::::.:.: ::::
NP_001 MQTFPSGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL
10 20 30 40
70 80 90 100 110 120
pF1KE1 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW
::::: ::::::::::::::::: :::::::::::::::::::::::::::::::::::
NP_001 TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR
50 60 70 80 90 100
130 140 150 160 170
pF1KE1 TTAVRPLRLPSSKAQVKPGQLCSVAGWGYVS-MSTLATTLQEVLLTVQKDCQCERLFHGN
: ::.::::::.:::::::: ::::::: .. .. . ::::: .:::.: .:: ..
NP_001 TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE1 YSRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWI
:. . :.:::::. .:.:::::::::::. :::::.::: ..: :: . ::: :. ::
NP_001 YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI
170 180 190 200 210 220
240
pF1KE1 KRTMKRL
:.::::
NP_001 KKTMKRY
230
>>NP_001902 (OMIM: 116830) cathepsin G preproprotein [Ho (255 aa)
initn: 967 init1: 707 opt: 982 Z-score: 1285.9 bits: 245.5 E(85289): 6.9e-65
Smith-Waterman score: 982; 57.8% identity (82.0% similar) in 244 aa overlap (1-244:1-243)
10 20 30 40 50 60
pF1KE1 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL
:::.:::::::: :: . :::::.:..::::::::..:. . ...::::.:::.::::
NP_001 MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW
::::: ::.::::::::::...: ::: : ..: : :: :: ....:::::::: :...
NP_001 TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 TTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNY
. : :. :: .. ..:: ::.::::: ::: . ::.:: : ::.: :: :.: :.:
NP_001 NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIF-GSY
130 140 150 160 170
190 200 210 220 230 240
pF1KE1 SRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIK
. .::::: .. ...:::::::::.:..::.::.:::...:.:: :. .:: :::::.
NP_001 DPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIR
180 190 200 210 220 230
pF1KE1 RTMKRL
::.
NP_001 TTMRSFKLLDQMETPL
240 250
>>NP_001257709 (OMIM: 116831) granzyme H isoform 2 precu (182 aa)
initn: 907 init1: 907 opt: 916 Z-score: 1201.8 bits: 229.4 E(85289): 3.3e-60
Smith-Waterman score: 1099; 74.0% identity (74.0% similar) in 246 aa overlap (1-246:1-182)
10 20 30 40 50 60
pF1KE1 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 TTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNY
:::::::::::::::
NP_001 TTAVRPLRLPSSKAQ---------------------------------------------
130
190 200 210 220 230 240
pF1KE1 SRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIK
:::::::::::::::::::::::::::::::::::::::::
NP_001 -------------------GDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIK
140 150 160 170
pF1KE1 RTMKRL
::::::
NP_001 RTMKRL
180
>>XP_011534801 (OMIM: 116830) PREDICTED: cathepsin G iso (269 aa)
initn: 959 init1: 634 opt: 910 Z-score: 1191.4 bits: 228.0 E(85289): 1.3e-59
Smith-Waterman score: 949; 55.0% identity (77.9% similar) in 258 aa overlap (1-244:1-257)
10 20 30 40
pF1KE1 MQPFLLLLAFLLTPGA--GTE------------EIIGGHEAKPHSRPYMAFVQFLQEKSR
:::.:::::::: :: :. :::::.:..::::::::..:. . ..
XP_011 MQPLLLLLAFLLPTGAEAGSASIELSAKCFLPGEIIGGRESRPHSRPYMAYLQIQSPAGQ
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 KRCGGILVRKDFVLTAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFS
.::::.:::.::::::::: ::.::::::::::...: ::: : ..: : :: :: ....
XP_011 SRCGGFLVREDFVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQ
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE1 NDIMLLQLERKAKWTTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTV
:::::::: :... . : :. :: .. ..:: ::.::::: ::: . ::.:: : :
XP_011 NDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRV
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE1 QKDCQCERLFHGNYSRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPP
:.: :: :.: :.:. .::::: .. ...:::::::::.:..::.::.:::...:.::
XP_011 QRDRQCLRIF-GSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPP
190 200 210 220 230
230 240
pF1KE1 GVYIKVSHFLPWIKRTMKRL
:. .:: :::::. ::.
XP_011 EVFTRVSSFLPWIRTTMRSFKLLDQMETPL
240 250 260
>>NP_001827 (OMIM: 118938) chymase isoform 1 preproprote (247 aa)
initn: 637 init1: 374 opt: 775 Z-score: 1015.4 bits: 195.4 E(85289): 8e-50
Smith-Waterman score: 775; 48.4% identity (74.4% similar) in 246 aa overlap (1-244:3-245)
10 20 30 40 50
pF1KE1 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKS-RKRCGGILVRKD
. :. ::: ::: : . ::::: : :::::::::..... .. : :::.:.:..
NP_001 MLLLPLPLLL-FLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRN
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 FVLTAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERK
:::::::: : ::.:::::::: :.: : : . : . . :: :: ... .:::::.:..:
NP_001 FVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 AKWTTAVRPLRLPSSKAQVKPGQLCSVAGWGYVS-MSTLATTLQEVLLTVQKDCQCERLF
:. : :: : .::. : ::..: ::::: .. .. . ::::: : .. : ..
NP_001 ASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHF-
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 HGNYSRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFL
.... ..:::.:.::...:::::::::.: :::::.::: . . ::.:. ..::.
NP_001 -RDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYR
180 190 200 210 220 230
240
pF1KE1 PWIKRTMKRL
:::.. ..
NP_001 PWINQILQAN
240
>>NP_001257710 (OMIM: 116831) granzyme H isoform 3 precu (160 aa)
initn: 765 init1: 765 opt: 765 Z-score: 1005.2 bits: 192.8 E(85289): 3e-49
Smith-Waterman score: 913; 65.0% identity (65.0% similar) in 246 aa overlap (1-246:1-160)
10 20 30 40 50 60
pF1KE1 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQ-------
70 80 90 100 110
130 140 150 160 170 180
pF1KE1 TTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNY
NP_001 ------------------------------------------------------------
190 200 210 220 230 240
pF1KE1 SRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIK
:::::::::::::::::::::::::::::::::::::::::
NP_001 -------------------GDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIK
120 130 140 150
pF1KE1 RTMKRL
::::::
NP_001 RTMKRL
160
>>NP_006135 (OMIM: 140050) granzyme A precursor [Homo sa (262 aa)
initn: 529 init1: 242 opt: 567 Z-score: 743.1 bits: 145.1 E(85289): 1.2e-34
Smith-Waterman score: 585; 41.8% identity (69.9% similar) in 249 aa overlap (6-244:14-259)
10 20 30 40 50
pF1KE1 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGI
.....:: : :.::::.:. :::::::.... :..:. :.:
NP_006 MRNSYRFLASSLSVVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLS-LDRKT--ICAGA
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 LVRKDFVLTAAHCQ-GSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIML
:. ::.:::::::. .. .: ::::.: ..: :.:.. ::. .:.: :.: . .:. :
NP_006 LIAKDWVLTAAHCNLNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 LQLERKAKWTTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMS-TLATTLQEVLLTVQKDC
::: .::: . : :.::.. .:::: .:.::::: . : . . ::.:: .:.
NP_006 LQLTEKAKINKYVTILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITIIDRK
120 130 140 150 160 170
180 190 200 210 220
pF1KE1 QCERLFHGNYSRA---TEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYG--NKKGTP
:. : :.. . . .:.:. . . . .::::.::.:. : .:. :.: :: : :
NP_006 VCNDRNHYNFNPVIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDP
180 190 200 210 220 230
230 240
pF1KE1 --PGVYIKVSH-FLPWIKRTMKRL
::::: .:. : :: :.:
NP_006 RGPGVYILLSKKHLNWIIMTIKGAV
240 250 260
246 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 00:23:35 2016 done: Mon Nov 7 00:23:37 2016
Total Scan time: 6.950 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]