Result of FASTA (omim) for
pFN21AE1549
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1549, 509 aa
1>>>pF1KE1549 509 - 509 aa - 509 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9691+/-0.000379; mu= 20.3375+/- 0.024
mean_var=70.6976+/-14.685, 0's: 0 Z-trim(112.7): 175 B-trim: 304 in 1/55
Lambda= 0.152536
statistics sampled from 21502 (21681) to 21502 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.622), E-opt: 0.2 (0.254), width: 16
Scan time: 8.680
The best scores are: opt bits E(85289)
NP_000777 (OMIM: 601637) lanosterol 14-alpha demet ( 509) 3392 756.0 6e-218
NP_001139624 (OMIM: 601637) lanosterol 14-alpha de ( 404) 2717 607.3 2.6e-173
NP_057677 (OMIM: 605994) 24-hydroxycholesterol 7-a ( 469) 433 104.8 5.9e-22
NP_063938 (OMIM: 605207,614416) cytochrome P450 26 ( 512) 386 94.4 8.2e-19
XP_011525994 (OMIM: 611495) PREDICTED: cytochrome ( 531) 385 94.2 9.9e-19
NP_775754 (OMIM: 611495) cytochrome P450 4F22 [Hom ( 531) 385 94.2 9.9e-19
XP_011525995 (OMIM: 611495) PREDICTED: cytochrome ( 531) 385 94.2 9.9e-19
XP_005249228 (OMIM: 605994) PREDICTED: 24-hydroxyc ( 420) 382 93.5 1.3e-18
XP_016866410 (OMIM: 605994) PREDICTED: 24-hydroxyc ( 471) 382 93.5 1.4e-18
XP_005264490 (OMIM: 605207,614416) PREDICTED: cyto ( 454) 373 91.5 5.5e-18
XP_016863526 (OMIM: 210370,608614) PREDICTED: cyto ( 393) 352 86.9 1.2e-16
NP_997235 (OMIM: 210370,608614) cytochrome P450 4V ( 525) 352 87.0 1.5e-16
NP_001307219 (OMIM: 614999) cytochrome P450 4X1 is ( 444) 345 85.4 3.8e-16
NP_001307218 (OMIM: 614999) cytochrome P450 4X1 is ( 508) 345 85.4 4.3e-16
NP_828847 (OMIM: 614999) cytochrome P450 4X1 isofo ( 509) 345 85.4 4.3e-16
XP_016876422 (OMIM: 604087) PREDICTED: cholesterol ( 462) 344 85.2 4.6e-16
XP_016856462 (OMIM: 614999) PREDICTED: cytochrome ( 470) 344 85.2 4.7e-16
NP_006659 (OMIM: 604087) cholesterol 24-hydroxylas ( 500) 344 85.2 4.9e-16
NP_001189784 (OMIM: 124010) cytochrome P450 3A4 is ( 502) 343 85.0 5.7e-16
NP_059488 (OMIM: 124010) cytochrome P450 3A4 isofo ( 503) 343 85.0 5.7e-16
XP_011534667 (OMIM: 604087) PREDICTED: cholesterol ( 347) 340 84.2 6.8e-16
NP_001306092 (OMIM: 124075) cytochrome P450 4B1 is ( 348) 340 84.2 6.8e-16
NP_001306091 (OMIM: 124075) cytochrome P450 4B1 is ( 349) 340 84.2 6.9e-16
XP_005267331 (OMIM: 604087) PREDICTED: cholesterol ( 355) 340 84.2 7e-16
NP_076433 (OMIM: 611485) cytochrome P450 4F12 [Hom ( 524) 341 84.6 8e-16
XP_016855955 (OMIM: 124075) PREDICTED: cytochrome ( 496) 340 84.3 9e-16
NP_001306090 (OMIM: 124075) cytochrome P450 4B1 is ( 497) 340 84.3 9e-16
NP_000770 (OMIM: 124075) cytochrome P450 4B1 isofo ( 511) 340 84.3 9.2e-16
NP_001093242 (OMIM: 124075) cytochrome P450 4B1 is ( 512) 340 84.3 9.2e-16
XP_011526509 (OMIM: 611485) PREDICTED: cytochrome ( 334) 336 83.3 1.2e-15
XP_011526507 (OMIM: 611485) PREDICTED: cytochrome ( 352) 336 83.3 1.3e-15
XP_011526506 (OMIM: 611485) PREDICTED: cytochrome ( 352) 336 83.3 1.3e-15
XP_011526505 (OMIM: 611485) PREDICTED: cytochrome ( 352) 336 83.3 1.3e-15
XP_011526504 (OMIM: 611485) PREDICTED: cytochrome ( 375) 336 83.3 1.3e-15
XP_011526510 (OMIM: 611485) PREDICTED: cytochrome ( 375) 336 83.3 1.3e-15
XP_006722913 (OMIM: 611485) PREDICTED: cytochrome ( 375) 336 83.3 1.3e-15
NP_000756 (OMIM: 605340) cytochrome P450 3A7 [Homo ( 503) 337 83.7 1.4e-15
XP_016877442 (OMIM: 108330) PREDICTED: cytochrome ( 484) 335 83.2 1.9e-15
XP_005262992 (OMIM: 210370,608614) PREDICTED: cyto ( 524) 335 83.2 2e-15
NP_001265850 (OMIM: 606534) cytochrome P450 3A43 i ( 393) 330 82.0 3.5e-15
NP_067010 (OMIM: 611517) phylloquinone omega-hydro ( 524) 331 82.4 3.7e-15
NP_001122404 (OMIM: 611517) phylloquinone omega-hy ( 524) 331 82.4 3.7e-15
NP_476436 (OMIM: 606534) cytochrome P450 3A43 isof ( 503) 330 82.1 4.2e-15
NP_476498 (OMIM: 602239) cytochrome P450 26A1 isof ( 428) 329 81.8 4.3e-15
NP_000774 (OMIM: 602239) cytochrome P450 26A1 isof ( 497) 329 81.9 4.8e-15
NP_001073 (OMIM: 604426) phylloquinone omega-hydro ( 520) 328 81.7 5.8e-15
NP_009184 (OMIM: 611545) cytochrome P450 4F8 precu ( 520) 324 80.8 1.1e-14
XP_011526316 (OMIM: 601270) PREDICTED: docosahexae ( 371) 319 79.6 1.8e-14
XP_005259968 (OMIM: 601270) PREDICTED: docosahexae ( 371) 319 79.6 1.8e-14
XP_016868034 (OMIM: 606534) PREDICTED: cytochrome ( 360) 318 79.4 2e-14
>>NP_000777 (OMIM: 601637) lanosterol 14-alpha demethyla (509 aa)
initn: 3392 init1: 3392 opt: 3392 Z-score: 4033.8 bits: 756.0 E(85289): 6e-218
Smith-Waterman score: 3392; 99.8% identity (100.0% similar) in 509 aa overlap (1-509:1-509)
10 20 30 40 50 60
pF1KE1 MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 PAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 ALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 IEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 SHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 PLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 DQLKDLNLLDRCIKETLRLRPPVMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDS
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
NP_000 DQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 WVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 WVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDL
430 440 450 460 470 480
490 500
pF1KE1 IDGYFPTVNYTTMIHTPENPVIRYKRRSK
:::::::::::::::::::::::::::::
NP_000 IDGYFPTVNYTTMIHTPENPVIRYKRRSK
490 500
>>NP_001139624 (OMIM: 601637) lanosterol 14-alpha demeth (404 aa)
initn: 2717 init1: 2717 opt: 2717 Z-score: 3232.4 bits: 607.3 E(85289): 2.6e-173
Smith-Waterman score: 2717; 99.8% identity (100.0% similar) in 404 aa overlap (106-509:1-404)
80 90 100 110 120 130
pF1KE1 FLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAED
::::::::::::::::::::::::::::::
NP_001 MVGKTFTYLLGSDAAALLFNSKNEDLNAED
10 20 30
140 150 160 170 180 190
pF1KE1 VYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGES
40 50 60 70 80 90
200 210 220 230 240 250
pF1KE1 GEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPS
100 110 120 130 140 150
260 270 280 290 300 310
pF1KE1 FRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLL
160 170 180 190 200 210
320 330 340 350 360 370
pF1KE1 LAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKE
220 230 240 250 260 270
380 390 400 410 420 430
pF1KE1 TLRLRPPVMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQD
:::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQD
280 290 300 310 320 330
440 450 460 470 480 490
pF1KE1 NPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIH
340 350 360 370 380 390
500
pF1KE1 TPENPVIRYKRRSK
::::::::::::::
NP_001 TPENPVIRYKRRSK
400
>>NP_057677 (OMIM: 605994) 24-hydroxycholesterol 7-alpha (469 aa)
initn: 194 init1: 170 opt: 433 Z-score: 515.1 bits: 104.8 E(85289): 5.9e-22
Smith-Waterman score: 433; 23.6% identity (55.7% similar) in 483 aa overlap (45-507:7-468)
20 30 40 50 60 70
pF1KE1 AGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPI
... .. : :. ... :: : . :
NP_057 MELISPTVIIILGCLALFLLLQRKNLRRPPCIKGWI
10 20 30
80 90 100 110 120 130
pF1KE1 PFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNED--LN
:..: .. :::.:.::.:.: ::::.:. .:. .:.. .. ....::. : :
NP_057 PWIGVGFEFGKAPLEFIEKARIKYGPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELA
40 50 60 70 80 90
140 150 160 170 180
pF1KE1 AEDVYSRLTTPVFGKGVAYDVPNPVFLEQKK----MLKSGLNIAHFKQHVSIIEKETKEY
.... : .. .:. ::: .. :::. .. ....: .. . .: .:
NP_057 VQNIVYRTAS----------IPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEELHEQ
100 110 120 130 140
190 200 210 220 230 240
pF1KE1 FESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVA---QLYADLDGGFSHAAW
.:. : : .. . . .:. .. . : .: . : ..:. : . : : ...
NP_057 LENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQVYDEDFEYGSQ
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE1 LLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDD
: : .: ..... . ..: : : . . :. . :::.:: . :.
NP_057 L-----PECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSM-TLLQATLDIVETETSK
210 220 230 240 250 260
310 320 330 340 350
pF1KE1 EVA---GMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTV---CGENLPPLT
: . :.: :: :. .. .. : .. ..: . ..: :.. ..
NP_057 ENSPNYGLL--LLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVS
270 280 290 300 310
360 370 380 390 400 410
pF1KE1 YDQLKDLNLLDRCIKETLRLRPPVMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKD
:.:..: :. :. ::.::. : .: .... : . .: :: : . .:: .:
NP_057 EDDLENLLLIKWCVLETIRLKAPGVITRKVVK-PVEILNYIIPSGDLLMLSPFWLHRNPK
320 330 340 350 360 370
420 430 440 450 460 470
pF1KE1 SWVERLDFNPDRYLQDNPASGEKF--AYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYE
. : :.:.:. . : ..: .. ::.:. .: .. :: .... .: :.
NP_057 YFPEPELFKPERWKKAN-LEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYD
380 390 400 410 420 430
480 490 500
pF1KE1 FDLIDGYFPTVNYTTMIHTPENP---VIRYKRRSK
.:.: .: .: .. .:. :.::.:
NP_057 CSLLDP-LPKQSYLHLVGVPQPEGQCRIEYKQRI
440 450 460
>>NP_063938 (OMIM: 605207,614416) cytochrome P450 26B1 i (512 aa)
initn: 183 init1: 91 opt: 386 Z-score: 458.7 bits: 94.4 E(85289): 8.2e-19
Smith-Waterman score: 388; 22.0% identity (55.2% similar) in 495 aa overlap (29-504:5-490)
10 20 30 40 50
pF1KE1 MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSML--LIACAFTLSLV-------YLIR
: .:.: : : :: ...:. . .:
NP_063 MLFEGLDLVSALATLAACLVSVTLLLAVSQQLWQLR
10 20 30
60 70 80 90 100 110
pF1KE1 LAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTF
:: . . . . . : : :: . :.. : . :::: ::. ..:. .
NP_063 WAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSG---FQSSRREKYGNVFKTHLLGRPL
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE1 TYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNI
. :.. . .. .... ...: . : : ..: ... . . . ...:.... ..
NP_063 IRVTGAENVRKILMGEHHLVSTE--WPRSTRMLLGPNTVSNSIGDIHRNKRKVFSKIFSH
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE1 AHFKQHVSIIEKETKEYFESWGESGEK-NVFEALSELIILTASHCLHGKEIRSQLNEKVA
..... :. .. ...:. : ::.. ..: . : . : : : .: ..
NP_063 EALESYLPKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIP---EEDLG
160 170 180 190 200
240 250 260 270 280
pF1KE1 QLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKID--DIL
.:. .. : .. :: ::. ..:: .:.. .. . :::... : . : : :
NP_063 HLF-EVYQQFVDNVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYLDAL
210 220 230 240 250 260
290 300 310 320 330 340
pF1KE1 QTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQK
. :.... . :. .: .:. . :..:. :....:. . . : . :. .: : .
NP_063 DLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELR
270 280 290 300 310 320
350 360 370 380 390 400
pF1KE1 T---VCGENLP---PLTYDQLKDLNLLDRCIKETLRLRPPVMIMMRMARTPQTVAGYTIP
. . . . : : : :. : :: :::..:: :. .: . . :. ::
NP_063 AHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIP
330 340 350 360 370 380
410 420 430 440 450 460
pF1KE1 PGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGE-KFAYVPFGAGRHRCIGENFA
: .: : .. . . :.:::. : . . .: :.:::.: . :.:...:
NP_063 KGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLA
390 400 410 420 430 440
470 480 490 500
pF1KE1 YVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK
. .:.. . .:.: :: .. . ..: .. ...
NP_063 KLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAM
450 460 470 480 490 500
NP_063 LSATV
510
>>XP_011525994 (OMIM: 611495) PREDICTED: cytochrome P450 (531 aa)
initn: 320 init1: 155 opt: 385 Z-score: 457.3 bits: 94.2 E(85289): 9.9e-19
Smith-Waterman score: 414; 25.1% identity (58.2% similar) in 371 aa overlap (134-475:129-496)
110 120 130 140 150 160
pF1KE1 FTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKK
.:.. . : .: :. . . . ....
XP_011 WMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDK-WSRHRR
100 110 120 130 140 150
170 180 190 200 210
pF1KE1 MLKSGLNIAHFKQHVSIIEKETKEYFESW-----GESGEKNVFEALSELIILTASHCL--
.: .... .: ...:... . . .: : . ..:: .: . . . ..:.
XP_011 LLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFS
160 170 180 190 200 210
220 230 240 250 260 270
pF1KE1 HGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRD-RAHREIKDIFY----
.... . .... .. . .:.. . . : .: . .: : : :. :. .
XP_011 YNSNCQEKMSDYISAII-ELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTT
220 230 240 250 260 270
280 290 300 310
pF1KE1 KAIQKRRQS-------------QEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAG
..::.::.. : : :....:: : .::. :.:... . ... :
XP_011 EVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEG
280 290 300 310 320 330
320 330 340 350 360 370
pF1KE1 QHTSSTTSAWMGFFLARDKTLQKKCYLE-QKTVCGENLPPLTYDQLKDLNLLDRCIKETL
. :.:. .:: : ::. :.:: : :... :..: : .:.: .: . ::::.:
XP_011 HDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESL
340 350 360 370 380 390
380 390 400 410 420 430
pF1KE1 RLRPPVMIMMRMARTPQTVA-GYTIPPGHQVC-VSPTVNQRLKDSWVERLDFNPDRYLQD
: ::: .. :. . : :: : .: :: ... : . .:: :. :
XP_011 RQYPPVTLVSRQCTEDIKLPDGRIIPKG-IICLVSIYGTHHNPTVWPDSKVYNPYRFDPD
400 410 420 430 440 450
440 450 460 470 480 490
pF1KE1 NPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWS-TMLRLYEFDLIDGYFPTVNYTTMI
:: . .:::::.:: . :::..::....... . :.::.
XP_011 NPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPELILR
460 470 480 490 500 510
500
pF1KE1 HTPENPVIRYKRRSK
XP_011 TENGLWLKVEPLPPRA
520 530
>>NP_775754 (OMIM: 611495) cytochrome P450 4F22 [Homo sa (531 aa)
initn: 320 init1: 155 opt: 385 Z-score: 457.3 bits: 94.2 E(85289): 9.9e-19
Smith-Waterman score: 414; 25.1% identity (58.2% similar) in 371 aa overlap (134-475:129-496)
110 120 130 140 150 160
pF1KE1 FTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKK
.:.. . : .: :. . . . ....
NP_775 WMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDK-WSRHRR
100 110 120 130 140 150
170 180 190 200 210
pF1KE1 MLKSGLNIAHFKQHVSIIEKETKEYFESW-----GESGEKNVFEALSELIILTASHCL--
.: .... .: ...:... . . .: : . ..:: .: . . . ..:.
NP_775 LLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFS
160 170 180 190 200 210
220 230 240 250 260 270
pF1KE1 HGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRD-RAHREIKDIFY----
.... . .... .. . .:.. . . : .: . .: : : :. :. .
NP_775 YNSNCQEKMSDYISAII-ELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTT
220 230 240 250 260 270
280 290 300 310
pF1KE1 KAIQKRRQS-------------QEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAG
..::.::.. : : :....:: : .::. :.:... . ... :
NP_775 EVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEG
280 290 300 310 320 330
320 330 340 350 360 370
pF1KE1 QHTSSTTSAWMGFFLARDKTLQKKCYLE-QKTVCGENLPPLTYDQLKDLNLLDRCIKETL
. :.:. .:: : ::. :.:: : :... :..: : .:.: .: . ::::.:
NP_775 HDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESL
340 350 360 370 380 390
380 390 400 410 420 430
pF1KE1 RLRPPVMIMMRMARTPQTVA-GYTIPPGHQVC-VSPTVNQRLKDSWVERLDFNPDRYLQD
: ::: .. :. . : :: : .: :: ... : . .:: :. :
NP_775 RQYPPVTLVSRQCTEDIKLPDGRIIPKG-IICLVSIYGTHHNPTVWPDSKVYNPYRFDPD
400 410 420 430 440 450
440 450 460 470 480 490
pF1KE1 NPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWS-TMLRLYEFDLIDGYFPTVNYTTMI
:: . .:::::.:: . :::..::....... . :.::.
NP_775 NPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPELILR
460 470 480 490 500 510
500
pF1KE1 HTPENPVIRYKRRSK
NP_775 TENGLWLKVEPLPPRA
520 530
>>XP_011525995 (OMIM: 611495) PREDICTED: cytochrome P450 (531 aa)
initn: 320 init1: 155 opt: 385 Z-score: 457.3 bits: 94.2 E(85289): 9.9e-19
Smith-Waterman score: 414; 25.1% identity (58.2% similar) in 371 aa overlap (134-475:129-496)
110 120 130 140 150 160
pF1KE1 FTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKK
.:.. . : .: :. . . . ....
XP_011 WMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDK-WSRHRR
100 110 120 130 140 150
170 180 190 200 210
pF1KE1 MLKSGLNIAHFKQHVSIIEKETKEYFESW-----GESGEKNVFEALSELIILTASHCL--
.: .... .: ...:... . . .: : . ..:: .: . . . ..:.
XP_011 LLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFS
160 170 180 190 200 210
220 230 240 250 260 270
pF1KE1 HGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRD-RAHREIKDIFY----
.... . .... .. . .:.. . . : .: . .: : : :. :. .
XP_011 YNSNCQEKMSDYISAII-ELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTT
220 230 240 250 260 270
280 290 300 310
pF1KE1 KAIQKRRQS-------------QEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAG
..::.::.. : : :....:: : .::. :.:... . ... :
XP_011 EVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEG
280 290 300 310 320 330
320 330 340 350 360 370
pF1KE1 QHTSSTTSAWMGFFLARDKTLQKKCYLE-QKTVCGENLPPLTYDQLKDLNLLDRCIKETL
. :.:. .:: : ::. :.:: : :... :..: : .:.: .: . ::::.:
XP_011 HDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESL
340 350 360 370 380 390
380 390 400 410 420 430
pF1KE1 RLRPPVMIMMRMARTPQTVA-GYTIPPGHQVC-VSPTVNQRLKDSWVERLDFNPDRYLQD
: ::: .. :. . : :: : .: :: ... : . .:: :. :
XP_011 RQYPPVTLVSRQCTEDIKLPDGRIIPKG-IICLVSIYGTHHNPTVWPDSKVYNPYRFDPD
400 410 420 430 440 450
440 450 460 470 480 490
pF1KE1 NPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWS-TMLRLYEFDLIDGYFPTVNYTTMI
:: . .:::::.:: . :::..::....... . :.::.
XP_011 NPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPELILR
460 470 480 490 500 510
500
pF1KE1 HTPENPVIRYKRRSK
XP_011 TENGLWLKVEPLPPRA
520 530
>>XP_005249228 (OMIM: 605994) PREDICTED: 24-hydroxychole (420 aa)
initn: 194 init1: 170 opt: 382 Z-score: 455.1 bits: 93.5 E(85289): 1.3e-18
Smith-Waterman score: 382; 23.6% identity (55.6% similar) in 428 aa overlap (45-455:7-414)
20 30 40 50 60 70
pF1KE1 AGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPI
... .. : :. ... :: : . :
XP_005 MELISPTVIIILGCLALFLLLQRKNLRRPPCIKGWI
10 20 30
80 90 100 110 120 130
pF1KE1 PFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNED--LN
:..: .. :::.:.::.:.: ::::.:. .:. .:.. .. ....::. : :
XP_005 PWIGVGFEFGKAPLEFIEKARIKYGPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELA
40 50 60 70 80 90
140 150 160 170 180
pF1KE1 AEDVYSRLTTPVFGKGVAYDVPNPVFLEQKK----MLKSGLNIAHFKQHVSIIEKETKEY
.... : .. .:. ::: .. :::. .. ....: .. . .: .:
XP_005 VQNIVYRTAS----------IPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEELHEQ
100 110 120 130 140
190 200 210 220 230 240
pF1KE1 FESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVA---QLYADLDGGFSHAAW
.:. : : .. . . .:. .. . : .: . : ..:. : . : : ...
XP_005 LENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQVYDEDFEYGS-
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE1 LLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDD
:: .: ..... . ..: : : . . :. . :::.:: . :.
XP_005 ----QLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSM-TLLQATLDIVETETSK
210 220 230 240 250 260
310 320 330 340 350
pF1KE1 EVA---GMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTV---CGENLPPLT
: . :.: :: :. .. .. : .. ..: . ..: :.. ..
XP_005 ENSPNYGLL--LLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVS
270 280 290 300 310
360 370 380 390 400 410
pF1KE1 YDQLKDLNLLDRCIKETLRLRPPVMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKD
:.:..: :. :. ::.::. : .: .... : . .: :: : . .:: .:
XP_005 EDDLENLLLIKWCVLETIRLKAPGVITRKVVK-PVEILNYIIPSGDLLMLSPFWLHRNPK
320 330 340 350 360 370
420 430 440 450 460 470
pF1KE1 SWVERLDFNPDRYLQDNPASGEKF--AYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYE
. : :.:.:. . : ..: .. ::.:. .:
XP_005 YFPEPELFKPERWKKAN-LEKHSFLDCFMAFGSGKFQCPARKGF
380 390 400 410 420
480 490 500
pF1KE1 FDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK
>>XP_016866410 (OMIM: 605994) PREDICTED: 24-hydroxychole (471 aa)
initn: 194 init1: 170 opt: 382 Z-score: 454.4 bits: 93.5 E(85289): 1.4e-18
Smith-Waterman score: 382; 23.6% identity (55.6% similar) in 428 aa overlap (45-455:7-414)
20 30 40 50 60 70
pF1KE1 AGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPI
... .. : :. ... :: : . :
XP_016 MELISPTVIIILGCLALFLLLQRKNLRRPPCIKGWI
10 20 30
80 90 100 110 120 130
pF1KE1 PFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNED--LN
:..: .. :::.:.::.:.: ::::.:. .:. .:.. .. ....::. : :
XP_016 PWIGVGFEFGKAPLEFIEKARIKYGPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELA
40 50 60 70 80 90
140 150 160 170 180
pF1KE1 AEDVYSRLTTPVFGKGVAYDVPNPVFLEQKK----MLKSGLNIAHFKQHVSIIEKETKEY
.... : .. .:. ::: .. :::. .. ....: .. . .: .:
XP_016 VQNIVYRTAS----------IPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEELHEQ
100 110 120 130 140
190 200 210 220 230 240
pF1KE1 FESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVA---QLYADLDGGFSHAAW
.:. : : .. . . .:. .. . : .: . : ..:. : . : : ...
XP_016 LENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQVYDEDFEYGS-
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE1 LLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDD
:: .: ..... . ..: : : . . :. . :::.:: . :.
XP_016 ----QLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSM-TLLQATLDIVETETSK
210 220 230 240 250 260
310 320 330 340 350
pF1KE1 EVA---GMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTV---CGENLPPLT
: . :.: :: :. .. .. : .. ..: . ..: :.. ..
XP_016 ENSPNYGLL--LLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVS
270 280 290 300 310
360 370 380 390 400 410
pF1KE1 YDQLKDLNLLDRCIKETLRLRPPVMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKD
:.:..: :. :. ::.::. : .: .... : . .: :: : . .:: .:
XP_016 EDDLENLLLIKWCVLETIRLKAPGVITRKVVK-PVEILNYIIPSGDLLMLSPFWLHRNPK
320 330 340 350 360 370
420 430 440 450 460 470
pF1KE1 SWVERLDFNPDRYLQDNPASGEKF--AYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYE
. : :.:.:. . : ..: .. ::.:. .:
XP_016 YFPEPELFKPERWKKAN-LEKHSFLDCFMAFGSGKFQCPARKTNRKEQHEPPDFFRNCSL
380 390 400 410 420 430
480 490 500
pF1KE1 FDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK
XP_016 QSEESHYSRQSHIKLYDLNGGIRRRVFSVEENFFE
440 450 460 470
>>XP_005264490 (OMIM: 605207,614416) PREDICTED: cytochro (454 aa)
initn: 183 init1: 91 opt: 373 Z-score: 443.9 bits: 91.5 E(85289): 5.5e-18
Smith-Waterman score: 373; 21.9% identity (56.7% similar) in 425 aa overlap (90-504:14-432)
60 70 80 90 100 110
pF1KE1 LPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDA
: . :::: ::. ..:. . . :..
XP_005 MKNKTCVLVCGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAEN
10 20 30 40
120 130 140 150 160 170
pF1KE1 AALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVS
. .. .... ...: . : : ..: ... . . . ...:.... .. .....
XP_005 VRKILMGEHHLVSTE--WPRSTRMLLGPNTVSNSIGDIHRNKRKVFSKIFSHEALESYLP
50 60 70 80 90 100
180 190 200 210 220 230
pF1KE1 IIEKETKEYFESWGESGEK-NVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDG
:. .. ...:. : ::.. ..: . : . : : : .: ...:. ..
XP_005 KIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIP---EEDLGHLF-EVYQ
110 120 130 140 150
240 250 260 270 280 290
pF1KE1 GFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKID--DILQTLLDATY
: .. :: ::. ..:: .:.. .. . :::... : . : : :. :....
XP_005 QFVDNVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSK
160 170 180 190 200 210
300 310 320 330 340 350
pF1KE1 KDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKT---VCGE
. :. .: .:. . :..:. :....:. . . : . :. .: : .. . .
XP_005 EHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSG
220 230 240 250 260 270
360 370 380 390 400 410
pF1KE1 NLP---PLTYDQLKDLNLLDRCIKETLRLRPPVMIMMRMARTPQTVAGYTIPPGHQVCVS
. : : : :. : :: :::..:: :. .: . . :. :: : .: :
XP_005 GCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYS
280 290 300 310 320 330
420 430 440 450 460
pF1KE1 PTVNQRLKDSWVERLDFNPDRYLQDNPASGE-KFAYVPFGAGRHRCIGENFAYVQIKTIW
.. . . :.:::. : . . .: :.:::.: . :.:...: . .:..
XP_005 IRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLA
340 350 360 370 380 390
470 480 490 500
pF1KE1 STMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK
. .:.: :: .. . ..: .. ...
XP_005 VELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV
400 410 420 430 440 450
509 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 00:06:48 2016 done: Mon Nov 7 00:06:49 2016
Total Scan time: 8.680 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]