Result of FASTA (omim) for
pFN21AE1535
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1535, 777 aa
1>>>pF1KE1535 777 - 777 aa - 777 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 14.5014+/-0.00045; mu= -20.4362+/- 0.028
mean_var=569.8987+/-120.033, 0's: 0 Z-trim(123.5): 34 B-trim: 601 in 1/59
Lambda= 0.053725
statistics sampled from 43356 (43412) to 43356 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.785), E-opt: 0.2 (0.509), width: 16
Scan time: 12.970
The best scores are: opt bits E(85289)
NP_004703 (OMIM: 604375) hepatocyte growth factor- ( 777) 5205 418.5 5.2e-116
XP_016880786 (OMIM: 604375) PREDICTED: hepatocyte ( 768) 5128 412.6 3.2e-114
XP_011523765 (OMIM: 604375) PREDICTED: hepatocyte ( 777) 4947 398.5 5.5e-110
XP_016880787 (OMIM: 604375) PREDICTED: hepatocyte ( 602) 4039 328.1 6.9e-89
>>NP_004703 (OMIM: 604375) hepatocyte growth factor-regu (777 aa)
initn: 5205 init1: 5205 opt: 5205 Z-score: 2203.7 bits: 418.5 E(85289): 5.2e-116
Smith-Waterman score: 5205; 100.0% identity (100.0% similar) in 777 aa overlap (1-777:1-777)
10 20 30 40 50 60
pF1KE1 MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 ALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 NEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 HCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 PLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 APPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 APPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 PGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 NRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 RGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 KERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 GSPMHGVYMSQPAPAAGPYPSMPSTAADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GSPMHGVYMSQPAPAAGPYPSMPSTAADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 SSYQPTPTAGYQNVASQAPQSLPAISQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SSYQPTPTAGYQNVASQAPQSLPAISQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPS
670 680 690 700 710 720
730 740 750 760 770
pF1KE1 QDASLPPQQPYIAGQQPMYQQMAPSGGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QDASLPPQQPYIAGQQPMYQQMAPSGGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD
730 740 750 760 770
>>XP_016880786 (OMIM: 604375) PREDICTED: hepatocyte grow (768 aa)
initn: 5128 init1: 5128 opt: 5128 Z-score: 2171.5 bits: 412.6 E(85289): 3.2e-114
Smith-Waterman score: 5128; 99.7% identity (99.9% similar) in 767 aa overlap (11-777:2-768)
10 20 30 40 50 60
pF1KE1 MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHV
. ::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MMTDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHV
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 ALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFR
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE1 NEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKH
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE1 HCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTS
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE1 PLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASS
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE1 APPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQ
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE1 PGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFV
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE1 NRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDA
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE1 RGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQE
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE1 KERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVE
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE1 GSPMHGVYMSQPAPAAGPYPSMPSTAADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSPMHGVYMSQPAPAAGPYPSMPSTAADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAY
600 610 620 630 640 650
670 680 690 700 710 720
pF1KE1 SSYQPTPTAGYQNVASQAPQSLPAISQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSYQPTPTAGYQNVASQAPQSLPAISQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPS
660 670 680 690 700 710
730 740 750 760 770
pF1KE1 QDASLPPQQPYIAGQQPMYQQMAPSGGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDASLPPQQPYIAGQQPMYQQMAPSGGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD
720 730 740 750 760
>>XP_011523765 (OMIM: 604375) PREDICTED: hepatocyte grow (777 aa)
initn: 4946 init1: 4946 opt: 4947 Z-score: 2095.7 bits: 398.5 E(85289): 5.5e-110
Smith-Waterman score: 4947; 99.2% identity (99.5% similar) in 749 aa overlap (1-748:1-749)
10 20 30 40 50 60
pF1KE1 MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 ALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 NEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 HCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 PLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 APPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 PGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 NRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 RGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 KERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 GSPMHGVYMSQPAPAAGPYPSMPSTAADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSPMHGVYMSQPAPAAGPYPSMPSTAADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 SSYQPTPTAGYQNVASQAPQSLPAISQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSYQPTPTAGYQNVASQAPQSLPAISQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPS
670 680 690 700 710 720
730 740 750 760 770
pF1KE1 QDASLPPQQPYIAGQQPMYQQ-MAPSGGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD
::::::::::::::::::::: . . ::
XP_011 QDASLPPQQPYIAGQQPMYQQGETHTRGPFSADRTRTQVSGQIRASASVDRKNREFT
730 740 750 760 770
>>XP_016880787 (OMIM: 604375) PREDICTED: hepatocyte grow (602 aa)
initn: 4039 init1: 4039 opt: 4039 Z-score: 1716.8 bits: 328.1 E(85289): 6.9e-89
Smith-Waterman score: 4039; 100.0% identity (100.0% similar) in 602 aa overlap (176-777:1-602)
150 160 170 180 190 200
pF1KE1 KESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGI
::::::::::::::::::::::::::::::
XP_016 MTRKHHCRACGQIFCGKCSSKYSTIPKFGI
10 20 30
210 220 230 240 250 260
pF1KE1 EKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTSPLSQQSQLPPKRDETALQEEEELQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTSPLSQQSQLPPKRDETALQEEEELQL
40 50 60 70 80 90
270 280 290 300 310 320
pF1KE1 ALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASSAPPASSLYSSPVNSSAPLAEDIDPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASSAPPASSLYSSPVNSSAPLAEDIDPE
100 110 120 130 140 150
330 340 350 360 370 380
pF1KE1 LARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQPGEGHAAPTNVVENPLPETDSQPIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQPGEGHAAPTNVVENPLPETDSQPIP
160 170 180 190 200 210
390 400 410 420 430 440
pF1KE1 PSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFVNRMKSNHMRGRSITNDSAVLSLFQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFVNRMKSNHMRGRSITNDSAVLSLFQS
220 230 240 250 260 270
450 460 470 480 490 500
pF1KE1 INGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQ
280 290 300 310 320 330
510 520 530 540 550 560
pF1KE1 RQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRLEQQKQTVQMRAQMPAFPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRLEQQKQTVQMRAQMPAFPL
340 350 360 370 380 390
570 580 590 600 610 620
pF1KE1 PYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVEGSPMHGVYMSQPAPAAGPYPSMPST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVEGSPMHGVYMSQPAPAAGPYPSMPST
400 410 420 430 440 450
630 640 650 660 670 680
pF1KE1 AADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAYSSYQPTPTAGYQNVASQAPQSLPAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAYSSYQPTPTAGYQNVASQAPQSLPAI
460 470 480 490 500 510
690 700 710 720 730 740
pF1KE1 SQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPSQDASLPPQQPYIAGQQPMYQQMAPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPSQDASLPPQQPYIAGQQPMYQQMAPS
520 530 540 550 560 570
750 760 770
pF1KE1 GGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD
::::::::::::::::::::::::::::::::
XP_016 GGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD
580 590 600
777 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 20:14:30 2016 done: Sun Nov 6 20:14:32 2016
Total Scan time: 12.970 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]