Result of FASTA (omim) for
pFN21AE1489
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1489, 455 aa
1>>>pF1KE1489 455 - 455 aa - 455 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.1664+/-0.000361; mu= 5.1853+/- 0.022
mean_var=201.8315+/-40.214, 0's: 0 Z-trim(120.7): 76 B-trim: 0 in 0/57
Lambda= 0.090278
statistics sampled from 36152 (36233) to 36152 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.763), E-opt: 0.2 (0.425), width: 16
Scan time: 9.820
The best scores are: opt bits E(85289)
NP_001056 (OMIM: 142680,191190,614810) tumor necro ( 455) 3212 430.9 3.5e-120
NP_001333020 (OMIM: 142680,191190,614810) tumor ne ( 347) 2426 328.4 1.9e-89
NP_001333021 (OMIM: 142680,191190,614810) tumor ne ( 302) 1857 254.2 3.4e-67
NP_683866 (OMIM: 603366) tumor necrosis factor rec ( 426) 483 75.4 3.3e-13
NP_002333 (OMIM: 600979) tumor necrosis factor rec ( 435) 329 55.4 3.6e-07
NP_001257916 (OMIM: 600979) tumor necrosis factor ( 416) 319 54.1 8.6e-07
XP_006719046 (OMIM: 600979) PREDICTED: tumor necro ( 255) 311 52.8 1.2e-06
XP_005253745 (OMIM: 600979) PREDICTED: tumor necro ( 399) 313 53.3 1.4e-06
NP_001034753 (OMIM: 603366) tumor necrosis factor ( 181) 297 50.9 3.4e-06
NP_683871 (OMIM: 603366) tumor necrosis factor rec ( 234) 275 48.1 3e-05
NP_683868 (OMIM: 603366) tumor necrosis factor rec ( 372) 268 47.4 7.9e-05
NP_683867 (OMIM: 603366) tumor necrosis factor rec ( 380) 268 47.4 8.1e-05
NP_003781 (OMIM: 603366) tumor necrosis factor rec ( 417) 268 47.4 8.6e-05
NP_003811 (OMIM: 602746) tumor necrosis factor rec ( 283) 240 43.6 0.00081
NP_002537 (OMIM: 239000,602643) tumor necrosis fac ( 401) 233 42.8 0.002
XP_011540743 (OMIM: 153243) PREDICTED: tumor necro ( 594) 229 42.5 0.0038
NP_001234 (OMIM: 153243) tumor necrosis factor rec ( 595) 229 42.5 0.0038
NP_001233 (OMIM: 186711,615122) CD27 antigen precu ( 260) 222 41.2 0.0039
NP_001284534 (OMIM: 602746) tumor necrosis factor ( 184) 218 40.6 0.0043
XP_006711082 (OMIM: 602746) PREDICTED: tumor necro ( 197) 216 40.4 0.0054
>>NP_001056 (OMIM: 142680,191190,614810) tumor necrosis (455 aa)
initn: 3212 init1: 3212 opt: 3212 Z-score: 2278.7 bits: 430.9 E(85289): 3.5e-120
Smith-Waterman score: 3212; 100.0% identity (100.0% similar) in 455 aa overlap (1-455:1-455)
10 20 30 40 50 60
pF1KE1 MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 KCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 RDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 SCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 SKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 PGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 AVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLEL
370 380 390 400 410 420
430 440 450
pF1KE1 LGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR
:::::::::::::::::::::::::::::::::::
NP_001 LGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR
430 440 450
>>NP_001333020 (OMIM: 142680,191190,614810) tumor necros (347 aa)
initn: 2426 init1: 2426 opt: 2426 Z-score: 1727.0 bits: 328.4 E(85289): 1.9e-89
Smith-Waterman score: 2426; 100.0% identity (100.0% similar) in 347 aa overlap (109-455:1-347)
80 90 100 110 120 130
pF1KE1 TDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVDRDTVCGCRKNQYRHYWSE
::::::::::::::::::::::::::::::
NP_001 MGQVEISSCTVDRDTVCGCRKNQYRHYWSE
10 20 30
140 150 160 170 180 190
pF1KE1 NLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECVSCSNCKKSLECTKLCLPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECVSCSNCKKSLECTKLCLPQ
40 50 60 70 80 90
200 210 220 230 240 250
pF1KE1 IENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWKSKLYSIVCGKSTPEKEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWKSKLYSIVCGKSTPEKEGE
100 110 120 130 140 150
260 270 280 290 300 310
pF1KE1 LEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYTPGDCPNFAAPRREVAPPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYTPGDCPNFAAPRREVAPPY
160 170 180 190 200 210
320 330 340 350 360 370
pF1KE1 QGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRL
220 230 240 250 260 270
380 390 400 410 420 430
pF1KE1 GLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLELLGRVLRDMDLLGCLEDIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLELLGRVLRDMDLLGCLEDIE
280 290 300 310 320 330
440 450
pF1KE1 EALCGPAALPPAPSLLR
:::::::::::::::::
NP_001 EALCGPAALPPAPSLLR
340
>>NP_001333021 (OMIM: 142680,191190,614810) tumor necros (302 aa)
initn: 1857 init1: 1857 opt: 1857 Z-score: 1327.3 bits: 254.2 E(85289): 3.4e-67
Smith-Waterman score: 1857; 99.6% identity (100.0% similar) in 272 aa overlap (184-455:31-302)
160 170 180 190 200 210
pF1KE1 VHLSCQEKQNTVCTCHAGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVL
.:::::::::::::::::::::::::::::
NP_001 MQWRDLGSLQPLPPRFKQFSCFSLPSSWDYSCKKSLECTKLCLPQIENVKGTEDSGTTVL
10 20 30 40 50 60
220 230 240 250 260 270
pF1KE1 LPLVIFFGLCLLSLLFIGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPLVIFFGLCLLSLLFIGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSF
70 80 90 100 110 120
280 290 300 310 320 330
pF1KE1 SPTPGFTPTLGFSPVPSSTFTSSSTYTPGDCPNFAAPRREVAPPYQGADPILATALASDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPTPGFTPTLGFSPVPSSTFTSSSTYTPGDCPNFAAPRREVAPPYQGADPILATALASDP
130 140 150 160 170 180
340 350 360 370 380 390
pF1KE1 IPNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRLGLSDHEIDRLELQNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRLGLSDHEIDRLELQNG
190 200 210 220 230 240
400 410 420 430 440 450
pF1KE1 RCLREAQYSMLATWRRRTPRREATLELLGRVLRDMDLLGCLEDIEEALCGPAALPPAPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RCLREAQYSMLATWRRRTPRREATLELLGRVLRDMDLLGCLEDIEEALCGPAALPPAPSL
250 260 270 280 290 300
pF1KE1 LR
::
NP_001 LR
>>NP_683866 (OMIM: 603366) tumor necrosis factor recepto (426 aa)
initn: 415 init1: 132 opt: 483 Z-score: 358.2 bits: 75.4 E(85289): 3.3e-13
Smith-Waterman score: 538; 28.9% identity (50.8% similar) in 429 aa overlap (34-444:20-426)
10 20 30 40 50 60
pF1KE1 STVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREK---RDSVCPQGKYIHPQNNSICCT
:: : . :. : . .: . . .::
NP_683 MEQRPRGCAAVAAALLLVLLGARAQGGTRSPRCDCAGDFHKKIGLFCCR
10 20 30 40
70 80 90 100 110
pF1KE1 KCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLR-HCLSCSKCRKEMGQVEISSCTV
: : :: : : .. : : . .: : ::: .: :. : .. .:: . .:..
NP_683 GCPAGHYLKAPCTEPCGNSTCLVCPQDTFLAWENHHNSECARCQACDEQASQVALENCSA
50 60 70 80 90 100
120 130 140 150 160
pF1KE1 DRDTVCGCRKNQYRHYWSENLFQC-----FNCSLCLN-GTVH----LSCQEKQNTVCTCH
:: :::. . . . .. :: : :. ::. :..: : :..... ::
NP_683 VADTRCGCKPGWFVEC---QVSQCVSSSPFYCQPCLDCGALHRHTRLLCSRRDTDCGTCL
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE1 AGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLF
::. . . :::: . :: . : .. . . :. :.. :: . ::
NP_683 PGFYEHGDGCVSCPTPPPSLAGAPWGAVQSAVPLSVAGGRVGVFWVQVLLAGLVVPLLLG
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE1 IGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVP
: : :.. : : .. : . :.: :. .: . ..: :
NP_683 ATLTYTYRH---------CWPHKPLVTADEAG--MEALTPPPATHLSPLDSAHTLLAP-P
230 240 250 260 270
290 300 310 320 330 340
pF1KE1 SSTFTSSSTYTPGDC--PNFAAPRREVAPPYQGA-DPILATALASDPIPNPLQKWEDSAH
.:. .. :. :.. .. . : . : . . ::. : : . :. :
NP_683 DSSEKICTVQLVGNSWTPGYPETQEALCPQVTWSWDQLPSRALG--PAAAPTLSPESPAG
280 290 300 310 320 330
350 360 370 380 390 400
pF1KE1 KPQSLDTDDPATLYAVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLAT
.: . : :: :.. :: ::::::: ::: . ::. .:.. :: .:. :: ::
NP_683 SPAMMLQPGPQ-LYDVMDAVPARRWKEFVRTLGLREAEIEAVEVEIGR-FRDQQYEMLKR
340 350 360 370 380 390
410 420 430 440 450
pF1KE1 WRRRTPRREATLELLGRVLRDMDLLGCLEDIEEALC-GPAALPPAPSLLR
::.. : : : . .:. : : ::.::.. : ::
NP_683 WRQQQP---AGLGAVYAALERMGLDGCVEDLRSRLQRGP
400 410 420
>>NP_002333 (OMIM: 600979) tumor necrosis factor recepto (435 aa)
initn: 161 init1: 98 opt: 329 Z-score: 249.7 bits: 55.4 E(85289): 3.6e-07
Smith-Waterman score: 332; 30.3% identity (49.4% similar) in 346 aa overlap (4-319:7-321)
10 20 30 40 50
pF1KE1 MGLSTVPDLLL-PLVL--LELLVGIYPSGVIGLVPHLGDREK-RDSVCPQGKYIHPQ
...: : :::: . ::.. :..: :. .. . ::. . .: .::
NP_002 MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVP---PYASENQTCRDQ---EKEYYEPQ
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 NNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVE
. :::..: :::. : . .:: : : .:.. :.: : : : :: :
NP_002 HR-ICCSRCPPGTYVSAKC-SRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEE
60 70 80 90 100 110
120 130 140 150 160
pF1KE1 ISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSL---CLNGTVHLSCQE--KQNTVCT-
:. :: : : : :. ... :. ..: .: : : :: .: : :. :.
NP_002 IAPCTSKRKTQCRCQPGMFCAAWA---LECTHCELLSDCPPGTEAELKDEVGKGNNHCVP
120 130 140 150 160
170 180 190 200 210
pF1KE1 CHAGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPL---------VI
:.:: : .: . :. .: . : .: . :: .: :: :: ..
NP_002 CKAGHF--QNTSSPSARCQPHTRCENQGL--VEAAPGTAQSDTTCKNPLEPLPPEMSGTM
170 180 190 200 210 220
220 230 240 250 260
pF1KE1 FFGLCLLSLLFIGLMYRYQR--WKS------KLYSIVCGKSTPEKEGE--LEGTTTKPLA
.. :: : :. :. ::: :: :.. : :. :: . :. : :
NP_002 LMLAVLLPLAFFLLLATVFSCIWKSHPSLCRKLGSLL--KRRPQGEGPNPVAGSWEPPKA
230 240 250 260 270 280
270 280 290 300 310 320
pF1KE1 PNPSFSPTPGFT-PTLGFSPVPSSTFTSSSTYTPGDCPNFAAPRREVAPPYQGADPILAT
.: : : .. : : :. :. . :: : ::: :.. : :
NP_002 -HPYF---PDLVQPLL---PI-SGDVSPVSTGLP------AAPVLEAGVPQQQSPLDLTR
290 300 310 320
330 340 350 360 370 380
pF1KE1 ALASDPIPNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRLGLSDHEIDR
NP_002 EPQLEPGEQSQVAHGTNGIHVTGGSMTITGNIYIYNGPVLGGPPGPGDLPATPEPPYPIP
330 340 350 360 370 380
>>NP_001257916 (OMIM: 600979) tumor necrosis factor rece (416 aa)
initn: 188 init1: 98 opt: 319 Z-score: 242.9 bits: 54.1 E(85289): 8.6e-07
Smith-Waterman score: 322; 29.5% identity (48.3% similar) in 325 aa overlap (21-319:5-302)
10 20 30 40 50
pF1KE1 MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREK-RDSVCPQGKYIHPQNNSICC
:: .. . . :. .. . ::. . .: .::. :::
NP_001 MEATGISLASQLKVPPYASENQTCRDQ---EKEYYEPQHR-ICC
10 20 30 40
60 70 80 90 100 110
pF1KE1 TKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTV
..: :::. : .:: : : .:.. :.: : : : :: ::. ::
NP_001 SRCPPGTYVSAKCSRI-RDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTS
50 60 70 80 90
120 130 140 150 160 170
pF1KE1 DRDTVCGCRKNQYRHYWSENLFQCFNCSL---CLNGTVHLSCQE--KQNTVCT-CHAGFF
: : : :. ... :. ..: .: : : :: .: : :. :. :.:: :
NP_001 KRKTQCRCQPGMFCAAWA---LECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHF
100 110 120 130 140 150
180 190 200 210 220
pF1KE1 LRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPL---------VIFFGLCL
.: . :. .: . : .: . :: .: :: :: .... :
NP_001 --QNTSSPSARCQPHTRCENQGL--VEAAPGTAQSDTTCKNPLEPLPPEMSGTMLMLAVL
160 170 180 190 200 210
230 240 250 260 270
pF1KE1 LSLLFIGLMYRYQR--WKS------KLYSIVCGKSTPEKEGE--LEGTTTKPLAPNPSFS
: : :. :. ::: :: :.. : :. :: . :. : : .: :
NP_001 LPLAFFLLLATVFSCIWKSHPSLCRKLGSLL--KRRPQGEGPNPVAGSWEPPKA-HPYF-
220 230 240 250 260
280 290 300 310 320 330
pF1KE1 PTPGFTPTLGFSPVPSSTFTSSSTYTPGDCPNFAAPRREVAPPYQGADPILATALASDPI
: .. : :. :. . :: : ::: :.. : :
NP_001 --PDLVQPL--LPI-SGDVSPVSTGLP------AAPVLEAGVPQQQSPLDLTREPQLEPG
270 280 290 300 310
340 350 360 370 380 390
pF1KE1 PNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGR
NP_001 EQSQVAHGTNGIHVTGGSMTITGNIYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGP
320 330 340 350 360 370
>>XP_006719046 (OMIM: 600979) PREDICTED: tumor necrosis (255 aa)
initn: 188 init1: 98 opt: 311 Z-score: 240.1 bits: 52.8 E(85289): 1.2e-06
Smith-Waterman score: 311; 31.8% identity (52.5% similar) in 223 aa overlap (4-216:7-214)
10 20 30 40 50
pF1KE1 MGLSTVPDLLL-PLVL--LELLVGIYPSGVIGLVPHLGDREK-RDSVCPQGKYIHPQ
...: : :::: . ::.. :..: :. .. . ::. . .: .::
XP_006 MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVP---PYASENQTCRDQ---EKEYYEPQ
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 NNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVE
. :::..: :::. : .:: : : .:.. :.: : : : :: :
XP_006 HR-ICCSRCPPGTYVSAKCSRI-RDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEE
60 70 80 90 100 110
120 130 140 150 160
pF1KE1 ISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSL---CLNGTVHLSCQE--KQNTVCT-
:. :: : : : :. ... :. ..: .: : : :: .: : :. :.
XP_006 IAPCTSKRKTQCRCQPGMFCAAWA---LECTHCELLSDCPPGTEAELKDEVGKGNNHCVP
120 130 140 150 160
170 180 190 200 210 220
pF1KE1 CHAGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSL
:.:: : .: . :. .: . : .: . :: .: :: ::
XP_006 CKAGHF--QNTSSPSARCQPHTRCENQGL--VEAAPGTAQSDTTCKNPLEPLPPEMSEPA
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE1 LFIGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSP
XP_006 LSKGVENLQALLYQAATGSSEASFPTLSPL
230 240 250
>>XP_005253745 (OMIM: 600979) PREDICTED: tumor necrosis (399 aa)
initn: 215 init1: 98 opt: 313 Z-score: 238.9 bits: 53.3 E(85289): 1.4e-06
Smith-Waterman score: 313; 29.4% identity (49.8% similar) in 289 aa overlap (4-281:7-273)
10 20 30 40 50
pF1KE1 MGLSTVPDLLL-PLVL--LELLVGIYPSGVIGLVPHLGDREK-RDSVCPQGKYIHPQ
...: : :::: . ::.. :..: :. .. . ::. . .: .::
XP_005 MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVP---PYASENQTCRDQ---EKEYYEPQ
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 NNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVE
. :::..: :::. : . .:: : : .:.. :.: : : : :: :
XP_005 HR-ICCSRCPPGTYVSAKC-SRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEE
60 70 80 90 100 110
120 130 140 150 160
pF1KE1 ISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSL---CLNGTVHLSCQE--KQNTVCT-
:. :: : : : :. ... :. ..: .: : : :: .: : :. :.
XP_005 IAPCTSKRKTQCRCQPGMFCAAWA---LECTHCELLSDCPPGTEAELKDEVGKGNNHCVP
120 130 140 150 160
170 180 190 200 210 220
pF1KE1 CHAGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSL
:.:: : .: . :. .: . : .: . :: .: :: :: . ::
XP_005 CKAGHF--QNTSSPSARCQPHTRCENQGL--VEAAPGTAQSDTTCKNPLEPLPPEMSGSL
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE1 LFIGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTKPLAP-NPSFSPTPGFTPTLGFS
: .: ... . : :. : : ..:: : . . ::. :
XP_005 L-------KRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISGDVSPVSTGLPAAPVL
230 240 250 260 270
290 300 310 320 330 340
pF1KE1 PVPSSTFTSSSTYTPGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAH
XP_005 EAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHVTGGSMTITGNIYIYNGPVLGGPPG
280 290 300 310 320 330
>>NP_001034753 (OMIM: 603366) tumor necrosis factor rece (181 aa)
initn: 222 init1: 116 opt: 297 Z-score: 232.2 bits: 50.9 E(85289): 3.4e-06
Smith-Waterman score: 297; 30.7% identity (54.0% similar) in 163 aa overlap (34-182:20-179)
10 20 30 40 50 60
pF1KE1 STVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREK---RDSVCPQGKYIHPQNNSICCT
:: : . :. : . .: . . .::
NP_001 MEQRPRGCAAVAAALLLVLLGARAQGGTRSPRCDCAGDFHKKIGLFCCR
10 20 30 40
70 80 90 100 110
pF1KE1 KCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLR-HCLSCSKCRKEMGQVEISSCTV
: : :: : : .. : : . .: : ::: .: :. : .. .:: . .:..
NP_001 GCPAGHYLKAPCTEPCGNSTCLVCPQDTFLAWENHHNSECARCQACDEQASQVALENCSA
50 60 70 80 90 100
120 130 140 150 160
pF1KE1 DRDTVCGCRKNQYRHYWSENLFQC-----FNCSLCLN-GTVH----LSCQEKQNTVCTCH
:: :::. . . . .. :: : :. ::. :..: : :..... ::
NP_001 VADTRCGCKPGWFVEC---QVSQCVSSSPFYCQPCLDCGALHRHTRLLCSRRDTDCGTCL
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE1 AGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLF
::. . . ::::
NP_001 PGFYEHGDGCVSCPT
170 180
>>NP_683871 (OMIM: 603366) tumor necrosis factor recepto (234 aa)
initn: 227 init1: 132 opt: 275 Z-score: 215.2 bits: 48.1 E(85289): 3e-05
Smith-Waterman score: 275; 30.9% identity (54.1% similar) in 207 aa overlap (242-444:41-234)
220 230 240 250 260 270
pF1KE1 VLLPLVIFFGLCLLSLLFIGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTKPLAPNP
: .. : .. : :. .:. :.: :
NP_683 VAAALLLVLLGARAQGGTRSPRCDCAGDFHKKIGLFCCRGCPADEAGMEA-----LTPPP
20 30 40 50 60
280 290 300 310 320
pF1KE1 SFSPTPGFTPTLGFSPVPSSTFTSSSTYTPGDC--PNFAAPRREVAPPYQGA-DPILATA
. .: . ..: :.:. .. :. :.. .. . : . : . . :
NP_683 ATHLSPLDSAHTLLAP-PDSSEKICTVQLVGNSWTPGYPETQEALCPQVTWSWDQLPSRA
70 80 90 100 110 120
330 340 350 360 370 380
pF1KE1 LASDPIPNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRLGLSDHEIDRL
:. : : . :. : .: . : :: :.. :: ::::::: ::: . ::. .
NP_683 LG--PAAAPTLSPESPAGSPAMMLQPGPQ-LYDVMDAVPARRWKEFVRTLGLREAEIEAV
130 140 150 160 170 180
390 400 410 420 430 440
pF1KE1 ELQNGRCLREAQYSMLATWRRRTPRREATLELLGRVLRDMDLLGCLEDIEEALC-GPAAL
:.. :: .:. :: :: ::.. : : : . .:. : : ::.::.. : ::
NP_683 EVEIGR-FRDQQYEMLKRWRQQQP---AGLGAVYAALERMGLDGCVEDLRSRLQRGP
190 200 210 220 230
450
pF1KE1 PPAPSLLR
455 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 01:57:41 2016 done: Mon Nov 7 01:57:43 2016
Total Scan time: 9.820 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]