Result of FASTA (omim) for
pFN21AE1488
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1488, 285 aa
1>>>pF1KE1488 285 - 285 aa - 285 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6545+/-0.00029; mu= 14.5921+/- 0.018
mean_var=80.5365+/-16.199, 0's: 0 Z-trim(118.1): 18 B-trim: 0 in 0/53
Lambda= 0.142915
statistics sampled from 30609 (30625) to 30609 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.726), E-opt: 0.2 (0.359), width: 16
Scan time: 7.590
The best scores are: opt bits E(85289)
NP_006564 (OMIM: 603969) tumor necrosis factor lig ( 285) 1847 389.8 3.1e-108
NP_001139117 (OMIM: 603969) tumor necrosis factor ( 266) 906 195.8 7.4e-50
NP_003799 (OMIM: 604472) tumor necrosis factor lig ( 250) 308 72.5 9.2e-13
NP_742085 (OMIM: 604472) tumor necrosis factor lig ( 247) 299 70.6 3.3e-12
NP_001185551 (OMIM: 604472) tumor necrosis factor ( 223) 297 70.2 4e-12
NP_001185553 (OMIM: 604472) tumor necrosis factor ( 205) 296 70.0 4.3e-12
NP_001185552 (OMIM: 604472) tumor necrosis factor ( 222) 296 70.0 4.6e-12
NP_742084 (OMIM: 604472) tumor necrosis factor lig ( 234) 284 67.5 2.7e-11
>>NP_006564 (OMIM: 603969) tumor necrosis factor ligand (285 aa)
initn: 1847 init1: 1847 opt: 1847 Z-score: 2064.2 bits: 389.8 E(85289): 3.1e-108
Smith-Waterman score: 1847; 100.0% identity (100.0% similar) in 285 aa overlap (1-285:1-285)
10 20 30 40 50 60
pF1KE1 MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 GEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 KENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 KENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETL
190 200 210 220 230 240
250 260 270 280
pF1KE1 PNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL
:::::::::::::::::::::::::::::::::::::::::::::
NP_006 PNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL
250 260 270 280
>>NP_001139117 (OMIM: 603969) tumor necrosis factor liga (266 aa)
initn: 924 init1: 906 opt: 906 Z-score: 1016.1 bits: 195.8 E(85289): 7.4e-50
Smith-Waterman score: 1677; 93.3% identity (93.3% similar) in 285 aa overlap (1-285:1-266)
10 20 30 40 50 60
pF1KE1 MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 GEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEE
::::::::::::::::::::: ::::::::::::::::::::
NP_001 GEGNSSQNSRNKRAVQGPEET-------------------GSYTFVPWLLSFKRGSALEE
130 140 150 160
190 200 210 220 230 240
pF1KE1 KENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETL
170 180 190 200 210 220
250 260 270 280
pF1KE1 PNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL
:::::::::::::::::::::::::::::::::::::::::::::
NP_001 PNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL
230 240 250 260
>>NP_003799 (OMIM: 604472) tumor necrosis factor ligand (250 aa)
initn: 298 init1: 135 opt: 308 Z-score: 350.1 bits: 72.5 E(85289): 9.2e-13
Smith-Waterman score: 320; 31.3% identity (62.2% similar) in 217 aa overlap (73-284:52-250)
50 60 70 80 90 100
pF1KE1 KDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPA--GAGAPKA
: .: ::: :.. .. :. : : :
NP_003 VREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQ
30 40 50 60 70 80
110 120 130 140 150 160
pF1KE1 GLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQK
.: : . .:. .: ... ::..::: .. .. :.:. . : . .
NP_003 SLPEQS--SDALEAWE--------NGERSRKRRAVLTQKQKKQHSVLHLVPINAT-SKDD
90 100 110 120 130
170 180 190 200 210 220
pF1KE1 GSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVF
.. : : : ...:: .:. . . ....: ...:.:::. : :..::....:.
NP_003 SDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSRE-----
140 150 160 170 180
230 240 250 260 270
pF1KE1 GDELSLVTLFRCIQNMPETLPN---NSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVT
. ::::::..:: . :. :::::::. .:..:: :.. ::: :...:. :
NP_003 -GQGRQETLFRCIRSMP-SHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGT
190 200 210 220 230 240
280
pF1KE1 FFGALKLL
:.: .::
NP_003 FLGFVKL
250
>>NP_742085 (OMIM: 604472) tumor necrosis factor ligand (247 aa)
initn: 289 init1: 126 opt: 299 Z-score: 340.2 bits: 70.6 E(85289): 3.3e-12
Smith-Waterman score: 311; 31.0% identity (62.0% similar) in 213 aa overlap (73-280:52-246)
50 60 70 80 90 100
pF1KE1 KDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPA--GAGAPKA
: .: ::: :.. .. :. : : :
NP_742 VREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQ
30 40 50 60 70 80
110 120 130 140 150 160
pF1KE1 GLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQK
.: : . .:. .: ... ::..::: .. .. :.:. . : . .
NP_742 SLPEQS--SDALEAWE--------NGERSRKRRAVLTQKQKKQHSVLHLVPINAT-SKDD
90 100 110 120 130
170 180 190 200 210 220
pF1KE1 GSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVF
.. : : : ...:: .:. . . ....: ...:.:::. : :..::....:.
NP_742 SDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSRE-----
140 150 160 170 180
230 240 250 260 270
pF1KE1 GDELSLVTLFRCIQNMPETLPN---NSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVT
. ::::::..:: . :. :::::::. .:..:: :.. ::: :...:. :
NP_742 -GQGRQETLFRCIRSMP-SHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGT
190 200 210 220 230 240
280
pF1KE1 FFGALKLL
:.:
NP_742 FLGL
>>NP_001185551 (OMIM: 604472) tumor necrosis factor liga (223 aa)
initn: 295 init1: 135 opt: 297 Z-score: 338.6 bits: 70.2 E(85289): 4e-12
Smith-Waterman score: 297; 33.5% identity (66.5% similar) in 167 aa overlap (121-284:67-223)
100 110 120 130 140 150
pF1KE1 LPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLI
: :. :::... . ::. .. :.:.
NP_001 AALGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQSLPEQ--QHSVLHLV
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE1 ADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGH
. : . . .. : : : ...:: .:. . . ....: ...:.:::. : :..::.
NP_001 PINAT-SKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ
100 110 120 130 140 150
220 230 240 250 260
pF1KE1 LIQRKKVHVFGDELSLVTLFRCIQNMPETLPN---NSCYSAGIAKLEEGDELQLAIPREN
...:. . ::::::..:: . :. :::::::. .:..:: :.. :::
NP_001 VVSRE------GQGRQETLFRCIRSMP-SHPDRAYNSCYSAGVFHLHQGDILSVIIPRAR
160 170 180 190 200
270 280
pF1KE1 AQISLDGDVTFFGALKLL
:...:. ::.: .::
NP_001 AKLNLSPHGTFLGFVKL
210 220
>>NP_001185553 (OMIM: 604472) tumor necrosis factor liga (205 aa)
initn: 295 init1: 135 opt: 296 Z-score: 338.0 bits: 70.0 E(85289): 4.3e-12
Smith-Waterman score: 296; 33.5% identity (66.5% similar) in 167 aa overlap (121-284:50-205)
100 110 120 130 140 150
pF1KE1 LPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLI
: :. :::... . ::. .. :.:.
NP_001 AALGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQSLPEQ---HSVLHLV
20 30 40 50 60 70
160 170 180 190 200 210
pF1KE1 ADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGH
. : . . .. : : : ...:: .:. . . ....: ...:.:::. : :..::.
NP_001 PINAT-SKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ
80 90 100 110 120 130
220 230 240 250 260
pF1KE1 LIQRKKVHVFGDELSLVTLFRCIQNMPETLPN---NSCYSAGIAKLEEGDELQLAIPREN
...:. . ::::::..:: . :. :::::::. .:..:: :.. :::
NP_001 VVSRE------GQGRQETLFRCIRSMP-SHPDRAYNSCYSAGVFHLHQGDILSVIIPRAR
140 150 160 170 180
270 280
pF1KE1 AQISLDGDVTFFGALKLL
:...:. ::.: .::
NP_001 AKLNLSPHGTFLGFVKL
190 200
>>NP_001185552 (OMIM: 604472) tumor necrosis factor liga (222 aa)
initn: 295 init1: 135 opt: 296 Z-score: 337.5 bits: 70.0 E(85289): 4.6e-12
Smith-Waterman score: 296; 33.5% identity (66.5% similar) in 167 aa overlap (121-284:67-222)
100 110 120 130 140 150
pF1KE1 LPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLI
: :. :::... . ::. .. :.:.
NP_001 AALGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQSLPEQ---HSVLHLV
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE1 ADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGH
. : . . .. : : : ...:: .:. . . ....: ...:.:::. : :..::.
NP_001 PINAT-SKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ
100 110 120 130 140 150
220 230 240 250 260
pF1KE1 LIQRKKVHVFGDELSLVTLFRCIQNMPETLPN---NSCYSAGIAKLEEGDELQLAIPREN
...:. . ::::::..:: . :. :::::::. .:..:: :.. :::
NP_001 VVSRE------GQGRQETLFRCIRSMP-SHPDRAYNSCYSAGVFHLHQGDILSVIIPRAR
160 170 180 190 200
270 280
pF1KE1 AQISLDGDVTFFGALKLL
:...:. ::.: .::
NP_001 AKLNLSPHGTFLGFVKL
210 220
>>NP_742084 (OMIM: 604472) tumor necrosis factor ligand (234 aa)
initn: 315 init1: 135 opt: 284 Z-score: 323.8 bits: 67.5 E(85289): 2.7e-11
Smith-Waterman score: 287; 31.8% identity (59.4% similar) in 217 aa overlap (73-284:52-234)
50 60 70 80 90 100
pF1KE1 KDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPA--GAGAPKA
: .: ::: :.. .. :. : : :
NP_742 VREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQ
30 40 50 60 70 80
110 120 130 140 150 160
pF1KE1 GLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQK
.: : . .:. .: ... ::..::: .:: . ::..
NP_742 SLPEQS--SDALEAWE--------NGERSRKRRAV------LTQ---KQKNDSDV-----
90 100 110
170 180 190 200 210 220
pF1KE1 GSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVF
: : : ...:: .:. . . ....: ...:.:::. : :..::....:.
NP_742 ---TEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSRE-----
120 130 140 150 160
230 240 250 260 270
pF1KE1 GDELSLVTLFRCIQNMPETLPN---NSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVT
. ::::::..:: . :. :::::::. .:..:: :.. ::: :...:. :
NP_742 -GQGRQETLFRCIRSMP-SHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGT
170 180 190 200 210 220
280
pF1KE1 FFGALKLL
:.: .::
NP_742 FLGFVKL
230
285 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 00:43:55 2016 done: Mon Nov 7 00:43:56 2016
Total Scan time: 7.590 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]