Result of FASTA (omim) for
pFN21AE1466
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1466, 665 aa
1>>>pF1KE1466 665 - 665 aa - 665 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.6801+/-0.000419; mu= -13.4838+/- 0.026
mean_var=447.9194+/-94.098, 0's: 0 Z-trim(123.3): 136 B-trim: 320 in 1/60
Lambda= 0.060600
statistics sampled from 42792 (42943) to 42792 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.789), E-opt: 0.2 (0.503), width: 16
Scan time: 12.210
The best scores are: opt bits E(85289)
NP_114098 (OMIM: 300374) SH3 domain-containing kin ( 665) 4393 398.6 3.8e-110
XP_016884952 (OMIM: 300374) PREDICTED: SH3 domain- ( 634) 4022 366.2 2.1e-100
XP_016884954 (OMIM: 300374) PREDICTED: SH3 domain- ( 624) 4019 365.9 2.5e-100
NP_001019837 (OMIM: 300374) SH3 domain-containing ( 628) 4019 365.9 2.5e-100
XP_016884955 (OMIM: 300374) PREDICTED: SH3 domain- ( 622) 3352 307.6 9e-83
XP_016884950 (OMIM: 300374) PREDICTED: SH3 domain- ( 649) 3235 297.4 1.1e-79
XP_016884949 (OMIM: 300374) PREDICTED: SH3 domain- ( 668) 3235 297.4 1.1e-79
XP_011543801 (OMIM: 300374) PREDICTED: SH3 domain- ( 672) 3235 297.4 1.1e-79
XP_016884948 (OMIM: 300374) PREDICTED: SH3 domain- ( 678) 3235 297.4 1.2e-79
XP_005274551 (OMIM: 300374) PREDICTED: SH3 domain- ( 690) 3235 297.4 1.2e-79
XP_011543800 (OMIM: 300374) PREDICTED: SH3 domain- ( 709) 3235 297.4 1.2e-79
XP_016884957 (OMIM: 300374) PREDICTED: SH3 domain- ( 581) 2978 274.9 6e-73
NP_001171889 (OMIM: 300374) SH3 domain-containing ( 427) 2803 259.5 1.9e-68
XP_011543804 (OMIM: 300374) PREDICTED: SH3 domain- ( 444) 2797 259.0 2.8e-68
XP_016884958 (OMIM: 300374) PREDICTED: SH3 domain- ( 404) 2681 248.8 3e-65
XP_016884956 (OMIM: 300374) PREDICTED: SH3 domain- ( 606) 2194 206.3 2.6e-52
XP_016884953 (OMIM: 300374) PREDICTED: SH3 domain- ( 625) 2194 206.3 2.7e-52
XP_016884951 (OMIM: 300374) PREDICTED: SH3 domain- ( 647) 2194 206.4 2.8e-52
XP_011543802 (OMIM: 300374) PREDICTED: SH3 domain- ( 666) 2194 206.4 2.8e-52
XP_016884959 (OMIM: 300374) PREDICTED: SH3 domain- ( 384) 1762 168.4 4.4e-41
XP_011543805 (OMIM: 300374) PREDICTED: SH3 domain- ( 426) 1385 135.5 4e-31
NP_036252 (OMIM: 604241,607832) CD2-associated pro ( 639) 1125 112.9 3.8e-24
XP_016866130 (OMIM: 604241,607832) PREDICTED: CD2- ( 476) 1085 109.3 3.4e-23
XP_011512751 (OMIM: 604241,607832) PREDICTED: CD2- ( 590) 878 91.3 1.1e-17
XP_005249033 (OMIM: 604241,607832) PREDICTED: CD2- ( 635) 449 53.8 2.3e-06
NP_006425 (OMIM: 605264) sorbin and SH3 domain-con ( 684) 314 42.0 0.0087
XP_006717656 (OMIM: 605264) PREDICTED: sorbin and ( 740) 314 42.0 0.0093
NP_001030129 (OMIM: 605264) sorbin and SH3 domain- ( 740) 314 42.0 0.0093
NP_001277224 (OMIM: 605264) sorbin and SH3 domain- ( 749) 314 42.0 0.0094
XP_016871029 (OMIM: 605264) PREDICTED: sorbin and ( 765) 314 42.0 0.0095
XP_016871028 (OMIM: 605264) PREDICTED: sorbin and ( 768) 314 42.1 0.0096
XP_016871027 (OMIM: 605264) PREDICTED: sorbin and ( 769) 314 42.1 0.0096
XP_016871026 (OMIM: 605264) PREDICTED: sorbin and ( 772) 314 42.1 0.0096
XP_016871025 (OMIM: 605264) PREDICTED: sorbin and ( 774) 314 42.1 0.0096
XP_016871024 (OMIM: 605264) PREDICTED: sorbin and ( 777) 314 42.1 0.0096
XP_016871023 (OMIM: 605264) PREDICTED: sorbin and ( 778) 314 42.1 0.0097
NP_079267 (OMIM: 605264) sorbin and SH3 domain-con ( 781) 314 42.1 0.0097
XP_016871022 (OMIM: 605264) PREDICTED: sorbin and ( 793) 314 42.1 0.0098
XP_016871021 (OMIM: 605264) PREDICTED: sorbin and ( 800) 314 42.1 0.0099
XP_016871020 (OMIM: 605264) PREDICTED: sorbin and ( 802) 314 42.1 0.0099
XP_016871019 (OMIM: 605264) PREDICTED: sorbin and ( 806) 314 42.1 0.0099
XP_016871018 (OMIM: 605264) PREDICTED: sorbin and ( 809) 314 42.1 0.01
NP_001277226 (OMIM: 605264) sorbin and SH3 domain- ( 811) 314 42.1 0.01
>>NP_114098 (OMIM: 300374) SH3 domain-containing kinase- (665 aa)
initn: 4393 init1: 4393 opt: 4393 Z-score: 2098.5 bits: 398.6 E(85289): 3.8e-110
Smith-Waterman score: 4393; 99.8% identity (100.0% similar) in 665 aa overlap (1-665:1-665)
10 20 30 40 50 60
pF1KE1 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 VGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 VGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 SESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 SESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 EKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 EKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 CIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 CIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 IKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 IKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 RPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 RPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 TSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 TSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTIS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 QVSDNKASLPPKPGTMAAGGGGPAPLSSAVPSPLSSSLGTAGHRANSPSLFGTEGKPKME
:::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::
NP_114 QVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKME
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 PAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 PAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKK
610 620 630 640 650 660
pF1KE1 ALQSK
:::::
NP_114 ALQSK
>>XP_016884952 (OMIM: 300374) PREDICTED: SH3 domain-cont (634 aa)
initn: 4019 init1: 4019 opt: 4022 Z-score: 1923.5 bits: 366.2 E(85289): 2.1e-100
Smith-Waterman score: 4022; 98.9% identity (99.4% similar) in 619 aa overlap (47-665:17-634)
20 30 40 50 60 70
pF1KE1 ELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHE
:. : . ::::::::::::::::::::::
XP_016 MDSDKPRKSLLLWGEFLYTDLYF-EIKKEMKKDPLTNKAPEKPLHE
10 20 30 40
80 90 100 110 120 130
pF1KE1 VPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWW
50 60 70 80 90 100
140 150 160 170 180 190
pF1KE1 EGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGA
110 120 130 140 150 160
200 210 220 230 240 250
pF1KE1 NGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPD
170 180 190 200 210 220
260 270 280 290 300 310
pF1KE1 SSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRG
230 240 250 260 270 280
320 330 340 350 360 370
pF1KE1 VFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRT
290 300 310 320 330 340
380 390 400 410 420 430
pF1KE1 EEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDS
350 360 370 380 390 400
440 450 460 470 480 490
pF1KE1 PKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSL
410 420 430 440 450 460
500 510 520 530 540 550
pF1KE1 TSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTM
470 480 490 500 510 520
560 570 580 590 600 610
pF1KE1 AAGGGGPAPLSSAVPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQV
:::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQV
530 540 550 560 570 580
620 630 640 650 660
pF1KE1 RELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK
590 600 610 620 630
>>XP_016884954 (OMIM: 300374) PREDICTED: SH3 domain-cont (624 aa)
initn: 4019 init1: 4019 opt: 4019 Z-score: 1922.1 bits: 365.9 E(85289): 2.5e-100
Smith-Waterman score: 4019; 99.8% identity (100.0% similar) in 611 aa overlap (55-665:14-624)
30 40 50 60 70 80
pF1KE1 IITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLL
::::::::::::::::::::::::::::::
XP_016 MEAGGRDRSTAGEEIKKEMKKDPLTNKAPEKPLHEVPSGNSLL
10 20 30 40
90 100 110 120 130 140
pF1KE1 SSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKT
50 60 70 80 90 100
150 160 170 180 190 200
pF1KE1 GMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAA
110 120 130 140 150 160
210 220 230 240 250 260
pF1KE1 IQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDS
170 180 190 200 210 220
270 280 290 300 310 320
pF1KE1 RTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVK
230 240 250 260 270 280
330 340 350 360 370 380
pF1KE1 LLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPER
290 300 310 320 330 340
390 400 410 420 430 440
pF1KE1 EPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGS
350 360 370 380 390 400
450 460 470 480 490 500
pF1KE1 SLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSP
410 420 430 440 450 460
510 520 530 540 550 560
pF1KE1 DIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPA
470 480 490 500 510 520
570 580 590 600 610 620
pF1KE1 PLSSAVPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIE
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIE
530 540 550 560 570 580
630 640 650 660
pF1KE1 TMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK
:::::::::::::::::::::::::::::::::::::::::
XP_016 TMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK
590 600 610 620
>>NP_001019837 (OMIM: 300374) SH3 domain-containing kina (628 aa)
initn: 4019 init1: 4019 opt: 4019 Z-score: 1922.1 bits: 365.9 E(85289): 2.5e-100
Smith-Waterman score: 4019; 99.8% identity (100.0% similar) in 611 aa overlap (55-665:18-628)
30 40 50 60 70 80
pF1KE1 IITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLL
::::::::::::::::::::::::::::::
NP_001 MEVSAAKAPSAADLSEIEIKKEMKKDPLTNKAPEKPLHEVPSGNSLL
10 20 30 40
90 100 110 120 130 140
pF1KE1 SSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKT
50 60 70 80 90 100
150 160 170 180 190 200
pF1KE1 GMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAA
110 120 130 140 150 160
210 220 230 240 250 260
pF1KE1 IQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDS
170 180 190 200 210 220
270 280 290 300 310 320
pF1KE1 RTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVK
230 240 250 260 270 280
330 340 350 360 370 380
pF1KE1 LLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPER
290 300 310 320 330 340
390 400 410 420 430 440
pF1KE1 EPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGS
350 360 370 380 390 400
450 460 470 480 490 500
pF1KE1 SLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSP
410 420 430 440 450 460
510 520 530 540 550 560
pF1KE1 DIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPA
470 480 490 500 510 520
570 580 590 600 610 620
pF1KE1 PLSSAVPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIE
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIE
530 540 550 560 570 580
630 640 650 660
pF1KE1 TMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK
:::::::::::::::::::::::::::::::::::::::::
NP_001 TMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK
590 600 610 620
>>XP_016884955 (OMIM: 300374) PREDICTED: SH3 domain-cont (622 aa)
initn: 3714 init1: 3349 opt: 3352 Z-score: 1607.0 bits: 307.6 E(85289): 9e-83
Smith-Waterman score: 4027; 93.4% identity (93.5% similar) in 665 aa overlap (1-665:1-622)
10 20 30 40 50 60
pF1KE1 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 VGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 SESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 EKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 CIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 IKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 RPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 TSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTIS
::::::::::::::::::
XP_016 TSRPKATGRRPPSQSLTS------------------------------------------
490
550 560 570 580 590 600
pF1KE1 QVSDNKASLPPKPGTMAAGGGGPAPLSSAVPSPLSSSLGTAGHRANSPSLFGTEGKPKME
::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::
XP_016 -VSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKME
500 510 520 530 540 550
610 620 630 640 650 660
pF1KE1 PAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKK
560 570 580 590 600 610
pF1KE1 ALQSK
:::::
XP_016 ALQSK
620
>>XP_016884950 (OMIM: 300374) PREDICTED: SH3 domain-cont (649 aa)
initn: 3235 init1: 3235 opt: 3235 Z-score: 1551.5 bits: 297.4 E(85289): 1.1e-79
Smith-Waterman score: 3959; 95.9% identity (96.1% similar) in 636 aa overlap (55-665:14-649)
30 40 50 60 70 80
pF1KE1 IITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLL
::::::::::::::::::::::::::::::
XP_016 MEAGGRDRSTAGEEIKKEMKKDPLTNKAPEKPLHEVPSGNSLL
10 20 30 40
90 100 110 120 130 140
pF1KE1 SSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKT
50 60 70 80 90 100
150 160 170
pF1KE1 GMFPSNFIKELSGESDELGISQDEQLSKS-------------------------SLRETT
::::::::::::::::::::::::::::: ::::::
XP_016 GMFPSNFIKELSGESDELGISQDEQLSKSRKTTFEGTILYRAAPGKTEGHRRYYSLRETT
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE1 GSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLP
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE1 VEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINK
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE1 DCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKH
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE1 EIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPP
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE1 RRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHP
410 420 430 440 450 460
480 490 500 510 520 530
pF1KE1 TTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTI
470 480 490 500 510 520
540 550 560 570 580 590
pF1KE1 SQVSDNKASLPPKPGTMAAGGGGPAPLSSAVPSPLSSSLGTAGHRANSPSLFGTEGKPKM
::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::
XP_016 SQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKM
530 540 550 560 570 580
600 610 620 630 640 650
pF1KE1 EPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIK
590 600 610 620 630 640
660
pF1KE1 KALQSK
::::::
XP_016 KALQSK
>>XP_016884949 (OMIM: 300374) PREDICTED: SH3 domain-cont (668 aa)
initn: 4005 init1: 3235 opt: 3235 Z-score: 1551.3 bits: 297.4 E(85289): 1.1e-79
Smith-Waterman score: 3921; 93.1% identity (93.3% similar) in 655 aa overlap (55-665:14-668)
30 40 50 60 70 80
pF1KE1 IITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLL
::::::::::::::::::::::::::::::
XP_016 MEAGGRDRSTAGEEIKKEMKKDPLTNKAPEKPLHEVPSGNSLL
10 20 30 40
90 100 110 120 130 140
pF1KE1 SSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKT
50 60 70 80 90 100
150 160 170
pF1KE1 GMFPSNFIKELSGESDELGISQDEQLSKS-------------------------------
:::::::::::::::::::::::::::::
XP_016 GMFPSNFIKELSGESDELGISQDEQLSKSRPEGLPPASLLPFPAHGAKGKTTFEGTILYR
110 120 130 140 150 160
180 190 200 210 220
pF1KE1 -------------SLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFK
:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAPGKTEGHRRYYSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFK
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE1 DKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEA
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE1 QNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKP
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE1 PPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPP
350 360 370 380 390 400
410 420 430 440 450 460
pF1KE1 KKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSND
410 420 430 440 450 460
470 480 490 500 510 520
pF1KE1 IDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHI
470 480 490 500 510 520
530 540 550 560 570 580
pF1KE1 SLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAVPSPLSSSLGT
:::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::
XP_016 SLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGT
530 540 550 560 570 580
590 600 610 620 630 640
pF1KE1 AGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSE
590 600 610 620 630 640
650 660
pF1KE1 LDEEKKIRLRLQMEVNDIKKALQSK
:::::::::::::::::::::::::
XP_016 LDEEKKIRLRLQMEVNDIKKALQSK
650 660
>>XP_011543801 (OMIM: 300374) PREDICTED: SH3 domain-cont (672 aa)
initn: 4005 init1: 3235 opt: 3235 Z-score: 1551.2 bits: 297.4 E(85289): 1.1e-79
Smith-Waterman score: 3921; 93.1% identity (93.3% similar) in 655 aa overlap (55-665:18-672)
30 40 50 60 70 80
pF1KE1 IITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLL
::::::::::::::::::::::::::::::
XP_011 MEVSAAKAPSAADLSEIEIKKEMKKDPLTNKAPEKPLHEVPSGNSLL
10 20 30 40
90 100 110 120 130 140
pF1KE1 SSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKT
50 60 70 80 90 100
150 160 170
pF1KE1 GMFPSNFIKELSGESDELGISQDEQLSKS-------------------------------
:::::::::::::::::::::::::::::
XP_011 GMFPSNFIKELSGESDELGISQDEQLSKSRPEGLPPASLLPFPAHGAKGKTTFEGTILYR
110 120 130 140 150 160
180 190 200 210 220
pF1KE1 -------------SLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFK
:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAPGKTEGHRRYYSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFK
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE1 DKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEA
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE1 QNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKP
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE1 PPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPP
350 360 370 380 390 400
410 420 430 440 450 460
pF1KE1 KKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSND
410 420 430 440 450 460
470 480 490 500 510 520
pF1KE1 IDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHI
470 480 490 500 510 520
530 540 550 560 570 580
pF1KE1 SLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAVPSPLSSSLGT
:::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::
XP_011 SLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGT
530 540 550 560 570 580
590 600 610 620 630 640
pF1KE1 AGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSE
590 600 610 620 630 640
650 660
pF1KE1 LDEEKKIRLRLQMEVNDIKKALQSK
:::::::::::::::::::::::::
XP_011 LDEEKKIRLRLQMEVNDIKKALQSK
650 660 670
>>XP_016884948 (OMIM: 300374) PREDICTED: SH3 domain-cont (678 aa)
initn: 4005 init1: 3235 opt: 3235 Z-score: 1551.2 bits: 297.4 E(85289): 1.2e-79
Smith-Waterman score: 3924; 92.3% identity (92.8% similar) in 663 aa overlap (47-665:17-678)
20 30 40 50 60 70
pF1KE1 ELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHE
:. : . ::::::::::::::::::::::
XP_016 MDSDKPRKSLLLWGEFLYTDLYF-EIKKEMKKDPLTNKAPEKPLHE
10 20 30 40
80 90 100 110 120 130
pF1KE1 VPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWW
50 60 70 80 90 100
140 150 160 170
pF1KE1 EGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKS-----------------------
:::::::::::::::::::::::::::::::::::::
XP_016 EGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSRPEGLPPASLLPFPAHGAKGKTT
110 120 130 140 150 160
180 190 200 210
pF1KE1 ---------------------SLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKG
:::::::::::::::::::::::::::::::::::::::
XP_016 FEGTILYRAAPGKTEGHRRYYSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKG
170 180 190 200 210 220
220 230 240 250 260 270
pF1KE1 VGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYC
230 240 250 260 270 280
280 290 300 310 320 330
pF1KE1 KVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEK
290 300 310 320 330 340
340 350 360 370 380 390
pF1KE1 EGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQK
350 360 370 380 390 400
400 410 420 430 440 450
pF1KE1 PSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDK
410 420 430 440 450 460
460 470 480 490 500 510
pF1KE1 DLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSP
470 480 490 500 510 520
520 530 540 550 560 570
pF1KE1 EEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAVPS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::
XP_016 EEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPS
530 540 550 560 570 580
580 590 600 610 620 630
pF1KE1 PLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKR
590 600 610 620 630 640
640 650 660
pF1KE1 EIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK
:::::::::::::::::::::::::::::::::
XP_016 EIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK
650 660 670
>>XP_005274551 (OMIM: 300374) PREDICTED: SH3 domain-cont (690 aa)
initn: 3235 init1: 3235 opt: 3235 Z-score: 1551.1 bits: 297.4 E(85289): 1.2e-79
Smith-Waterman score: 4333; 96.2% identity (96.4% similar) in 690 aa overlap (1-665:1-690)
10 20 30 40 50 60
pF1KE1 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK
70 80 90 100 110 120
130 140 150 160 170
pF1KE1 VGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKS-------
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSRKTTFEG
130 140 150 160 170 180
180 190 200 210
pF1KE1 ------------------SLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGF
::::::::::::::::::::::::::::::::::::::::::
XP_005 TILYRAAPGKTEGHRRYYSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGF
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE1 GDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVI
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE1 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE1 RPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSV
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE1 PAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLS
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE1 DRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEED
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE1 KEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAVPSPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::
XP_005 KEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLS
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE1 SSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIK
610 620 630 640 650 660
640 650 660
pF1KE1 QLLSELDEEKKIRLRLQMEVNDIKKALQSK
::::::::::::::::::::::::::::::
XP_005 QLLSELDEEKKIRLRLQMEVNDIKKALQSK
670 680 690
665 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 01:16:04 2016 done: Mon Nov 7 01:16:05 2016
Total Scan time: 12.210 Total Display time: 0.130
Function used was FASTA [36.3.4 Apr, 2011]