Result of FASTA (omim) for
pFN21AE1457
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1457, 1269 aa
1>>>pF1KE1457 1269 - 1269 aa - 1269 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.1789+/-0.000479; mu= 20.1086+/- 0.030
mean_var=158.5606+/-31.714, 0's: 0 Z-trim(113.7): 416 B-trim: 942 in 1/57
Lambda= 0.101854
statistics sampled from 22624 (23138) to 22624 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.618), E-opt: 0.2 (0.271), width: 16
Scan time: 14.430
The best scores are: opt bits E(85289)
NP_002009 (OMIM: 600362) protein flightless-1 homo (1269) 8502 1263.2 0
XP_005256615 (OMIM: 600362) PREDICTED: protein fli (1268) 8485 1260.7 0
NP_001243193 (OMIM: 600362) protein flightless-1 h (1258) 8368 1243.5 0
XP_005256612 (OMIM: 600362) PREDICTED: protein fli (1296) 8193 1217.8 0
XP_005256613 (OMIM: 600362) PREDICTED: protein fli (1295) 8176 1215.3 0
NP_001243194 (OMIM: 600362) protein flightless-1 h (1214) 7335 1091.7 0
XP_016874199 (OMIM: 613397) PREDICTED: advillin is ( 819) 536 92.4 1.3e-17
NP_006567 (OMIM: 613397) advillin [Homo sapiens] ( 819) 536 92.4 1.3e-17
NP_149119 (OMIM: 613416) adseverin isoform 2 [Homo ( 468) 516 89.2 7.2e-17
NP_001106177 (OMIM: 613416) adseverin isoform 1 [H ( 715) 516 89.4 9.4e-17
NP_001255968 (OMIM: 602775,607721) leucine-rich re ( 536) 491 85.6 1e-15
XP_016872191 (OMIM: 602775,607721) PREDICTED: leuc ( 582) 489 85.3 1.3e-15
NP_001311265 (OMIM: 602775,607721) leucine-rich re ( 582) 489 85.3 1.3e-15
NP_001311266 (OMIM: 602775,607721) leucine-rich re ( 582) 489 85.3 1.3e-15
XP_016872193 (OMIM: 602775,607721) PREDICTED: leuc ( 582) 489 85.3 1.3e-15
XP_016872192 (OMIM: 602775,607721) PREDICTED: leuc ( 582) 489 85.3 1.3e-15
NP_031399 (OMIM: 602775,607721) leucine-rich repea ( 582) 489 85.3 1.3e-15
NP_009058 (OMIM: 193040) villin-1 [Homo sapiens] ( 827) 489 85.5 1.6e-15
NP_000168 (OMIM: 105120,137350) gelsolin isoform a ( 782) 472 83.0 8.8e-15
NP_001244958 (OMIM: 105120,137350) gelsolin isofor ( 748) 469 82.5 1.2e-14
XP_011516894 (OMIM: 105120,137350) PREDICTED: gels ( 731) 464 81.8 1.9e-14
NP_001121137 (OMIM: 105120,137350) gelsolin isofor ( 731) 464 81.8 1.9e-14
NP_937895 (OMIM: 105120,137350) gelsolin isoform b ( 731) 464 81.8 1.9e-14
NP_001121134 (OMIM: 105120,137350) gelsolin isofor ( 731) 464 81.8 1.9e-14
XP_005252002 (OMIM: 105120,137350) PREDICTED: gels ( 731) 464 81.8 1.9e-14
XP_011516893 (OMIM: 105120,137350) PREDICTED: gels ( 731) 464 81.8 1.9e-14
XP_011516895 (OMIM: 105120,137350) PREDICTED: gels ( 731) 464 81.8 1.9e-14
NP_001121136 (OMIM: 105120,137350) gelsolin isofor ( 731) 464 81.8 1.9e-14
NP_001244959 (OMIM: 105120,137350) gelsolin isofor ( 739) 464 81.8 1.9e-14
XP_016870136 (OMIM: 105120,137350) PREDICTED: gels ( 742) 464 81.8 1.9e-14
XP_011516889 (OMIM: 105120,137350) PREDICTED: gels ( 742) 464 81.8 1.9e-14
NP_001121139 (OMIM: 105120,137350) gelsolin isofor ( 742) 464 81.8 1.9e-14
XP_005252001 (OMIM: 105120,137350) PREDICTED: gels ( 742) 464 81.8 1.9e-14
XP_016870135 (OMIM: 105120,137350) PREDICTED: gels ( 742) 464 81.8 1.9e-14
XP_005252000 (OMIM: 105120,137350) PREDICTED: gels ( 742) 464 81.8 1.9e-14
XP_011516892 (OMIM: 105120,137350) PREDICTED: gels ( 742) 464 81.8 1.9e-14
XP_011516888 (OMIM: 105120,137350) PREDICTED: gels ( 742) 464 81.8 1.9e-14
XP_011516890 (OMIM: 105120,137350) PREDICTED: gels ( 742) 464 81.8 1.9e-14
NP_001121138 (OMIM: 105120,137350) gelsolin isofor ( 742) 464 81.8 1.9e-14
XP_011516891 (OMIM: 105120,137350) PREDICTED: gels ( 742) 464 81.8 1.9e-14
XP_006717142 (OMIM: 105120,137350) PREDICTED: gels ( 742) 464 81.8 1.9e-14
XP_016870137 (OMIM: 105120,137350) PREDICTED: gels ( 742) 464 81.8 1.9e-14
XP_016870134 (OMIM: 105120,137350) PREDICTED: gels ( 752) 464 81.8 1.9e-14
XP_011516887 (OMIM: 105120,137350) PREDICTED: gels ( 761) 464 81.8 2e-14
NP_001121135 (OMIM: 105120,137350) gelsolin isofor ( 767) 464 81.8 2e-14
XP_016870132 (OMIM: 105120,137350) PREDICTED: gels ( 780) 464 81.8 2e-14
XP_016870133 (OMIM: 105120,137350) PREDICTED: gels ( 780) 464 81.8 2e-14
XP_011516886 (OMIM: 105120,137350) PREDICTED: gels ( 780) 464 81.8 2e-14
XP_016866486 (OMIM: 608195) PREDICTED: leucine-ric ( 331) 439 77.7 1.5e-13
XP_016857384 (OMIM: 614453) PREDICTED: leucine-ric (1255) 445 79.3 1.9e-13
>>NP_002009 (OMIM: 600362) protein flightless-1 homolog (1269 aa)
initn: 8502 init1: 8502 opt: 8502 Z-score: 6761.0 bits: 1263.2 E(85289): 0
Smith-Waterman score: 8502; 100.0% identity (100.0% similar) in 1269 aa overlap (1-1269:1-1269)
10 20 30 40 50 60
pF1KE1 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSGP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE1 VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE1 NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE1 GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE1 MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE1 NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE1 ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE1 GQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHA
1210 1220 1230 1240 1250 1260
pF1KE1 WSAFCKALA
:::::::::
NP_002 WSAFCKALA
>>XP_005256615 (OMIM: 600362) PREDICTED: protein flightl (1268 aa)
initn: 5835 init1: 5835 opt: 8485 Z-score: 6747.5 bits: 1260.7 E(85289): 0
Smith-Waterman score: 8485; 99.9% identity (99.9% similar) in 1269 aa overlap (1-1269:1-1268)
10 20 30 40 50 60
pF1KE1 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_005 FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAA-GSGP
370 380 390 400 410
430 440 450 460 470 480
pF1KE1 KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE1 EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE1 LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE1 IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR
600 610 620 630 640 650
670 680 690 700 710 720
pF1KE1 GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED
660 670 680 690 700 710
730 740 750 760 770 780
pF1KE1 FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC
720 730 740 750 760 770
790 800 810 820 830 840
pF1KE1 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD
780 790 800 810 820 830
850 860 870 880 890 900
pF1KE1 VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW
840 850 860 870 880 890
910 920 930 940 950 960
pF1KE1 NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE
900 910 920 930 940 950
970 980 990 1000 1010 1020
pF1KE1 GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KE1 MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120 1130 1140
pF1KE1 NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP
1080 1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KE1 ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250 1260
pF1KE1 GQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHA
1200 1210 1220 1230 1240 1250
pF1KE1 WSAFCKALA
:::::::::
XP_005 WSAFCKALA
1260
>>NP_001243193 (OMIM: 600362) protein flightless-1 homol (1258 aa)
initn: 8363 init1: 8363 opt: 8368 Z-score: 6654.6 bits: 1243.5 E(85289): 0
Smith-Waterman score: 8368; 99.4% identity (99.5% similar) in 1258 aa overlap (13-1269:1-1258)
10 20 30 40 50
pF1KE1 MEATGVLPFVRGVDLSG-NDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLE
.:: : ::::::::::::::::::::::::::::::::::::::
NP_001 MDLRGLRPVPGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLE
10 20 30 40
60 70 80 90 100 110
pF1KE1 HLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTEC
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE1 PRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTL
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE1 VLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVP
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE1 ECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYL
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE1 NSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAI
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE1 HFLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HFLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSG
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE1 PKDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQG
410 420 430 440 450 460
480 490 500 510 520 530
pF1KE1 LEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSG
470 480 490 500 510 520
540 550 560 570 580 590
pF1KE1 SLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDIS
530 540 550 560 570 580
600 610 620 630 640 650
pF1KE1 YIEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YIEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVW
590 600 610 620 630 640
660 670 680 690 700 710
pF1KE1 RGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPE
650 660 670 680 690 700
720 730 740 750 760 770
pF1KE1 DFWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DFWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILD
710 720 730 740 750 760
780 790 800 810 820 830
pF1KE1 CWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWD
770 780 790 800 810 820
840 850 860 870 880 890
pF1KE1 DVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEE
830 840 850 860 870 880
900 910 920 930 940 950
pF1KE1 WNEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WNEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKA
890 900 910 920 930 940
960 970 980 990 1000 1010
pF1KE1 EGKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVV
950 960 970 980 990 1000
1020 1030 1040 1050 1060 1070
pF1KE1 RMTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RMTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSL
1010 1020 1030 1040 1050 1060
1080 1090 1100 1110 1120 1130
pF1KE1 LNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEE
1070 1080 1090 1100 1110 1120
1140 1150 1160 1170 1180 1190
pF1KE1 PENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLD
1130 1140 1150 1160 1170 1180
1200 1210 1220 1230 1240 1250
pF1KE1 NGQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFH
1190 1200 1210 1220 1230 1240
1260
pF1KE1 AWSAFCKALA
::::::::::
NP_001 AWSAFCKALA
1250
>>XP_005256612 (OMIM: 600362) PREDICTED: protein flightl (1296 aa)
initn: 8193 init1: 8193 opt: 8193 Z-score: 6515.5 bits: 1217.8 E(85289): 0
Smith-Waterman score: 8438; 97.9% identity (97.9% similar) in 1296 aa overlap (1-1269:1-1296)
10 20 30 40 50 60
pF1KE1 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSGP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE1 VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE1 NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE1 GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE1 MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE1 NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE1 ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN
1150 1160 1170 1180 1190 1200
1210 1220 1230
pF1KE1 GQEVYMWVGTQTSQVEIKLSLKACQV---------------------------YIQHMRS
:::::::::::::::::::::::::: :::::::
XP_005 GQEVYMWVGTQTSQVEIKLSLKACQVIWVEGGPRWACGQGRVITQGSLSPCQVYIQHMRS
1210 1220 1230 1240 1250 1260
1240 1250 1260
pF1KE1 KEHERPRRLRLVRKGNEQHAFTRCFHAWSAFCKALA
::::::::::::::::::::::::::::::::::::
XP_005 KEHERPRRLRLVRKGNEQHAFTRCFHAWSAFCKALA
1270 1280 1290
>>XP_005256613 (OMIM: 600362) PREDICTED: protein flightl (1295 aa)
initn: 5526 init1: 5526 opt: 8176 Z-score: 6502.0 bits: 1215.3 E(85289): 0
Smith-Waterman score: 8421; 97.8% identity (97.8% similar) in 1296 aa overlap (1-1269:1-1295)
10 20 30 40 50 60
pF1KE1 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_005 FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAA-GSGP
370 380 390 400 410
430 440 450 460 470 480
pF1KE1 KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE1 EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE1 LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE1 IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR
600 610 620 630 640 650
670 680 690 700 710 720
pF1KE1 GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED
660 670 680 690 700 710
730 740 750 760 770 780
pF1KE1 FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC
720 730 740 750 760 770
790 800 810 820 830 840
pF1KE1 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD
780 790 800 810 820 830
850 860 870 880 890 900
pF1KE1 VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW
840 850 860 870 880 890
910 920 930 940 950 960
pF1KE1 NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE
900 910 920 930 940 950
970 980 990 1000 1010 1020
pF1KE1 GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KE1 MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120 1130 1140
pF1KE1 NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP
1080 1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KE1 ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN
1140 1150 1160 1170 1180 1190
1210 1220 1230
pF1KE1 GQEVYMWVGTQTSQVEIKLSLKACQV---------------------------YIQHMRS
:::::::::::::::::::::::::: :::::::
XP_005 GQEVYMWVGTQTSQVEIKLSLKACQVIWVEGGPRWACGQGRVITQGSLSPCQVYIQHMRS
1200 1210 1220 1230 1240 1250
1240 1250 1260
pF1KE1 KEHERPRRLRLVRKGNEQHAFTRCFHAWSAFCKALA
::::::::::::::::::::::::::::::::::::
XP_005 KEHERPRRLRLVRKGNEQHAFTRCFHAWSAFCKALA
1260 1270 1280 1290
>>NP_001243194 (OMIM: 600362) protein flightless-1 homol (1214 aa)
initn: 6833 init1: 5835 opt: 7335 Z-score: 5834.4 bits: 1091.7 E(85289): 0
Smith-Waterman score: 8021; 95.7% identity (95.7% similar) in 1269 aa overlap (1-1269:1-1214)
10 20 30 40 50 60
pF1KE1 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV
:::::::::::::::::
NP_001 RELENAKNMLVLNLSHN-------------------------------------------
130
190 200 210 220 230 240
pF1KE1 LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -----------RQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE
140 150 160 170 180
250 260 270 280 290 300
pF1KE1 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN
190 200 210 220 230 240
310 320 330 340 350 360
pF1KE1 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH
250 260 270 280 290 300
370 380 390 400 410 420
pF1KE1 FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
NP_001 FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAA-GSGP
310 320 330 340 350 360
430 440 450 460 470 480
pF1KE1 KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL
370 380 390 400 410 420
490 500 510 520 530 540
pF1KE1 EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS
430 440 450 460 470 480
550 560 570 580 590 600
pF1KE1 LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY
490 500 510 520 530 540
610 620 630 640 650 660
pF1KE1 IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR
550 560 570 580 590 600
670 680 690 700 710 720
pF1KE1 GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED
610 620 630 640 650 660
730 740 750 760 770 780
pF1KE1 FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC
670 680 690 700 710 720
790 800 810 820 830 840
pF1KE1 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD
730 740 750 760 770 780
850 860 870 880 890 900
pF1KE1 VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW
790 800 810 820 830 840
910 920 930 940 950 960
pF1KE1 NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE
850 860 870 880 890 900
970 980 990 1000 1010 1020
pF1KE1 GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR
910 920 930 940 950 960
1030 1040 1050 1060 1070 1080
pF1KE1 MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL
970 980 990 1000 1010 1020
1090 1100 1110 1120 1130 1140
pF1KE1 NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP
1030 1040 1050 1060 1070 1080
1150 1160 1170 1180 1190 1200
pF1KE1 ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN
1090 1100 1110 1120 1130 1140
1210 1220 1230 1240 1250 1260
pF1KE1 GQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHA
1150 1160 1170 1180 1190 1200
pF1KE1 WSAFCKALA
:::::::::
NP_001 WSAFCKALA
1210
>>XP_016874199 (OMIM: 613397) PREDICTED: advillin isofor (819 aa)
initn: 460 init1: 201 opt: 536 Z-score: 437.0 bits: 92.4 E(85289): 1.3e-17
Smith-Waterman score: 979; 29.9% identity (56.8% similar) in 783 aa overlap (499-1261:14-711)
470 480 490 500 510 520
pF1KE1 PSGKVRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCY
::. .:.::.. .:: . ::.:::.:::
XP_016 MPLTSAFRAVDNDPGIIVWRIEKMELALVPVSAHGNFYEGDCY
10 20 30 40
530 540 550 560 570 580
pF1KE1 IVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESE
..:.: : :. .:..::: ... :...:.::....: .:::. :: . ::.
XP_016 VILSTRRVAS-LLSQDIHFWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESD
50 60 70 80 90 100
590 600 610 620 630 640
pF1KE1 EFLQVFDNDISYIEGGTASGFYTVE-DTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFV
: : . : : .::.:::. :: .:. : :. .: ::.::. : .. :.. :
XP_016 TFRGYFKQGIIYKQGGVASGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDV
110 120 130 140 150 160
650 660 670 680 690 700
pF1KE1 FLLDRGLDIYVWRGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQEL--PEFWEA
:::: : : : : ... . :: :.:. : :: :.:.: .. .: ::. ..
XP_016 FLLDLGKVIIQWNGPESNSGERLKAMLLAKDIRDRERGGRAKIGVIEGDKEAASPELMKV
170 180 190 200 210 220
710 720 730 740 750
pF1KE1 LG---GEPSEIKKHVPEDFWPPQPK----LYKVGLGLGYLELPQINYKLSVEHKQRPKVE
: :. : :: ::... . : ::... . : : . .. ::
XP_016 LQDTLGRRSIIKPTVPDEIIDQKQKSTIMLYHISDSAGQLAVTEVA--------TRP---
230 240 250 260 270
760 770 780 790 800 810
pF1KE1 LMPRMRLLQSLLDTRCVYILD-CWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHA
:.:.::. :::: . ...: :. . . . ::.. . . : : .
XP_016 ------LVQDLLNHDDCYILDQSGTKIYVWKGKGATKAEKQAAMSKALGFIKMKSYPSST
280 290 300 310 320
820 830 840 850 860 870
pF1KE1 TVSRSLEGTEAQVFKAKFKNWDDVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADL
.: .:.:. .:: :..:. . : : . .. : : .:: .: : :.
XP_016 NVETVNDGAESAMFKQLFQKWS---VKDQTMGLGKTF-SIGKIAKVFQD-------KFDV
330 340 350 360 370
880 890 900 910 920 930
pF1KE1 TALFLPRQPPMSLAEAEQLMEEWNEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFL
: .: .: . : :..... : .: . .:. ... . . .: :: :::. :
XP_016 T--LLHTKPEV--AAQERMVDDGN---GKVEVWRIENLELVPVEYQWYGFFYGGDCYLVL
380 390 400 410 420
940 950 960 970 980 990
pF1KE1 CRYWVPVEYEEEEKKEDKEEKAEGKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGW
: : .:: :.. :.:.::::.::.
XP_016 YTYEV-----------------NGK-------------PHH----ILYIWQGRHASQ-DE
430 440 450
1000 1010 1020 1030 1040 1050
pF1KE1 LTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLSHFKRKFIIHRG--KRKAVQGAQQP-
:. . . . : : ::. . : .:.. :: :..: .: .::. . :
XP_016 LAASAYQAVEVDRQFDGAAVQVRVRMGTEPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPV
460 470 480 490 500 510
1060 1070 1080 1090 1100 1110
pF1KE1 SLYQIRTNGSALCTRCIQINTDSSLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEA
:.::. : .. :. ... . .: :::. :.:.. : : : :..:. ::
XP_016 RLFQIHGNDKS-NTKAVEVPAFASSLNSNDVFLLRTQAEH-------YLWYGKGSSGDER
520 530 540 550 560
1120 1130 1140 1150 1160
pF1KE1 KLAEDILNTMFDTSYSKQVINEGEEPENFFWVGIGAQKPYDDDAEYMK-----HTRLFRC
.:... . . : :.... ::.:: .: : .:.. :: .: . .. ..:::.:
XP_016 AMAKELASLLCDG--SENTVAEGQEPAEF-WDLLGGKTPYANDKRLQQEILDVQSRLFEC
570 580 590 600 610 620
1170 1180 1190 1200 1210 1220
pF1KE1 SNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQ
::. : :.::: .:: :::: :.::::. ..:..:.:.... .: . .: . : :..
XP_016 SNKTGQFVVTE-ITDFTQDDLNPTDVMLLDTWDQVFLWIGAEANATEKESALATAQQYLH
630 640 650 660 670 680
1230 1240 1250 1260
pF1KE1 -HMRSKEHERPRRLRLVRKGNEQHAFTRCFHAWSAFCKALA
: ... . : . ....: : :: : ::
XP_016 THPSGRDPDTP--ILIIKQGFEPPIFTGWFLAWDPNIWSAGKTYEQLKEELGDAAAIMRI
690 700 710 720 730
XP_016 TADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITR
740 750 760 770 780 790
>>NP_006567 (OMIM: 613397) advillin [Homo sapiens] (819 aa)
initn: 460 init1: 201 opt: 536 Z-score: 437.0 bits: 92.4 E(85289): 1.3e-17
Smith-Waterman score: 979; 29.9% identity (56.8% similar) in 783 aa overlap (499-1261:14-711)
470 480 490 500 510 520
pF1KE1 PSGKVRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCY
::. .:.::.. .:: . ::.:::.:::
NP_006 MPLTSAFRAVDNDPGIIVWRIEKMELALVPVSAHGNFYEGDCY
10 20 30 40
530 540 550 560 570 580
pF1KE1 IVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESE
..:.: : :. .:..::: ... :...:.::....: .:::. :: . ::.
NP_006 VILSTRRVAS-LLSQDIHFWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESD
50 60 70 80 90 100
590 600 610 620 630 640
pF1KE1 EFLQVFDNDISYIEGGTASGFYTVE-DTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFV
: : . : : .::.:::. :: .:. : :. .: ::.::. : .. :.. :
NP_006 TFRGYFKQGIIYKQGGVASGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDV
110 120 130 140 150 160
650 660 670 680 690 700
pF1KE1 FLLDRGLDIYVWRGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQEL--PEFWEA
:::: : : : : ... . :: :.:. : :: :.:.: .. .: ::. ..
NP_006 FLLDLGKVIIQWNGPESNSGERLKAMLLAKDIRDRERGGRAKIGVIEGDKEAASPELMKV
170 180 190 200 210 220
710 720 730 740 750
pF1KE1 LG---GEPSEIKKHVPEDFWPPQPK----LYKVGLGLGYLELPQINYKLSVEHKQRPKVE
: :. : :: ::... . : ::... . : : . .. ::
NP_006 LQDTLGRRSIIKPTVPDEIIDQKQKSTIMLYHISDSAGQLAVTEVA--------TRP---
230 240 250 260 270
760 770 780 790 800 810
pF1KE1 LMPRMRLLQSLLDTRCVYILD-CWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHA
:.:.::. :::: . ...: :. . . . ::.. . . : : .
NP_006 ------LVQDLLNHDDCYILDQSGTKIYVWKGKGATKAEKQAAMSKALGFIKMKSYPSST
280 290 300 310 320
820 830 840 850 860 870
pF1KE1 TVSRSLEGTEAQVFKAKFKNWDDVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADL
.: .:.:. .:: :..:. . : : . .. : : .:: .: : :.
NP_006 NVETVNDGAESAMFKQLFQKWS---VKDQTMGLGKTF-SIGKIAKVFQD-------KFDV
330 340 350 360 370
880 890 900 910 920 930
pF1KE1 TALFLPRQPPMSLAEAEQLMEEWNEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFL
: .: .: . : :..... : .: . .:. ... . . .: :: :::. :
NP_006 T--LLHTKPEV--AAQERMVDDGN---GKVEVWRIENLELVPVEYQWYGFFYGGDCYLVL
380 390 400 410 420
940 950 960 970 980 990
pF1KE1 CRYWVPVEYEEEEKKEDKEEKAEGKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGW
: : .:: :.. :.:.::::.::.
NP_006 YTYEV-----------------NGK-------------PHH----ILYIWQGRHASQ-DE
430 440 450
1000 1010 1020 1030 1040 1050
pF1KE1 LTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLSHFKRKFIIHRG--KRKAVQGAQQP-
:. . . . : : ::. . : .:.. :: :..: .: .::. . :
NP_006 LAASAYQAVEVDRQFDGAAVQVRVRMGTEPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPV
460 470 480 490 500 510
1060 1070 1080 1090 1100 1110
pF1KE1 SLYQIRTNGSALCTRCIQINTDSSLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEA
:.::. : .. :. ... . .: :::. :.:.. : : : :..:. ::
NP_006 RLFQIHGNDKS-NTKAVEVPAFASSLNSNDVFLLRTQAEH-------YLWYGKGSSGDER
520 530 540 550 560
1120 1130 1140 1150 1160
pF1KE1 KLAEDILNTMFDTSYSKQVINEGEEPENFFWVGIGAQKPYDDDAEYMK-----HTRLFRC
.:... . . : :.... ::.:: .: : .:.. :: .: . .. ..:::.:
NP_006 AMAKELASLLCDG--SENTVAEGQEPAEF-WDLLGGKTPYANDKRLQQEILDVQSRLFEC
570 580 590 600 610 620
1170 1180 1190 1200 1210 1220
pF1KE1 SNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQ
::. : :.::: .:: :::: :.::::. ..:..:.:.... .: . .: . : :..
NP_006 SNKTGQFVVTE-ITDFTQDDLNPTDVMLLDTWDQVFLWIGAEANATEKESALATAQQYLH
630 640 650 660 670 680
1230 1240 1250 1260
pF1KE1 -HMRSKEHERPRRLRLVRKGNEQHAFTRCFHAWSAFCKALA
: ... . : . ....: : :: : ::
NP_006 THPSGRDPDTP--ILIIKQGFEPPIFTGWFLAWDPNIWSAGKTYEQLKEELGDAAAIMRI
690 700 710 720 730
NP_006 TADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITR
740 750 760 770 780 790
>>NP_149119 (OMIM: 613416) adseverin isoform 2 [Homo sap (468 aa)
initn: 430 init1: 225 opt: 516 Z-score: 423.8 bits: 89.2 E(85289): 7.2e-17
Smith-Waterman score: 612; 30.1% identity (58.1% similar) in 511 aa overlap (769-1263:30-465)
740 750 760 770 780 790
pF1KE1 ELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILD--CWSDVFIWLGRKSPRLV
::. .: .::: ...:.: :. .
NP_149 MAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEEC-FILDHGAAKQIFVWKGKDANPQE
10 20 30 40 50
800 810 820 830 840 850
pF1KE1 RAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDDVLTVDYTRNAEAVLQS
: ::.: ..:. ... ... .. :: :. .:: ::.: : : ::
NP_149 RKAAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDK---D---------QS
60 70 80 90 100
860 870 880 890 900 910
pF1KE1 PGLSGKVKRDAEKKDQMKA-DLTALFLPRQPPMSLAEAEQLMEEWNEDLDG-MEGFVLEG
:. ::: .:: :.: . : : .: :. :.. : . : .: .: . .:.
NP_149 DGF-GKV-YVTEKVAQIKQIPFDASKLHSSPQMA---AQHNMVD---DGSGKVEIWRVEN
110 120 130 140 150
920 930 940 950 960 970
pF1KE1 KKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAEGKEGEEATAEAEEK
. .. .. .:.:: :::..: : : .:.
NP_149 NGRIQVDQNSYGEFYGGDCYIILYTY--P----------------RGQ------------
160 170 180
980 990 1000 1010 1020 1030
pF1KE1 QPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLSHF
:.: ::: .:. :: . : ... . :. .:..: .: ..:: :
NP_149 --------IIYTWQGANATR-DELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLF
190 200 210 220 230
1040 1050 1060 1070 1080
pF1KE1 KRK-FIIHR-GKRKAVQGAQQPS----LYQIRTNGSALCTRCIQINTDSSLLNSEFCFIL
: : .::.. : : .:.: :. :.:.: : ... :: .....:.. :::. :.:
NP_149 KDKPLIIYKNGTSK--KGGQAPAPPTRLFQVRRNLASI-TRIVEVDVDANSLNSNDVFVL
240 250 260 270 280 290
1090 1100 1110 1120 1130 1140
pF1KE1 KVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEPENFFWVGI
:.: .:.: : :::.... .: : :: . ... . . :.::::::.: : ..
NP_149 KLP----QNSG--YIWVGKGASQEEEKGAEYVASVL---KCKTLRIQEGEEPEEF-WNSL
300 310 320 330 340
1150 1160 1170 1180 1190 1200
pF1KE1 GAQKPYDD----DAEYMKHT-RLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQE
:..: :. ... : ::. :::. : :.. : ..: :::::.::.:::: ..
NP_149 GGKKDYQTSPLLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQ
350 360 370 380 390 400
1210 1220 1230 1240 1250 1260
pF1KE1 VYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHER-PRRLRLVRKGNEQHAFTRCFHAWS
...:.: ....:: : :::. ..:.. : . .: : . ....:.: .:: : .:.
NP_149 IFIWIGKDANEVEKKESLKSAKMYLETDPSGRDKRTP--IVIIKQGHEPPTFTGWFLGWD
410 420 430 440 450 460
pF1KE1 AFCKALA
.
NP_149 SSKW
>>NP_001106177 (OMIM: 613416) adseverin isoform 1 [Homo (715 aa)
initn: 597 init1: 225 opt: 516 Z-score: 421.7 bits: 89.4 E(85289): 9.4e-17
Smith-Waterman score: 996; 29.2% identity (58.1% similar) in 797 aa overlap (487-1263:6-712)
460 470 480 490 500 510
pF1KE1 NKKQEESADARAPSGKVRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEE
: : :.. .:. :: .:.::.. : : .
NP_001 MARELYHEEFAR-AGKQAGLQVWRIEKLELVPVPQ
10 20 30
520 530 540 550 560 570
pF1KE1 AFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAEC
. :: :: .: :.::.: . : .......:.: : . :... .:: .:.. .:::..
NP_001 SAHGDFYVGDAYLVLHTAKTSRG-FTYHLHFWLGKECSQDESTAAAIFTVQMDDYLGGKP
40 50 60 70 80 90
580 590 600 610 620 630
pF1KE1 RTVREEMGDESEEFLQVFDNDISYIEGGTASGF-YTVEDTHYVTRMYRVYGKKNIKLEPV
:: .: ::..:.. : . ..: ::.:::. ... . . :. .: :.. .. :
NP_001 VQNRELQGYESNDFVSYFKGGLKYKAGGVASGLNHVLTNDLTAKRLLHVKGRRVVRATEV
100 110 120 130 140 150
640 650 660 670 680 690
pF1KE1 PLKGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQ
::. :.. :..: : .:: : :.. . :: : : :::::..:. .. .
NP_001 PLSWDSFNKGDCFIIDLGTEIYQWCGSSCNKYERLKANQVATGIRYNERKGRSELIVVEE
160 170 180 190 200 210
700 710 720 730 740 750
pF1KE1 GQELPEFWEALGGEPSEIKKHVPEDFWPP-----QPKLYKVGLGLGYLELPQINYKLSVE
:.: :. ..:: .: .:. . ::: :. . : . ...:
NP_001 GSEPSELIKVLGEKPELPDGGDDDDIIADISNRKMAKLYMVSDASGSM-------RVTVV
220 230 240 250 260
760 770 780 790 800
pF1KE1 HKQRPKVELMPRMRLLQSLLDTRCVYILD--CWSDVFIWLGRKSPRLVRAAALKLGQELC
.. : : ::. .: .::: ...:.: :. . : ::.: ..:.
NP_001 AEENPFSMAM--------LLSEEC-FILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFL
270 280 290 300 310
810 820 830 840 850 860
pF1KE1 GMLHRPRHATVSRSLEGTEAQVFKAKFKNWDDVLTVDYTRNAEAVLQSPGLSGKVKRDAE
... ... .. :: :. .:: ::.: : .. :: :. ::: .:
NP_001 QQMNYSKNTQIQVLPEGGETPIFKQFFKDWRD-------KD-----QSDGF-GKV-YVTE
320 330 340 350 360
870 880 890 900 910 920
pF1KE1 KKDQMKA-DLTALFLPRQPPMSLAEAEQLMEEWNEDLDG-MEGFVLEGKKFARLPEEEFG
: :.: . : : .: :. :.. : .: .: .: . .:.. .. .. .:
NP_001 KVAQIKQIPFDASKLHSSPQMA---AQHNMV---DDGSGKVEIWRVENNGRIQVDQNSYG
370 380 390 400 410
930 940 950 960 970 980
pF1KE1 HFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAEGKEGEEATAEAEEKQPEEDFQCIVYF
.:: :::..: : : .:. :.:
NP_001 EFYGGDCYIIL--YTYP-------------------RGQ-----------------IIYT
420 430
990 1000 1010 1020 1030 1040
pF1KE1 WQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLSHFKRKFIIHRGKRK
::: .:. :: . : ... . :. .:..: .: ..:: :: : .: .
NP_001 WQGANATR-DELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGT
440 450 460 470 480 490
1050 1060 1070 1080 1090 1100
pF1KE1 AVQGAQQPS----LYQIRTNGSALCTRCIQINTDSSLLNSEFCFILKVPFESEDNQGIVY
. .:.: :. :.:.: : ... :: .....:.. :::. :.::.: .:.: :
NP_001 SKKGGQAPAPPTRLFQVRRNLASI-TRIVEVDVDANSLNSNDVFVLKLP----QNSG--Y
500 510 520 530 540 550
1110 1120 1130 1140 1150
pF1KE1 AWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEPENFFWVGIGAQKPYDD----DA
:::.... .: : :: . ... . . :.::::::.: : ..:..: :. ..
NP_001 IWVGKGASQEEEKGAEYVASVL---KCKTLRIQEGEEPEEF-WNSLGGKKDYQTSPLLET
560 570 580 590 600
1160 1170 1180 1190 1200 1210
pF1KE1 EYMKHT-RLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQEVYMWVGTQTSQVEI
. : ::. :::. : :.. : ..: :::::.::.:::: .....:.: ....::
NP_001 QAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEK
610 620 630 640 650 660
1220 1230 1240 1250 1260
pF1KE1 KLSLKACQVYIQHMRSKEHER-PRRLRLVRKGNEQHAFTRCFHAWSAFCKALA
: :::. ..:.. : . .: : . ....:.: .:: : .:..
NP_001 KESLKSAKMYLETDPSGRDKRTP--IVIIKQGHEPPTFTGWFLGWDSSKW
670 680 690 700 710
1269 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 06:45:26 2016 done: Tue Nov 8 06:45:28 2016
Total Scan time: 14.430 Total Display time: 0.560
Function used was FASTA [36.3.4 Apr, 2011]