FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE1448, 363 aa
  1>>>pF1KE1448 363 - 363 aa - 363 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.1038+/-0.000334; mu= 17.5174+/- 0.021
 mean_var=63.4040+/-12.926, 0's: 0 Z-trim(114.2): 13  B-trim: 11 in 1/53
 Lambda= 0.161070
 statistics sampled from 23961 (23973) to 23961 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.669), E-opt: 0.2 (0.281), width:  16
 Scan time:  6.130

The best scores are:                                      opt bits E(85289)
NP_060084 (OMIM: 605932) S-methylmethionine--homoc ( 363) 2508 591.4  1e-168
NP_001704 (OMIM: 602888) betaine--homocysteine S-m ( 406) 1545 367.7 2.6e-101
NP_001171476 (OMIM: 605932) S-methylmethionine--ho ( 299) 1525 362.9 5.2e-100


>>NP_060084 (OMIM: 605932) S-methylmethionine--homocyste  (363 aa)
 initn: 2508 init1: 2508 opt: 2508  Z-score: 3149.8  bits: 591.4 E(85289): 1e-168
Smith-Waterman score: 2508; 100.0% identity (100.0% similar) in 363 aa overlap (1-363:1-363)

               10        20        30        40        50        60
pF1KE1 MAPAGRPGAKKGILERLESGEVVIGDGSFLITLEKRGYVKAGLWTPEAVIEHPDAVRQLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MAPAGRPGAKKGILERLESGEVVIGDGSFLITLEKRGYVKAGLWTPEAVIEHPDAVRQLH
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 MEFLRAGSNVMQTFTFSASEDNMESKWEDVNAAACDLAREVAGKGDALVAGGICQTSIYK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MEFLRAGSNVMQTFTFSASEDNMESKWEDVNAAACDLAREVAGKGDALVAGGICQTSIYK
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 YQKDEARIKKLFRQQLEVFAWKNVDFLIAEYFEHVEEAVWAVEVLKESDRPVAVTMCIGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 YQKDEARIKKLFRQQLEVFAWKNVDFLIAEYFEHVEEAVWAVEVLKESDRPVAVTMCIGP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE1 EGDMHDITPGECAVRLVKAGASIVGVNCRFGPDTSLKTMELMKEGLEWAGLKAHLMVQPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EGDMHDITPGECAVRLVKAGASIVGVNCRFGPDTSLKTMELMKEGLEWAGLKAHLMVQPL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE1 GFHAPDCGKEGFVDLPEYPFGLESRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GFHAPDCGKEGFVDLPEYPFGLESRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE1 IAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARREYWENLLPASGRPFCPSLSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 IAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARREYWENLLPASGRPFCPSLSK
              310       320       330       340       350       360

          
pF1KE1 PDF
       :::
NP_060 PDF
          

>>NP_001704 (OMIM: 602888) betaine--homocysteine S-methy  (406 aa)
 initn: 1947 init1: 1545 opt: 1545  Z-score: 1939.7  bits: 367.7 E(85289): 2.6e-101
Smith-Waterman score: 1948; 76.0% identity (88.4% similar) in 371 aa overlap (1-362:1-371)

               10        20        30        40        50        60
pF1KE1 MAPAGRPGAKKGILERLESGEVVIGDGSFLITLEKRGYVKAGLWTPEAVIEHPDAVRQLH
       : :.:   :::::::::..::.:::::.:...:::::::::: :::::..:::.::::::
NP_001 MPPVGGKKAKKGILERLNAGEIVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLH
               10        20        30        40        50        60

               70        80                 90       100       110 
pF1KE1 MEFLRAGSNVMQTFTFSASEDNMESKW---------EDVNAAACDLAREVAGKGDALVAG
        ::::::::::::::: ::::..:..          ..:: ::::.::.:: .:::::::
NP_001 REFLRAGSNVMQTFTFYASEDKLENRGNYVLEKISGQEVNEAACDIARQVADEGDALVAG
               70        80        90       100       110       120

             120       130       140       150       160       170 
pF1KE1 GICQTSIYKYQKDEARIKKLFRQQLEVFAWKNVDFLIAEYFEHVEEAVWAVEVLKESDRP
       :. ::  :   :.:...::.: ::::::  ::::::::::::::::::::::.:  : .:
NP_001 GVSQTPSYLSCKSETEVKKVFLQQLEVFMKKNVDFLIAEYFEHVEEAVWAVETLIASGKP
              130       140       150       160       170       180

             180       190       200       210       220       230 
pF1KE1 VAVTMCIGPEGDMHDITPGECAVRLVKAGASIVGVNCRFGPDTSLKTMELMKEGLEWAGL
       ::.:::::::::.: . :::::::::::::::.::::.: :  ::::..::::::: : :
NP_001 VAATMCIGPEGDLHGVPPGECAVRLVKAGASIIGVNCHFDPTISLKTVKLMKEGLEAARL
              190       200       210       220       230       240

             240       250       260       270       280       290 
pF1KE1 KAHLMVQPLGFHAPDCGKEGFVDLPEYPFGLESRVATRWDIQKYAREAYNLGVRYIGGCC
       ::::: :::..:.:::.:.::.::::.::::: :::::::::::::::::::::::::::
NP_001 KAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCC
              250       260       270       280       290       300

             300       310       320       330       340       350 
pF1KE1 GFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARREYWENLLPASG
       ::::::::::::::::::::::::::::::::::::::::::.:::::.::::::  :::
NP_001 GFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWVRARARKEYWENLRIASG
              310       320       330       340       350       360

             360                                     
pF1KE1 RPFCPSLSKPDF                                  
       ::. ::.::::                                   
NP_001 RPYNPSMSKPDGWGVTKGTAELMQQKEATTEQQLKELFEKQKFKSQ
              370       380       390       400      

>>NP_001171476 (OMIM: 605932) S-methylmethionine--homocy  (299 aa)
 initn: 1522 init1: 1522 opt: 1525  Z-score: 1916.5  bits: 362.9 E(85289): 5.2e-100
Smith-Waterman score: 1943; 82.4% identity (82.4% similar) in 363 aa overlap (1-363:1-299)

               10        20        30        40        50        60
pF1KE1 MAPAGRPGAKKGILERLESGEVVIGDGSFLITLEKRGYVKAGLWTPEAVIEHPDAVRQLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAPAGRPGAKKGILERLESGEVVIGDGSFLITLEKRGYVKAGLWTPEAVIEHPDAVRQLH
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 MEFLRAGSNVMQTFTFSASEDNMESKWEDVNAAACDLAREVAGKGDALVAGGICQTSIYK
       ::::::::::::::::::::::::::                                  
NP_001 MEFLRAGSNVMQTFTFSASEDNMESK----------------------------------
               70        80                                        

              130       140       150       160       170       180
pF1KE1 YQKDEARIKKLFRQQLEVFAWKNVDFLIAEYFEHVEEAVWAVEVLKESDRPVAVTMCIGP
                                     ::::::::::::::::::::::::::::::
NP_001 ------------------------------YFEHVEEAVWAVEVLKESDRPVAVTMCIGP
                                       90       100       110      

              190       200       210       220       230       240
pF1KE1 EGDMHDITPGECAVRLVKAGASIVGVNCRFGPDTSLKTMELMKEGLEWAGLKAHLMVQPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGDMHDITPGECAVRLVKAGASIVGVNCRFGPDTSLKTMELMKEGLEWAGLKAHLMVQPL
        120       130       140       150       160       170      

              250       260       270       280       290       300
pF1KE1 GFHAPDCGKEGFVDLPEYPFGLESRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFHAPDCGKEGFVDLPEYPFGLESRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRA
        180       190       200       210       220       230      

              310       320       330       340       350       360
pF1KE1 IAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARREYWENLLPASGRPFCPSLSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARREYWENLLPASGRPFCPSLSK
        240       250       260       270       280       290      

          
pF1KE1 PDF
       :::
NP_001 PDF
          




363 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sun Nov  6 22:45:26 2016 done: Sun Nov  6 22:45:27 2016
 Total Scan time:  6.130 Total Display time: -0.020

Function used was FASTA [36.3.4 Apr, 2011]