Result of FASTA (omim) for
pFN21AE1442
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1442, 255 aa
1>>>pF1KE1442 255 - 255 aa - 255 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.9841+/-0.000297; mu= 8.7160+/- 0.019
mean_var=156.8326+/-31.238, 0's: 0 Z-trim(122.9): 97 B-trim: 44 in 1/54
Lambda= 0.102413
statistics sampled from 41804 (41916) to 41804 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.816), E-opt: 0.2 (0.491), width: 16
Scan time: 5.240
The best scores are: opt bits E(85289)
XP_011539688 (OMIM: 602250) PREDICTED: tumor necro ( 255) 1848 283.9 1.9e-76
NP_001552 (OMIM: 602250) tumor necrosis factor rec ( 255) 1848 283.9 1.9e-76
XP_006710681 (OMIM: 602250) PREDICTED: tumor necro ( 239) 1629 251.5 1e-66
XP_016866233 (OMIM: 605732) PREDICTED: tumor necro ( 444) 319 58.2 2.9e-08
NP_055267 (OMIM: 605732) tumor necrosis factor rec ( 655) 319 58.4 3.8e-08
NP_001265197 (OMIM: 174810,602080,603499,612301) t ( 602) 254 48.7 2.8e-05
NP_683700 (OMIM: 603905) tumor necrosis factor rec ( 234) 224 43.9 0.00031
NP_004186 (OMIM: 603905) tumor necrosis factor rec ( 241) 224 43.9 0.00032
XP_016858211 (OMIM: 603905) PREDICTED: tumor necro ( 347) 224 44.1 0.00041
NP_001233 (OMIM: 186711,615122) CD27 antigen precu ( 260) 210 41.9 0.0014
NP_001284534 (OMIM: 602746) tumor necrosis factor ( 184) 207 41.3 0.0015
XP_006711082 (OMIM: 602746) PREDICTED: tumor necro ( 197) 207 41.3 0.0016
XP_016875723 (OMIM: 186711,615122) PREDICTED: CD27 ( 358) 210 42.0 0.0018
XP_016875721 (OMIM: 186711,615122) PREDICTED: CD27 ( 405) 210 42.1 0.0019
NP_003811 (OMIM: 602746) tumor necrosis factor rec ( 283) 207 41.5 0.002
NP_001289682 (OMIM: 109535,606843) tumor necrosis ( 237) 204 41.0 0.0024
XP_016883624 (OMIM: 109535,606843) PREDICTED: tumo ( 323) 204 41.1 0.003
>>XP_011539688 (OMIM: 602250) PREDICTED: tumor necrosis (255 aa)
initn: 1848 init1: 1848 opt: 1848 Z-score: 1493.3 bits: 283.9 E(85289): 1.9e-76
Smith-Waterman score: 1848; 100.0% identity (100.0% similar) in 255 aa overlap (1-255:1-255)
10 20 30 40 50 60
pF1KE1 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 CFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPARE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPARE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 PGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIFKQPFMRPVQTTQEEDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIFKQPFMRPVQTTQEEDG
190 200 210 220 230 240
250
pF1KE1 CSCRFPEEEEGGCEL
:::::::::::::::
XP_011 CSCRFPEEEEGGCEL
250
>>NP_001552 (OMIM: 602250) tumor necrosis factor recepto (255 aa)
initn: 1848 init1: 1848 opt: 1848 Z-score: 1493.3 bits: 283.9 E(85289): 1.9e-76
Smith-Waterman score: 1848; 100.0% identity (100.0% similar) in 255 aa overlap (1-255:1-255)
10 20 30 40 50 60
pF1KE1 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 CFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPARE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPARE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 PGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIFKQPFMRPVQTTQEEDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIFKQPFMRPVQTTQEEDG
190 200 210 220 230 240
250
pF1KE1 CSCRFPEEEEGGCEL
:::::::::::::::
NP_001 CSCRFPEEEEGGCEL
250
>>XP_006710681 (OMIM: 602250) PREDICTED: tumor necrosis (239 aa)
initn: 1629 init1: 1629 opt: 1629 Z-score: 1318.8 bits: 251.5 E(85289): 1e-66
Smith-Waterman score: 1629; 100.0% identity (100.0% similar) in 226 aa overlap (1-226:1-226)
10 20 30 40 50 60
pF1KE1 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 CFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPARE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPARE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 PGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIFKQPFMRPVQTTQEEDG
::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIFKQHGSSGDTFTILES
190 200 210 220 230
250
pF1KE1 CSCRFPEEEEGGCEL
>>XP_016866233 (OMIM: 605732) PREDICTED: tumor necrosis (444 aa)
initn: 227 init1: 64 opt: 319 Z-score: 269.3 bits: 58.2 E(85289): 2.9e-08
Smith-Waterman score: 325; 32.2% identity (54.6% similar) in 174 aa overlap (28-183:67-239)
10 20 30 40 50
pF1KE1 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTF----CDNNRNQICSPCPPNSF
:..:::::. : :. ..:: :: ..:
XP_016 STTTAQPEQKASNLIGTYRHVDRATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVGTF
40 50 60 70 80 90
60 70 80 90 100 110
pF1KE1 SS-AGGQRTCDICRQ-CKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQE
. .: . : : : : . . :.. .. :: : ::. .: :. . : :
XP_016 TRHENGIEKCHDCSQPCPWPMIEKLPCAALTDRECTCPPGMFQSNATCAP-HTVCPVGWG
100 110 120 130 140 150
120 130 140 150 160
pF1KE1 LTKKG-------CKDCCFGTFNDQKRGI--CRPWTNCSLDGKSVLVNGTKERDVVCGPSP
. ::: ::.: :::.: .. :. .:.: .. :. :::: : ::: :
XP_016 VRKKGTETEDVRCKQCARGTFSDVPSSVMKCKAYTDCLSQNLVVIKPGTKETDNVCGTLP
160 170 180 190 200 210
170 180 190 200 210
pF1KE1 A---DLSPGASSVTPPAPAREPGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKK
. . ::. ... : : . :
XP_016 SFSSSTSPSPGTAIFPRPEHMETHEVPSSTYVPKGMNSTESNSSASVRPKVLSSIQEGTV
220 230 240 250 260 270
>>NP_055267 (OMIM: 605732) tumor necrosis factor recepto (655 aa)
initn: 227 init1: 64 opt: 319 Z-score: 267.1 bits: 58.4 E(85289): 3.8e-08
Smith-Waterman score: 325; 32.2% identity (54.6% similar) in 174 aa overlap (28-183:67-239)
10 20 30 40 50
pF1KE1 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTF----CDNNRNQICSPCPPNSF
:..:::::. : :. ..:: :: ..:
NP_055 STTTAQPEQKASNLIGTYRHVDRATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVGTF
40 50 60 70 80 90
60 70 80 90 100 110
pF1KE1 SS-AGGQRTCDICRQ-CKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQE
. .: . : : : : . . :.. .. :: : ::. .: :. . : :
NP_055 TRHENGIEKCHDCSQPCPWPMIEKLPCAALTDRECTCPPGMFQSNATCAP-HTVCPVGWG
100 110 120 130 140 150
120 130 140 150 160
pF1KE1 LTKKG-------CKDCCFGTFNDQKRGI--CRPWTNCSLDGKSVLVNGTKERDVVCGPSP
. ::: ::.: :::.: .. :. .:.: .. :. :::: : ::: :
NP_055 VRKKGTETEDVRCKQCARGTFSDVPSSVMKCKAYTDCLSQNLVVIKPGTKETDNVCGTLP
160 170 180 190 200 210
170 180 190 200 210
pF1KE1 A---DLSPGASSVTPPAPAREPGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKK
. . ::. ... : : . :
NP_055 SFSSSTSPSPGTAIFPRPEHMETHEVPSSTYVPKGMNSTESNSSASVRPKVLSSIQEGTV
220 230 240 250 260 270
>>NP_001265197 (OMIM: 174810,602080,603499,612301) tumor (602 aa)
initn: 128 init1: 128 opt: 254 Z-score: 215.7 bits: 48.7 E(85289): 2.8e-05
Smith-Waterman score: 260; 25.6% identity (52.8% similar) in 246 aa overlap (28-254:47-269)
10 20 30 40 50
pF1KE1 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTF----CDNNRNQICSPCPPNSF
:..: : . : .. ...: :: :. .
NP_001 LCALLARLQVALQIAPPCTSEKHYEHLGRCCNKCEPGKYMSSKCTTTSDSVCLPCGPDEY
20 30 40 50 60 70
60 70 80 90 100
pF1KE1 -SSAGGQRTCDICRQCKG--VFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQD--CKQ
.: . . : . . : .. . .::. .: :: :.: . : :... :
NP_001 LDSWNEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTAGYH-WSQDCECCRRNTECAP
80 90 100 110 120 130
110 120 130 140 150 160
pF1KE1 GQELTKKGCKDCCFGTFND--QKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLS
: : . :. :.: .. :::::::.. :: : .::.. :.::
NP_001 GL-----GAQHPCY--FSDAFSSTDKCRPWTNCTFLGKRVEHHGTEKSDAVC--------
140 150 160 170 180
170 180 190 200 210 220
pF1KE1 PGASSVTPPAPAREPGHSPQI----ISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLY
.::. :::.: . :.. . ..: ..:.::. ..: . . : .: .
NP_001 --SSSL----PARKPPNEPHVYLPGLIILLLFASVALVAAIIFGVCYRKKGKALTANLWH
190 200 210 220 230
230 240 250
pF1KE1 IFKQPFMRPVQTTQEEDGCSCRFPEE----EEGGCEL
... : .. .: .: :: . ..:.::
NP_001 WINEACGR-LSGDKESSGDSCVSTHTANFGQQGACEGVLLLTLEEKTFPEDMCYPDQGGV
240 250 260 270 280 290
NP_001 CQGTCVGGGPYAQGEDARMLSLVSKTEIEEDSFRQMPTEDEYMDRPSQPTDQLLFLTEPG
300 310 320 330 340 350
>>NP_683700 (OMIM: 603905) tumor necrosis factor recepto (234 aa)
initn: 263 init1: 149 opt: 224 Z-score: 197.0 bits: 43.9 E(85289): 0.00031
Smith-Waterman score: 270; 29.5% identity (50.2% similar) in 237 aa overlap (31-251:14-219)
10 20 30 40 50
pF1KE1 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQ--ICSP-CPPNSFSSAG
: . .: . .: .: : :. . .
NP_683 MAQHGAMGAFRALCGLALLCALSLGQRPTGGPGCGPGRLLLGT
10 20 30 40
60 70 80 90 100 110
pF1KE1 GQ--RTCDI--CRQCKGVFRTRKECSSTSNAECDCT-PGFHCLGAGCSMCEQD-CKQGQE
: : : . : :. .:: :. .: :. : ::: :. :.. : ::
NP_683 GTDARCCRVHTTRCCRDY--PGEECC--SEWDCMCVQPEFHCGDPCCTTCRHHPCPPGQG
50 60 70 80 90
120 130 140 150 160
pF1KE1 LTKKG-------CKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPAD
. ..: : :: :::. ..: :.:::.:. : .. :.: ...::
NP_683 VQSQGKFSFGFQCIDCASGTFSGGHEGHCKPWTDCTQFGFLTVFPGNKTHNAVC------
100 110 120 130 140 150
170 180 190 200 210 220
pF1KE1 LSPGASSVTPPAPAREPGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIF
:: .::: :: .. .::... .::. : :. . . :: : .
NP_683 -VPG----SPPA---EPLGWLTVV--LLAVAACVLLLTSAQLGLH---IWQLRKTQLLLE
160 170 180 190 200
230 240 250
pF1KE1 KQPFMRPVQTTQEEDGCSCRFPEEEEGGCEL
: . ::. ::.:::::.:
NP_683 VPP--------STEDARSCQFPEEERGERSAEEKGRLGDLWV
210 220 230
>>NP_004186 (OMIM: 603905) tumor necrosis factor recepto (241 aa)
initn: 259 init1: 145 opt: 224 Z-score: 196.9 bits: 43.9 E(85289): 0.00032
Smith-Waterman score: 275; 28.7% identity (51.9% similar) in 237 aa overlap (31-251:14-226)
10 20 30 40 50
pF1KE1 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQ--ICSP-CPPNSFSSAG
: . .: . .: .: : :. . .
NP_004 MAQHGAMGAFRALCGLALLCALSLGQRPTGGPGCGPGRLLLGT
10 20 30 40
60 70 80 90 100 110
pF1KE1 GQ--RTCDI--CRQCKGVFRTRKECSSTSNAECDCT-PGFHCLGAGCSMCEQD-CKQGQE
: : : . : :. .:: :. .: :. : ::: :. :.. : ::
NP_004 GTDARCCRVHTTRCCRDY--PGEECC--SEWDCMCVQPEFHCGDPCCTTCRHHPCPPGQG
50 60 70 80 90
120 130 140 150 160
pF1KE1 LTKKG-------CKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPAD
. ..: : :: :::. ..: :.:::.:. : .. :.: ...::
NP_004 VQSQGKFSFGFQCIDCASGTFSGGHEGHCKPWTDCTQFGFLTVFPGNKTHNAVC------
100 110 120 130 140 150
170 180 190 200 210 220
pF1KE1 LSPGASSVTPPAPAREPGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIF
:: .::: :: .. .::... .::. : :. . . :.. ..
NP_004 -VPG----SPPA---EPLGWLTVV--LLAVAACVLLLTSAQLGLH---IWQLRSQCMWPR
160 170 180 190 200
230 240 250
pF1KE1 KQPFMRPVQTTQEEDGCSCRFPEEEEGGCEL
. .. : . : :. ::.:::::.:
NP_004 ETQLLLEVPPSTE-DARSCQFPEEERGERSAEEKGRLGDLWV
210 220 230 240
>>XP_016858211 (OMIM: 603905) PREDICTED: tumor necrosis (347 aa)
initn: 230 init1: 149 opt: 224 Z-score: 194.8 bits: 44.1 E(85289): 0.00041
Smith-Waterman score: 233; 29.4% identity (51.0% similar) in 153 aa overlap (31-167:14-162)
10 20 30 40 50
pF1KE1 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQ--ICSP-CPPNSFSSAG
: . .: . .: .: : :. . .
XP_016 MAQHGAMGAFRALCGLALLCALSLGQRPTGGPGCGPGRLLLGT
10 20 30 40
60 70 80 90 100 110
pF1KE1 GQ--RTCDI--CRQCKGVFRTRKECSSTSNAECDCT-PGFHCLGAGCSMCEQD-CKQGQE
: : : . : :. .:: :. .: :. : ::: :. :.. : ::
XP_016 GTDARCCRVHTTRCCRD--YPGEECC--SEWDCMCVQPEFHCGDPCCTTCRHHPCPPGQG
50 60 70 80 90
120 130 140 150 160
pF1KE1 LTKKG-------CKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPAD
. ..: : :: :::. ..: :.:::.:. : .. :.: ...:: :.
XP_016 VQSQGKFSFGFQCIDCASGTFSGGHEGHCKPWTDCTQFGFLTVFPGNKTHNAVCVPGSPP
100 110 120 130 140 150
170 180 190 200 210 220
pF1KE1 LSPGASSVTPPAPAREPGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIF
:
XP_016 AEPLGWLTVVLLAVAACVLLLTSAQLGLHIWQLRSQCMWPRGLSQPGAGRWEHGCLLTVA
160 170 180 190 200 210
>>NP_001233 (OMIM: 186711,615122) CD27 antigen precursor (260 aa)
initn: 138 init1: 83 opt: 210 Z-score: 185.3 bits: 41.9 E(85289): 0.0014
Smith-Waterman score: 210; 38.6% identity (61.4% similar) in 83 aa overlap (28-103:40-121)
10 20 30 40 50
pF1KE1 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTF----CDNNRNQI-CSPCPPN-
:. : ::: ::..:. :.:: :.
NP_001 CVLGTLVGLSATPAPKSCPERHYWAQGKLCCQMCEPGTFLVKDCDQHRKAAQCDPCIPGV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 SFSSAGGQRT-CDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQ
::: : :. ::.:.. . .:. :. :.:::: : :..: :. :.
NP_001 SFSPDHHTRPHCESCRHCNSGLLVRN-CTITANAECACRNGWQCRDKECTECDPLPNPSL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 ELTKKGCKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGAS
NP_001 TARSSQALSPHPQPTHLPYVSEMLEARTAGHMQTLADFRQLPARTLSTHWPPQRSLCSSD
130 140 150 160 170 180
255 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 02:17:25 2016 done: Mon Nov 7 02:17:26 2016
Total Scan time: 5.240 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]