Result of FASTA (omim) for
pFN21AE1431
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1431, 764 aa
1>>>pF1KE1431 764 - 764 aa - 764 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5458+/-0.000443; mu= 19.7426+/- 0.028
mean_var=113.0657+/-23.060, 0's: 0 Z-trim(112.8): 292 B-trim: 649 in 1/49
Lambda= 0.120617
statistics sampled from 21466 (21877) to 21466 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.625), E-opt: 0.2 (0.257), width: 16
Scan time: 11.860
The best scores are: opt bits E(85289)
NP_001701 (OMIM: 138470,612924,615489,615561) comp ( 764) 5255 926.6 0
NP_000054 (OMIM: 217000,613927,615489) complement ( 752) 1846 333.3 2.2e-90
NP_001269387 (OMIM: 217000,613927,615489) compleme ( 723) 1694 306.9 2e-82
NP_001139375 (OMIM: 217000,613927,615489) compleme ( 620) 1434 261.5 7.5e-69
NP_001269386 (OMIM: 217000,613927,615489) compleme ( 506) 1099 203.2 2.3e-51
NP_001269388 (OMIM: 217000,613927,615489) compleme ( 328) 752 142.6 2.6e-33
XP_016855679 (OMIM: 608398) PREDICTED: CUB and sus (3362) 307 66.2 2.5e-09
NP_443128 (OMIM: 608398) CUB and sushi domain-cont (3487) 307 66.3 2.6e-09
XP_016855678 (OMIM: 608398) PREDICTED: CUB and sus (3506) 307 66.3 2.6e-09
XP_016855683 (OMIM: 608398) PREDICTED: CUB and sus (3566) 307 66.3 2.6e-09
XP_016855677 (OMIM: 608398) PREDICTED: CUB and sus (3567) 307 66.3 2.6e-09
XP_016855676 (OMIM: 608398) PREDICTED: CUB and sus (3606) 307 66.3 2.6e-09
XP_016855674 (OMIM: 608398) PREDICTED: CUB and sus (3607) 307 66.3 2.6e-09
XP_016855675 (OMIM: 608398) PREDICTED: CUB and sus (3607) 307 66.3 2.6e-09
NP_001268885 (OMIM: 608398) CUB and sushi domain-c (3631) 307 66.3 2.6e-09
NP_001017366 (OMIM: 120831) C4b-binding protein be ( 251) 292 62.4 2.7e-09
NP_001017364 (OMIM: 120831) C4b-binding protein be ( 251) 292 62.4 2.7e-09
XP_005273311 (OMIM: 120831) PREDICTED: C4b-binding ( 252) 292 62.4 2.7e-09
NP_000707 (OMIM: 120831) C4b-binding protein beta ( 252) 292 62.4 2.7e-09
NP_001017367 (OMIM: 120831) C4b-binding protein be ( 252) 292 62.4 2.7e-09
NP_001017365 (OMIM: 120831) C4b-binding protein be ( 252) 292 62.4 2.7e-09
XP_011528291 (OMIM: 206200,609862) PREDICTED: tran ( 680) 296 63.6 3.3e-09
NP_001275929 (OMIM: 206200,609862) transmembrane p ( 824) 296 63.7 3.7e-09
XP_011533056 (OMIM: 608397) PREDICTED: CUB and sus (2238) 282 61.7 3.9e-08
XP_011533055 (OMIM: 608397) PREDICTED: CUB and sus (2595) 282 61.8 4.3e-08
XP_016869220 (OMIM: 608397) PREDICTED: CUB and sus (3327) 282 61.9 5.1e-08
XP_011533054 (OMIM: 608397) PREDICTED: CUB and sus (3549) 282 61.9 5.3e-08
NP_150094 (OMIM: 608397) CUB and sushi domain-cont (3564) 282 61.9 5.3e-08
NP_001171534 (OMIM: 217000,613927,615489) compleme ( 538) 267 58.4 9.2e-08
XP_005245497 (OMIM: 147050,173610) PREDICTED: P-se ( 768) 268 58.7 1e-07
XP_005245496 (OMIM: 147050,173610) PREDICTED: P-se ( 790) 268 58.8 1.1e-07
XP_005245495 (OMIM: 147050,173610) PREDICTED: P-se ( 790) 268 58.8 1.1e-07
XP_005245492 (OMIM: 147050,173610) PREDICTED: P-se ( 830) 268 58.8 1.1e-07
XP_005245493 (OMIM: 147050,173610) PREDICTED: P-se ( 830) 268 58.8 1.1e-07
NP_002996 (OMIM: 147050,173610) P-selectin precurs ( 830) 268 58.8 1.1e-07
XP_011515117 (OMIM: 608399) PREDICTED: CUB and sus (2173) 258 57.5 6.9e-07
XP_016868501 (OMIM: 608399) PREDICTED: CUB and sus (3463) 258 57.7 9.5e-07
XP_016868500 (OMIM: 608399) PREDICTED: CUB and sus (3507) 258 57.7 9.5e-07
NP_699197 (OMIM: 611691) sushi, von Willebrand fac (3571) 258 57.7 9.7e-07
XP_016868499 (OMIM: 608399) PREDICTED: CUB and sus (3577) 258 57.7 9.7e-07
XP_011515118 (OMIM: 608399) PREDICTED: CUB and sus (3603) 258 57.7 9.7e-07
XP_016868498 (OMIM: 608399) PREDICTED: CUB and sus (3637) 258 57.7 9.8e-07
NP_937757 (OMIM: 608399) CUB and sushi domain-cont (3667) 258 57.8 9.8e-07
XP_016868497 (OMIM: 608399) PREDICTED: CUB and sus (3681) 258 57.8 9.9e-07
NP_937756 (OMIM: 608399) CUB and sushi domain-cont (3707) 258 57.8 9.9e-07
NP_443132 (OMIM: 608399) CUB and sushi domain-cont (3538) 256 57.4 1.2e-06
XP_016855680 (OMIM: 608398) PREDICTED: CUB and sus (2973) 255 57.1 1.2e-06
XP_011507588 (OMIM: 134580,613235) PREDICTED: coag ( 628) 226 51.3 1.4e-05
NP_001985 (OMIM: 134580,613235) coagulation factor ( 661) 226 51.4 1.5e-05
XP_011507585 (OMIM: 134580,613235) PREDICTED: coag ( 676) 226 51.4 1.5e-05
>>NP_001701 (OMIM: 138470,612924,615489,615561) compleme (764 aa)
initn: 5255 init1: 5255 opt: 5255 Z-score: 4949.5 bits: 926.6 E(85289): 0
Smith-Waterman score: 5255; 99.9% identity (99.9% similar) in 764 aa overlap (1-764:1-764)
10 20 30 40 50 60
pF1KE1 MGSNLSPQLCLMPFILGLLSGGVTTTPWSLAWPQGSCSLEGVEIKGGSFRLLQEGQALEY
::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
NP_001 MGSNLSPQLCLMPFILGLLSGGVTTTPWSLARPQGSCSLEGVEIKGGSFRLLQEGQALEY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 VCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 YNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 YRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 TIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 ASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 AVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPRE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 DYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 VWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 VGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 EGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 QYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG
670 680 690 700 710 720
730 740 750 760
pF1KE1 VVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
730 740 750 760
>>NP_000054 (OMIM: 217000,613927,615489) complement C2 i (752 aa)
initn: 1524 init1: 548 opt: 1846 Z-score: 1743.6 bits: 333.3 E(85289): 2.2e-90
Smith-Waterman score: 1846; 39.8% identity (69.6% similar) in 757 aa overlap (30-764:17-750)
10 20 30 40 50
pF1KE1 MGSNLSPQLCLMPFILGLLSGGVTTTPWSLAWPQGSCSLEGVEIKGGSFRLLQ---EGQA
:: :: ..:.:.::.: : . :.
NP_000 MGPLMVLFCLLFLYPGLADSAPSCP-QNVNISGGTFTLSHGWAPGSL
10 20 30 40
60 70 80 90 100 110
pF1KE1 LEYVCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPR
: : ::.:.:: :. .: :.:.:.:.: ... :: :. ..:: : .:::: : ::
NP_000 LTYSCPQGLYPSPA-SRLCKSSGQWQT--PGATRSLSKAVCKPVRCPAPVSFENGIYTPR
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE1 SPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKV
: :. ..::.: ::. :::: : :. :: :.:.::.::::::.: :::: .:. ..
NP_000 LGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRT
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE1 GSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSS
: .. :.: :.:: .:.: ::..: :: .: :::::: :.. . :: :..:: :. .:
NP_000 GFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTS
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE1 LTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLI
... . ... . :. ::: .. :: .:.::.:: :.:.. ..: :. ..
NP_000 FSHMLGATNPT--QKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMV
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE1 EKVASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKK
... :. .. ...:.:. ::. ..: . .: . : ..:.. ::.::. .::::
NP_000 DRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYA
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE1 ALQAVYSMMSWPD---DVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKD
::..:: ::. . .:.. ::.:::.::: ::::.: :..:.::..: :..
NP_000 ALNSVYLMMNNQMRLLGMETMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQK
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE1 RKNPREDYLDVYVFGVGPL-VNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQ
: .::::.:..::: : :. ..: :.::::.:.:.: ..: . :..:: .:.: :.
NP_000 R----NDYLDIYAIGVGKLDVDWRELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSK
410 420 430 440 450
480 490 500 510 520 530
pF1KE1 -SLSLCGMVWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDD
. ..::. ...: .. ::.. .:.: :..:.: ::..:. .:::::::: :
NP_000 LTDTICGVGNMSANASDQERTPWHV---TIKP-KSQETCRGALISDQWVLTAAHCFR-DG
460 470 480 490 500 510
540 550 560 570 580
pF1KE1 KEHSI-KVSVGGEK----RDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLK
..::. .:.:: : ... :: ... :.... .::. :: ::: :.::.:: .:.:
NP_000 NDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVK
520 530 540 550 560 570
590 600 610 620 630 640
pF1KE1 YGQTIRPICLPCTEGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYI
.. :::::::: .. ::: : .::.....::: :.. : ::. . .:: .. .
NP_000 MSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKL---NINL
580 590 600 610 620
650 660 670 680 690 700
pF1KE1 KNGDKKGSC-ERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVH
: : . :: : .: . .. :. :::: .:::.: : . :.:.::: ....
NP_000 KMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSG---TQEDESPCKGESGGAVFLE
630 640 650 660 670 680
710 720 730 740 750
pF1KE1 KRSRFIQVGVISWGVVDVC-----KNQKRQ---KQVPAHARDFHINLFQVLPWLKEKLQD
.: ::.:::..:::. . : ::.... ..:: ::::::::.. :::...: :
NP_000 RRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRSKVPP-PRDFHINLFRMQPWLRQHLGD
690 700 710 720 730 740
760
pF1KE1 EDLGFL
:.::
NP_000 V-LNFLPL
750
>>NP_001269387 (OMIM: 217000,613927,615489) complement C (723 aa)
initn: 1502 init1: 526 opt: 1694 Z-score: 1600.8 bits: 306.9 E(85289): 2e-82
Smith-Waterman score: 1694; 40.0% identity (70.4% similar) in 685 aa overlap (99-764:56-721)
70 80 90 100 110 120
pF1KE1 YPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEIS
.:..:: : .:::: : :: : :. ..:
NP_001 ARAADSGRPQEPPGLCLRRSANVRLPVGFAQAVRCPAPVSFENGIYTPRLGSYPVGGNVS
30 40 50 60 70 80
130 140 150 160 170 180
pF1KE1 FHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVT
:.: ::. :::: : :. :: :.:.::.::::::.: :::: .:. ..: .. :.:
NP_001 FECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVR
90 100 110 120 130 140
190 200 210 220 230 240
pF1KE1 YHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAE
:.:: .:.: ::..: :: .: :::::: :.. . :: :..:: :. .:... . ...
NP_001 YRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPT
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE1 DGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKVASYGVKPR
. :. ::: .. :: .:.::.:: :.:.. ..: :. ..... :. ..
NP_001 --QKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVS
210 220 230 240 250 260
310 320 330 340 350 360
pF1KE1 YGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQAVYSMMSW
...:.:. ::. ..: . .: . : ..:.. ::.::. .:::: ::..:: ::.
NP_001 VAIITFASEPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNN
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE1 PD---DVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPREDYLDV
. .:.. ::.:::.::: ::::.: :..:.::..: :.. :. ::::.
NP_001 QMRLLGMETMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKRN----DYLDI
330 340 350 360 370
430 440 450 460 470 480
pF1KE1 YVFGVGPL-VNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQ-SLSLCGMVWE
:..::: : :. ..: :.::::.:.:.: ..: . :..:: .:.: :. . ..::.
NP_001 YAIGVGKLDVDWRELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNM
380 390 400 410 420 430
490 500 510 520 530 540
pF1KE1 HRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSI-KVSVG
...: .. ::.. .:.: :..:.: ::..:. .:::::::: : ..::. .:.::
NP_001 SANASDQERTPWHV---TIKP-KSQETCRGALISDQWVLTAAHCFR-DGNDHSLWRVNVG
440 450 460 470 480 490
550 560 570 580 590
pF1KE1 GEK----RDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLP
: ... :: ... :.... .::. :: ::: :.::.:: .:.:.. ::::::
NP_001 DPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLP
500 510 520 530 540 550
600 610 620 630 640 650
pF1KE1 CTEGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSC-E
:: .. ::: : .::.....::: :.. : ::. . .:: .. .: : . :: :
NP_001 CTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKL---NINLKMGVEWTSCAE
560 570 580 590 600 610
660 670 680 690 700 710
pF1KE1 RDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVI
.: . .. :. :::: .:::.: : . :.:.::: .....: ::.:::..
NP_001 VVSQEKTMFPNLTDVREVVTDQFLCSG---TQEDESPCKGESGGAVFLERRFRFFQVGLV
620 630 640 650 660
720 730 740 750 760
pF1KE1 SWGVVDVC-----KNQKRQ---KQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
:::. . : ::.... ..:: ::::::::.. :::...: : :.::
NP_001 SWGLYNPCLGSADKNSRKRAPRSKVPP-PRDFHINLFRMQPWLRQHLGDV-LNFLPL
670 680 690 700 710 720
>>NP_001139375 (OMIM: 217000,613927,615489) complement C (620 aa)
initn: 1351 init1: 266 opt: 1434 Z-score: 1357.1 bits: 261.5 E(85289): 7.5e-69
Smith-Waterman score: 1434; 38.6% identity (69.9% similar) in 622 aa overlap (162-764:16-618)
140 150 160 170 180 190
pF1KE1 YDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVTYHC
::.: :::: .:. ..: .. :.: :.:
NP_001 MGPLMVLFCLLFLYPAGHCPNPGISLGAVRTGFRFGHGDKVRYRC
10 20 30 40
200 210 220 230 240 250
pF1KE1 SRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGH
: .:.: ::..: :: .: :::::: :.. . :: :..:: :. .:... . ... .
NP_001 SSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPT--Q
50 60 70 80 90 100
260 270 280 290 300 310
pF1KE1 GPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKVASYGVKPRYGL
:. ::: .. :: .:.::.:: :.:.. ..: :. ..... :. .. ..
NP_001 KTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAI
110 120 130 140 150 160
320 330 340 350 360 370
pF1KE1 VTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQAVYSMMSWPD-
.:.:. ::. ..: . .: . : ..:.. ::.::. .:::: ::..:: ::.
NP_001 ITFASEPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMR
170 180 190 200 210 220
380 390 400 410 420
pF1KE1 --DVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPREDYLDVYVF
. .:.. ::.:::.::: ::::.: :..:.::..: :.. : .::::.:..
NP_001 LLGMETMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKR----NDYLDIYAI
230 240 250 260 270
430 440 450 460 470 480
pF1KE1 GVGPL-VNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQ-SLSLCGMVWEHRK
::: : :. ..: :.::::.:.:.: ..: . :..:: .:.: :. . ..::. .
NP_001 GVGKLDVDWRELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSAN
280 290 300 310 320 330
490 500 510 520 530 540
pF1KE1 GTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSI-KVSVGGEK
..: .. ::.. .:.: :..:.: ::..:. .:::::::: : ..::. .:.:: :
NP_001 ASDQERTPWHV---TIKP-KSQETCRGALISDQWVLTAAHCFR-DGNDHSLWRVNVGDPK
340 350 360 370 380 390
550 560 570 580 590 600
pF1KE1 ----RDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTE
... :: ... :.... .::. :: ::: :.::.:: .:.:.. ::::::::
NP_001 SQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTM
400 410 420 430 440 450
610 620 630 640 650 660
pF1KE1 GTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSC-ERDA
.. ::: : .::.....::: :.. : ::. . .::. . .: : . :: : .
NP_001 EANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLN---INLKMGVEWTSCAEVVS
460 470 480 490 500 510
670 680 690 700 710 720
pF1KE1 QYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG
: . .. :. :::: .:::.: : . :.:.::: .....: ::.:::..:::
NP_001 QEKTMFPNLTDVREVVTDQFLCSG---TQEDESPCKGESGGAVFLERRFRFFQVGLVSWG
520 530 540 550 560
730 740 750 760
pF1KE1 VVDVC-----KNQKRQ---KQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
. . : ::.... ..:: ::::::::.. :::...: : :.::
NP_001 LYNPCLGSADKNSRKRAPRSKVPP-PRDFHINLFRMQPWLRQHLGDV-LNFLPL
570 580 590 600 610 620
>>NP_001269386 (OMIM: 217000,613927,615489) complement C (506 aa)
initn: 894 init1: 256 opt: 1099 Z-score: 1043.1 bits: 203.2 E(85289): 2.3e-51
Smith-Waterman score: 1099; 39.0% identity (70.0% similar) in 484 aa overlap (300-764:38-504)
270 280 290 300 310 320
pF1KE1 NIYLVLDGSDSIGASNFTGAKKCLVNLIEKVASYGVKPRYGLVTYATYPKIWVKVSEADS
. :. .. ...:.:. ::. ..: . .:
NP_001 AAPRILCSRGLRSGSARATGSGVERSPSAAIFSFEINVSVAIITFASEPKVLMSVLNDNS
10 20 30 40 50 60
330 340 350 360 370 380
pF1KE1 SNADWVTKQLNEINYEDHKLKSGTNTKKALQAVYSMMSWPD---DVPPEGWNRTRHVIIL
. : ..:.. ::.::. .:::: ::..:: ::. . .:.. ::.:::
NP_001 RDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGMETMAWQEIRHAIIL
70 80 90 100 110 120
390 400 410 420 430 440
pF1KE1 MTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPREDYLDVYVFGVGPL-VNQVNINALASK
.::: ::::.: :..:.::..: :.. :. ::::.:..::: : :. ..: :.::
NP_001 LTDGKSNMGGSPKTAVDHIREILNINQKRN----DYLDIYAIGVGKLDVDWRELNELGSK
130 140 150 160 170 180
450 460 470 480 490 500
pF1KE1 KDNEQHVFKVKDMENLEDVFYQMIDESQ-SLSLCGMVWEHRKGTDYHKQPWQAKISVIRP
::.:.:.: ..: . :..:: .:.: :. . ..::. ...: .. ::.. .:.:
NP_001 KDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPWHV---TIKP
190 200 210 220 230 240
510 520 530 540 550
pF1KE1 SKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSI-KVSVGGEK----RDLEIEVVLFHPNY
:..:.: ::..:. .:::::::: : ..::. .:.:: : ... :: ... :..
NP_001 -KSQETCRGALISDQWVLTAAHCFR-DGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGF
250 260 270 280 290
560 570 580 590 600 610
pF1KE1 NINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTEGTTRALRLPPTTTCQQQK
.. .::. :: ::: :.::.:: .:.:.. :::::::: .. ::: : .::....
NP_001 DVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHE
300 310 320 330 340 350
620 630 640 650 660 670
pF1KE1 EELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSC-ERDAQYAPGYDKVKDISEVVTP
.::: :.. : ::. . .:: .. .: : . :: : .: . .. :. ::::
NP_001 NELLNKQSVPAHFVALNGSKL---NINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTD
360 370 380 390 400 410
680 690 700 710 720 730
pF1KE1 RFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVC-----KNQKRQ--
.:::.: : . :.:.::: .....: ::.:::..:::. . : ::....
NP_001 QFLCSG---TQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAP
420 430 440 450 460 470
740 750 760
pF1KE1 -KQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
..:: ::::::::.. :::...: : :.::
NP_001 RSKVPP-PRDFHINLFRMQPWLRQHLGDV-LNFLPL
480 490 500
>>NP_001269388 (OMIM: 217000,613927,615489) complement C (328 aa)
initn: 840 init1: 543 opt: 752 Z-score: 719.0 bits: 142.6 E(85289): 2.6e-33
Smith-Waterman score: 752; 41.2% identity (69.0% similar) in 274 aa overlap (30-300:17-284)
10 20 30 40 50
pF1KE1 MGSNLSPQLCLMPFILGLLSGGVTTTPWSLAWPQGSCSLEGVEIKGGSFRLLQ---EGQA
:: :: ..:.:.::.: : . :.
NP_001 MGPLMVLFCLLFLYPGLADSAPSCP-QNVNISGGTFTLSHGWAPGSL
10 20 30 40
60 70 80 90 100 110
pF1KE1 LEYVCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPR
: : ::.:.:: :. .: :.:.:.:.: ... :: :. ..:: : .:::: : ::
NP_001 LTYSCPQGLYPSPA-SRLCKSSGQWQT--PGATRSLSKAVCKPVRCPAPVSFENGIYTPR
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE1 SPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKV
: :. ..::.: ::. :::: : :. :: :.:.::.::::::.: :::: .:. ..
NP_001 LGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRT
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE1 GSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSS
: .. :.: :.:: .:.: ::..: :: .: :::::: :.. . :: :..:: :. .:
NP_001 GFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTS
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE1 LTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLI
... . ... . :. ::: .. :: .:.::.:: :.:.. ..: :. ..
NP_001 FSHMLGATNPT--QKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMV
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE1 EKVASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKK
..:
NP_001 DRVRNQESACSRGLPVLTISLCLLPLLRTPLTAHLLQEVFSDYTHAM
290 300 310 320
>>XP_016855679 (OMIM: 608398) PREDICTED: CUB and sushi d (3362 aa)
initn: 598 init1: 178 opt: 307 Z-score: 288.4 bits: 66.2 E(85289): 2.5e-09
Smith-Waterman score: 337; 28.7% identity (54.2% similar) in 216 aa overlap (14-220:2799-2999)
10 20 30
pF1KE1 MGSNLSPQLCLMPFILGLLSGGVTTT-PWSLAWPQG---SCSL
. :::: ... :. . :. .:.
XP_016 NPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGD
2770 2780 2790 2800 2810 2820
40 50 60 70 80 90
pF1KE1 EGVEIKGGSFRL---LQEGQALEYVCPSGFY--PYPVQTRTCRSTGSWSTLKTQDQKTVR
:. .: .:: .. .... : : :.. . :.. .: . .:. :
XP_016 PGIPANG--LRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPV------
2830 2840 2850 2860 2870 2880
100 110 120 130 140 150
pF1KE1 KAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQ
:.:. : : . ::. . ... : ... : .:: : : ::. :: :.:.
XP_016 ---CKALMCKPPPLIPNGKVVGSDFMWGSS--VTYACLEGYQLSLPAVFTCEGNGSWTGE
2890 2900 2910 2920 2930
160 170 180 190 200 210
pF1KE1 TAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGT
: .:..::.: :. . ..::.. : :.: :: :: :: :.::::
XP_016 LPQC--FPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGT
2940 2950 2960 2970 2980 2990
220 230 240 250 260 270
pF1KE1 EPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLV
.::: :
XP_016 QPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWS
3000 3010 3020 3030 3040 3050
>--
initn: 330 init1: 175 opt: 255 Z-score: 239.5 bits: 57.2 E(85289): 1.3e-06
Smith-Waterman score: 340; 30.3% identity (59.4% similar) in 165 aa overlap (55-218:2609-2762)
30 40 50 60 70 80
pF1KE1 TTPWSLAWPQGSCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWST
: .. : : ::: . . .:.. :.:.
XP_016 TCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGFYLLGTPVLSCQGDGTWDR
2580 2590 2600 2610 2620 2630
90 100 110 120 130 140
pF1KE1 LKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRT
. : : . : .: . .... : :.:. . . : :: :...:
XP_016 PRPQ---------CLLVSCGHPGSPPHSQMSGDS--YTVGAVVRYSCIGKRTLVGNSTRM
2640 2650 2660 2670 2680
150 160 170 180 190 200
pF1KE1 CQVNGRWSGQTAICDN-GAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRR
: ..:.:.:. :.. ..: :..:::: ..:... . . : : .::::..:
XP_016 CGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSER
2690 2700 2710 2720 2730 2740
210 220 230 240 250 260
pF1KE1 TCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVL
::: .:::::..: :
XP_016 TCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRH
2750 2760 2770 2780 2790 2800
>--
initn: 311 init1: 175 opt: 255 Z-score: 239.5 bits: 57.2 E(85289): 1.3e-06
Smith-Waterman score: 314; 31.2% identity (54.0% similar) in 189 aa overlap (36-218:2345-2522)
10 20 30 40 50
pF1KE1 SPQLCLMPFILGLLSGGVTTTPWSLAWPQGSC-SLEGVEIKGGSFRLLQEGQ-----ALE
.: .. .. .. : .::. : : :
XP_016 HLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLM
2320 2330 2340 2350 2360 2370
60 70 80 90 100 110
pF1KE1 YVCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSP
.: :.: .. :...:.:: :. . :: : : . ::.
XP_016 LICDPGYYYTGQRVIRCQANGKWSL---GDSTPT----CRIISCGELPIPPNGHRIGTLS
2380 2390 2400 2410 2420
120 130 140 150 160 170
pF1KE1 YYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGS
:... : : .:::: :: : :..:: :::. . : ::.:..: .. . :
XP_016 VYGAT--AIFSCNSGYTLVGSRVRECMANGLWSGSEVRC--LAGHCGTPEPIVNGHINGE
2430 2440 2450 2460 2470 2480
180 190 200 210 220 230
pF1KE1 QYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLT
.: . ::.:.:. :. : : . : ::. ::: : :
XP_016 NYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVPITCGHPGNPVNGLTQGNQF
2490 2500 2510 2520 2530 2540
240 250 260 270 280 290
pF1KE1 ETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEK
XP_016 NLNDVVKFVCNPGYMAEGAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQVHASGP
2550 2560 2570 2580 2590 2600
>--
initn: 169 init1: 123 opt: 233 Z-score: 218.8 bits: 53.4 E(85289): 1.9e-05
Smith-Waterman score: 233; 36.5% identity (60.6% similar) in 104 aa overlap (118-218:3019-3119)
90 100 110 120 130 140
pF1KE1 QDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQV
: :.:.. . :.: :: :.::..:::
XP_016 TWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLP
2990 3000 3010 3020 3030 3040
150 160 170 180 190 200
pF1KE1 NGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQY--RLEDSVTYHCSRGLTLRG-SQRRT
: ::: : .: .: : . .::. . .. : :..:..:.: :..::
XP_016 NLTWSGTPPDC--VPHHCRQPETPTHA-NVGALDLPSMGYTLIYSCQEGFSLKGGSEHRT
3050 3060 3070 3080 3090 3100
210 220 230 240 250 260
pF1KE1 CQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLD
:. :::.: : :
XP_016 CKADGSWTGKPPICLAEVRPSGRPINTAREPPLTQALIPGDVFAKNSLWKGAYEYQGKKQ
3110 3120 3130 3140 3150 3160
>>NP_443128 (OMIM: 608398) CUB and sushi domain-containi (3487 aa)
initn: 682 init1: 197 opt: 307 Z-score: 288.2 bits: 66.3 E(85289): 2.6e-09
Smith-Waterman score: 337; 28.7% identity (54.2% similar) in 216 aa overlap (14-220:2925-3125)
10 20 30
pF1KE1 MGSNLSPQLCLMPFILGLLSGGVTTT-PWSLAWPQG---SCSL
. :::: ... :. . :. .:.
NP_443 NPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGD
2900 2910 2920 2930 2940 2950
40 50 60 70 80 90
pF1KE1 EGVEIKGGSFRL---LQEGQALEYVCPSGFY--PYPVQTRTCRSTGSWSTLKTQDQKTVR
:. .: .:: .. .... : : :.. . :.. .: . .:. :
NP_443 PGIPANG--LRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPV------
2960 2970 2980 2990 3000
100 110 120 130 140 150
pF1KE1 KAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQ
:.:. : : . ::. . ... : ... : .:: : : ::. :: :.:.
NP_443 ---CKALMCKPPPLIPNGKVVGSDFMWGSS--VTYACLEGYQLSLPAVFTCEGNGSWTGE
3010 3020 3030 3040 3050 3060
160 170 180 190 200 210
pF1KE1 TAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGT
: .:..::.: :. . ..::.. : :.: :: :: :: :.::::
NP_443 LPQC--FPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGT
3070 3080 3090 3100 3110
220 230 240 250 260 270
pF1KE1 EPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLV
.::: :
NP_443 QPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWS
3120 3130 3140 3150 3160 3170
>--
initn: 578 init1: 175 opt: 255 Z-score: 239.3 bits: 57.2 E(85289): 1.4e-06
Smith-Waterman score: 319; 30.0% identity (58.1% similar) in 160 aa overlap (60-218:2740-2888)
30 40 50 60 70 80
pF1KE1 LAWPQGSCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWSTLKTQD
: : .:: ...: :.. ::
NP_443 RCLAGHCGTPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSG-----
2710 2720 2730 2740 2750 2760
90 100 110 120 130 140
pF1KE1 QKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNG
. : . : .: . .... : :.:. . . : :: :...: : ..:
NP_443 ----KTPFCVLVSCGHPGSPPHSQMSGDS--YTVGAVVRYSCIGKRTLVGNSTRMCGLDG
2770 2780 2790 2800 2810
150 160 170 180 190 200
pF1KE1 RWSGQTAICDN-GAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEG
.:.:. :.. ..: :..:::: ..:... . . : : .::::..:::: .
NP_443 HWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSERTCQAN
2820 2830 2840 2850 2860 2870
210 220 230 240 250 260
pF1KE1 GSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLDPSGS
:::::..: :
NP_443 GSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNG
2880 2890 2900 2910 2920 2930
>--
initn: 481 init1: 175 opt: 255 Z-score: 239.3 bits: 57.2 E(85289): 1.4e-06
Smith-Waterman score: 255; 27.0% identity (50.4% similar) in 230 aa overlap (28-244:2519-2736)
10 20 30 40 50
pF1KE1 MGSNLSPQLCLMPFILGLLSGGVTTTPWSLAWP--QG-SCSLEGVEIKGGSF-RLLQ
:: : : :. ::.: . .: : .
NP_443 GSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQALSCGLPEAPKNGMVFGKEYT
2490 2500 2510 2520 2530 2540
60 70 80 90 100
pF1KE1 EGQALEYVCPSGFY--PYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDF--
: : : :.. : : .:: ::. .. : : . :: ..
NP_443 VGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQ-------CVPVTCPDVSSISV
2550 2560 2570 2580 2590 2600
110 120 130 140 150 160
pF1KE1 ENGEYWPRSPY---YNVSDEISFHCYDGYTLRGSANRTCQVNGRWS--GQTAICDNGAGY
:.:. : : . :. . .. . : :: :. ::.::.:: .: : .
NP_443 EHGR-W-RLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIIS--
2610 2620 2630 2640 2650
170 180 190 200 210 220
pF1KE1 CSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMY
:.. :: . ...:. .. . :. : :: ::. : :. .: :::.: : .
NP_443 CGELPIPPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHC-
2660 2670 2680 2690 2700 2710
230 240 250 260 270 280
pF1KE1 DTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGAS
::. .... ... . . .:
NP_443 GTPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGH
2720 2730 2740 2750 2760 2770
>--
initn: 169 init1: 123 opt: 234 Z-score: 219.6 bits: 53.6 E(85289): 1.7e-05
Smith-Waterman score: 234; 32.7% identity (57.3% similar) in 150 aa overlap (118-260:3145-3289)
90 100 110 120 130 140
pF1KE1 QDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQV
: :.:.. . :.: :: :.::..:::
NP_443 TWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLP
3120 3130 3140 3150 3160 3170
150 160 170 180 190 200
pF1KE1 NGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQY--RLEDSVTYHCSRGLTLRG-SQRRT
: ::: : .: .: : . .::. . .. : :..:..:.: :..::
NP_443 NLTWSGTPPDCV--PHHCRQPETPTHA-NVGALDLPSMGYTLIYSCQEGFSLKGGSEHRT
3180 3190 3200 3210 3220 3230
210 220 230 240 250 260
pF1KE1 CQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTET-IEG-VDAEDG--HGPGEQQKRK
:. :::.: : : . . . . . : ::.. : : : :... .: : : .:
NP_443 CKADGSWTGKPPICLE--VRPSGRPINTAREPPLTQALIPGDVFAKNSLWKGAYEYQGKK
3240 3250 3260 3270 3280
270 280 290 300 310 320
pF1KE1 IVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKVASYGVKPRYGLVTYATYPKI
NP_443 QPAMLRVTGFQVANSKVNATMIDHSGVELHLAGTYKKEDFHLLLQVYQITGPVEIFMNKF
3290 3300 3310 3320 3330 3340
>>XP_016855678 (OMIM: 608398) PREDICTED: CUB and sushi d (3506 aa)
initn: 846 init1: 178 opt: 307 Z-score: 288.2 bits: 66.3 E(85289): 2.6e-09
Smith-Waterman score: 337; 28.7% identity (54.2% similar) in 216 aa overlap (14-220:3044-3244)
10 20 30
pF1KE1 MGSNLSPQLCLMPFILGLLSGGVTTT-PWSLAWPQG---SCSL
. :::: ... :. . :. .:.
XP_016 NPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGD
3020 3030 3040 3050 3060 3070
40 50 60 70 80 90
pF1KE1 EGVEIKGGSFRL---LQEGQALEYVCPSGFY--PYPVQTRTCRSTGSWSTLKTQDQKTVR
:. .: .:: .. .... : : :.. . :.. .: . .:. :
XP_016 PGIPANG--LRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPV------
3080 3090 3100 3110 3120
100 110 120 130 140 150
pF1KE1 KAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQ
:.:. : : . ::. . ... : ... : .:: : : ::. :: :.:.
XP_016 ---CKALMCKPPPLIPNGKVVGSDFMWGSS--VTYACLEGYQLSLPAVFTCEGNGSWTGE
3130 3140 3150 3160 3170 3180
160 170 180 190 200 210
pF1KE1 TAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGT
: .:..::.: :. . ..::.. : :.: :: :: :: :.::::
XP_016 LPQC--FPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGT
3190 3200 3210 3220 3230
220 230 240 250 260 270
pF1KE1 EPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLV
.::: :
XP_016 QPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWS
3240 3250 3260 3270 3280 3290
>--
initn: 578 init1: 175 opt: 255 Z-score: 239.3 bits: 57.2 E(85289): 1.4e-06
Smith-Waterman score: 340; 30.3% identity (59.4% similar) in 165 aa overlap (55-218:2854-3007)
30 40 50 60 70 80
pF1KE1 TTPWSLAWPQGSCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWST
: .. : : ::: . . .:.. :.:.
XP_016 TCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGFYLLGTPVLSCQGDGTWDR
2830 2840 2850 2860 2870 2880
90 100 110 120 130 140
pF1KE1 LKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRT
. : : . : .: . .... : :.:. . . : :: :...:
XP_016 PRPQ---------CLLVSCGHPGSPPHSQMSGDS--YTVGAVVRYSCIGKRTLVGNSTRM
2890 2900 2910 2920 2930
150 160 170 180 190 200
pF1KE1 CQVNGRWSGQTAICDN-GAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRR
: ..:.:.:. :.. ..: :..:::: ..:... . . : : .::::..:
XP_016 CGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSER
2940 2950 2960 2970 2980 2990
210 220 230 240 250 260
pF1KE1 TCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVL
::: .:::::..: :
XP_016 TCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRH
3000 3010 3020 3030 3040 3050
>--
initn: 559 init1: 175 opt: 255 Z-score: 239.3 bits: 57.2 E(85289): 1.4e-06
Smith-Waterman score: 314; 31.2% identity (54.0% similar) in 189 aa overlap (36-218:2590-2767)
10 20 30 40 50
pF1KE1 SPQLCLMPFILGLLSGGVTTTPWSLAWPQGSC-SLEGVEIKGGSFRLLQEGQ-----ALE
.: .. .. .. : .::. : : :
XP_016 HLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLM
2560 2570 2580 2590 2600 2610
60 70 80 90 100 110
pF1KE1 YVCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSP
.: :.: .. :...:.:: :. . :: : : . ::.
XP_016 LICDPGYYYTGQRVIRCQANGKWSL---GDSTPT----CRIISCGELPIPPNGHRIGTLS
2620 2630 2640 2650 2660 2670
120 130 140 150 160 170
pF1KE1 YYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGS
:... : : .:::: :: : :..:: :::. . : ::.:..: .. . :
XP_016 VYGAT--AIFSCNSGYTLVGSRVRECMANGLWSGSEVRC--LAGHCGTPEPIVNGHINGE
2680 2690 2700 2710 2720
180 190 200 210 220 230
pF1KE1 QYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLT
.: . ::.:.:. :. : : . : ::. ::: : :
XP_016 NYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVPITCGHPGNPVNGLTQGNQF
2730 2740 2750 2760 2770 2780
240 250 260 270 280 290
pF1KE1 ETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEK
XP_016 NLNDVVKFVCNPGYMAEGAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQVHASGP
2790 2800 2810 2820 2830 2840
>--
initn: 169 init1: 123 opt: 233 Z-score: 218.6 bits: 53.4 E(85289): 1.9e-05
Smith-Waterman score: 233; 36.5% identity (60.6% similar) in 104 aa overlap (118-218:3264-3364)
90 100 110 120 130 140
pF1KE1 QDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQV
: :.:.. . :.: :: :.::..:::
XP_016 TWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLP
3240 3250 3260 3270 3280 3290
150 160 170 180 190 200
pF1KE1 NGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQY--RLEDSVTYHCSRGLTLRG-SQRRT
: ::: : .: .: : . .::. . .. : :..:..:.: :..::
XP_016 NLTWSGTPPDC--VPHHCRQPETPTHA-NVGALDLPSMGYTLIYSCQEGFSLKGGSEHRT
3300 3310 3320 3330 3340 3350
210 220 230 240 250 260
pF1KE1 CQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLD
:. :::.: : :
XP_016 CKADGSWTGKPPICLAEVRPSGRPINTAREPPLTQALIPGDVFAKNSLWKGAYEYQGKKQ
3360 3370 3380 3390 3400 3410
>>XP_016855683 (OMIM: 608398) PREDICTED: CUB and sushi d (3566 aa)
initn: 682 init1: 197 opt: 307 Z-score: 288.1 bits: 66.3 E(85289): 2.6e-09
Smith-Waterman score: 337; 28.7% identity (54.2% similar) in 216 aa overlap (14-220:3004-3204)
10 20 30
pF1KE1 MGSNLSPQLCLMPFILGLLSGGVTTT-PWSLAWPQG---SCSL
. :::: ... :. . :. .:.
XP_016 NPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGD
2980 2990 3000 3010 3020 3030
40 50 60 70 80 90
pF1KE1 EGVEIKGGSFRL---LQEGQALEYVCPSGFY--PYPVQTRTCRSTGSWSTLKTQDQKTVR
:. .: .:: .. .... : : :.. . :.. .: . .:. :
XP_016 PGIPANG--LRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPV------
3040 3050 3060 3070 3080
100 110 120 130 140 150
pF1KE1 KAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQ
:.:. : : . ::. . ... : ... : .:: : : ::. :: :.:.
XP_016 ---CKALMCKPPPLIPNGKVVGSDFMWGSS--VTYACLEGYQLSLPAVFTCEGNGSWTGE
3090 3100 3110 3120 3130 3140
160 170 180 190 200 210
pF1KE1 TAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGT
: .:..::.: :. . ..::.. : :.: :: :: :: :.::::
XP_016 LPQC--FPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGT
3150 3160 3170 3180 3190
220 230 240 250 260 270
pF1KE1 EPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLV
.::: :
XP_016 QPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWS
3200 3210 3220 3230 3240 3250
>--
initn: 578 init1: 175 opt: 255 Z-score: 239.2 bits: 57.2 E(85289): 1.4e-06
Smith-Waterman score: 340; 30.3% identity (59.4% similar) in 165 aa overlap (55-218:2814-2967)
30 40 50 60 70 80
pF1KE1 TTPWSLAWPQGSCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWST
: .. : : ::: . . .:.. :.:.
XP_016 TCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGFYLLGTPVLSCQGDGTWDR
2790 2800 2810 2820 2830 2840
90 100 110 120 130 140
pF1KE1 LKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRT
. : : . : .: . .... : :.:. . . : :: :...:
XP_016 PRPQ---------CLLVSCGHPGSPPHSQMSGDS--YTVGAVVRYSCIGKRTLVGNSTRM
2850 2860 2870 2880 2890
150 160 170 180 190 200
pF1KE1 CQVNGRWSGQTAICDN-GAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRR
: ..:.:.:. :.. ..: :..:::: ..:... . . : : .::::..:
XP_016 CGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSER
2900 2910 2920 2930 2940 2950
210 220 230 240 250 260
pF1KE1 TCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVL
::: .:::::..: :
XP_016 TCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRH
2960 2970 2980 2990 3000 3010
>--
initn: 559 init1: 175 opt: 255 Z-score: 239.2 bits: 57.2 E(85289): 1.4e-06
Smith-Waterman score: 314; 31.2% identity (54.0% similar) in 189 aa overlap (36-218:2550-2727)
10 20 30 40 50
pF1KE1 SPQLCLMPFILGLLSGGVTTTPWSLAWPQGSC-SLEGVEIKGGSFRLLQEGQ-----ALE
.: .. .. .. : .::. : : :
XP_016 HLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLM
2520 2530 2540 2550 2560 2570
60 70 80 90 100 110
pF1KE1 YVCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSP
.: :.: .. :...:.:: :. . :: : : . ::.
XP_016 LICDPGYYYTGQRVIRCQANGKWSL---GDSTPT----CRIISCGELPIPPNGHRIGTLS
2580 2590 2600 2610 2620 2630
120 130 140 150 160 170
pF1KE1 YYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGS
:... : : .:::: :: : :..:: :::. . : ::.:..: .. . :
XP_016 VYGAT--AIFSCNSGYTLVGSRVRECMANGLWSGSEVRC--LAGHCGTPEPIVNGHINGE
2640 2650 2660 2670 2680
180 190 200 210 220 230
pF1KE1 QYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLT
.: . ::.:.:. :. : : . : ::. ::: : :
XP_016 NYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVPITCGHPGNPVNGLTQGNQF
2690 2700 2710 2720 2730 2740
240 250 260 270 280 290
pF1KE1 ETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEK
XP_016 NLNDVVKFVCNPGYMAEGAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQVHASGP
2750 2760 2770 2780 2790 2800
>--
initn: 169 init1: 123 opt: 234 Z-score: 219.4 bits: 53.6 E(85289): 1.7e-05
Smith-Waterman score: 234; 32.7% identity (57.3% similar) in 150 aa overlap (118-260:3224-3368)
90 100 110 120 130 140
pF1KE1 QDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQV
: :.:.. . :.: :: :.::..:::
XP_016 TWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLP
3200 3210 3220 3230 3240 3250
150 160 170 180 190 200
pF1KE1 NGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQY--RLEDSVTYHCSRGLTLRG-SQRRT
: ::: : .: .: : . .::. . .. : :..:..:.: :..::
XP_016 NLTWSGTPPDCV--PHHCRQPETPTHA-NVGALDLPSMGYTLIYSCQEGFSLKGGSEHRT
3260 3270 3280 3290 3300 3310
210 220 230 240 250 260
pF1KE1 CQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTET-IEG-VDAEDG--HGPGEQQKRK
:. :::.: : : . . . . . : ::.. : : : :... .: : : .:
XP_016 CKADGSWTGKPPICLE--VRPSGRPINTAREPPLTQALIPGDVFAKNSLWKGAYEYQGKK
3320 3330 3340 3350 3360
270 280 290 300 310 320
pF1KE1 IVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKVASYGVKPRYGLVTYATYPKI
XP_016 QPAMLRVTGFQVANSKVNATMIDHSGVELHLAGTYKKEDFHLLLQVYQITGPVEIFMNKF
3370 3380 3390 3400 3410 3420
764 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 23:19:24 2016 done: Sun Nov 6 23:19:26 2016
Total Scan time: 11.860 Total Display time: 0.160
Function used was FASTA [36.3.4 Apr, 2011]