FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE1414, 224 aa
  1>>>pF1KE1414 224 - 224 aa - 224 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.8209+/-0.000305; mu= 17.2220+/- 0.019
 mean_var=69.6822+/-13.854, 0's: 0 Z-trim(118.0): 11  B-trim: 2 in 1/55
 Lambda= 0.153643
 statistics sampled from 30505 (30510) to 30505 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.735), E-opt: 0.2 (0.358), width:  16
 Scan time:  6.530

The best scores are:                                      opt bits E(85289)
NP_003247 (OMIM: 601915) metalloproteinase inhibit ( 224) 1590 360.8 1.1e-99
NP_003246 (OMIM: 188825) metalloproteinase inhibit ( 220)  780 181.2 1.2e-45
NP_000353 (OMIM: 136900,188826) metalloproteinase  ( 211)  706 164.8 9.9e-41
NP_003245 (OMIM: 305370) metalloproteinase inhibit ( 207)  502 119.6   4e-27


>>NP_003247 (OMIM: 601915) metalloproteinase inhibitor 4  (224 aa)
 initn: 1590 init1: 1590 opt: 1590  Z-score: 1910.9  bits: 360.8 E(85289): 1.1e-99
Smith-Waterman score: 1590; 100.0% identity (100.0% similar) in 224 aa overlap (1-224:1-224)

               10        20        30        40        50        60
pF1KE1 MPGSPRPAPSWVLLLRLLALLRPPGLGEACSCAPAHPQQHICHSALVIRAKISSEKVVPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MPGSPRPAPSWVLLLRLLALLRPPGLGEACSCAPAHPQQHICHSALVIRAKISSEKVVPA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 SADPADTEKMLRYEIKQIKMFKGFEKVKDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SADPADTEKMLRYEIKQIKMFKGFEKVKDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 LSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCGCQITTCYTVPCTISAPNECLWTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCGCQITTCYTVPCTISAPNECLWTD
              130       140       150       160       170       180

              190       200       210       220    
pF1KE1 WLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP
       ::::::::::::::::::::::::::::::::::::::::::::
NP_003 WLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP
              190       200       210       220    

>>NP_003246 (OMIM: 188825) metalloproteinase inhibitor 2  (220 aa)
 initn: 812 init1: 564 opt: 780  Z-score: 940.6  bits: 181.2 E(85289): 1.2e-45
Smith-Waterman score: 780; 50.0% identity (80.2% similar) in 212 aa overlap (14-224:14-220)

               10        20        30        40        50        60
pF1KE1 MPGSPRPAPSWVLLLRLLALLRPPGLGEACSCAPAHPQQHICHSALVIRAKISSEKVVPA
                    :: : .::::   ..::::.:.:::: .:.. .:::::  ::: : .
NP_003 MGAAARTLRLALGLLLLATLLRP---ADACSCSPVHPQQAFCNADVVIRAKAVSEKEVDS
               10        20           30        40        50       

                70        80        90       100       110         
pF1KE1 SADP-ADTEKMLRYEIKQIKMFKGFEKVKDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQ
       . :  ..  : ..::::::::::: :  ::...:::  .:..:::.:.....:.::..:.
NP_003 GNDIYGNPIKRIQYEIKQIKMFKGPE--KDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGK
        60        70        80          90       100       110     

     120       130       140       150       160       170         
pF1KE1 VLSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCGCQITTCYTVPCTISAPNECLWT
       . .:::. : ::..: ::. :: .:..::::.:...: :.:: :  .:: ::.:.:::: 
NP_003 AEGDGKMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWM
         120       130       140       150       160       170     

     180       190       200       210       220    
pF1KE1 DWLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP
       ::. :... :.::. ..:.:. ::.:.::::  : ..::.:: .:
NP_003 DWVTEKNINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP
         180       190       200       210       220

>>NP_000353 (OMIM: 136900,188826) metalloproteinase inhi  (211 aa)
 initn: 688 init1: 392 opt: 706  Z-score: 852.2  bits: 164.8 E(85289): 9.9e-41
Smith-Waterman score: 706; 47.4% identity (73.5% similar) in 215 aa overlap (11-224:4-211)

               10        20         30        40        50         
pF1KE1 MPGSPRPAPSWVLLLRLLALLRPPGLG-EACSCAPAHPQQHICHSALVIRAKISSEKVVP
                 :. :. ::.       : :::.:.:.:::. .:.: .:::::. ..:.: 
NP_000        MTPWLGLIVLLGSWSLGDWGAEACTCSPSHPQDAFCNSDIVIRAKVVGKKLVK
                      10        20        30        40        50   

      60        70        80        90       100       110         
pF1KE1 ASADPADTEKMLRYEIKQIKMFKGFEKVKDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQ
        .  :  :   : : :::.::..:: :.  ::::.:  . ::::.:::.: . ::::::.
NP_000 EG--PFGT---LVYTIKQMKMYRGFTKMPHVQYIHTEASESLCGLKLEVN-KYQYLLTGR
                 60        70        80        90        100       

     120       130       140       150       160       170         
pF1KE1 VLSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCGCQITTCYTVPCTISAPNECLWT
       :  :::..  :::..: :..:.: ::..::..:::.:.:.: .:: .:: ... ::::::
NP_000 VY-DGKMYTGLCNFVERWDQLTLSQRKGLNYRYHLGCNCKIKSCYYLPCFVTSKNECLWT
        110       120       130       140       150       160      

     180       190       200       210       220    
pF1KE1 DWLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP
       : : .    :::..::.:...  : ::::::  :  : ... ..:
NP_000 DMLSNFGYPGYQSKHYACIRQKGGYCSWYRGWAPPDKSIINATDP
        170       180       190       200       210 

>>NP_003245 (OMIM: 305370) metalloproteinase inhibitor 1  (207 aa)
 initn: 408 init1: 152 opt: 502  Z-score: 608.0  bits: 119.6 E(85289): 4e-27
Smith-Waterman score: 502; 37.4% identity (67.5% similar) in 206 aa overlap (7-207:6-199)

               10        20        30        40        50        60
pF1KE1 MPGSPRPAPSWVLLLRLLALLRPPGLGEACSCAPAHPQQHICHSALVIRAKISSEKVVPA
             :  : .:::  : :. :   ..::.:.: :::  .:.: ::::::. .   :  
NP_003  MAPFEPLASGILLL--LWLIAP---SRACTCVPPHPQTAFCNSDLVIRAKFVGTPEV--
                10          20           30        40        50    

               70        80           90       100        110      
pF1KE1 SADPADTEKMLRYEIKQIKMFKGFEKV---KDVQYIYTPFDSSLCGVKLEA-NSQKQYLL
            .:  . :::::. ::.:::. .    :....:::   :.::   .. : ....:.
NP_003 ----NQTTLYQRYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLI
                 60        70        80        90       100        

        120       130       140       150        160       170     
pF1KE1 TGQVLSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCG-CQITTCYTVPCTISAPNE
       .:. :.:: . :  :... ::..:::.::..... : ..:  : .  : ..:: ... ..
NP_003 AGK-LQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTH
      110        120       130       140       150       160       

         180       190       200       210       220    
pF1KE1 CLWTDWLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP
       ::::: ::. .  :.:..: .:. .  : :.:                 
NP_003 CLWTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLRSQIA         
       170       180       190       200                




224 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Mon Nov  7 15:32:08 2016 done: Mon Nov  7 15:32:09 2016
 Total Scan time:  6.530 Total Display time: -0.030

Function used was FASTA [36.3.4 Apr, 2011]