Result of FASTA (omim) for
pFN21AE1413
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1413, 500 aa
1>>>pF1KE1413 500 - 500 aa - 500 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.2951+/-0.000448; mu= 11.1083+/- 0.028
mean_var=170.9479+/-35.097, 0's: 0 Z-trim(114.7): 116 B-trim: 696 in 1/57
Lambda= 0.098094
statistics sampled from 24645 (24761) to 24645 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.63), E-opt: 0.2 (0.29), width: 16
Scan time: 10.060
The best scores are: opt bits E(85289)
NP_000053 (OMIM: 106100,120790,606860) plasma prot ( 500) 3178 462.3 1.4e-129
NP_001027466 (OMIM: 106100,120790,606860) plasma p ( 500) 3178 462.3 1.4e-129
NP_000925 (OMIM: 262850,613168) alpha-2-antiplasmi ( 491) 613 99.3 2.7e-20
NP_001159392 (OMIM: 262850,613168) alpha-2-antipla ( 491) 613 99.3 2.7e-20
XP_016880254 (OMIM: 262850,613168) PREDICTED: alph ( 495) 613 99.3 2.7e-20
XP_005256758 (OMIM: 262850,613168) PREDICTED: alph ( 507) 613 99.3 2.7e-20
NP_001159393 (OMIM: 262850,613168) alpha-2-antipla ( 427) 551 90.5 1.1e-17
NP_002606 (OMIM: 172860,613982) pigment epithelium ( 418) 510 84.7 5.8e-16
NP_001316832 (OMIM: 172860,613982) pigment epithel ( 418) 510 84.7 5.8e-16
NP_001076 (OMIM: 107280) alpha-1-antichymotrypsin ( 423) 437 74.3 7.6e-13
NP_000615 (OMIM: 601841) plasma serine protease in ( 406) 420 71.9 3.9e-12
NP_001121179 (OMIM: 107400,606963,613490) alpha-1- ( 418) 405 69.8 1.7e-11
NP_001121178 (OMIM: 107400,606963,613490) alpha-1- ( 418) 405 69.8 1.7e-11
NP_001002236 (OMIM: 107400,606963,613490) alpha-1- ( 418) 405 69.8 1.7e-11
NP_001121174 (OMIM: 107400,606963,613490) alpha-1- ( 418) 405 69.8 1.7e-11
NP_001121175 (OMIM: 107400,606963,613490) alpha-1- ( 418) 405 69.8 1.7e-11
NP_001002235 (OMIM: 107400,606963,613490) alpha-1- ( 418) 405 69.8 1.7e-11
NP_001121177 (OMIM: 107400,606963,613490) alpha-1- ( 418) 405 69.8 1.7e-11
NP_001121173 (OMIM: 107400,606963,613490) alpha-1- ( 418) 405 69.8 1.7e-11
XP_016876859 (OMIM: 107400,606963,613490) PREDICTE ( 418) 405 69.8 1.7e-11
NP_001121176 (OMIM: 107400,606963,613490) alpha-1- ( 418) 405 69.8 1.7e-11
NP_001121172 (OMIM: 107400,606963,613490) alpha-1- ( 418) 405 69.8 1.7e-11
NP_000286 (OMIM: 107400,606963,613490) alpha-1-ant ( 418) 405 69.8 1.7e-11
NP_001094077 (OMIM: 605271) protein Z-dependent pr ( 444) 401 69.3 2.7e-11
XP_005267790 (OMIM: 605271) PREDICTED: protein Z-d ( 444) 401 69.3 2.7e-11
NP_057270 (OMIM: 605271) protein Z-dependent prote ( 444) 401 69.3 2.7e-11
XP_016876842 (OMIM: 605271) PREDICTED: protein Z-d ( 484) 401 69.3 2.8e-11
NP_008850 (OMIM: 600517) serpin B3 [Homo sapiens] ( 390) 394 68.2 4.8e-11
NP_006208 (OMIM: 605587) serpin I2 isoform 2 precu ( 405) 390 67.7 7.4e-11
NP_001137290 (OMIM: 173390) plasminogen activator ( 415) 390 67.7 7.5e-11
NP_001012303 (OMIM: 605587) serpin I2 isoform 1 pr ( 415) 390 67.7 7.5e-11
NP_002566 (OMIM: 173390) plasminogen activator inh ( 415) 390 67.7 7.5e-11
NP_002965 (OMIM: 600518) serpin B4 isoform 1 [Homo ( 390) 388 67.4 8.7e-11
XP_011524440 (OMIM: 600518) PREDICTED: serpin B4 i ( 390) 388 67.4 8.7e-11
XP_011524329 (OMIM: 602058) PREDICTED: serpin B10 ( 397) 382 66.5 1.6e-10
NP_005015 (OMIM: 602058) serpin B10 [Homo sapiens] ( 397) 382 66.5 1.6e-10
NP_001747 (OMIM: 122500,611489) corticosteroid-bin ( 405) 382 66.5 1.6e-10
NP_006211 (OMIM: 107410) putative alpha-1-antitryp ( 421) 378 66.0 2.5e-10
NP_006206 (OMIM: 147935) kallistatin isoform 2 pre ( 427) 376 65.7 3e-10
NP_001275962 (OMIM: 147935) kallistatin isoform 2 ( 427) 376 65.7 3e-10
NP_001275961 (OMIM: 147935) kallistatin isoform 1 ( 464) 376 65.7 3.2e-10
NP_942130 (OMIM: 601697,617115) serpin B8 isoform ( 374) 368 64.5 6e-10
NP_002631 (OMIM: 601697,617115) serpin B8 isoform ( 374) 368 64.5 6e-10
NP_000345 (OMIM: 300932,314200) thyroxine-binding ( 415) 367 64.4 7.2e-10
NP_001271204 (OMIM: 615677) serpin A9 isoform C [H ( 399) 365 64.1 8.5e-10
XP_011535016 (OMIM: 615677) PREDICTED: serpin A9 i ( 417) 365 64.1 8.7e-10
XP_011535017 (OMIM: 615677) PREDICTED: serpin A9 i ( 417) 365 64.1 8.7e-10
NP_783866 (OMIM: 615677) serpin A9 isoform A [Homo ( 435) 365 64.2 9e-10
XP_011524330 (OMIM: 602058) PREDICTED: serpin B10 ( 268) 360 63.3 1e-09
XP_011535018 (OMIM: 615677) PREDICTED: serpin A9 i ( 337) 359 63.2 1.4e-09
>>NP_000053 (OMIM: 106100,120790,606860) plasma protease (500 aa)
initn: 3178 init1: 3178 opt: 3178 Z-score: 2447.1 bits: 462.3 E(85289): 1.4e-129
Smith-Waterman score: 3178; 99.8% identity (100.0% similar) in 500 aa overlap (1-500:1-500)
10 20 30 40 50 60
pF1KE1 MASRLTLLTLLLLLLAGDRASSNPNATSSSSQDPESLQDRGEGKVATTVISKMLFVEPIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MASRLTLLTLLLLLLAGDRASSNPNATSSSSQDPESLQDRGEGKVATTVISKMLFVEPIL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 EVSSLPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EVSSLPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SFCPGPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SFCPGPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VLLGAGENTKTNLESILSYPKDFTCVHQALKGFTTKGVTSVSQIFHSPDLAIRDTFVNAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VLLGAGENTKTNLESILSYPKDFTCVHQALKGFTTKGVTSVSQIFHSPDLAIRDTFVNAS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 RTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 TTFDPKKTRMEPFHFKNSVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TTFDPKKTRMEPFHFKNSVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 QNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 FSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVARTLLVFEVQQPFLFM
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.
NP_000 FSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVARTLLVFEVQQPFLFV
430 440 450 460 470 480
490 500
pF1KE1 LWDQQHKFPVFMGRVYDPRA
::::::::::::::::::::
NP_000 LWDQQHKFPVFMGRVYDPRA
490 500
>>NP_001027466 (OMIM: 106100,120790,606860) plasma prote (500 aa)
initn: 3178 init1: 3178 opt: 3178 Z-score: 2447.1 bits: 462.3 E(85289): 1.4e-129
Smith-Waterman score: 3178; 99.8% identity (100.0% similar) in 500 aa overlap (1-500:1-500)
10 20 30 40 50 60
pF1KE1 MASRLTLLTLLLLLLAGDRASSNPNATSSSSQDPESLQDRGEGKVATTVISKMLFVEPIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MASRLTLLTLLLLLLAGDRASSNPNATSSSSQDPESLQDRGEGKVATTVISKMLFVEPIL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 EVSSLPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVSSLPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SFCPGPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFCPGPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VLLGAGENTKTNLESILSYPKDFTCVHQALKGFTTKGVTSVSQIFHSPDLAIRDTFVNAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLLGAGENTKTNLESILSYPKDFTCVHQALKGFTTKGVTSVSQIFHSPDLAIRDTFVNAS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 RTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 TTFDPKKTRMEPFHFKNSVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTFDPKKTRMEPFHFKNSVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 QNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 FSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVARTLLVFEVQQPFLFM
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.
NP_001 FSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVARTLLVFEVQQPFLFV
430 440 450 460 470 480
490 500
pF1KE1 LWDQQHKFPVFMGRVYDPRA
::::::::::::::::::::
NP_001 LWDQQHKFPVFMGRVYDPRA
490 500
>>NP_000925 (OMIM: 262850,613168) alpha-2-antiplasmin is (491 aa)
initn: 483 init1: 172 opt: 613 Z-score: 485.4 bits: 99.3 E(85289): 2.7e-20
Smith-Waterman score: 613; 28.5% identity (65.6% similar) in 410 aa overlap (95-498:36-436)
70 80 90 100 110 120
pF1KE1 LPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCP
:. :. . ..: : : . .: .
NP_000 GLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQ-EPGGQTALK
10 20 30 40 50 60
130 140 150 160 170 180
pF1KE1 GPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLG
.: .:: . :. :.. :. :. .. :. .. :. .::.:.: :... ::
NP_000 SPPGVCSRDPTPEQTHRLARAMMAFTADLF-SLVAQTSTCPNLILSPLSVALALSHLALG
70 80 90 100 110 120
190 200 210 220 230 240
pF1KE1 AGENTKTNLESILSYPKDFTCVHQAL----KGFTTKGVTSVSQIFHSPDLAIRDTFVNAS
: ..: :...: . . :. . : . . . ..... . . :.. :.. :
NP_000 AQNHTLQRLQQVL-HAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQS
130 140 150 160 170 180
250 260 270 280 290 300
pF1KE1 RTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK
. :....: :..... .: :: :: . :..::...:..:: :: :.:::::.... :.
NP_000 EQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWR
190 200 210 220 230 240
310 320 330 340 350
pF1KE1 TTFDPKKTRMEPFHFKNS-VIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILV
. :::. :. . ::. .. .. : ::... ::. :. . . .:... ...:.:.:.::
NP_000 NKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLV
250 260 270 280 290 300
360 370 380 390 400 410
pF1KE1 PQNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFF
: : .. :.:. . .. : . :: . ::.. . ..:... . .: .
NP_000 PT---HFEWNVSQVLANLSWDTLHPPLVWER--PTKVRLPKLYLKHQMDLVATLSQLGLQ
310 320 330 340 350
420 430 440 450 460 470
pF1KE1 DFSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVAR-TLLVFEVQQPFL
.. .: :..:. .: ::..:::..:::.:.:::::::..:...: .: : :..:::
NP_000 ELFQAPDLRGISEQ-SLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFL
360 370 380 390 400 410
480 490 500
pF1KE1 FMLWDQQHKFPVFMGRVYDPRA
:..... .:.:.: : .:
NP_000 FFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKL
420 430 440 450 460 470
>>NP_001159392 (OMIM: 262850,613168) alpha-2-antiplasmin (491 aa)
initn: 483 init1: 172 opt: 613 Z-score: 485.4 bits: 99.3 E(85289): 2.7e-20
Smith-Waterman score: 613; 28.5% identity (65.6% similar) in 410 aa overlap (95-498:36-436)
70 80 90 100 110 120
pF1KE1 LPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCP
:. :. . ..: : : . .: .
NP_001 GLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQ-EPGGQTALK
10 20 30 40 50 60
130 140 150 160 170 180
pF1KE1 GPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLG
.: .:: . :. :.. :. :. .. :. .. :. .::.:.: :... ::
NP_001 SPPGVCSRDPTPEQTHRLARAMMAFTADLF-SLVAQTSTCPNLILSPLSVALALSHLALG
70 80 90 100 110 120
190 200 210 220 230 240
pF1KE1 AGENTKTNLESILSYPKDFTCVHQAL----KGFTTKGVTSVSQIFHSPDLAIRDTFVNAS
: ..: :...: . . :. . : . . . ..... . . :.. :.. :
NP_001 AQNHTLQRLQQVL-HAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQS
130 140 150 160 170 180
250 260 270 280 290 300
pF1KE1 RTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK
. :....: :..... .: :: :: . :..::...:..:: :: :.:::::.... :.
NP_001 EQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWR
190 200 210 220 230 240
310 320 330 340 350
pF1KE1 TTFDPKKTRMEPFHFKNS-VIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILV
. :::. :. . ::. .. .. : ::... ::. :. . . .:... ...:.:.:.::
NP_001 NKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLV
250 260 270 280 290 300
360 370 380 390 400 410
pF1KE1 PQNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFF
: : .. :.:. . .. : . :: . ::.. . ..:... . .: .
NP_001 PT---HFEWNVSQVLANLSWDTLHPPLVWER--PTKVRLPKLYLKHQMDLVATLSQLGLQ
310 320 330 340 350
420 430 440 450 460 470
pF1KE1 DFSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVAR-TLLVFEVQQPFL
.. .: :..:. .: ::..:::..:::.:.:::::::..:...: .: : :..:::
NP_001 ELFQAPDLRGISEQ-SLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFL
360 370 380 390 400 410
480 490 500
pF1KE1 FMLWDQQHKFPVFMGRVYDPRA
:..... .:.:.: : .:
NP_001 FFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKL
420 430 440 450 460 470
>>XP_016880254 (OMIM: 262850,613168) PREDICTED: alpha-2- (495 aa)
initn: 483 init1: 172 opt: 613 Z-score: 485.4 bits: 99.3 E(85289): 2.7e-20
Smith-Waterman score: 613; 28.5% identity (65.6% similar) in 410 aa overlap (95-498:40-440)
70 80 90 100 110 120
pF1KE1 LPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCP
:. :. . ..: : : . .: .
XP_016 GLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQ-EPGGQTALK
10 20 30 40 50 60
130 140 150 160 170 180
pF1KE1 GPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLG
.: .:: . :. :.. :. :. .. :. .. :. .::.:.: :... ::
XP_016 SPPGVCSRDPTPEQTHRLARAMMAFTADLF-SLVAQTSTCPNLILSPLSVALALSHLALG
70 80 90 100 110 120
190 200 210 220 230 240
pF1KE1 AGENTKTNLESILSYPKDFTCVHQAL----KGFTTKGVTSVSQIFHSPDLAIRDTFVNAS
: ..: :...: . . :. . : . . . ..... . . :.. :.. :
XP_016 AQNHTLQRLQQVL-HAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQS
130 140 150 160 170 180
250 260 270 280 290 300
pF1KE1 RTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK
. :....: :..... .: :: :: . :..::...:..:: :: :.:::::.... :.
XP_016 EQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWR
190 200 210 220 230 240
310 320 330 340 350
pF1KE1 TTFDPKKTRMEPFHFKNS-VIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILV
. :::. :. . ::. .. .. : ::... ::. :. . . .:... ...:.:.:.::
XP_016 NKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLV
250 260 270 280 290 300
360 370 380 390 400 410
pF1KE1 PQNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFF
: : .. :.:. . .. : . :: . ::.. . ..:... . .: .
XP_016 PT---HFEWNVSQVLANLSWDTLHPPLVWER--PTKVRLPKLYLKHQMDLVATLSQLGLQ
310 320 330 340 350 360
420 430 440 450 460 470
pF1KE1 DFSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVAR-TLLVFEVQQPFL
.. .: :..:. .: ::..:::..:::.:.:::::::..:...: .: : :..:::
XP_016 ELFQAPDLRGISEQ-SLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFL
370 380 390 400 410 420
480 490 500
pF1KE1 FMLWDQQHKFPVFMGRVYDPRA
:..... .:.:.: : .:
XP_016 FFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKL
430 440 450 460 470 480
>>XP_005256758 (OMIM: 262850,613168) PREDICTED: alpha-2- (507 aa)
initn: 483 init1: 172 opt: 613 Z-score: 485.2 bits: 99.3 E(85289): 2.7e-20
Smith-Waterman score: 613; 28.5% identity (65.6% similar) in 410 aa overlap (95-498:52-452)
70 80 90 100 110 120
pF1KE1 LPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCP
:. :. . ..: : : . .: .
XP_005 GLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQ-EPGGQTALK
30 40 50 60 70 80
130 140 150 160 170 180
pF1KE1 GPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLG
.: .:: . :. :.. :. :. .. :. .. :. .::.:.: :... ::
XP_005 SPPGVCSRDPTPEQTHRLARAMMAFTADLF-SLVAQTSTCPNLILSPLSVALALSHLALG
90 100 110 120 130
190 200 210 220 230 240
pF1KE1 AGENTKTNLESILSYPKDFTCVHQAL----KGFTTKGVTSVSQIFHSPDLAIRDTFVNAS
: ..: :...: . . :. . : . . . ..... . . :.. :.. :
XP_005 AQNHTLQRLQQVL-HAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQS
140 150 160 170 180 190
250 260 270 280 290 300
pF1KE1 RTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK
. :....: :..... .: :: :: . :..::...:..:: :: :.:::::.... :.
XP_005 EQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWR
200 210 220 230 240 250
310 320 330 340 350
pF1KE1 TTFDPKKTRMEPFHFKNS-VIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILV
. :::. :. . ::. .. .. : ::... ::. :. . . .:... ...:.:.:.::
XP_005 NKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLV
260 270 280 290 300 310
360 370 380 390 400 410
pF1KE1 PQNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFF
: : .. :.:. . .. : . :: . ::.. . ..:... . .: .
XP_005 PT---HFEWNVSQVLANLSWDTLHPPLVWER--PTKVRLPKLYLKHQMDLVATLSQLGLQ
320 330 340 350 360 370
420 430 440 450 460 470
pF1KE1 DFSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVAR-TLLVFEVQQPFL
.. .: :..:. .: ::..:::..:::.:.:::::::..:...: .: : :..:::
XP_005 ELFQAPDLRGISEQ-SLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFL
380 390 400 410 420 430
480 490 500
pF1KE1 FMLWDQQHKFPVFMGRVYDPRA
:..... .:.:.: : .:
XP_005 FFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKL
440 450 460 470 480 490
>>NP_001159393 (OMIM: 262850,613168) alpha-2-antiplasmin (427 aa)
initn: 471 init1: 172 opt: 551 Z-score: 438.8 bits: 90.5 E(85289): 1.1e-17
Smith-Waterman score: 551; 30.1% identity (68.7% similar) in 335 aa overlap (170-498:45-372)
140 150 160 170 180 190
pF1KE1 AVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLESILSY
::... .: .:: :: ..: :...: .
NP_001 LQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQVQPGAQNHTLQRLQQVL-H
20 30 40 50 60 70
200 210 220 230 240 250
pF1KE1 PKDFTCVHQAL----KGFTTKGVTSVSQIFHSPDLAIRDTFVNASRTLYSSSPRVLSNNS
. :. . : . . . ..... . . :.. :.. :. :....: :....
NP_001 AGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQSEQLFGAKPVSLTGKQ
80 90 100 110 120 130
260 270 280 290 300 310
pF1KE1 DANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWKTTFDPKKTRMEPFHF
. .: :: :: . :..::...:..:: :: :.:::::.... :.. :::. :. . ::.
NP_001 EDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHL
140 150 160 170 180 190
320 330 340 350 360 370
pF1KE1 KNS-VIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVPQNLKHRLEDMEQAL
.. .. : ::... ::. :. . . .:... ...:.:.:.::: : .. :.:
NP_001 DEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLVP---THFEWNVSQVL
200 210 220 230 240 250
380 390 400 410 420 430
pF1KE1 SPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFDFSYDLNLCGLTEDP
. . .. : . :: . ::.. . ..:... . .: . .. .: :..:.
NP_001 ANLSWDTLHPPLVWER--PTKVRLPKLYLKHQMDLVATLSQLGLQELFQAPDLRGISEQ-
260 270 280 290 300
440 450 460 470 480 490
pF1KE1 DLQVSAMQHQTVLELTETGVEAAAASAISVAR-TLLVFEVQQPFLFMLWDQQHKFPVFMG
.: ::..:::..:::.:.:::::::..:...: .: : :..::::..... .:.:.:
NP_001 SLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIFEDTTGLPLFVG
310 320 330 340 350 360
500
pF1KE1 RVYDPRA
: .:
NP_001 SVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPMEEDYPQFGSPK
370 380 390 400 410 420
>>NP_002606 (OMIM: 172860,613982) pigment epithelium-der (418 aa)
initn: 416 init1: 194 opt: 510 Z-score: 407.5 bits: 84.7 E(85289): 5.8e-16
Smith-Waterman score: 510; 25.2% identity (63.6% similar) in 404 aa overlap (106-499:18-416)
80 90 100 110 120 130
pF1KE1 TKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCPGPVTLCSDLES
. : :.. : . . : .. :
NP_002 MQALVLLLCIGALLGHSSCQNPASPPEEGSPDPDSTGALVEEEDPFF
10 20 30 40
140 150 160 170 180 190
pF1KE1 HSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLES
. :. :. .:. ::.. :. . . ::. .::.:.:. :. . ::: . :.. ..
NP_002 KVPVNKLAAAVSNFGYDLYRVRSSTSPT-TNVLLSPLSVATALSALSLGAEQRTESIIHR
50 60 70 80 90 100
200 210 220 230 240
pF1KE1 ILSYP----KDFTCVHQALKGFTT---KGVTSVSQIFHSPDLAIRDTFVNASRTLYSSSP
: : :. ... : .: :.. :.:.: : :...:: . :.. :
NP_002 ALYYDLISSPDIHGTYKELLDTVTAPQKNLKSASRIVFEKKLRIKSSFVAPLEKSYGTRP
110 120 130 140 150 160
250 260 270 280 290 300
pF1KE1 RVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWKTTFDPKKT
:::..: .:. ::.:: . ..:..: .:.. ..::.. .....: : :: .::
NP_002 RVLTGNPRLDLQEINNWVQAQMKGKLARSTKEIPDEISILLLGVAHFKGQWVTKFDSRKT
170 180 190 200 210 220
310 320 330 340 350 360
pF1KE1 RMEPFHF-KNSVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVPQNLKHRL
.: :.. .. ...::::.. : . . .:. :. :..:: :. ..:.....: .. . :
NP_002 SLEDFYLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGSMSIIFFLPLKVTQNL
230 240 250 260 270 280
370 380 390 400 410 420
pF1KE1 EDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFDFSYDLNL
.:..:. : : ... :.. : ..::.:..:.. .. . ...... .. . ..
NP_002 TLIEESLT-SEFIHDIDR-ELKTVQ-AVLTVPKLKLSYEGEVTKSLQEMKLQSLFDSPDF
290 300 310 320 330 340
430 440 450 460 470 480
pF1KE1 CGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVARTL--LVFEVQQPFLFMLWDQQ
.: : .... ..:.. .: .: :. .. . ... :. : ....:::.:.: : .
NP_002 SKITGKP-IKLTQVEHRAGFEWNEDGAGTTPSPGLQPAHLTFPLDYHLNQPFIFVLRDTD
350 360 370 380 390 400
490 500
pF1KE1 HKFPVFMGRVYDPRA
.:.:.. :::
NP_002 TGALLFIGKILDPRGP
410
>>NP_001316832 (OMIM: 172860,613982) pigment epithelium- (418 aa)
initn: 416 init1: 194 opt: 510 Z-score: 407.5 bits: 84.7 E(85289): 5.8e-16
Smith-Waterman score: 510; 25.2% identity (63.6% similar) in 404 aa overlap (106-499:18-416)
80 90 100 110 120 130
pF1KE1 TKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCPGPVTLCSDLES
. : :.. : . . : .. :
NP_001 MQALVLLLCIGALLGHSSCQNPASPPEEGSPDPDSTGALVEEEDPFF
10 20 30 40
140 150 160 170 180 190
pF1KE1 HSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLES
. :. :. .:. ::.. :. . . ::. .::.:.:. :. . ::: . :.. ..
NP_001 KVPVNKLAAAVSNFGYDLYRVRSSTSPT-TNVLLSPLSVATALSALSLGAEQRTESIIHR
50 60 70 80 90 100
200 210 220 230 240
pF1KE1 ILSYP----KDFTCVHQALKGFTT---KGVTSVSQIFHSPDLAIRDTFVNASRTLYSSSP
: : :. ... : .: :.. :.:.: : :...:: . :.. :
NP_001 ALYYDLISSPDIHGTYKELLDTVTAPQKNLKSASRIVFEKKLRIKSSFVAPLEKSYGTRP
110 120 130 140 150 160
250 260 270 280 290 300
pF1KE1 RVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWKTTFDPKKT
:::..: .:. ::.:: . ..:..: .:.. ..::.. .....: : :: .::
NP_001 RVLTGNPRLDLQEINNWVQAQMKGKLARSTKEIPDEISILLLGVAHFKGQWVTKFDSRKT
170 180 190 200 210 220
310 320 330 340 350 360
pF1KE1 RMEPFHF-KNSVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVPQNLKHRL
.: :.. .. ...::::.. : . . .:. :. :..:: :. ..:.....: .. . :
NP_001 SLEDFYLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGSMSIIFFLPLKVTQNL
230 240 250 260 270 280
370 380 390 400 410 420
pF1KE1 EDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFDFSYDLNL
.:..:. : : ... :.. : ..::.:..:.. .. . ...... .. . ..
NP_001 TLIEESLT-SEFIHDIDR-ELKTVQ-AVLTVPKLKLSYEGEVTKSLQEMKLQSLFDSPDF
290 300 310 320 330 340
430 440 450 460 470 480
pF1KE1 CGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVARTL--LVFEVQQPFLFMLWDQQ
.: : .... ..:.. .: .: :. .. . ... :. : ....:::.:.: : .
NP_001 SKITGKP-IKLTQVEHRAGFEWNEDGAGTTPSPGLQPAHLTFPLDYHLNQPFIFVLRDTD
350 360 370 380 390 400
490 500
pF1KE1 HKFPVFMGRVYDPRA
.:.:.. :::
NP_001 TGALLFIGKILDPRGP
410
>>NP_001076 (OMIM: 107280) alpha-1-antichymotrypsin prec (423 aa)
initn: 345 init1: 155 opt: 437 Z-score: 351.6 bits: 74.3 E(85289): 7.6e-13
Smith-Waterman score: 500; 28.4% identity (63.8% similar) in 412 aa overlap (122-499:17-421)
100 110 120 130 140
pF1KE1 TEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCPG-------PV---TLCSDLESHSTEAV
:::. :. .: .. ....:..
NP_001 MERMLPLLALGLLAAGFCPAVLCHPNSPLDEENLTQENQDRGTHVD
10 20 30 40
150 160 170 180 190
pF1KE1 LG--DALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLESILSY
:: .: :::...::. . ..: . :. :::.::.. :. . ::: ..: :.. . :..
NP_001 LGLASANVDFAFSLYKQL-VLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKF
50 60 70 80 90 100
200 210 220 230 240
pF1KE1 PKDFTC---VHQALKGFTTKGVTSVSQI--------FHSPDLAIRDTFVNASRTLYSSSP
: .::... . : ... : . .:.. : :.. .. ::.:
NP_001 NLTETSEAEIHQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEA
110 120 130 140 150 160
250 260 270 280 290 300
pF1KE1 RVLS-NNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWKTTFDPKK
. . ..: : .::: .: ..: .::. :. .: :.: .::.: :...:::. :::.
NP_001 FATDFQDSAAAKKLINDYVKNGTRGKITDLIKDLDSQTMMVLVNYIFFKAKWEMPFDPQD
170 180 190 200 210 220
310 320 330 340 350 360
pF1KE1 TRMEPFHF-KNSVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVPQNLKHR
:.. :.. :.. . ::::. .. . .: :. :. : .:. . : : ....:. . .
NP_001 THQSRFYLSKKKWVMVPMMSLHHLTIPYFRDEELSCTVVELKYTGNASALFILPD--QDK
230 240 250 260 270 280
370 380 390 400 410 420
pF1KE1 LEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFD-FSYDL
.:..: : : ..: ..::. .. : ::..... . .. .:. .: . . :.
NP_001 MEEVEAMLLPETLKRWRDSLEFREIGE--LYLPKFSISRDYNLNDILLQLGIEEAFTSKA
290 300 310 320 330 340
430 440 450 460 470
pF1KE1 NLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVA------RTLLVFEVQQPFLF
.: :.: .: :: . :..::.. : :.::.::.:.... .: . . ..:::.
NP_001 DLSGITGARNLAVSQVVHKAVLDVFEEGTEASAATAVKITLLSALVETRTIVRFNRPFLM
350 360 370 380 390 400
480 490 500
pF1KE1 MLW--DQQHKFPVFMGRVYDPRA
.. : :. : ::..: .:.
NP_001 IIVPTDTQNIF--FMSKVTNPKQA
410 420
500 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 21:16:52 2016 done: Sun Nov 6 21:16:53 2016
Total Scan time: 10.060 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]