Result of FASTA (omim) for
pFN21AE1372
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1372, 578 aa
1>>>pF1KE1372 578 - 578 aa - 578 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.3349+/-0.00037; mu= 9.9207+/- 0.023
mean_var=144.2379+/-29.268, 0's: 0 Z-trim(118.0): 12 B-trim: 1573 in 1/54
Lambda= 0.106791
statistics sampled from 30566 (30578) to 30566 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.713), E-opt: 0.2 (0.359), width: 16
Scan time: 11.610
The best scores are: opt bits E(85289)
NP_001549 (OMIM: 146933,613148) interleukin-10 rec ( 578) 3896 612.2 1.5e-174
NP_055247 (OMIM: 605620) interleukin-20 receptor s ( 553) 250 50.5 1.8e-05
XP_016866443 (OMIM: 605620) PREDICTED: interleukin ( 554) 236 48.3 7.9e-05
NP_851826 (OMIM: 606648) interleukin-22 receptor s ( 231) 222 45.9 0.00018
NP_851827 (OMIM: 606648) interleukin-22 receptor s ( 130) 188 40.4 0.0043
>>NP_001549 (OMIM: 146933,613148) interleukin-10 recepto (578 aa)
initn: 3896 init1: 3896 opt: 3896 Z-score: 3254.9 bits: 612.2 E(85289): 1.5e-174
Smith-Waterman score: 3896; 99.8% identity (99.8% similar) in 578 aa overlap (1-578:1-578)
10 20 30 40 50 60
pF1KE1 MLPCLVVLLAALLSLRLGSDAHGTELPSPPSVWFEAEFFHHILHWTPIPNQSESTCYEVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLPCLVVLLAALLSLRLGSDAHGTELPSPPSVWFEAEFFHHILHWTPIPNQSESTCYEVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LLRYGIESWNSISNCSQTLSYDLTAVTLDLYHSNGYRARVRAVDGSRHSNWTVTNTRFSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLRYGIESWNSISNCSQTLSYDLTAVTLDLYHSNGYRARVRAVDGSRHSNWTVTNTRFSV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 DEVTLTVGSVNLEIHNGFILGKIQLPRPKMAPANDTYESIFSHFREYEIAIRKVPGNFTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DEVTLTVGSVNLEIHNGFILGKIQLPRPKMAPANDTYESIFSHFREYEIAIRKVPGNFTF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 THKKVKHENFSLLTSGEVGEFCVQVKPSVASRSNKGMWSKEECISLTRQYFTVTNVIIFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 THKKVKHENFSLLTSGEVGEFCVQVKPSVASRSNKGMWSKEECISLTRQYFTVTNVIIFF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 AFVLLLSGALAYCLALQLYVRRRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFVLLLSGALAYCLALQLYVRRRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 FLKVSPELKNLDLHGSTDSGFGSTKPSLQTEEPQFLLPDPHPQADRTLGNGEPPVLGDSC
:::::::::::::::::::::::::::::::::::::::::::::::::: :::::::::
NP_001 FLKVSPELKNLDLHGSTDSGFGSTKPSLQTEEPQFLLPDPHPQADRTLGNREPPVLGDSC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 SSGSSNSTDSGICLQEPSLSPSTGPTWEQQVGSNSRGQDDSGIDLVQNSEGRAGDTQGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSGSSNSTDSGICLQEPSLSPSTGPTWEQQVGSNSRGQDDSGIDLVQNSEGRAGDTQGGS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 ALGHHSPPEPEVPGEEDPAAVAFQGYLRQTRCAEEKATKTGCLEEESPLTDGLGPKFGRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALGHHSPPEPEVPGEEDPAAVAFQGYLRQTRCAEEKATKTGCLEEESPLTDGLGPKFGRC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 LVDEAGLHPPALAKGYLKQDPLEMTLASSGAPTGQWNQPTEEWSLLALSSCSDLGISDWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVDEAGLHPPALAKGYLKQDPLEMTLASSGAPTGQWNQPTEEWSLLALSSCSDLGISDWS
490 500 510 520 530 540
550 560 570
pF1KE1 FAHDLAPLGCVAAPGGLLGSFNSDLVTLPLISSLQSSE
::::::::::::::::::::::::::::::::::::::
NP_001 FAHDLAPLGCVAAPGGLLGSFNSDLVTLPLISSLQSSE
550 560 570
>>NP_055247 (OMIM: 605620) interleukin-20 receptor subun (553 aa)
initn: 124 init1: 65 opt: 250 Z-score: 219.3 bits: 50.5 E(85289): 1.8e-05
Smith-Waterman score: 256; 23.6% identity (53.8% similar) in 559 aa overlap (3-525:16-547)
10 20 30 40
pF1KE1 MLPCLVVLLAALLSLRLGSDAHGTELPSPPSVWFEAEFFHHILHWTP
: :..:::: . . . : ::.: .. : . ....:.:::
NP_055 MRAPGRPALRPLPLPPLLLLLLAAPWGRAVPCVSGG--LPKPANITFLSINMKNVLQWTP
10 20 30 40 50
50 60 70 80 90 100
pF1KE1 IPN--QSESTCYEVALLRYGIESWNSISNCSQ-TLSY-DLTAVTLDLYHSNGYRARVRAV
:. :. .. : : . :: ..: . :.: . . .: ::.: : : :. : :.:.:.
NP_055 -PEGLQGVKVTYTVQYFIYGQKKWLNKSECRNINRTYCDLSAETSDYEHQ--YYAKVKAI
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE1 DGSRHSNWTVTNTRFSVDEVTLTVGSVNLEIHNGFILGKIQLPRP-KMAPAND--TYESI
:.. :.:. .. . :. . : : . : . :. : : . ....:
NP_055 WGTKCSKWAESGRFYPFLETQIGPPEVALTTDEKSISVVLTAPEKWKRNPEDLPVSMQQI
120 130 140 150 160 170
170 180 190 200 210
pF1KE1 FSHFREYEIAIRKVPGNFTFTHKKVKHENFSLLTSGEVGE-FCVQVKPSVASRSNKGMWS
.:... :.... .. .: :... ..: .:: : . .::.:. : . ... :
NP_055 YSNLK-YNVSVLNTKSNRTWSQCVTNHT--LVLTWLEPNTLYCVHVESFVPGPPRRAQPS
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE1 KEECISLTRQYFTVTNVIIFFAFVLLLS------GALAYCLALQLYVRRRKKLPSVLLFK
...: .. . .. :.: .:: .: ....: . ..: ..:. :. :..
NP_055 EKQCARTLKDQSSEFKAKIIFWYVLPISITVFLFSVMGYSIYRYIHVGKEKH-PANLILI
240 250 260 270 280 290
280 290 300 310 320
pF1KE1 KPSPF---IFISQRPSPETQDTIHPLDEEAFLKVSPELKNLDLHGSTD-SGFGSTKPSLQ
. : .:. :. . .. :. :.: . .: : :.: :.... .:: .
NP_055 YGNEFDKRFFV---PAEKIVINFITLNISDDSKISHQDMSL-LGKSSDVSSLNDPQPSGN
300 310 320 330 340
330 340 350 360 370 380
pF1KE1 TEEPQFLLPDPHPQADRTLGNGEPPVLGDSCSSGSSNSTDSGICLQEPSLSPSTGPT---
. :: . . . :: . .. :.: :. ... :: ::: . :
NP_055 LRPPQ------EEEEVKHLGYASH-LMEIFCDS-EENTEGTSLTQQE-SLSRTIPPDKTV
350 360 370 380 390
390 400 410 420 430
pF1KE1 --WEQQVGSNS--RGQDDSGIDLVQ--NSEGRAGDTQGGSA-LGHHSPPEPEVPGEEDPA
.: .: ... : ... ..: . ...: ..:.. : :: .. .: .:
NP_055 IEYEYDVRTTDICAGPEEQELSLQEEVSTQGTLLESQAALAVLGPQTLQYSYTPQLQDLD
400 410 420 430 440 450
440 450 460 470 480 490
pF1KE1 AVAFQGYLRQTRCAEEKATKTGCLEEESPLTDGLG-PKFGRCLVDEAGLHPPALAKGYLK
.: : . . . ::. . : : . .: : : :... : : .: . . : :
NP_055 PLA-QEHTDSEEGPEEEPSTT--LVDWDPQTGRLCIPSLSSFDQDSEGCEP-SEGDG-LG
460 470 480 490 500 510
500 510 520 530 540 550
pF1KE1 QDPLEMTLASSGAPT---GQWN----QPTEEWSLLALSSCSDLGISDWSFAHDLAPLGCV
.. : : :: :. . : :::.:
NP_055 EEGLLSRLYEEPAPDRPPGENETYLMQFMEEWGLYVQMEN
520 530 540 550
560 570
pF1KE1 AAPGGLLGSFNSDLVTLPLISSLQSSE
>>XP_016866443 (OMIM: 605620) PREDICTED: interleukin-20 (554 aa)
initn: 124 init1: 65 opt: 236 Z-score: 207.7 bits: 48.3 E(85289): 7.9e-05
Smith-Waterman score: 258; 23.8% identity (54.1% similar) in 560 aa overlap (3-525:16-548)
10 20 30 40
pF1KE1 MLPCLVVLLAALLSLRLGSDAHGTELPSPPSVWFEAEFFHHILHWTP
: :..:::: . . . : ::.: .. : . ....:.:::
XP_016 MRAPGRPALRPLPLPPLLLLLLAAPWGRAVPCVSGG--LPKPANITFLSINMKNVLQWTP
10 20 30 40 50
50 60 70 80 90 100
pF1KE1 IPN--QSESTCYEVA-LLRYGIESWNSISNCSQ-TLSY-DLTAVTLDLYHSNGYRARVRA
:. :. .. : : ..::: ..: . :.: . . .: ::.: : : :. : :.:.:
XP_016 -PEGLQGVKVTYTVQYFIRYGQKKWLNKSECRNINRTYCDLSAETSDYEHQ--YYAKVKA
60 70 80 90 100 110
110 120 130 140 150
pF1KE1 VDGSRHSNWTVTNTRFSVDEVTLTVGSVNLEIHNGFILGKIQLPRP-KMAPAND--TYES
. :.. :.:. .. . :. . : : . : . :. : : . ....
XP_016 IWGTKCSKWAESGRFYPFLETQIGPPEVALTTDEKSISVVLTAPEKWKRNPEDLPVSMQQ
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE1 IFSHFREYEIAIRKVPGNFTFTHKKVKHENFSLLTSGEVGE-FCVQVKPSVASRSNKGMW
:.:... :.... .. .: :... ..: .:: : . .::.:. : . ...
XP_016 IYSNLK-YNVSVLNTKSNRTWSQCVTNHT--LVLTWLEPNTLYCVHVESFVPGPPRRAQP
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE1 SKEECISLTRQYFTVTNVIIFFAFVL------LLSGALAYCLALQLYVRRRKKLPSVLLF
:...: .. . .. :.: .:: .: ....: . ..: ..:. :. :..
XP_016 SEKQCARTLKDQSSEFKAKIIFWYVLPVSITVFLFSVMGYSIYRYIHVGKEKH-PANLIL
240 250 260 270 280 290
280 290 300 310 320
pF1KE1 KKPSPF---IFISQRPSPETQDTIHPLDEEAFLKVSPELKNLDLHGSTD-SGFGSTKPSL
. : .:. :. . .. :. :.: . .: : :.: :.... .::
XP_016 IYGNEFDKRFFV---PAEKIVINFITLNISDDSKISHQDMSL-LGKSSDVSSLNDPQPSG
300 310 320 330 340
330 340 350 360 370 380
pF1KE1 QTEEPQFLLPDPHPQADRTLGNGEPPVLGDSCSSGSSNSTDSGICLQEPSLSPSTGPT--
. . :: . . . :: . .. :.: :. ... :: ::: . :
XP_016 NLRPPQ------EEEEVKHLGYASH-LMEIFCDS-EENTEGTSLTQQE-SLSRTIPPDKT
350 360 370 380 390
390 400 410 420 430
pF1KE1 ---WEQQVGSNS--RGQDDSGIDLVQ--NSEGRAGDTQGGSA-LGHHSPPEPEVPGEEDP
.: .: ... : ... ..: . ...: ..:.. : :: .. .: .:
XP_016 VIEYEYDVRTTDICAGPEEQELSLQEEVSTQGTLLESQAALAVLGPQTLQYSYTPQLQDL
400 410 420 430 440 450
440 450 460 470 480 490
pF1KE1 AAVAFQGYLRQTRCAEEKATKTGCLEEESPLTDGLG-PKFGRCLVDEAGLHPPALAKGYL
.: : . . . ::. . : : . .: : : :... : : .: . . : :
XP_016 DPLA-QEHTDSEEGPEEEPSTT--LVDWDPQTGRLCIPSLSSFDQDSEGCEP-SEGDG-L
460 470 480 490 500 510
500 510 520 530 540 550
pF1KE1 KQDPLEMTLASSGAPT---GQWN----QPTEEWSLLALSSCSDLGISDWSFAHDLAPLGC
.. : : :: :. . : :::.:
XP_016 GEEGLLSRLYEEPAPDRPPGENETYLMQFMEEWGLYVQMEN
520 530 540 550
560 570
pF1KE1 VAAPGGLLGSFNSDLVTLPLISSLQSSE
>>NP_851826 (OMIM: 606648) interleukin-22 receptor subun (231 aa)
initn: 98 init1: 54 opt: 222 Z-score: 201.3 bits: 45.9 E(85289): 0.00018
Smith-Waterman score: 222; 26.2% identity (55.7% similar) in 244 aa overlap (1-226:1-230)
10 20 30 40 50
pF1KE1 MLP--CLVVLLAALLSLRLGSDAHGTELPSPPSVWFEAEFFHHILHWTPIPNQS-ESTCY
:.: :.. .: ... ... : .: : :... ::.::.: : . .:. :
NP_851 MMPKHCFLGFLISFFLTGVAGTQSTHESLKPQRVQFQSRNFHNILQWQPGRALTGNSSVY
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 EVALLRYGIESWNSISNC--SQTLSYDLTAVTLDLYHSNGYRARVRAVDGSRHSNWTVTN
: :: ..:.. .: .: :: :::. : :. . : .::::.... .:.:..:
NP_851 FVQYKIYGQRQWKNKEDCWGTQELSCDLTSETSDIQEP--YYGRVRAASAGSYSEWSMT-
70 80 90 100 110
120 130 140 150 160
pF1KE1 TRFS------VDEVTLTVGSVNLEIHNGFILGKIQLP----RPKMAPANDTYESIFSHFR
::. .: .... .:: . :: .:: . : . .: :: .. :
NP_851 PRFTPWWETKIDPPVMNITQVNGSLL--VILHAPNLPYRYQKEKNVSIEDYYELLYRVFI
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE1 EYEIAIRKVPGNFTFTHKKVKHENFSLLTSGEVGEFCVQV---KPSVASRSNKGMWSKEE
. ...: . .:. :. : .. .: .:: . .: . ::.. :.:.
NP_851 -INNSLEKEQKVYEGAHRAVEIEALTPHSS-----YCVVAEIYQPMLDRRSQR---SEER
180 190 200 210 220
230 240 250 260 270 280
pF1KE1 CISLTRQYFTVTNVIIFFAFVLLLSGALAYCLALQLYVRRRKKLPSVLLFKKPSPFIFIS
:. .
NP_851 CVEIP
230
>>NP_851827 (OMIM: 606648) interleukin-22 receptor subun (130 aa)
initn: 114 init1: 54 opt: 188 Z-score: 176.5 bits: 40.4 E(85289): 0.0043
Smith-Waterman score: 188; 31.5% identity (62.9% similar) in 124 aa overlap (1-119:1-121)
10 20 30 40 50
pF1KE1 MLP--CLVVLLAALLSLRLGSDAHGTELPSPPSVWFEAEFFHHILHWTPIPNQS-ESTCY
:.: :.. .: ... ... : .: : :... ::.::.: : . .:. :
NP_851 MMPKHCFLGFLISFFLTGVAGTQSTHESLKPQRVQFQSRNFHNILQWQPGRALTGNSSVY
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 EVALLRYGIESWNSISNC--SQTLSYDLTAVTLDLYHSNGYRARVRAVDGSRHSNWTVTN
: :: ..:.. .: .: :: :::. : :. .. : .::::.... .:.:..:
NP_851 FVQYKIYGQRQWKNKEDCWGTQELSCDLTSETSDI--QEPYYGRVRAASAGSYSEWSMT-
70 80 90 100 110
120 130 140 150 160 170
pF1KE1 TRFSVDEVTLTVGSVNLEIHNGFILGKIQLPRPKMAPANDTYESIFSHFREYEIAIRKVP
::.
NP_851 PRFTPWWERAKGL
120 130
578 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 00:21:19 2016 done: Mon Nov 7 00:21:21 2016
Total Scan time: 11.610 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]